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Protein

Riboflavin kinase

Gene

fmn1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.By similarity

Catalytic activityi

ATP + riboflavin = ADP + FMN.

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Zinc or magnesium.By similarity

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin kinase (fmn1)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Magnesium or zincBy similarity1
Active sitei113NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
Flavin mononucleotide kinase 1
Gene namesi
Name:fmn1
ORF Names:AN7469
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018411 – 210Riboflavin kinaseAdd BLAST210

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00000562

Structurei

3D structure databases

ProteinModelPortaliQ5AW61
SMRiQ5AW61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the flavokinase family.Curated

Phylogenomic databases

HOGENOMiHOG000260803
InParanoidiQ5AW61
KOiK00861
OMAiSIEIHIM
OrthoDBiEOG092C5F1Q

Family and domain databases

Gene3Di2.40.30.30, 1 hit
InterProiView protein in InterPro
IPR023468 Riboflavin_kinase
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
PANTHERiPTHR22749 PTHR22749, 1 hit
PfamiView protein in Pfam
PF01687 Flavokinase, 1 hit
SMARTiView protein in SMART
SM00904 Flavokinase, 1 hit
SUPFAMiSSF82114 SSF82114, 1 hit

Sequencei

Sequence statusi: Complete.

Q5AW61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSNPRPPV TGPDSGPEAP FPIRLSGPVI KGFGRGSKEL GIPTANIPVD
60 70 80 90 100
GLEEVLPKEL GVGVYYGVVA LDPATAPAPS SSDSTSGDAA PILPAVLSIG
110 120 130 140 150
YNPYYKNKTR SIEIHIMPSL TLPSPTAPSE EKEKVKFHKL PDFYGTKLNL
160 170 180 190 200
LMLGYIRPEY DYVSMEALVE DIRIDCEVAR ASLLRPAYRV YLDGNEDETV
210
SAQRDWLRSF
Length:210
Mass (Da):22,916
Last modified:April 26, 2005 - v1
Checksum:iCFA2B4DD973852A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000129 Genomic DNA Translation: EAA62049.1
BN001304 Genomic DNA Translation: CBF79442.1
RefSeqiXP_680738.1, XM_675646.1

Genome annotation databases

EnsemblFungiiCADANIAT00000562; CADANIAP00000562; CADANIAG00000562
EAA62049; EAA62049; AN7469.2
GeneIDi2869537
KEGGiani:AN7469.2

Similar proteinsi

Entry informationi

Entry nameiRIFK_EMENI
AccessioniPrimary (citable) accession number: Q5AW61
Secondary accession number(s): C8VBE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health