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Protein

Mannan endo-1,4-beta-mannosidase D

Gene

manD

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei192Proton donorBy similarity1
Active sitei299NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5

Names & Taxonomyi

Protein namesi
Recommended name:
Mannan endo-1,4-beta-mannosidase D (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase D
Gene namesi
Name:manD
ORF Names:AN7639
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039371123 – 381Mannan endo-1,4-beta-mannosidase DAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00000757

Structurei

3D structure databases

ProteinModelPortaliQ5AVP1
SMRiQ5AVP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000169951
InParanoidiQ5AVP1
KOiK19355
OMAiGSMPSAN
OrthoDBiEOG092C2KMO

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AVP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLLSLVCT LGAATLAASA AAEAGSMPSA NGLDFVIDGE ASYFAGSNAY
60 70 80 90 100
WLSFLTNNAD VDLALDHFAE SGLKILRIWG FSDVTAEPSD NKVYFQLHQN
110 120 130 140 150
GSSTVNTGPN GLERLDYIIS GAEKRGIKLV IPLVNYWDDF GGMNAYISAY
160 170 180 190 200
GGDKPGWYTN DKIQAAYHAY VKAVVSRYVD SPAIFAWELA NEPRCSGCDT
210 220 230 240 250
SIINQWATKT SSFIKSLDPN HMVAMGDEGM GLPGDSNYPY SYYEGNDFAL
260 270 280 290 300
NLAIPDIDFG TLHLYTTDWG VSNNSWGNKW VQDHAAVCKS AGKPCLFEEY
310 320 330 340 350
GMKGNHCTYE LAWQKTALAT PGMAADLFWQ FGENLSSGQT HNDKYTVYYG
360 370 380
SNEWKCVVSD HVAAVAVRRY RLPVGGGQHG P
Length:381
Mass (Da):41,603
Last modified:April 26, 2005 - v1
Checksum:i2D1871678CF69515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000130 Genomic DNA Translation: EAA61825.1
BN001304 Genomic DNA Translation: CBF79796.1
RefSeqiXP_680908.1, XM_675816.1

Genome annotation databases

EnsemblFungiiCADANIAT00000757; CADANIAP00000757; CADANIAG00000757
EAA61825; EAA61825; AN7639.2
GeneIDi2869716
KEGGiani:AN7639.2

Similar proteinsi

Entry informationi

Entry nameiMAND_EMENI
AccessioniPrimary (citable) accession number: Q5AVP1
Secondary accession number(s): C8VBY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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