Q5AUG9 (CWC27_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl isomerase cwc27
Short name=PPIase cwc27
EC=5.2.1.8

Alternative name(s):
Rotamase cwc27

Gene names

Name:	cwc27
ORF Names:	AN8061

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Associated with the spliceosome By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 558	558	Peptidyl-prolyl isomerase cwc27		PRO_0000064184
Regions
	Domain	11 – 184	174	PPIase cyclophilin-type
	Compositional bias	274 – 318	45	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5AUG9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 6CC2F07401DE6661	FASTA	558	61,731
	10 20 30 40 50 60 MSAHYATEPA PTASATLHTT FGPLHIALFA KQTPLTCRNF LQHCMDNYYA GTIFHRVVPD 70 80 90 100 110 120 FIIQGGDPTG TGSGGTSIYE YPEFEYDPDA RDPNEKVVLR DEIHSRLRFN RRGLVGMAKS 130 140 150 160 170 180 EDGSYGSQFF ITLANTEREL NGQCTLFGRL EGDSLYNMLK IAEAERIEGT ERPVYPVKIT 190 200 210 220 230 240 SCEVGDLGPF VDKVKKRQVV ATGPKTEEKP AAKKKKKAKP GKALLSFGGD DEEDEDMPIR 250 260 270 280 290 300 PAKPKFNPML VTDTKLPEKE SSTKGEASQT RKRPRSPSPK RQPQPSAPPK NRPKTPEPTK 310 320 330 340 350 360 QLPLPNPESP ERSPSPPPKQ SFLSRTNAEI ENLKASMRRT AHAPAAETKP KSALEAMIPQ 370 380 390 400 410 420 TAIRGRKRPP PGSVSASTSA PNGITGFSSN SAEAEALKMF NAFRAKLESS DSQPTAAAAK 430 440 450 460 470 480 RLSVAKTDAA EERKETPDED EESQLCDLHF IANCQSCKSW DNDVEGGANN GADDDVNDSG 490 500 510 520 530 540 WLNHQLRFGK DTLGKDLNWK REHQDVDTLM VIDPREKEKE LADSSRPGTK RVKGRGLERD 550 RERERKKGRV GDLEWSKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed: 19146970] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACD01000139 Genomic DNA. Translation: EAA59683.1. BN001302 Genomic DNA. Translation: CBF73806.1.
RefSeq	XP_681330.1. XM_676238.1.
3D structure databases
ProteinModelPortal	Q5AUG9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANIAT00004087; CADANIAP00004087; CADANIAG00004087.
GeneID	2869127.
KEGG	ani:AN8061.2.
Phylogenomic databases
OMA	FIANCQS.
OrthoDB	EOG4XD70H.
PhylomeDB	Q5AUG9.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
KO	K12737.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CWC27_EMENI

Accession

Primary (citable) accession number: Q5AUG9
Secondary accession number(s): C8V676

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program