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Q5AWB7

- MANE_EMENI

UniProt

Q5AWB7 - MANE_EMENI

Protein

Probable mannan endo-1,4-beta-mannosidase E

Gene

manE

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

    GO - Molecular functioni

    1. cellulase activity Source: InterPro
    2. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. substituted mannan metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism

    Protein family/group databases

    CAZyiGH26. Glycoside Hydrolase Family 26.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannan endo-1,4-beta-mannosidase E (EC:3.2.1.78)
    Alternative name(s):
    Endo-beta-1,4-mannanase E
    Gene namesi
    Name:manE
    ORF Names:AN7413
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome IV

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 355333Probable mannan endo-1,4-beta-mannosidase EPRO_0000395077Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AWB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 26 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4124.
    HOGENOMiHOG000235025.
    OMAiNDYCISH.
    OrthoDBiEOG76X68B.

    Family and domain databases

    Gene3Di3.20.20.80. 2 hits.
    InterProiIPR022790. EndoGluc_H/Glyco_hydro_26.
    IPR000805. Glyco_hydro_26.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR016714. Mannan-1_4-b-mannosidase.
    [Graphical view]
    PfamiPF02156. Glyco_hydro_26. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018168. Mannan-1_4-beta-mannosidase. 1 hit.
    PRINTSiPR00739. GLHYDRLASE26.
    SUPFAMiSSF51445. SSF51445. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5AWB7-1 [UniParc]FASTAAdd to Basket

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    MKFSQLILPF SAALSLVGSG VATPTTKPVN PRASRPARNL LAHLVRSAGN    50
    GTTLSGQQEL KDADWVTDNV GFSPVILGVD LMDYSPSRVE FGAVSTSIED 100
    AITYATQGGI ITICWHWGEL SHDWMTDERL TTLLTLGSPS GTYNTTEQPW 150
    WSNFYTEATS FNLSAAMNPA SRDYKLILRD IDAIAEQLAR LKDIPVLFRP 200
    LHEAEGGWFW WGATGAEPCK ALYRLLFDRL TKKHGLNNLL WVWNSKDPLW 250
    YPGNEYVDVV SVDVYADNGD HSSQLEAYQA LQGLTGNFSK LIALGEVGNI 300
    PDPELMREDG AQWAYWVTWN GDFIRGETKN PMEFKKAVYA SELVYTLDEI 350
    QGWNL 355
    Length:355
    Mass (Da):39,620
    Last modified:April 26, 2005 - v1
    Checksum:i37816EA753D5E877
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000128 Genomic DNA. Translation: EAA61784.1.
    BN001304 Genomic DNA. Translation: CBF78427.1.
    RefSeqiXP_680682.1. XM_675590.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00000012; CADANIAP00000012; CADANIAG00000012.
    GeneIDi2869806.
    KEGGiani:AN7413.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000128 Genomic DNA. Translation: EAA61784.1 .
    BN001304 Genomic DNA. Translation: CBF78427.1 .
    RefSeqi XP_680682.1. XM_675590.1.

    3D structure databases

    ProteinModelPortali Q5AWB7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH26. Glycoside Hydrolase Family 26.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00000012 ; CADANIAP00000012 ; CADANIAG00000012 .
    GeneIDi 2869806.
    KEGGi ani:AN7413.2.

    Phylogenomic databases

    eggNOGi COG4124.
    HOGENOMi HOG000235025.
    OMAi NDYCISH.
    OrthoDBi EOG76X68B.

    Family and domain databases

    Gene3Di 3.20.20.80. 2 hits.
    InterProi IPR022790. EndoGluc_H/Glyco_hydro_26.
    IPR000805. Glyco_hydro_26.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR016714. Mannan-1_4-b-mannosidase.
    [Graphical view ]
    Pfami PF02156. Glyco_hydro_26. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018168. Mannan-1_4-beta-mannosidase. 1 hit.
    PRINTSi PR00739. GLHYDRLASE26.
    SUPFAMi SSF51445. SSF51445. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiMANE_EMENI
    AccessioniPrimary (citable) accession number: Q5AWB7
    Secondary accession number(s): C8VCC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3