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Q5AVP1

- MAND_EMENI

UniProt

Q5AVP1 - MAND_EMENI

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Protein

Mannan endo-1,4-beta-mannosidase D

Gene

manD

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921Proton donorBy similarity
Active sitei299 – 2991NucleophileBy similarity

GO - Molecular functioni

  1. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Mannan endo-1,4-beta-mannosidase D (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase D
Gene namesi
Name:manD
ORF Names:AN7639
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome IV

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 381359Mannan endo-1,4-beta-mannosidase DPRO_0000393711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AVP1.
SMRiQ5AVP1. Positions 26-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3934.
HOGENOMiHOG000169951.
InParanoidiQ5AVP1.
OMAiGSMPSAN.
OrthoDBiEOG7M3J90.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AVP1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHLLSLVCT LGAATLAASA AAEAGSMPSA NGLDFVIDGE ASYFAGSNAY
60 70 80 90 100
WLSFLTNNAD VDLALDHFAE SGLKILRIWG FSDVTAEPSD NKVYFQLHQN
110 120 130 140 150
GSSTVNTGPN GLERLDYIIS GAEKRGIKLV IPLVNYWDDF GGMNAYISAY
160 170 180 190 200
GGDKPGWYTN DKIQAAYHAY VKAVVSRYVD SPAIFAWELA NEPRCSGCDT
210 220 230 240 250
SIINQWATKT SSFIKSLDPN HMVAMGDEGM GLPGDSNYPY SYYEGNDFAL
260 270 280 290 300
NLAIPDIDFG TLHLYTTDWG VSNNSWGNKW VQDHAAVCKS AGKPCLFEEY
310 320 330 340 350
GMKGNHCTYE LAWQKTALAT PGMAADLFWQ FGENLSSGQT HNDKYTVYYG
360 370 380
SNEWKCVVSD HVAAVAVRRY RLPVGGGQHG P
Length:381
Mass (Da):41,603
Last modified:April 26, 2005 - v1
Checksum:i2D1871678CF69515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000130 Genomic DNA. Translation: EAA61825.1.
BN001304 Genomic DNA. Translation: CBF79796.1.
RefSeqiXP_680908.1. XM_675816.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000757; CADANIAP00000757; CADANIAG00000757.
GeneIDi2869716.
KEGGiani:AN7639.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000130 Genomic DNA. Translation: EAA61825.1 .
BN001304 Genomic DNA. Translation: CBF79796.1 .
RefSeqi XP_680908.1. XM_675816.1.

3D structure databases

ProteinModelPortali Q5AVP1.
SMRi Q5AVP1. Positions 26-365.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00000757 ; CADANIAP00000757 ; CADANIAG00000757 .
GeneIDi 2869716.
KEGGi ani:AN7639.2.

Phylogenomic databases

eggNOGi COG3934.
HOGENOMi HOG000169951.
InParanoidi Q5AVP1.
OMAi GSMPSAN.
OrthoDBi EOG7M3J90.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMAND_EMENI
AccessioniPrimary (citable) accession number: Q5AVP1
Secondary accession number(s): C8VBY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3