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Q5AVZ7

- EXGD_EMENI

UniProt

Q5AVZ7 - EXGD_EMENI

Protein

Glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.1 Publication

    Catalytic activityi

    Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei598 – 5981Proton donorBy similarity
    Active sitei703 – 7031NucleophileBy similarity

    GO - Molecular functioni

    1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB

    GO - Biological processi

    1. glucan catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH5. Glycoside Hydrolase Family 5.
    mycoCLAPiEXG5D_EMENI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
    Alternative name(s):
    Exo-1,3-beta-glucanase D
    Gene namesi
    Name:exgD
    ORF Names:AN7533
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome IV

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 831831Glucan 1,3-beta-glucosidase DPRO_0000395168Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi611 – 6111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi637 – 6371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AVZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 300300CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini322 – 831510ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei301 – 32121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 280275Arg-richAdd
    BLAST
    Compositional biasi33 – 7442Asp-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2730.
    HOGENOMiHOG000114462.
    KOiK01210.
    OMAiNIITHYG.
    OrthoDBiEOG7ZPNTV.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5AVZ7-1 [UniParc]FASTAAdd to Basket

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    MPSQSRSRDR YGRDSDRDRS RVQPRRRYHV SEDDDDDDDF DDNPRDRRYR    50
    RDGYRRAPVD SRAYDSHDDY EVVDVEEEPR RYRSDTERRR ERARASPGTS 100
    PRKRERTRDS GGGHRRRRTE ESDGSQAPQA HRDRRSRTRR DRGLDDEDLE 150
    DAARRLRRRE RERERERRAE TSKHKSTDSS NSSAGLLNAN ALAKLRAQHE 200
    ELDRQEQRRA EKEAKAERKR RRKRPAVEGQ MRTLDPFPDE VPRGQSKGRI 250
    VSGAYLEEGR APDMEVRLRG GGRGPPRERR WEKDSDGSAP LTPFWKRKKW 300
    WWIGAIVLVI VVIIIVVAVV VSNNKKSDSD SDSDSNSGSS DSWGGDKSSL 350
    NGLDHDSIPK SAQGTVLDPW TWYETTDFNV TYTDETVGGL SVMGLNSTWD 400
    DSVAPNENVP PLNKPFPYGS QPIRGVNIGG LLSLEPFITP SLFEGYSSDV 450
    VDEYTLTTKL GDNAARKLEE HYATFITEQD FADMAEAGID HVRIPFSYWA 500
    VNPREDEPYV AKISWRYLLR VIEYCRKYGL RVNLDPHGMP GSQNGMNHSG 550
    RQGSIRWLNG DDGDTYAQRS LEFHEKISKF FAQDRYKNII TIYGLINEPY 600
    MLSLDVEKVL NWTVTAAELV QKNGITAKIA FHDGFLNLSK WKTMLKNGPS 650
    NLLLDTHQYT IYNVAQIVLN HTAKVNFVCN DWVGMIGEIN STSEGWGPTI 700
    CGEFTQADTD CAKNLNNVGR GTRWEGTYSE GDSTMYCPTA EQRTCSCTEA 750
    NADPSEYSDD YKLFLKTYAE AQMYAFEQAQ GWFYWTWHTE SAPQWSYKTG 800
    WKNGFMPAKA YNPDYKCGDD IPSFGNLPEY Y 831
    Length:831
    Mass (Da):95,363
    Last modified:April 26, 2005 - v1
    Checksum:i9A08532CA04B7B3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490510 mRNA. Translation: ABF50886.1.
    AACD01000129 Genomic DNA. Translation: EAA62113.1.
    BN001304 Genomic DNA. Translation: CBF79583.1.
    RefSeqiXP_680802.1. XM_675710.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00000639; CADANIAP00000639; CADANIAG00000639.
    GeneIDi2869497.
    KEGGiani:AN7533.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490510 mRNA. Translation: ABF50886.1 .
    AACD01000129 Genomic DNA. Translation: EAA62113.1 .
    BN001304 Genomic DNA. Translation: CBF79583.1 .
    RefSeqi XP_680802.1. XM_675710.1.

    3D structure databases

    ProteinModelPortali Q5AVZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH5. Glycoside Hydrolase Family 5.
    mycoCLAPi EXG5D_EMENI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00000639 ; CADANIAP00000639 ; CADANIAG00000639 .
    GeneIDi 2869497.
    KEGGi ani:AN7533.2.

    Phylogenomic databases

    eggNOGi COG2730.
    HOGENOMi HOG000114462.
    KOi K01210.
    OMAi NIITHYG.
    OrthoDBi EOG7ZPNTV.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
      Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
      Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiEXGD_EMENI
    AccessioniPrimary (citable) accession number: Q5AVZ7
    Secondary accession number(s): C8VBL9, Q1HFR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3