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Protein

Alpha-fucosidase A

Gene

afcA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-fucosidase involved in degradation of fucosylated xyloglucans. Hydrolyzes alpha-1,2-linked fucose. Active on cotton xyloglucan oligomers but not active on paranitrophenyl-fucoside.1 Publication

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

GO - Molecular functioni

  • alpha-L-fucosidase activity Source: UniProtKB

GO - Biological processi

  • polysaccharide catabolic process Source: UniProtKB-KW
  • xyloglucan metabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18214

Protein family/group databases

CAZyiGH95 Glycoside Hydrolase Family 95

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-fucosidase A (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase A
Gene namesi
Name:afcA
ORF Names:AN8149
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039470420 – 809Alpha-fucosidase AAdd BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi614N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi642N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AU81
SMRiQ5AU81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 95 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000235039
InParanoidiQ5AU81
KOiK15923
OMAiMGAAWLC
OrthoDBiEOG092C0OYW

Family and domain databases

Gene3Di1.50.10.10, 2 hits
2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR016518 Alpha-L-fucosidase
IPR027414 GH95_N_dom
IPR013780 Glyco_hydro_b
PfamiView protein in Pfam
PF14498 Glyco_hyd_65N_2, 1 hit
PIRSFiPIRSF007663 UCP007663, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AU81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTTLFLAV TFATSNAQGR ALRSSSPATY GTTDGSDYIL KTGYLIGNGK
60 70 80 90 100
LGVIPFGPPD TEKLNLNVDS LWSGGPFEVE NYTGGNPSSP IYDALPGIRE
110 120 130 140 150
RIFENGTGGM EELLGSGNHY GSSRVLGNIT IALDGVEAYS KYKRTLDLSD
160 170 180 190 200
GVHRTSFTIA NRTTAALKSS IFCSYPDQVC VYHLESASDA RLPKVTISIE
210 220 230 240 250
NLLVNQSLLQ TSCESEAKRA VLRHSGVTQA GPPEGMKYAA VAEVVNPRSS
260 270 280 290 300
VTTCLGEGAL QISSRKKQLT IIIGAATNYD QKAGNAKSGW SFKNAKDPAS
310 320 330 340 350
IVDGIASAAG WKGYQRLLDR HVKDYKKLMG DFSLELPDTT DSASKDTSEL
360 370 380 390 400
IEKYSYASAT GNPYLENLLL DYARHLLVSS SRPNSLPANL QGRWTESLTP
410 420 430 440 450
SWSADYHANI NLQMNYWLAD QTGLGETQHA LWNYMADTWV PRGTETARLL
460 470 480 490 500
YNASGWVVHN EINIFGFTAM KEDAGWANYP AAAAWMMQHV WDNFDYTHDT
510 520 530 540 550
AWLVSQGYAL LKGIASFWLS SLQEDKFFND GSLVVNPCNS PETGPTTFGC
560 570 580 590 600
THYQQLIHQV FETVLAAQEY IHESDTKFVD SVASALERLD TGLHLSSWGG
610 620 630 640 650
LKEWKLPDSY GYDNMSTHRH LSHLAGWYPG YSISSFAHGY RNKTIQDAVK
660 670 680 690 700
ETLTARGMGN AADANAGWAK VWRAACWARL NDSSMAYDEL RYAIDENFVG
710 720 730 740 750
NGLSMYWGAS PPFQIDANFG FAGAVLSMLV VDLPTPRSDP GQRTVVLGPA
760 770 780 790 800
IPSAWGGGRA KGLRLRGGAK VDFGWDKRGV VNWVNIVKRG KGTSRVKLVN

KEGDILAEM
Length:809
Mass (Da):88,536
Last modified:April 26, 2005 - v1
Checksum:iFDF201647A4BF899
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ490516 mRNA Translation: ABF50892.1
AACD01000141 Genomic DNA Translation: EAA59171.1
BN001302 Genomic DNA Translation: CBF73981.1
RefSeqiXP_681418.1, XM_676326.1

Genome annotation databases

EnsemblFungiiCADANIAT00004184; CADANIAP00004184; CADANIAG00004184
EAA59171; EAA59171; AN8149.2
GeneIDi2869274
KEGGiani:AN8149.2

Similar proteinsi

Entry informationi

Entry nameiAFCA_EMENI
AccessioniPrimary (citable) accession number: Q5AU81
Secondary accession number(s): C8V6V7, Q1HFQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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