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Q5AUW5

- BGLD_EMENI

UniProt

Q5AUW5 - BGLD_EMENI

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Protein

Probable beta-glucosidase D

Gene

bglD

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei324 – 3241By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
  2. secondary metabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase D (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase D
Cellobiase D
Gentiobiase D
Gene namesi
Name:bglD
ORF Names:AN7915
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 812794Probable beta-glucosidase DPRO_0000394108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi646 – 6461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AUW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 24656Gly-richAdd
BLAST
Compositional biasi212 – 26251Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
InParanoidiQ5AUW5.
OMAiTYQGHLA.
OrthoDBiEOG7XH6ZD.

Family and domain databases

Gene3Di3.20.20.300. 2 hits.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF52279. SSF52279. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AUW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVPSLSVLS FLLGTALAAA SNFEAGLLSS GKVSLGDWKS AHEKASQFVA
60 70 80 90 100
KLNTTEKIKL ITGSSVTTTN GETFTALDIL DGDMGAQAYY YVSAFSLSSA
110 120 130 140 150
LAMTWDKEAM YEQGRAIAAE FYGKGIQMVA GPTSQPLGRT PWGGRLVESF
160 170 180 190 200
GPDPYLNGIA TGLETRAYAD VGVIAGAKHF ILNEQETNRT GGMGGGGGAP
210 220 230 240 250
GGGGMGRGAE FSSSVPGGMS PTSSAGAIPS STSTPGGSGM GGGMAGSSAF
260 270 280 290 300
SSSSSSGAPY SSNADDKTLH ETYLWSFYDA VHSGLGGVMC AMTKVNGTLS
310 320 330 340 350
CQSSSLLLDI LKTELGFPGM VWPDTNGQQD ALASAANGLD YGSSSLWSES
360 370 380 390 400
TIEGYLESNN ITEARLNDMA IRNLMGYYYV NLDNGTQPST AAQDDYVDVR
410 420 430 440 450
ANHAKLIRSH GSKSMVLLKN KNNTLPLYKP HKMAIFGSHA RAAVAGPNMQ
460 470 480 490 500
FSVEGSGPTY DGHIATDSGS GQASLPYLIT PENALNIKAS QDGTMLRWIA
510 520 530 540 550
NDTYSSSTGS ALVMQGSSST SVTPSVSAYS ENMDVCLVFI NALAGEGADR
560 570 580 590 600
TELRNTDQDN LINEVADNCD NTVVVINTVG ARILDSWIEH ENVTAVLYGS
610 620 630 640 650
LLGQESGNSI VDVLYGDVNP SGRLTYTIAK TESDYNVDIC YTAQCNFTEG
660 670 680 690 700
NYIDYRYFDA YNVTPRYEFG YGLSYTDFAY SNLHIQGPSA LSTYPTGQLA
710 720 730 740 750
VGGYEDLWDT VAKVTVTIRN AGSLDGAEVP QLYISYPDVA KQPVRQLRGF
760 770 780 790 800
HNVYIKKGQS TKVTFELRRR DISYWDVQHQ KWAVAPGTYE AWVGASSRDL
810
RTHGSFVVKT KA
Length:812
Mass (Da):86,383
Last modified:May 18, 2010 - v2
Checksum:iA70CFB5FF35CBD1B
GO

Sequence cautioni

The sequence EAA59569.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000135 Genomic DNA. Translation: EAA59569.1. Sequence problems.
BN001302 Genomic DNA. Translation: CBF73514.1.
RefSeqiXP_681184.1. XM_676092.1.

Genome annotation databases

EnsemblFungiiCADANIAT00003933; CADANIAP00003933; CADANIAG00003933.
GeneIDi2869248.
KEGGiani:AN7915.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000135 Genomic DNA. Translation: EAA59569.1 . Sequence problems.
BN001302 Genomic DNA. Translation: CBF73514.1 .
RefSeqi XP_681184.1. XM_676092.1.

3D structure databases

ProteinModelPortali Q5AUW5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00003933 ; CADANIAP00003933 ; CADANIAG00003933 .
GeneIDi 2869248.
KEGGi ani:AN7915.2.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
InParanoidi Q5AUW5.
OMAi TYQGHLA.
OrthoDBi EOG7XH6ZD.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 2 hits.
3.40.50.1700. 1 hit.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF52279. SSF52279. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiBGLD_EMENI
AccessioniPrimary (citable) accession number: Q5AUW5
Secondary accession number(s): C8V4V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3