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Q5AWI5

- AGDC_EMENI

UniProt

Q5AWI5 - AGDC_EMENI

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Protein

Alpha/beta-glucosidase agdC

Gene
agdC, agdD, AN7345
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei429 – 4291Nucleophile By similarity
Active sitei432 – 4321 By similarity
Active sitei600 – 6001Proton donor By similarity

GO - Molecular functioni

  1. alpha-glucosidase activity Source: UniProtKB
  2. beta-glucosidase activity Source: UniProtKB
  3. carbohydrate binding Source: InterPro
  4. glucosidase activity Source: ASPGD
  5. hydrolase activity, hydrolyzing O-glycosyl compounds Source: ASPGD
  6. maltose alpha-glucosidase activity Source: UniProtKB-EC
  7. transferase activity, transferring glycosyl groups Source: ASPGD

GO - Biological processi

  1. cellular carbohydrate catabolic process Source: ASPGD
  2. glucan catabolic process Source: UniProtKB
  3. maltose metabolic process Source: ASPGD
  4. starch metabolic process Source: ASPGD
  5. xyloglucan metabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.
mycoCLAPiAGL31C_EMENI.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha/beta-glucosidase agdC (EC:3.2.1.20, EC:3.2.1.21)
Gene namesi
Name:agdC
Synonyms:agdD
ORF Names:AN7345
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome IV

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 894873Alpha/beta-glucosidase agdCPRO_0000394919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi482 – 4821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi536 – 5361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi601 – 6011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi637 – 6371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi802 – 8021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00000088.

Structurei

3D structure databases

ProteinModelPortaliQ5AWI5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiMMSTATH.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AWI5-1 [UniParc]FASTAAdd to Basket

« Hide

MAGTLLSWTP LALALMARAL SQLPLTDCPG YRVINVEERP RGLTADLTLA    50
GTPCNVYGVD IENLRLETDY DTNQRLHVKI YDADENVYQV PDSVFPRPVV 100
NDQACADENT PELRFSYAED PFSFAVSRAS NDETLFNTTG HNLIFQSQYV 150
NLRTSLPQNP NLYGLGEHSD PLRLNTINYT RTLWNRDAYT IPAGTNLYGA 200
HPMYIDHRGE AGTHGVFLLN SNGMDIKIDK NSDNIQFLEY NILGGVLDFY 250
FFAGPSPKDV SVQYAEVAGL PAMVPYWGLG FHQCRYGYRD IFEVAAVVHN 300
YSEARIPLET MWTDIDYMDH RKVFTLDRER FPLDTVRALV QYLHQRDQHY 350
IVMVDPAVAH SENGAFTRGL EKDVFMRKQD GTLYQGAVWP GATVFPDWFH 400
PNTSDYWINE FALFFNAESG VDIDALWIDM NEAANFCDWP CTDPVAYAEE 450
NNLPPEPPAV RPNPSSLPGF PAEFQPVNSN NNNSSRKRET QVVIAARQGF 500
VKVGNDNGNG RRLGLQGREL IDPPYKIANA AGSLSNKTMN TDIFHANGLA 550
EYDTHNLYGT MMSSLSRDAM LYRRPEKRPL VITRSTFAGA GSYVGHWLGD 600
NASTWTKYRI SIAQMLAFAS IFQIPMVGSD ACGFTGNTTE ELCSRWATLA 650
AFNPFFRNHN EYGMVSQEFY RWNSVAEAAR KAISIRYSLL DYLYTEFHEQ 700
TVTGEPFLLP LFFVYPNDPN VVGIDSQFFY GDAILVSPVI EEGKTEVHAY 750
FPGDLFYDWY TGLPLRGNGE VITLTDIGYT DIPLHVRGGK IVPVRTGSAG 800
MNTTTEVRKS GFRLVIAPGL DGRAAGRLYI DDGESLEQTA MVDVVFTYED 850
GRVSVDGVFT LQTDLRVEAV TVFGDNVVER TIDLPLSGPG GVEL 894
Length:894
Mass (Da):100,075
Last modified:June 15, 2010 - v2
Checksum:i6AE3AD13A10C594D
GO

Sequence cautioni

The sequence EAA61716.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ490507 mRNA. Translation: ABF50883.1.
AACD01000128 Genomic DNA. Translation: EAA61716.1. Sequence problems.
BN001304 Genomic DNA. Translation: CBF78576.1.
RefSeqiXP_680614.1. XM_675522.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000088; CADANIAP00000088; CADANIAG00000088.
GeneIDi2869771.
KEGGiani:AN7345.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ490507 mRNA. Translation: ABF50883.1 .
AACD01000128 Genomic DNA. Translation: EAA61716.1 . Sequence problems.
BN001304 Genomic DNA. Translation: CBF78576.1 .
RefSeqi XP_680614.1. XM_675522.1.

3D structure databases

ProteinModelPortali Q5AWI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00000088.

Protein family/group databases

CAZyi GH31. Glycoside Hydrolase Family 31.
mycoCLAPi AGL31C_EMENI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00000088 ; CADANIAP00000088 ; CADANIAG00000088 .
GeneIDi 2869771.
KEGGi ani:AN7345.2.

Phylogenomic databases

eggNOGi COG1501.
HOGENOMi HOG000041175.
KOi K01187.
OMAi MMSTATH.
OrthoDBi EOG77T1CZ.

Family and domain databases

InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
    Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
    Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiAGDC_EMENI
AccessioniPrimary (citable) accession number: Q5AWI5
Secondary accession number(s): C8VCK6, Q1HFR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi