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Q5AUX2

- AXHA2_EMENI

UniProt

Q5AUX2 - AXHA2_EMENI

Protein

Alpha-L-arabinofuranosidase axhA-2

Gene

axhA-2

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.

    pH dependencei

    Optimum pH is 5.4.1 Publication

    Temperature dependencei

    Optimum temperature is 47 degrees Celsius.1 Publication

    GO - Molecular functioni

    1. alpha-L-arabinofuranosidase activity Source: UniProtKB

    GO - Biological processi

    1. arabinose metabolic process Source: UniProtKB
    2. L-arabinose metabolic process Source: InterPro
    3. pectin catabolic process Source: UniProtKB
    4. xylan catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-L-arabinofuranosidase axhA-2 (EC:3.2.1.55)
    Alternative name(s):
    Arabinoxylan arabinofuranohydrolase axhA-2
    Gene namesi
    Name:axhA-2
    ORF Names:AN7908
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome II

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 325303Alpha-L-arabinofuranosidase axhA-2PRO_0000393537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00003927.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AUX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 62 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG81570.
    HOGENOMiHOG000164911.
    OMAiSHALAPC.
    OrthoDBiEOG74J9JT.

    Family and domain databases

    InterProiIPR005193. GH62_arabinosidase.
    IPR023296. Glyco_hydro_beta-prop.
    [Graphical view]
    PfamiPF03664. Glyco_hydro_62. 1 hit.
    [Graphical view]
    SUPFAMiSSF75005. SSF75005. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5AUX2-1 [UniParc]FASTAAdd to Basket

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    MRNLSTWPTF AALLWSAPRV LAQCGLPSTY SWTSTGPLAE PKDGWASLKD    50
    FTAVPYNGQY LVYATYHDTG TSWGSMNFGL FSNWSDMATA SQNAMTQSTV 100
    APTLFYFEPK DVWILAYQWG PTAFSYLTSS DPTDANGWSS PQPLFSGSIS 150
    DSDTGVIDQT VIGDSTTMYL FFAGDNGRIY RASMPIDQFP GDFGTESEII 200
    LSDERNNLFE AVQVYTVSGQ SKDTYLMIVE AIGAQGRYFR SFTADSLGGS 250
    WTPQAATESA PFAGKANSGA TWTDDISHGD LVRSTPDQTM SIDPCNLQLL 300
    YQGRDPSLNP GYDLLPYRPG LLTLK 325
    Length:325
    Mass (Da):35,560
    Last modified:April 26, 2005 - v1
    Checksum:iCD0DC28566CB8064
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000135 Genomic DNA. Translation: EAA59562.1.
    BN001302 Genomic DNA. Translation: CBF73503.1.
    RefSeqiXP_681177.1. XM_676085.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00003927; CADANIAP00003927; CADANIAG00003927.
    GeneIDi2869048.
    KEGGiani:AN7908.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000135 Genomic DNA. Translation: EAA59562.1 .
    BN001302 Genomic DNA. Translation: CBF73503.1 .
    RefSeqi XP_681177.1. XM_676085.1.

    3D structure databases

    ProteinModelPortali Q5AUX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00003927.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00003927 ; CADANIAP00003927 ; CADANIAG00003927 .
    GeneIDi 2869048.
    KEGGi ani:AN7908.2.

    Phylogenomic databases

    eggNOGi NOG81570.
    HOGENOMi HOG000164911.
    OMAi SHALAPC.
    OrthoDBi EOG74J9JT.

    Family and domain databases

    InterProi IPR005193. GH62_arabinosidase.
    IPR023296. Glyco_hydro_beta-prop.
    [Graphical view ]
    Pfami PF03664. Glyco_hydro_62. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75005. SSF75005. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
      Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
      Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

    Entry informationi

    Entry nameiAXHA2_EMENI
    AccessioniPrimary (citable) accession number: Q5AUX2
    Secondary accession number(s): C8V4U9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3