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Q5AYH8

- BGLE_EMENI

UniProt

Q5AYH8 - BGLE_EMENI

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Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei415 – 4151By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:AN6652
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10231023Probable beta-glucosidase EPRO_0000394874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi964 – 9641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi979 – 9791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00007435.

Structurei

3D structure databases

ProteinModelPortaliQ5AYH8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 128128CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini150 – 1023874ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei129 – 14921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
InParanoidiQ5AYH8.
KOiK05349.
OMAiGTGWSMG.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5AYH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKSYTPVHD SIPEEDHFSS DDESNFRLHR IDRSASRSQS PKENEGEPSI
60 70 80 90 100
LAPLVRKSTD FETYLDSLTE DEQQLLSASK DHDIEDLDRF GDGTAAARRR
110 120 130 140 150
FSESKKRRKL LAKRGGWRAV YYSKTWWRTL VVVIIALGLL VWGFLKYAST
160 170 180 190 200
RGDIWEEYDM PGPDSYFPTP KGGTLKHWAE SYEKASKLVE RMTLIEKVNI
210 220 230 240 250
TTGTGWQMGI NSKLTISGPA ALVGFPSLCL QDGPLGIRFA DHITAFPAGI
260 270 280 290 300
TTGATWNRDL MRQRGAAIGL EARLKGVNVI LGPSMGPLGM MPAGGRNWEG
310 320 330 340 350
FGSDPVLQAV AAVETIHGIQ SNGVMATAKH YIMNEQEHFR QPNEWGIPYA
360 370 380 390 400
LSSNIDDRAL HEVFLWPFAE SIRADVASVM CSYNQVNNSH ACENSKLLNG
410 420 430 440 450
ILKDELGFQG FVQSDWLAQR SGVNSALGGL DMSMPGDGLH WADGRSLWGS
460 470 480 490 500
ELTRAALNTS VPMERLNDMV TRIVAAWYQL GQDSWESPAP DGDGGPNFSS
510 520 530 540 550
WTDDEFGFRY PGSPGDTSAA RVNRFIDAQG RGEEGHWNIA RKVAAEGIVL
560 570 580 590 600
VKNVGGVLPL SRSPRANAER PYRVGVYGDD GGPAAGPNIC TDRGCNSGTL
610 620 630 640 650
AMGWGSGTVE FPYLISPIDA LQGAWQSDVQ MTPYLRNAVM PADTSDKDLC
660 670 680 690 700
LVFVNADSGE GYISAGGIHG DRNNLFLQKG GDTLVHTVAT NCGGPTVVVV
710 720 730 740 750
HAVGPVIVEP WIDLPGVQAV LFAHLPGEES GNALLDVLFG DVDASGRLPY
760 770 780 790 800
TVGKSLEDYG PGAQVLYEPN APVPQVDFSD ALYIDHRYFD RNNINPRYEF
810 820 830 840 850
GFGLSYTKWE LTNMKITRLQ RNPSRLPAAR PPDAVAPPSY DANPPLANES
860 870 880 890 900
VLFPPGFRIL SKYIYPYLPT LEATTPPPPN PEASGSATDQ KPHRTKPSDA
910 920 930 940 950
GGGAGGNPSL YEEVARIDLT VQNTGTRSGQ QVIQLYVSFP HTVTESSGQK
960 970 980 990 1000
SHENIDFPDR VLRNFTKISL APGQKMDVNM TLTRKDLSYW SVREQNWVLP
1010 1020
KDEFYFWVGY SSRNLPLGKP FDP
Length:1,023
Mass (Da):112,164
Last modified:April 26, 2005 - v1
Checksum:iF69D09D353F85C37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000110 Genomic DNA. Translation: EAA58181.1.
BN001301 Genomic DNA. Translation: CBF71178.1.
RefSeqiXP_664256.1. XM_659164.1.

Genome annotation databases

EnsemblFungiiCADANIAT00007435; CADANIAP00007435; CADANIAG00007435.
GeneIDi2870419.
KEGGiani:AN6652.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000110 Genomic DNA. Translation: EAA58181.1 .
BN001301 Genomic DNA. Translation: CBF71178.1 .
RefSeqi XP_664256.1. XM_659164.1.

3D structure databases

ProteinModelPortali Q5AYH8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00007435.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00007435 ; CADANIAP00007435 ; CADANIAG00007435 .
GeneIDi 2870419.
KEGGi ani:AN6652.2.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
InParanoidi Q5AYH8.
KOi K05349.
OMAi GTGWSMG.
OrthoDBi EOG7HMS8F.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiBGLE_EMENI
AccessioniPrimary (citable) accession number: Q5AYH8
Secondary accession number(s): C8V1D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3