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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

tpc1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:tpc1
ORF Names:AN7569
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei79 – 99Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei185 – 205Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei291 – 308Helical; Name=6Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204651 – 328Mitochondrial thiamine pyrophosphate carrier 1Add BLAST328

Structurei

3D structure databases

ProteinModelPortaliQ5AVW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 110Solcar 1Add BLAST99
Repeati120 – 208Solcar 2Add BLAST89
Repeati221 – 316Solcar 3Add BLAST96

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165726.
InParanoidiQ5AVW1.
KOiK15108.
OMAiWKGNVPA.
OrthoDBiEOG092C3KDM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q5AVW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGEHLKD EGTRRQVVLA GGIAGLISRF CIAPLDVVKI RLQLQIHSLS
60 70 80 90 100
DPTSHAHITG PVYKGTLSTI KTILREEGLT GLWKGNIPAE LLYVCYGGIQ
110 120 130 140 150
FTTYRTTTQL LAQLDPHRLP QPIESFISGA LGGGIATAAT YPLDLLRTRF
160 170 180 190 200
AAQGSGDNRV YESLFASLRD IAKTEGTVGF FRGCSAAVGQ IVPYMGLFFA
210 220 230 240 250
TYEALRPVMA TAPELSPIPL PPGSGDAAAG IVASVLAKTG VFPLDLVRKR
260 270 280 290 300
LQVQGPTRAL YVHRNIPEYR GVFNTMGLIF RTQGLRGLYR GLTVSLVKAA
310 320
PASAVTMWTY ERALKLLREH EIAAGRDE
Length:328
Mass (Da):35,391
Last modified:April 26, 2005 - v1
Checksum:iB4F39FAA79C581D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000129 Genomic DNA. Translation: EAA62149.1.
BN001304 Genomic DNA. Translation: CBF79646.1.
RefSeqiXP_680838.1. XM_675746.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000676; CADANIAP00000676; CADANIAG00000676.
EAA62149; EAA62149; AN7569.2.
GeneIDi2869738.
KEGGiani:AN7569.2.

Similar proteinsi

Entry informationi

Entry nameiTPC1_EMENI
AccessioniPrimary (citable) accession number: Q5AVW1
Secondary accession number(s): C8VBQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 26, 2005
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families