Q5AZ42 (DPP4_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dipeptidyl peptidase 4
EC=3.4.14.5

Alternative name(s):
Dipeptidyl peptidase IV
Short name=DPP IV
Short name=DppIV

Gene names

Name:	dpp4
ORF Names:	AN6438

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella › Emericella nidulans › mitosporic Emericella nidulans

Protein attributes

Sequence length	773 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the peptidase S9B family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 773	755	Probable dipeptidyl peptidase 4		PRO_0000397813
Sites
	Active site	619	1	Charge relay system By similarity
	Active site	696	1	Charge relay system By similarity
	Active site	731	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	37	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	471	1	N-linked (GlcNAc...) Potential
	Glycosylation	496	1	N-linked (GlcNAc...) Potential
	Glycosylation	671	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5AZ42 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: DEEB398491278E67	FASTA	773	86,855
	10 20 30 40 50 60 MKLSVLSVLL VSVAQAAAAP WRPREPRAAG SKRLTFNETV ISAALSPSSI SVQWIATEND 70 80 90 100 110 120 GDYVYQEEDG SIKIESIVTN RSQTIVPAEK IPADAYSYWI SPDLSAVLWA TNYTKQYRHS 130 140 150 160 170 180 FFADYYIQDV ETLETVPLVE DMVGDIQYAE WSPSGDSIAF VRGNNLWTWS DGTVTAITKD 190 200 210 220 230 240 GGPDMFHGVP DWIYEEEILG DRFALWFSPD SELLAFLTFN ETGVPTFTVQ YFMDNQEIAP 250 260 270 280 290 300 PYPRELDIRY PKVSETNPTV KLNILQLSDN TVSTIPIDVF DPSELIVGEV AWVTDTHTEL 310 320 330 340 350 360 AVKAFNRVQD ESKVVIVETA SGETKIAHER DGTDGWLDNL LSISYVGPLA LGSGDASSAY 370 380 390 400 410 420 YVDLSDHSGW THLYLFSTSG GDPIPLTEGE WEVTSIVSID QERELVYYLS TQHHSTERHL 430 440 450 460 470 480 YSVSYRTFEI TPLVDDTVEA YWSVSFSAKA GYYILTYAGP SVPYQELYSV NQTAPLRTLT 490 500 510 520 530 540 SNAALIEKLE EYALPNISYF ELEIPSGEKL NVMQRLPVGF SPDKKYPVLF TPYGGPGAQE 550 560 570 580 590 600 VSKRWQSLDF NAYIASDPEL EYVTWTVDNR GTGYRGREFR SLVAKQLGKL EAEDQVYAAK 610 620 630 640 650 660 QAAKLDWVDS EHIAIWGWSY GGYLTGKVLE TDSGAFSLGL LTAPVSDWRL YDSMYTERYM 670 680 690 700 710 720 KTLSTNAEGY NTTAIRHTDG FKNVEGGFLI QHGTGDDNVH FQNAAALGDT LIGNGVTPEK 730 740 750 760 770 MQVQWFTDSD HSIRYNGGNV FLYRQLAQRL YKEKNRAKKE QHQWSKRSQD WVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACD01000108 Genomic DNA. Translation: EAA58460.1. BN001301 Genomic DNA. Translation: CBF69472.1.
RefSeq	XP_664042.1. XM_658950.1.
3D structure databases
ProteinModelPortal	Q5AZ42.
ModBase	Search...
Protein family/group databases
MEROPS	S09.008.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANIAT00006538; CADANIAP00006538; CADANIAG00006538.
GeneID	2871333.
KEGG	ani:AN6438.2.
Phylogenomic databases
eggNOG	COG1506.
HOGENOM	HOG000189891.
KO	K01278.
OMA	RDGTDGW.
OrthoDB	EOG4HB1TN.
Family and domain databases
InterPro	IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPP4_EMENI

Accession

Primary (citable) accession number: Q5AZ42
Secondary accession number(s): C8V0E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	April 26, 2005
Last modified:	March 6, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program