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Protein

Glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.1 Publication

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei598Proton donorBy similarity1
Active sitei703NucleophileBy similarity1

GO - Molecular functioni

  • glucan exo-1,3-beta-glucosidase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.
mycoCLAPiEXG5D_EMENI.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:AN7533
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 300CytoplasmicSequence analysisAdd BLAST300
Transmembranei301 – 321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini322 – 831ExtracellularSequence analysisAdd BLAST510

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003951681 – 831Glucan 1,3-beta-glucosidase DAdd BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Glycosylationi547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi611N-linked (GlcNAc...)Sequence analysis1
Glycosylationi637N-linked (GlcNAc...)Sequence analysis1
Glycosylationi670N-linked (GlcNAc...)Sequence analysis1
Glycosylationi690N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AVZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 280Arg-richAdd BLAST275
Compositional biasi33 – 74Asp-richAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000114462.
InParanoidiQ5AVZ7.
KOiK01210.
OMAiNIITHYG.
OrthoDBiEOG092C22A6.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AVZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQSRSRDR YGRDSDRDRS RVQPRRRYHV SEDDDDDDDF DDNPRDRRYR
60 70 80 90 100
RDGYRRAPVD SRAYDSHDDY EVVDVEEEPR RYRSDTERRR ERARASPGTS
110 120 130 140 150
PRKRERTRDS GGGHRRRRTE ESDGSQAPQA HRDRRSRTRR DRGLDDEDLE
160 170 180 190 200
DAARRLRRRE RERERERRAE TSKHKSTDSS NSSAGLLNAN ALAKLRAQHE
210 220 230 240 250
ELDRQEQRRA EKEAKAERKR RRKRPAVEGQ MRTLDPFPDE VPRGQSKGRI
260 270 280 290 300
VSGAYLEEGR APDMEVRLRG GGRGPPRERR WEKDSDGSAP LTPFWKRKKW
310 320 330 340 350
WWIGAIVLVI VVIIIVVAVV VSNNKKSDSD SDSDSNSGSS DSWGGDKSSL
360 370 380 390 400
NGLDHDSIPK SAQGTVLDPW TWYETTDFNV TYTDETVGGL SVMGLNSTWD
410 420 430 440 450
DSVAPNENVP PLNKPFPYGS QPIRGVNIGG LLSLEPFITP SLFEGYSSDV
460 470 480 490 500
VDEYTLTTKL GDNAARKLEE HYATFITEQD FADMAEAGID HVRIPFSYWA
510 520 530 540 550
VNPREDEPYV AKISWRYLLR VIEYCRKYGL RVNLDPHGMP GSQNGMNHSG
560 570 580 590 600
RQGSIRWLNG DDGDTYAQRS LEFHEKISKF FAQDRYKNII TIYGLINEPY
610 620 630 640 650
MLSLDVEKVL NWTVTAAELV QKNGITAKIA FHDGFLNLSK WKTMLKNGPS
660 670 680 690 700
NLLLDTHQYT IYNVAQIVLN HTAKVNFVCN DWVGMIGEIN STSEGWGPTI
710 720 730 740 750
CGEFTQADTD CAKNLNNVGR GTRWEGTYSE GDSTMYCPTA EQRTCSCTEA
760 770 780 790 800
NADPSEYSDD YKLFLKTYAE AQMYAFEQAQ GWFYWTWHTE SAPQWSYKTG
810 820 830
WKNGFMPAKA YNPDYKCGDD IPSFGNLPEY Y
Length:831
Mass (Da):95,363
Last modified:April 26, 2005 - v1
Checksum:i9A08532CA04B7B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ490510 mRNA. Translation: ABF50886.1.
AACD01000129 Genomic DNA. Translation: EAA62113.1.
BN001304 Genomic DNA. Translation: CBF79583.1.
RefSeqiXP_680802.1. XM_675710.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000639; CADANIAP00000639; CADANIAG00000639.
EAA62113; EAA62113; AN7533.2.
GeneIDi2869497.
KEGGiani:AN7533.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ490510 mRNA. Translation: ABF50886.1.
AACD01000129 Genomic DNA. Translation: EAA62113.1.
BN001304 Genomic DNA. Translation: CBF79583.1.
RefSeqiXP_680802.1. XM_675710.1.

3D structure databases

ProteinModelPortaliQ5AVZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.
mycoCLAPiEXG5D_EMENI.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00000639; CADANIAP00000639; CADANIAG00000639.
EAA62113; EAA62113; AN7533.2.
GeneIDi2869497.
KEGGiani:AN7533.2.

Phylogenomic databases

HOGENOMiHOG000114462.
InParanoidiQ5AVZ7.
KOiK01210.
OMAiNIITHYG.
OrthoDBiEOG092C22A6.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXGD_EMENI
AccessioniPrimary (citable) accession number: Q5AVZ7
Secondary accession number(s): C8VBL9, Q1HFR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.