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Q5AYH8

- BGLE_EMENI

UniProt

Q5AYH8 - BGLE_EMENI

Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei415 – 4151By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase E (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase E
    Cellobiase E
    Gentiobiase E
    Gene namesi
    Name:bglE
    ORF Names:AN6652
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10231023Probable beta-glucosidase EPRO_0000394874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi964 – 9641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi979 – 9791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00007435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AYH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 128128CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 1023874ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei129 – 14921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OMAiGTGWSMG.
    OrthoDBiEOG7HMS8F.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q5AYH8-1 [UniParc]FASTAAdd to Basket

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    MPKSYTPVHD SIPEEDHFSS DDESNFRLHR IDRSASRSQS PKENEGEPSI     50
    LAPLVRKSTD FETYLDSLTE DEQQLLSASK DHDIEDLDRF GDGTAAARRR 100
    FSESKKRRKL LAKRGGWRAV YYSKTWWRTL VVVIIALGLL VWGFLKYAST 150
    RGDIWEEYDM PGPDSYFPTP KGGTLKHWAE SYEKASKLVE RMTLIEKVNI 200
    TTGTGWQMGI NSKLTISGPA ALVGFPSLCL QDGPLGIRFA DHITAFPAGI 250
    TTGATWNRDL MRQRGAAIGL EARLKGVNVI LGPSMGPLGM MPAGGRNWEG 300
    FGSDPVLQAV AAVETIHGIQ SNGVMATAKH YIMNEQEHFR QPNEWGIPYA 350
    LSSNIDDRAL HEVFLWPFAE SIRADVASVM CSYNQVNNSH ACENSKLLNG 400
    ILKDELGFQG FVQSDWLAQR SGVNSALGGL DMSMPGDGLH WADGRSLWGS 450
    ELTRAALNTS VPMERLNDMV TRIVAAWYQL GQDSWESPAP DGDGGPNFSS 500
    WTDDEFGFRY PGSPGDTSAA RVNRFIDAQG RGEEGHWNIA RKVAAEGIVL 550
    VKNVGGVLPL SRSPRANAER PYRVGVYGDD GGPAAGPNIC TDRGCNSGTL 600
    AMGWGSGTVE FPYLISPIDA LQGAWQSDVQ MTPYLRNAVM PADTSDKDLC 650
    LVFVNADSGE GYISAGGIHG DRNNLFLQKG GDTLVHTVAT NCGGPTVVVV 700
    HAVGPVIVEP WIDLPGVQAV LFAHLPGEES GNALLDVLFG DVDASGRLPY 750
    TVGKSLEDYG PGAQVLYEPN APVPQVDFSD ALYIDHRYFD RNNINPRYEF 800
    GFGLSYTKWE LTNMKITRLQ RNPSRLPAAR PPDAVAPPSY DANPPLANES 850
    VLFPPGFRIL SKYIYPYLPT LEATTPPPPN PEASGSATDQ KPHRTKPSDA 900
    GGGAGGNPSL YEEVARIDLT VQNTGTRSGQ QVIQLYVSFP HTVTESSGQK 950
    SHENIDFPDR VLRNFTKISL APGQKMDVNM TLTRKDLSYW SVREQNWVLP 1000
    KDEFYFWVGY SSRNLPLGKP FDP 1023
    Length:1,023
    Mass (Da):112,164
    Last modified:April 26, 2005 - v1
    Checksum:iF69D09D353F85C37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000110 Genomic DNA. Translation: EAA58181.1.
    BN001301 Genomic DNA. Translation: CBF71178.1.
    RefSeqiXP_664256.1. XM_659164.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00007435; CADANIAP00007435; CADANIAG00007435.
    GeneIDi2870419.
    KEGGiani:AN6652.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000110 Genomic DNA. Translation: EAA58181.1 .
    BN001301 Genomic DNA. Translation: CBF71178.1 .
    RefSeqi XP_664256.1. XM_659164.1.

    3D structure databases

    ProteinModelPortali Q5AYH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00007435.

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00007435 ; CADANIAP00007435 ; CADANIAG00007435 .
    GeneIDi 2870419.
    KEGGi ani:AN6652.2.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OMAi GTGWSMG.
    OrthoDBi EOG7HMS8F.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiBGLE_EMENI
    AccessioniPrimary (citable) accession number: Q5AYH8
    Secondary accession number(s): C8V1D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3