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Protein

Acetylxylan esterase A

Gene

axeA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone.1 Publication

Caution

The C-terminal carbohydrate-binding module (CBM) extension found in some acetylxylan esterases from other species is absent.Curated

Catalytic activityi

Deacetylation of xylans and xylo-oligosaccharides.

pH dependencei

Optimum pH is 7.5.1 Publication

Temperature dependencei

Optimum temperature is 49 degrees Celsius.1 Publication

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei147Charge relay systemBy similarity1

GO - Molecular functioni

  • acetylxylan esterase activity Source: UniProtKB

GO - Biological processi

  • cellulose catabolic process Source: UniProtKB-KW
  • xylan catabolic process Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00114

Protein family/group databases

ESTHERiemeni-axe1 Esterase_phb
mycoCLAPiAXE1A_EMENI

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylxylan esterase A (EC:3.1.1.72)
Gene namesi
Name:axeA
Synonyms:aceA
ORF Names:AN6093
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome I
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039348220 – 304Acetylxylan esterase AAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00006921

Structurei

3D structure databases

ProteinModelPortaliQ5B037
SMRiQ5B037
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000171266
InParanoidiQ5B037
KOiK05972
OrthoDBiEOG092C3RN6

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR010126 Esterase_phb
PfamiView protein in Pfam
PF10503 Esterase_phd, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits
TIGRFAMsiTIGR01840 esterase_phb, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5B037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLQYLLSI LLYAYSCTAL MLDRRDPTPG QLSQVTDFGD NPTNVGFYIY
60 70 80 90 100
VPQNLASNPA IIVAIHYCTG TAQAYYSGTP YAQYAETYGF IVIYPESPYS
110 120 130 140 150
GTCWDVSSQS TLTHNGGGNS NSIANMVDWT INQYNADASR VYVTGTSSGA
160 170 180 190 200
MMTNVMAATY PNLFAAGIAY AGVPAGCFYS EANVEDQWNS TCAQGQSIST
210 220 230 240 250
PEHWAQIAQA MYSGYEGSRP KMQIYHGSAD ATLYPQNYYE TCKQWAGVFG
260 270 280 290 300
YNYDSPQEVQ NDTPVAGWAK TIWGENLQGI LADGVGHNIQ IQGEEDLKWF

GFTS
Length:304
Mass (Da):33,302
Last modified:April 20, 2010 - v2
Checksum:i6573784DF0261190
GO

Sequence cautioni

The sequence CBF70198 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA58068 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ490499 mRNA Translation: ABF50875.1
AACD01000104 Genomic DNA Translation: EAA58068.1 Sequence problems.
BN001301 Genomic DNA Translation: CBF70198.1 Sequence problems.
RefSeqiXP_663697.1, XM_658605.1

Genome annotation databases

EnsemblFungiiCADANIAT00006921; CADANIAP00006921; CADANIAG00006921
EAA58068; EAA58068; AN6093.2
GeneIDi2870922
KEGGiani:AN6093.2

Similar proteinsi

Entry informationi

Entry nameiAXE1_EMENI
AccessioniPrimary (citable) accession number: Q5B037
Secondary accession number(s): C8V2L3, Q1HFS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health