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Protein

Alpha-fucosidase A

Gene

afcA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-fucosidase involved in degradation of fucosylated xyloglucans. Hydrolyzes alpha-1,2-linked fucose. Active on cotton xyloglucan oligomers but not active on paranitrophenyl-fucoside.1 Publication

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

GO - Molecular functioni

  • alpha-L-fucosidase activity Source: UniProtKB

GO - Biological processi

  • polysaccharide catabolic process Source: UniProtKB-KW
  • xyloglucan metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18214.

Protein family/group databases

CAZyiGH95. Glycoside Hydrolase Family 95.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-fucosidase A (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase A
Gene namesi
Name:afcA
ORF Names:AN8149
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039470420 – 809Alpha-fucosidase AAdd BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi452N-linked (GlcNAc...)Sequence analysis1
Glycosylationi614N-linked (GlcNAc...)Sequence analysis1
Glycosylationi642N-linked (GlcNAc...)Sequence analysis1
Glycosylationi681N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5AU81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 95 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000235039.
InParanoidiQ5AU81.
KOiK15923.
OMAiSVDFSWD.
OrthoDBiEOG092C0OYW.

Family and domain databases

Gene3Di2.70.98.50. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR016518. Alpha-L-fucosidase.
IPR027414. GH_fam_N_dom.
[Graphical view]
PfamiPF14498. Glyco_hyd_65N_2. 1 hit.
[Graphical view]
PIRSFiPIRSF007663. UCP007663. 1 hit.
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AU81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTTLFLAV TFATSNAQGR ALRSSSPATY GTTDGSDYIL KTGYLIGNGK
60 70 80 90 100
LGVIPFGPPD TEKLNLNVDS LWSGGPFEVE NYTGGNPSSP IYDALPGIRE
110 120 130 140 150
RIFENGTGGM EELLGSGNHY GSSRVLGNIT IALDGVEAYS KYKRTLDLSD
160 170 180 190 200
GVHRTSFTIA NRTTAALKSS IFCSYPDQVC VYHLESASDA RLPKVTISIE
210 220 230 240 250
NLLVNQSLLQ TSCESEAKRA VLRHSGVTQA GPPEGMKYAA VAEVVNPRSS
260 270 280 290 300
VTTCLGEGAL QISSRKKQLT IIIGAATNYD QKAGNAKSGW SFKNAKDPAS
310 320 330 340 350
IVDGIASAAG WKGYQRLLDR HVKDYKKLMG DFSLELPDTT DSASKDTSEL
360 370 380 390 400
IEKYSYASAT GNPYLENLLL DYARHLLVSS SRPNSLPANL QGRWTESLTP
410 420 430 440 450
SWSADYHANI NLQMNYWLAD QTGLGETQHA LWNYMADTWV PRGTETARLL
460 470 480 490 500
YNASGWVVHN EINIFGFTAM KEDAGWANYP AAAAWMMQHV WDNFDYTHDT
510 520 530 540 550
AWLVSQGYAL LKGIASFWLS SLQEDKFFND GSLVVNPCNS PETGPTTFGC
560 570 580 590 600
THYQQLIHQV FETVLAAQEY IHESDTKFVD SVASALERLD TGLHLSSWGG
610 620 630 640 650
LKEWKLPDSY GYDNMSTHRH LSHLAGWYPG YSISSFAHGY RNKTIQDAVK
660 670 680 690 700
ETLTARGMGN AADANAGWAK VWRAACWARL NDSSMAYDEL RYAIDENFVG
710 720 730 740 750
NGLSMYWGAS PPFQIDANFG FAGAVLSMLV VDLPTPRSDP GQRTVVLGPA
760 770 780 790 800
IPSAWGGGRA KGLRLRGGAK VDFGWDKRGV VNWVNIVKRG KGTSRVKLVN

KEGDILAEM
Length:809
Mass (Da):88,536
Last modified:April 26, 2005 - v1
Checksum:iFDF201647A4BF899
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ490516 mRNA. Translation: ABF50892.1.
AACD01000141 Genomic DNA. Translation: EAA59171.1.
BN001302 Genomic DNA. Translation: CBF73981.1.
RefSeqiXP_681418.1. XM_676326.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004184; CADANIAP00004184; CADANIAG00004184.
EAA59171; EAA59171; AN8149.2.
GeneIDi2869274.
KEGGiani:AN8149.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ490516 mRNA. Translation: ABF50892.1.
AACD01000141 Genomic DNA. Translation: EAA59171.1.
BN001302 Genomic DNA. Translation: CBF73981.1.
RefSeqiXP_681418.1. XM_676326.1.

3D structure databases

ProteinModelPortaliQ5AU81.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH95. Glycoside Hydrolase Family 95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00004184; CADANIAP00004184; CADANIAG00004184.
EAA59171; EAA59171; AN8149.2.
GeneIDi2869274.
KEGGiani:AN8149.2.

Phylogenomic databases

HOGENOMiHOG000235039.
InParanoidiQ5AU81.
KOiK15923.
OMAiSVDFSWD.
OrthoDBiEOG092C0OYW.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18214.

Family and domain databases

Gene3Di2.70.98.50. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR016518. Alpha-L-fucosidase.
IPR027414. GH_fam_N_dom.
[Graphical view]
PfamiPF14498. Glyco_hyd_65N_2. 1 hit.
[Graphical view]
PIRSFiPIRSF007663. UCP007663. 1 hit.
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAFCA_EMENI
AccessioniPrimary (citable) accession number: Q5AU81
Secondary accession number(s): C8V6V7, Q1HFQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.