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Protein

DNA ligase

Gene

AN6069.2

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:AN6069.2Imported
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)Imported
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006948.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5B061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPKEGKQA TLGYVKDRQS TLGRFFGSNT NAPKKQTILS FGGNRSKSTS
60 70 80 90 100
ASRPNREPSS LNGNTKNASA VTRGDDVNTG DAFEVKPEMR AGADQNPLKR
110 120 130 140 150
DKSEDVSDSD ESEKVQPSNK RRRKSSGKTP AKPQIDSSPE STKGRKSQVK
160 170 180 190 200
EPTPEIVVKA SGEETPEDPD VSEAEEEGLS ASEDETDKKP ELKKKEIEKV
210 220 230 240 250
QATIKGSGND PYPDWQPGEP VPYAALCTTF SLIEMTTKRL QILAHCSLFL
260 270 280 290 300
RQVLRLTPQD FLPTVQLMIN KLAADYAGIE LGIGESLIMK AIGESTGRSL
310 320 330 340 350
AVIKADQHEI GDLGLVAAKS RSNQPTMFKP KALTVRGVHE GLLNIAKVQG
360 370 380 390 400
HGAQDKKISG IKKLLSAADA ATTGKGSKGI DITKNKGGPS EAKYIVRFLE
410 420 430 440 450
GKLRLGLAEK TVLVALAQAV VSHEAALKGK KAPSAEELAE GEAILKTVYS
460 470 480 490 500
ELPAYEVIIP ALLEHGLSNL REHCKLQPGI PIKPMLAKPT KSITEVLDRF
510 520 530 540 550
EGKDFTCEYK YDGERAQIHY VAPDETKNYP GAQLTLKESA GLSAIFSRNS
560 570 580 590 600
EDLSKKYPDV LAKLSTWIKP GVKSFVLDCE TVAWDVEAKK VLPFQQLMTR
610 620 630 640 650
KRKDVKAEDV KVKVCVFAFD LLFLNGEPTV KKPLRQRRDL LHSSFQPIEG
660 670 680 690 700
EFQFAQYGNT NDLEQIQTLL DDSVKASCEG LMVKMLDTEE SGYEPSKRSR
710 720 730 740 750
NWLKVKKDYL AGVGDSLDLL VLGAYYGRGK RTSVYGAFLL AAYNSNSQTY
760 770 780 790 800
ETICNIGTGF SEAMLDELHT TLSPLVIDRP KPFYSHSTVP KDQPDVWLEP
810 820 830 840 850
RYVWEVKTAD LTLSPRYKAA ADEFVGTTGG GGKGVSLRFP RFIKVRDDKK
860 870 880
PEQATTTRAV AEMYRKQEAV AKEGSGKGGV DDDFEY
Length:886
Mass (Da):97,263
Last modified:April 26, 2005 - v1
Checksum:iECFC100F297606E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000104 Genomic DNA. Translation: EAA58044.1.
RefSeqiXP_663673.1. XM_658581.1.

Genome annotation databases

GeneIDi2871154.
KEGGiani:AN6069.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000104 Genomic DNA. Translation: EAA58044.1.
RefSeqiXP_663673.1. XM_658581.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00006948.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2871154.
KEGGiani:AN6069.2.

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139Imported.

Entry informationi

Entry nameiQ5B061_EMENI
AccessioniPrimary (citable) accession number: Q5B061
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 29, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.