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Protein

Probable beta-glucosidase M

Gene

bglM

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei287By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase M (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase M
Cellobiase M
Gentiobiase M
Gene namesi
Name:bglM
ORF Names:AN7396
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000039490921 – 772Probable beta-glucosidase MAdd BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi523N-linked (GlcNAc...)Sequence analysis1
Glycosylationi547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi574N-linked (GlcNAc...)Sequence analysis1
Glycosylationi586N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AWD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000031215.
InParanoidiQ5AWD4.
KOiK05349.
OMAiNITPQFE.
OrthoDBiEOG092C0ZJY.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 2 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AWD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSWGKTGF VLALALGGRA AENVITSDTF FYGESPPVYP SPEGTGAGDW
60 70 80 90 100
ASAYTKARAF VAQLSDDEKI QLTAGVSSNT ACSGFIQPID RLGFPGICMS
110 120 130 140 150
DAGNGLRGTD YVNGWSSGIS VGASWNRDLA HSRGAYMGQE YRKKGVNMIL
160 170 180 190 200
GPVVGPLGRV ALGGRNWEGY AADPYLSGVL VSESVKGLQS QKVATSVKHF
210 220 230 240 250
IANEQETNRN PTTDSERNVV QSVSSNIDDK TMHELYLWPF QDAVLAGATN
260 270 280 290 300
LMCSYNRVNN SYACQNSKLL NGVLKTELGF QGYVVTDWGA QHAGIASANA
310 320 330 340 350
GLDVVMPRSS TWNSNLTTAI ANGTMEASRL DDMITRLMAT WYYLDQDTEF
360 370 380 390 400
PSPGVGMPSS PSAAHQAVIA TSPEAKPILL QSAIESHVLV KNTDGALPLK
410 420 430 440 450
SPKLISVFGY DAYAPLTYDL GNNFDFSSTR VRSDLYKNGT LYVGGGSGLN
460 470 480 490 500
SPAYIDAPID AIKRRAYEDG SSVLWDFTSE NPSVDYTSDV CLVFINAYAT
510 520 530 540 550
EGYDRQALSD THSDSVVENI AGNCSNTIVV VHNAGIRTAE AWVDHANVTA
560 570 580 590 600
IIYAHLPGQD IGRALVRLLY GESNFSGRLP YTVAKNSSDY GSLLEPSQPE
610 620 630 640 650
GKYQYFPQSD FSEGVYIDYR AFDKDGIVPQ YAFGYGLSYT TFEYSDLKIS
660 670 680 690 700
KNSDGVPSIY PAKASILPGG NPHLFDELVT VTAKIRNTGN VDGQEVAQLY
710 720 730 740 750
VGIPDGPVRQ LRGFDKVLIE SGSSATVTFS LTRRDLSTWD ANAQEWSLQR
760 770
GTYKIFVGRD SRDLPLEETL VF
Length:772
Mass (Da):83,526
Last modified:April 26, 2005 - v1
Checksum:i5EDBC03088B10ED2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000128 Genomic DNA. Translation: EAA61767.1.
BN001304 Genomic DNA. Translation: CBF78465.1.
RefSeqiXP_680665.1. XM_675573.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000031; CADANIAP00000031; CADANIAG00000031.
EAA61767; EAA61767; AN7396.2.
GeneIDi2869858.
KEGGiani:AN7396.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000128 Genomic DNA. Translation: EAA61767.1.
BN001304 Genomic DNA. Translation: CBF78465.1.
RefSeqiXP_680665.1. XM_675573.1.

3D structure databases

ProteinModelPortaliQ5AWD4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00000031; CADANIAP00000031; CADANIAG00000031.
EAA61767; EAA61767; AN7396.2.
GeneIDi2869858.
KEGGiani:AN7396.2.

Phylogenomic databases

HOGENOMiHOG000031215.
InParanoidiQ5AWD4.
KOiK05349.
OMAiNITPQFE.
OrthoDBiEOG092C0ZJY.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 2 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBGLM_EMENI
AccessioniPrimary (citable) accession number: Q5AWD4
Secondary accession number(s): C8VCE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.