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Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031SubstrateBy similarity
Binding sitei174 – 1741SubstrateBy similarity
Binding sitei290 – 2901SubstrateBy similarity
Binding sitei291 – 2911SubstrateBy similarity
Binding sitei373 – 3731ATPBy similarity
Binding sitei484 – 4841ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi480 – 4812ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:AN8790
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560 Componenti: Chromosome III

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Probable D-xylulose kinase APRO_0000393524Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006272.

Structurei

3D structure databases

ProteinModelPortaliQ5ASE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
InParanoidiQ5ASE0.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ASE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSSSPLK GPLYIGFDLS TQQLKGLVVN SDLKVVYSSI FDFDADSQGF
60 70 80 90 100
PIKKGVLTNE AEHEVFAPVA LWLQALDSVL DGLKKQGLDF SHVRGISGAG
110 120 130 140 150
QQHGSVYWGQ DAEKLLNGLD AGKRLQEQLE GAFSHPYSPN WQDSSTQKEC
160 170 180 190 200
DEFDEYLGGA DKLAEATGSK AHHRFTGPQI LRFQKKYPDV YKKTSRISLV
210 220 230 240 250
SSFLASLFLG HIAPLDISDV CGMNLWNIHK GAYDEDLLKL CAGPHGVEDL
260 270 280 290 300
KRKLGDVPED GGIDLGKVHR YYVDRYGFSP ECTVIPSTGD NPATILALPL
310 320 330 340 350
RPSDAMVSLG TSTTFLMSTP SYKADPATHF FNHPTTPGLY MFMLCYKNGG
360 370 380 390 400
LAREKIRDAI NDAKNEKNPS NPWANFDSVA LQTPPLGQTS PSDPMKMGLF
410 420 430 440 450
FPRPEIVPNL RAGQWLFNYD PSTGNLTETL NGEGWNRPAD EARAIIESQM
460 470 480 490 500
LSLRLRSRGL TSSPGGDIPA QPRRVYLVGG GSKNKTIAKI AGEILGGSEG
510 520 530 540 550
VYKLEIGDNA CALGAAYKAV WALERKKDQT FEDLIGARWH EEEFIEKIAD
560 570 580
GYQKEAFERY GKAVEGFEKM EQRVLEQEGR K
Length:581
Mass (Da):64,025
Last modified:April 25, 2005 - v1
Checksum:i551C8D374CDEF3D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000161 Genomic DNA. Translation: EAA60583.1.
BN001303 Genomic DNA. Translation: CBF78014.1.
RefSeqiXP_682059.1. XM_676967.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006272; CADANIAP00006272; CADANIAG00006272.
GeneIDi2868421.
KEGGiani:AN8790.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000161 Genomic DNA. Translation: EAA60583.1.
BN001303 Genomic DNA. Translation: CBF78014.1.
RefSeqiXP_682059.1. XM_676967.1.

3D structure databases

ProteinModelPortaliQ5ASE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00006272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00006272; CADANIAP00006272; CADANIAG00006272.
GeneIDi2868421.
KEGGiani:AN8790.2.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
InParanoidiQ5ASE0.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiXKS1_EMENI
AccessioniPrimary (citable) accession number: Q5ASE0
Secondary accession number(s): C8V9P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 19, 2010
Last sequence update: April 25, 2005
Last modified: January 6, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.