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Protein

Mannan endo-1,4-beta-mannosidase D

Gene

manD

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei192Proton donorBy similarity1
Active sitei299NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannan endo-1,4-beta-mannosidase D (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase D
Gene namesi
Name:manD
ORF Names:AN7639
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039371123 – 381Mannan endo-1,4-beta-mannosidase DAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi273N-linked (GlcNAc...)Sequence analysis1
Glycosylationi334N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AVP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000169951.
InParanoidiQ5AVP1.
KOiK19355.
OMAiSTIMAWE.
OrthoDBiEOG092C2KMO.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AVP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLLSLVCT LGAATLAASA AAEAGSMPSA NGLDFVIDGE ASYFAGSNAY
60 70 80 90 100
WLSFLTNNAD VDLALDHFAE SGLKILRIWG FSDVTAEPSD NKVYFQLHQN
110 120 130 140 150
GSSTVNTGPN GLERLDYIIS GAEKRGIKLV IPLVNYWDDF GGMNAYISAY
160 170 180 190 200
GGDKPGWYTN DKIQAAYHAY VKAVVSRYVD SPAIFAWELA NEPRCSGCDT
210 220 230 240 250
SIINQWATKT SSFIKSLDPN HMVAMGDEGM GLPGDSNYPY SYYEGNDFAL
260 270 280 290 300
NLAIPDIDFG TLHLYTTDWG VSNNSWGNKW VQDHAAVCKS AGKPCLFEEY
310 320 330 340 350
GMKGNHCTYE LAWQKTALAT PGMAADLFWQ FGENLSSGQT HNDKYTVYYG
360 370 380
SNEWKCVVSD HVAAVAVRRY RLPVGGGQHG P
Length:381
Mass (Da):41,603
Last modified:April 26, 2005 - v1
Checksum:i2D1871678CF69515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000130 Genomic DNA. Translation: EAA61825.1.
BN001304 Genomic DNA. Translation: CBF79796.1.
RefSeqiXP_680908.1. XM_675816.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000757; CADANIAP00000757; CADANIAG00000757.
EAA61825; EAA61825; AN7639.2.
GeneIDi2869716.
KEGGiani:AN7639.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000130 Genomic DNA. Translation: EAA61825.1.
BN001304 Genomic DNA. Translation: CBF79796.1.
RefSeqiXP_680908.1. XM_675816.1.

3D structure databases

ProteinModelPortaliQ5AVP1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00000757; CADANIAP00000757; CADANIAG00000757.
EAA61825; EAA61825; AN7639.2.
GeneIDi2869716.
KEGGiani:AN7639.2.

Phylogenomic databases

HOGENOMiHOG000169951.
InParanoidiQ5AVP1.
KOiK19355.
OMAiSTIMAWE.
OrthoDBiEOG092C2KMO.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMAND_EMENI
AccessioniPrimary (citable) accession number: Q5AVP1
Secondary accession number(s): C8VBY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.