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Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei415By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:AN6652
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome I
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 128CytoplasmicSequence analysisAdd BLAST128
Transmembranei129 – 149Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini150 – 1023ExtracellularSequence analysisAdd BLAST874

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003948741 – 1023Probable beta-glucosidase EAdd BLAST1023

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Glycosylationi848N-linked (GlcNAc...)Sequence analysis1
Glycosylationi964N-linked (GlcNAc...)Sequence analysis1
Glycosylationi979N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AYH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000031215.
InParanoidiQ5AYH8.
KOiK05349.
OMAiGTGWSMG.
OrthoDBiEOG092C0ZJY.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 3 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5AYH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKSYTPVHD SIPEEDHFSS DDESNFRLHR IDRSASRSQS PKENEGEPSI
60 70 80 90 100
LAPLVRKSTD FETYLDSLTE DEQQLLSASK DHDIEDLDRF GDGTAAARRR
110 120 130 140 150
FSESKKRRKL LAKRGGWRAV YYSKTWWRTL VVVIIALGLL VWGFLKYAST
160 170 180 190 200
RGDIWEEYDM PGPDSYFPTP KGGTLKHWAE SYEKASKLVE RMTLIEKVNI
210 220 230 240 250
TTGTGWQMGI NSKLTISGPA ALVGFPSLCL QDGPLGIRFA DHITAFPAGI
260 270 280 290 300
TTGATWNRDL MRQRGAAIGL EARLKGVNVI LGPSMGPLGM MPAGGRNWEG
310 320 330 340 350
FGSDPVLQAV AAVETIHGIQ SNGVMATAKH YIMNEQEHFR QPNEWGIPYA
360 370 380 390 400
LSSNIDDRAL HEVFLWPFAE SIRADVASVM CSYNQVNNSH ACENSKLLNG
410 420 430 440 450
ILKDELGFQG FVQSDWLAQR SGVNSALGGL DMSMPGDGLH WADGRSLWGS
460 470 480 490 500
ELTRAALNTS VPMERLNDMV TRIVAAWYQL GQDSWESPAP DGDGGPNFSS
510 520 530 540 550
WTDDEFGFRY PGSPGDTSAA RVNRFIDAQG RGEEGHWNIA RKVAAEGIVL
560 570 580 590 600
VKNVGGVLPL SRSPRANAER PYRVGVYGDD GGPAAGPNIC TDRGCNSGTL
610 620 630 640 650
AMGWGSGTVE FPYLISPIDA LQGAWQSDVQ MTPYLRNAVM PADTSDKDLC
660 670 680 690 700
LVFVNADSGE GYISAGGIHG DRNNLFLQKG GDTLVHTVAT NCGGPTVVVV
710 720 730 740 750
HAVGPVIVEP WIDLPGVQAV LFAHLPGEES GNALLDVLFG DVDASGRLPY
760 770 780 790 800
TVGKSLEDYG PGAQVLYEPN APVPQVDFSD ALYIDHRYFD RNNINPRYEF
810 820 830 840 850
GFGLSYTKWE LTNMKITRLQ RNPSRLPAAR PPDAVAPPSY DANPPLANES
860 870 880 890 900
VLFPPGFRIL SKYIYPYLPT LEATTPPPPN PEASGSATDQ KPHRTKPSDA
910 920 930 940 950
GGGAGGNPSL YEEVARIDLT VQNTGTRSGQ QVIQLYVSFP HTVTESSGQK
960 970 980 990 1000
SHENIDFPDR VLRNFTKISL APGQKMDVNM TLTRKDLSYW SVREQNWVLP
1010 1020
KDEFYFWVGY SSRNLPLGKP FDP
Length:1,023
Mass (Da):112,164
Last modified:April 26, 2005 - v1
Checksum:iF69D09D353F85C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000110 Genomic DNA. Translation: EAA58181.1.
BN001301 Genomic DNA. Translation: CBF71178.1.
RefSeqiXP_664256.1. XM_659164.1.

Genome annotation databases

EnsemblFungiiCADANIAT00007435; CADANIAP00007435; CADANIAG00007435.
EAA58181; EAA58181; AN6652.2.
GeneIDi2870419.
KEGGiani:AN6652.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000110 Genomic DNA. Translation: EAA58181.1.
BN001301 Genomic DNA. Translation: CBF71178.1.
RefSeqiXP_664256.1. XM_659164.1.

3D structure databases

ProteinModelPortaliQ5AYH8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00007435; CADANIAP00007435; CADANIAG00007435.
EAA58181; EAA58181; AN6652.2.
GeneIDi2870419.
KEGGiani:AN6652.2.

Phylogenomic databases

HOGENOMiHOG000031215.
InParanoidiQ5AYH8.
KOiK05349.
OMAiGTGWSMG.
OrthoDBiEOG092C0ZJY.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 3 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBGLE_EMENI
AccessioniPrimary (citable) accession number: Q5AYH8
Secondary accession number(s): C8V1D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.