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Q5AZ42

- DPP4_EMENI

UniProt

Q5AZ42 - DPP4_EMENI

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Protein
Probable dipeptidyl peptidase 4
Gene
dpp4, AN6438
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei619 – 6191Charge relay system By similarity
Active sitei696 – 6961Charge relay system By similarity
Active sitei731 – 7311Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:AN6438
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome I

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: ASPGD
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 773755Probable dipeptidyl peptidase 4
PRO_0000397813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi471 – 4711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi496 – 4961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi671 – 6711N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006538.

Structurei

3D structure databases

ProteinModelPortaliQ5AZ42.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiQYYTARF.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AZ42-1 [UniParc]FASTAAdd to Basket

« Hide

MKLSVLSVLL VSVAQAAAAP WRPREPRAAG SKRLTFNETV ISAALSPSSI    50
SVQWIATEND GDYVYQEEDG SIKIESIVTN RSQTIVPAEK IPADAYSYWI 100
SPDLSAVLWA TNYTKQYRHS FFADYYIQDV ETLETVPLVE DMVGDIQYAE 150
WSPSGDSIAF VRGNNLWTWS DGTVTAITKD GGPDMFHGVP DWIYEEEILG 200
DRFALWFSPD SELLAFLTFN ETGVPTFTVQ YFMDNQEIAP PYPRELDIRY 250
PKVSETNPTV KLNILQLSDN TVSTIPIDVF DPSELIVGEV AWVTDTHTEL 300
AVKAFNRVQD ESKVVIVETA SGETKIAHER DGTDGWLDNL LSISYVGPLA 350
LGSGDASSAY YVDLSDHSGW THLYLFSTSG GDPIPLTEGE WEVTSIVSID 400
QERELVYYLS TQHHSTERHL YSVSYRTFEI TPLVDDTVEA YWSVSFSAKA 450
GYYILTYAGP SVPYQELYSV NQTAPLRTLT SNAALIEKLE EYALPNISYF 500
ELEIPSGEKL NVMQRLPVGF SPDKKYPVLF TPYGGPGAQE VSKRWQSLDF 550
NAYIASDPEL EYVTWTVDNR GTGYRGREFR SLVAKQLGKL EAEDQVYAAK 600
QAAKLDWVDS EHIAIWGWSY GGYLTGKVLE TDSGAFSLGL LTAPVSDWRL 650
YDSMYTERYM KTLSTNAEGY NTTAIRHTDG FKNVEGGFLI QHGTGDDNVH 700
FQNAAALGDT LIGNGVTPEK MQVQWFTDSD HSIRYNGGNV FLYRQLAQRL 750
YKEKNRAKKE QHQWSKRSQD WVV 773
Length:773
Mass (Da):86,855
Last modified:April 26, 2005 - v1
Checksum:iDEEB398491278E67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000108 Genomic DNA. Translation: EAA58460.1.
BN001301 Genomic DNA. Translation: CBF69472.1.
RefSeqiXP_664042.1. XM_658950.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006538; CADANIAP00006538; CADANIAG00006538.
GeneIDi2871333.
KEGGiani:AN6438.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000108 Genomic DNA. Translation: EAA58460.1 .
BN001301 Genomic DNA. Translation: CBF69472.1 .
RefSeqi XP_664042.1. XM_658950.1.

3D structure databases

ProteinModelPortali Q5AZ42.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00006538.

Protein family/group databases

MEROPSi S09.008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00006538 ; CADANIAP00006538 ; CADANIAG00006538 .
GeneIDi 2871333.
KEGGi ani:AN6438.2.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01278.
OMAi QYYTARF.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiDPP4_EMENI
AccessioniPrimary (citable) accession number: Q5AZ42
Secondary accession number(s): C8V0E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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