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Protein

FK506-binding protein 2

Gene

fkbB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to farnesol Source: AspGD
  • chaperone-mediated protein folding Source: GO_Central

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:fkbB
ORF Names:AN8343
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome V
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000023306821 – 135FK506-binding protein 2Add BLAST115

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00002809

Structurei

3D structure databases

ProteinModelPortaliQ5ATN7
SMRiQ5ATN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 128PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 135Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000154887
InParanoidiQ5ATN7
KOiK09569
OMAiGILGMCE
OrthoDBiEOG092C52SD

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ATN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVPIITTLL TLALTGLSQA ASLGVETTHG VECNRKTTKG DTVKMHYRGT
60 70 80 90 100
LAEDGSQFDA SYDRGTPFKF KLGAGRVIKG WDEGLLDMCV GEKRTLTIPP
110 120 130
EYGYGDRGIG PIPGGATLIF QTELLEIEGV PKDEL
Length:135
Mass (Da):14,572
Last modified:April 26, 2005 - v1
Checksum:i594AC6EFC3A8DCF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ192016 Genomic DNA Translation: ABA39173.1
AACD01000151 Genomic DNA Translation: EAA66905.1
BN001305 Genomic DNA Translation: CBF80348.1
RefSeqiXP_681612.1, XM_676520.1

Genome annotation databases

EnsemblFungiiCADANIAT00002809; CADANIAP00002809; CADANIAG00002809
EAA66905; EAA66905; AN8343.2
GeneIDi2868823
KEGGiani:AN8343.2

Similar proteinsi

Entry informationi

Entry nameiFKBP2_EMENI
AccessioniPrimary (citable) accession number: Q5ATN7
Secondary accession number(s): C8VE36, Q3HV69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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