ID   HAT1_EMENI              Reviewed;         496 AA.
AC   Q5AZR6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Histone acetyltransferase type B catalytic subunit;
DE            EC=2.3.1.48;
GN   Name=hat1; ORFNames=AN6214;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC 4;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
CC   -!- FUNCTION: Catalytic component of the histone acetylase B (HAT-B)
CC       complex. Acetylates 'Lys-12' of histone H4 which is required for
CC       telomeric silencing. Has intrinsic substrate specificity that
CC       modifies lysine in recognition sequence GXGKXG. Involved in DNA
CC       double-strand break repair (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + histone = CoA + acetylhistone.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least hat1
CC       and hat2. The HAT-B complex binds to histone H4 tail (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the HAT1 family.
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DR   EMBL; AACD01000105; EAA58000.1; -; Genomic_DNA.
DR   RefSeq; XP_663818.1; -.
DR   GeneID; 2870802; -.
DR   KEGG; ani:AN6214.2; -.
DR   BRENDA; 2.3.1.48; 3859.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:EC.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0006348; P:chromatin silencing at telomere; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR019467; Hat1_N.
DR   InterPro; IPR017380; Hist_AcTrfase_B-typ_cat-su.
DR   Gene3D; G3DSA:3.40.630.30; Acyl_CoA_acyltransferase; 1.
DR   Pfam; PF10394; Hat1_N; 1.
DR   PIRSF; PIRSF038084; HAT-B_cat; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Chromatin regulator; Cytoplasm; DNA damage;
KW   DNA repair; Nucleus; Transferase.
FT   CHAIN         1    496       Histone acetyltransferase type B
FT                                catalytic subunit.
FT                                /FTId=PRO_0000227722.
SQ   SEQUENCE   496 AA;  57779 MW;  92441200489692C4 CRC64;
     MSAEGEWSCD ANDAVQITIV HPDQQKPKTL SSFHPQFTYP IFGEEERIFG YKGLIIRLRF
     AAHNLRPHVH VSYDEKFTAV DDAEPVDIIG ALKEFLPEEA FSSLPEFESA VQEEDAKEFV
     PPGKLSHSYS IRGRNYEIWA ASLADPQVQL LLNRFQIMVS FYIEAGTPLS TDDPEWTLDR
     WTVYFVLTAA RYEKVEPPTP TASSYSIVGY ATTYRWWFYK RDRSENPMPR DGPFPPPELV
     RPGELPSRLR IAQFLILPPH QGTGHGVNLY NTIHKTCLDD PTIMELTVED PNESFDVLRD
     SADYHILRPE FLKHNIQINP DPWSDFSKKT KRVPTSSLLP LKTLNEIRTA YKIEPTQFAH
     IQEMFLLGQI PLKNRRKGGA NMARLLVKKY RDDDPNNRRY YWWRMLTKQR LYKRSRDVLI
     QLKMSERHKA LEDTVTNVED GYEQLFGFFN EREERLRAQQ EEAETSNNRD QRTKRKFTVE
     DEDDEDESAA AKRPKA
//