Reviewed,
UniProtKB/Swiss-Prot Q5AZR6 (HAT1_EMENI)
Last modified
February 9, 2010.
Version 29.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase type B catalytic subunit EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Emericella nidulans (Aspergillus nidulans) [Complete proteome] | ||||
| Taxonomic identifier | 162425 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella |
Protein attributes
| Sequence length | 496 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity. |
| Catalytic activity | Acetyl-CoA + [histone] = CoA + acetyl-[histone]. |
| Subunit structure | Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the HAT1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair |
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Acyltransferase Chromatin regulator Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin silencing at telomereInferred from electronic annotation. Source: InterPro histone acetylationInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | histone acetyltransferase activity Inferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 496 | 496 | Histone acetyltransferase type B catalytic subunit | PRO_0000227722 | |||
Sequences
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References
| [1] | "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. Birren B.W.Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / M139. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AACD01000105 Genomic DNA. Translation: EAA58000.1. |
| RefSeq | XP_663818.1. |
3D structure databases | |
| SMR | Q5AZR6. Positions 5-369. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2870802. |
| KEGG | ani:AN6214.2. |
Phylogenomic databases | |
| PhylomeDB | Q5AZR6. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.48. 3859. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. |
| Pfam | PF10394. Hat1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF038084. HAT-B_cat. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HAT1_EMENI | ||||||||
| Accession | Primary (citable) accession number: Q5AZR6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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