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Protein

Probable mannan endo-1,4-beta-mannosidase E

Gene

manE

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Protein family/group databases

CAZyiGH26. Glycoside Hydrolase Family 26.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannan endo-1,4-beta-mannosidase E (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase E
Gene namesi
Name:manE
ORF Names:AN7413
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560 Componenti: Chromosome IV

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 355333Probable mannan endo-1,4-beta-mannosidase EPRO_0000395077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AWB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 26 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4124.
HOGENOMiHOG000235025.
InParanoidiQ5AWB7.
KOiK01218.
OMAiSPAIYGC.
OrthoDBiEOG76X68B.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR022790. EndoGluc_H/Glyco_hydro_26.
IPR000805. Glyco_hydro_26.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR016714. Mannan-1_4-b-mannosidase.
[Graphical view]
PfamiPF02156. Glyco_hydro_26. 1 hit.
[Graphical view]
PIRSFiPIRSF018168. Mannan-1_4-beta-mannosidase. 1 hit.
PRINTSiPR00739. GLHYDRLASE26.
SUPFAMiSSF51445. SSF51445. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AWB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSQLILPF SAALSLVGSG VATPTTKPVN PRASRPARNL LAHLVRSAGN
60 70 80 90 100
GTTLSGQQEL KDADWVTDNV GFSPVILGVD LMDYSPSRVE FGAVSTSIED
110 120 130 140 150
AITYATQGGI ITICWHWGEL SHDWMTDERL TTLLTLGSPS GTYNTTEQPW
160 170 180 190 200
WSNFYTEATS FNLSAAMNPA SRDYKLILRD IDAIAEQLAR LKDIPVLFRP
210 220 230 240 250
LHEAEGGWFW WGATGAEPCK ALYRLLFDRL TKKHGLNNLL WVWNSKDPLW
260 270 280 290 300
YPGNEYVDVV SVDVYADNGD HSSQLEAYQA LQGLTGNFSK LIALGEVGNI
310 320 330 340 350
PDPELMREDG AQWAYWVTWN GDFIRGETKN PMEFKKAVYA SELVYTLDEI

QGWNL
Length:355
Mass (Da):39,620
Last modified:April 26, 2005 - v1
Checksum:i37816EA753D5E877
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000128 Genomic DNA. Translation: EAA61784.1.
BN001304 Genomic DNA. Translation: CBF78427.1.
RefSeqiXP_680682.1. XM_675590.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000012; CADANIAP00000012; CADANIAG00000012.
GeneIDi2869806.
KEGGiani:AN7413.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000128 Genomic DNA. Translation: EAA61784.1.
BN001304 Genomic DNA. Translation: CBF78427.1.
RefSeqiXP_680682.1. XM_675590.1.

3D structure databases

ProteinModelPortaliQ5AWB7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH26. Glycoside Hydrolase Family 26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00000012; CADANIAP00000012; CADANIAG00000012.
GeneIDi2869806.
KEGGiani:AN7413.2.

Phylogenomic databases

eggNOGiCOG4124.
HOGENOMiHOG000235025.
InParanoidiQ5AWB7.
KOiK01218.
OMAiSPAIYGC.
OrthoDBiEOG76X68B.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR022790. EndoGluc_H/Glyco_hydro_26.
IPR000805. Glyco_hydro_26.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR016714. Mannan-1_4-b-mannosidase.
[Graphical view]
PfamiPF02156. Glyco_hydro_26. 1 hit.
[Graphical view]
PIRSFiPIRSF018168. Mannan-1_4-beta-mannosidase. 1 hit.
PRINTSiPR00739. GLHYDRLASE26.
SUPFAMiSSF51445. SSF51445. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMANE_EMENI
AccessioniPrimary (citable) accession number: Q5AWB7
Secondary accession number(s): C8VCC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.