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Protein

FK506-binding protein 2

Gene

fkbB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to farnesol Source: ASPGD
  • chaperone-mediated protein folding Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:fkbB
ORF Names:AN8343
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome V
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000023306821 – 135FK506-binding protein 2Add BLAST115

Structurei

3D structure databases

ProteinModelPortaliQ5ATN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 128PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 135Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000154887.
InParanoidiQ5ATN7.
KOiK09569.
OMAiCTRKAKG.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ATN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVPIITTLL TLALTGLSQA ASLGVETTHG VECNRKTTKG DTVKMHYRGT
60 70 80 90 100
LAEDGSQFDA SYDRGTPFKF KLGAGRVIKG WDEGLLDMCV GEKRTLTIPP
110 120 130
EYGYGDRGIG PIPGGATLIF QTELLEIEGV PKDEL
Length:135
Mass (Da):14,572
Last modified:April 26, 2005 - v1
Checksum:i594AC6EFC3A8DCF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ192016 Genomic DNA. Translation: ABA39173.1.
AACD01000151 Genomic DNA. Translation: EAA66905.1.
BN001305 Genomic DNA. Translation: CBF80348.1.
RefSeqiXP_681612.1. XM_676520.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002809; CADANIAP00002809; CADANIAG00002809.
EAA66905; EAA66905; AN8343.2.
GeneIDi2868823.
KEGGiani:AN8343.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ192016 Genomic DNA. Translation: ABA39173.1.
AACD01000151 Genomic DNA. Translation: EAA66905.1.
BN001305 Genomic DNA. Translation: CBF80348.1.
RefSeqiXP_681612.1. XM_676520.1.

3D structure databases

ProteinModelPortaliQ5ATN7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002809; CADANIAP00002809; CADANIAG00002809.
EAA66905; EAA66905; AN8343.2.
GeneIDi2868823.
KEGGiani:AN8343.2.

Phylogenomic databases

HOGENOMiHOG000154887.
InParanoidiQ5ATN7.
KOiK09569.
OMAiCTRKAKG.
OrthoDBiEOG092C52SD.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_EMENI
AccessioniPrimary (citable) accession number: Q5ATN7
Secondary accession number(s): C8VE36, Q3HV69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.