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Protein

Glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.1 Publication

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei598Proton donorBy similarity1
Active sitei703NucleophileBy similarity1

GO - Molecular functioni

  • glucan exo-1,3-beta-glucosidase activity Source: UniProtKB

GO - Biological processi

  • cellular glucan metabolic process Source: GO_Central
  • cell wall organization Source: UniProtKB-KW
  • glucan catabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5
mycoCLAPiEXG5D_EMENI

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:AN7533
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 300CytoplasmicSequence analysisAdd BLAST300
Transmembranei301 – 321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini322 – 831ExtracellularSequence analysisAdd BLAST510

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003951681 – 831Glucan 1,3-beta-glucosidase DAdd BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi611N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi637N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi690N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00000639

Structurei

3D structure databases

ProteinModelPortaliQ5AVZ7
SMRiQ5AVZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 280Arg-richAdd BLAST275
Compositional biasi33 – 74Asp-richAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000114462
InParanoidiQ5AVZ7
KOiK01210
OMAiDNVPPLN
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Q5AVZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQSRSRDR YGRDSDRDRS RVQPRRRYHV SEDDDDDDDF DDNPRDRRYR
60 70 80 90 100
RDGYRRAPVD SRAYDSHDDY EVVDVEEEPR RYRSDTERRR ERARASPGTS
110 120 130 140 150
PRKRERTRDS GGGHRRRRTE ESDGSQAPQA HRDRRSRTRR DRGLDDEDLE
160 170 180 190 200
DAARRLRRRE RERERERRAE TSKHKSTDSS NSSAGLLNAN ALAKLRAQHE
210 220 230 240 250
ELDRQEQRRA EKEAKAERKR RRKRPAVEGQ MRTLDPFPDE VPRGQSKGRI
260 270 280 290 300
VSGAYLEEGR APDMEVRLRG GGRGPPRERR WEKDSDGSAP LTPFWKRKKW
310 320 330 340 350
WWIGAIVLVI VVIIIVVAVV VSNNKKSDSD SDSDSNSGSS DSWGGDKSSL
360 370 380 390 400
NGLDHDSIPK SAQGTVLDPW TWYETTDFNV TYTDETVGGL SVMGLNSTWD
410 420 430 440 450
DSVAPNENVP PLNKPFPYGS QPIRGVNIGG LLSLEPFITP SLFEGYSSDV
460 470 480 490 500
VDEYTLTTKL GDNAARKLEE HYATFITEQD FADMAEAGID HVRIPFSYWA
510 520 530 540 550
VNPREDEPYV AKISWRYLLR VIEYCRKYGL RVNLDPHGMP GSQNGMNHSG
560 570 580 590 600
RQGSIRWLNG DDGDTYAQRS LEFHEKISKF FAQDRYKNII TIYGLINEPY
610 620 630 640 650
MLSLDVEKVL NWTVTAAELV QKNGITAKIA FHDGFLNLSK WKTMLKNGPS
660 670 680 690 700
NLLLDTHQYT IYNVAQIVLN HTAKVNFVCN DWVGMIGEIN STSEGWGPTI
710 720 730 740 750
CGEFTQADTD CAKNLNNVGR GTRWEGTYSE GDSTMYCPTA EQRTCSCTEA
760 770 780 790 800
NADPSEYSDD YKLFLKTYAE AQMYAFEQAQ GWFYWTWHTE SAPQWSYKTG
810 820 830
WKNGFMPAKA YNPDYKCGDD IPSFGNLPEY Y
Length:831
Mass (Da):95,363
Last modified:April 26, 2005 - v1
Checksum:i9A08532CA04B7B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ490510 mRNA Translation: ABF50886.1
AACD01000129 Genomic DNA Translation: EAA62113.1
BN001304 Genomic DNA Translation: CBF79583.1
RefSeqiXP_680802.1, XM_675710.1

Genome annotation databases

EnsemblFungiiCADANIAT00000639; CADANIAP00000639; CADANIAG00000639
EAA62113; EAA62113; AN7533.2
GeneIDi2869497
KEGGiani:AN7533.2

Similar proteinsi

Entry informationi

Entry nameiEXGD_EMENI
AccessioniPrimary (citable) accession number: Q5AVZ7
Secondary accession number(s): C8VBL9, Q1HFR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health