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Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei619Charge relay systemBy similarity1
Active sitei696Charge relay systemBy similarity1
Active sitei731Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERiemeni-q5az42 DPP4N_Peptidase_S9
MEROPSiS09.008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:AN6438
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome I
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000039781319 – 773Probable dipeptidyl peptidase 4Add BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi671N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5AZ42

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006538

Structurei

3D structure databases

ProteinModelPortaliQ5AZ42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189891
InParanoidiQ5AZ42
KOiK01278
OMAiNEFEGYP
OrthoDBiEOG092C0PZJ

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AZ42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSVLSVLL VSVAQAAAAP WRPREPRAAG SKRLTFNETV ISAALSPSSI
60 70 80 90 100
SVQWIATEND GDYVYQEEDG SIKIESIVTN RSQTIVPAEK IPADAYSYWI
110 120 130 140 150
SPDLSAVLWA TNYTKQYRHS FFADYYIQDV ETLETVPLVE DMVGDIQYAE
160 170 180 190 200
WSPSGDSIAF VRGNNLWTWS DGTVTAITKD GGPDMFHGVP DWIYEEEILG
210 220 230 240 250
DRFALWFSPD SELLAFLTFN ETGVPTFTVQ YFMDNQEIAP PYPRELDIRY
260 270 280 290 300
PKVSETNPTV KLNILQLSDN TVSTIPIDVF DPSELIVGEV AWVTDTHTEL
310 320 330 340 350
AVKAFNRVQD ESKVVIVETA SGETKIAHER DGTDGWLDNL LSISYVGPLA
360 370 380 390 400
LGSGDASSAY YVDLSDHSGW THLYLFSTSG GDPIPLTEGE WEVTSIVSID
410 420 430 440 450
QERELVYYLS TQHHSTERHL YSVSYRTFEI TPLVDDTVEA YWSVSFSAKA
460 470 480 490 500
GYYILTYAGP SVPYQELYSV NQTAPLRTLT SNAALIEKLE EYALPNISYF
510 520 530 540 550
ELEIPSGEKL NVMQRLPVGF SPDKKYPVLF TPYGGPGAQE VSKRWQSLDF
560 570 580 590 600
NAYIASDPEL EYVTWTVDNR GTGYRGREFR SLVAKQLGKL EAEDQVYAAK
610 620 630 640 650
QAAKLDWVDS EHIAIWGWSY GGYLTGKVLE TDSGAFSLGL LTAPVSDWRL
660 670 680 690 700
YDSMYTERYM KTLSTNAEGY NTTAIRHTDG FKNVEGGFLI QHGTGDDNVH
710 720 730 740 750
FQNAAALGDT LIGNGVTPEK MQVQWFTDSD HSIRYNGGNV FLYRQLAQRL
760 770
YKEKNRAKKE QHQWSKRSQD WVV
Length:773
Mass (Da):86,855
Last modified:April 26, 2005 - v1
Checksum:iDEEB398491278E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000108 Genomic DNA Translation: EAA58460.1
BN001301 Genomic DNA Translation: CBF69472.1
RefSeqiXP_664042.1, XM_658950.1

Genome annotation databases

EnsemblFungiiCADANIAT00006538; CADANIAP00006538; CADANIAG00006538
EAA58460; EAA58460; AN6438.2
GeneIDi2871333
KEGGiani:AN6438.2

Similar proteinsi

Entry informationi

Entry nameiDPP4_EMENI
AccessioniPrimary (citable) accession number: Q5AZ42
Secondary accession number(s): C8V0E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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