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Q5AUX2

- AXHA2_EMENI

UniProt

Q5AUX2 - AXHA2_EMENI

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Protein

Alpha-L-arabinofuranosidase axhA-2

Gene

axhA-2

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.

pH dependencei

Optimum pH is 5.4.1 Publication

Temperature dependencei

Optimum temperature is 47 degrees Celsius.1 Publication

GO - Molecular functioni

  1. alpha-L-arabinofuranosidase activity Source: UniProtKB

GO - Biological processi

  1. arabinose metabolic process Source: UniProtKB
  2. L-arabinose metabolic process Source: InterPro
  3. pectin catabolic process Source: UniProtKB
  4. xylan catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-arabinofuranosidase axhA-2 (EC:3.2.1.55)
Alternative name(s):
Arabinoxylan arabinofuranohydrolase axhA-2
Gene namesi
Name:axhA-2
ORF Names:AN7908
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 325303Alpha-L-arabinofuranosidase axhA-2PRO_0000393537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00003927.

Structurei

3D structure databases

ProteinModelPortaliQ5AUX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 62 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG81570.
HOGENOMiHOG000164911.
InParanoidiQ5AUX2.
OMAiSHALAPC.
OrthoDBiEOG74J9JT.

Family and domain databases

InterProiIPR005193. GH62_arabinosidase.
IPR023296. Glyco_hydro_beta-prop.
[Graphical view]
PfamiPF03664. Glyco_hydro_62. 1 hit.
[Graphical view]
SUPFAMiSSF75005. SSF75005. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AUX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNLSTWPTF AALLWSAPRV LAQCGLPSTY SWTSTGPLAE PKDGWASLKD
60 70 80 90 100
FTAVPYNGQY LVYATYHDTG TSWGSMNFGL FSNWSDMATA SQNAMTQSTV
110 120 130 140 150
APTLFYFEPK DVWILAYQWG PTAFSYLTSS DPTDANGWSS PQPLFSGSIS
160 170 180 190 200
DSDTGVIDQT VIGDSTTMYL FFAGDNGRIY RASMPIDQFP GDFGTESEII
210 220 230 240 250
LSDERNNLFE AVQVYTVSGQ SKDTYLMIVE AIGAQGRYFR SFTADSLGGS
260 270 280 290 300
WTPQAATESA PFAGKANSGA TWTDDISHGD LVRSTPDQTM SIDPCNLQLL
310 320
YQGRDPSLNP GYDLLPYRPG LLTLK
Length:325
Mass (Da):35,560
Last modified:April 26, 2005 - v1
Checksum:iCD0DC28566CB8064
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000135 Genomic DNA. Translation: EAA59562.1.
BN001302 Genomic DNA. Translation: CBF73503.1.
RefSeqiXP_681177.1. XM_676085.1.

Genome annotation databases

EnsemblFungiiCADANIAT00003927; CADANIAP00003927; CADANIAG00003927.
GeneIDi2869048.
KEGGiani:AN7908.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000135 Genomic DNA. Translation: EAA59562.1 .
BN001302 Genomic DNA. Translation: CBF73503.1 .
RefSeqi XP_681177.1. XM_676085.1.

3D structure databases

ProteinModelPortali Q5AUX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00003927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00003927 ; CADANIAP00003927 ; CADANIAG00003927 .
GeneIDi 2869048.
KEGGi ani:AN7908.2.

Phylogenomic databases

eggNOGi NOG81570.
HOGENOMi HOG000164911.
InParanoidi Q5AUX2.
OMAi SHALAPC.
OrthoDBi EOG74J9JT.

Family and domain databases

InterProi IPR005193. GH62_arabinosidase.
IPR023296. Glyco_hydro_beta-prop.
[Graphical view ]
Pfami PF03664. Glyco_hydro_62. 1 hit.
[Graphical view ]
SUPFAMi SSF75005. SSF75005. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
    Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
    Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiAXHA2_EMENI
AccessioniPrimary (citable) accession number: Q5AUX2
Secondary accession number(s): C8V4U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3