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Q5ASE0

- XKS1_EMENI

UniProt

Q5ASE0 - XKS1_EMENI

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Protein

Probable D-xylulose kinase A

Gene
xkiA, AN8790
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Substrate By similarity
Binding sitei174 – 1741Substrate By similarity
Binding sitei290 – 2901Substrate By similarity
Binding sitei291 – 2911Substrate By similarity
Binding sitei373 – 3731ATP By similarity
Binding sitei484 – 4841ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi480 – 4812ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:AN8790
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome III

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Probable D-xylulose kinase APRO_0000393524Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006272.

Structurei

3D structure databases

ProteinModelPortaliQ5ASE0.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ASE0-1 [UniParc]FASTAAdd to Basket

« Hide

MSSRSSSPLK GPLYIGFDLS TQQLKGLVVN SDLKVVYSSI FDFDADSQGF    50
PIKKGVLTNE AEHEVFAPVA LWLQALDSVL DGLKKQGLDF SHVRGISGAG 100
QQHGSVYWGQ DAEKLLNGLD AGKRLQEQLE GAFSHPYSPN WQDSSTQKEC 150
DEFDEYLGGA DKLAEATGSK AHHRFTGPQI LRFQKKYPDV YKKTSRISLV 200
SSFLASLFLG HIAPLDISDV CGMNLWNIHK GAYDEDLLKL CAGPHGVEDL 250
KRKLGDVPED GGIDLGKVHR YYVDRYGFSP ECTVIPSTGD NPATILALPL 300
RPSDAMVSLG TSTTFLMSTP SYKADPATHF FNHPTTPGLY MFMLCYKNGG 350
LAREKIRDAI NDAKNEKNPS NPWANFDSVA LQTPPLGQTS PSDPMKMGLF 400
FPRPEIVPNL RAGQWLFNYD PSTGNLTETL NGEGWNRPAD EARAIIESQM 450
LSLRLRSRGL TSSPGGDIPA QPRRVYLVGG GSKNKTIAKI AGEILGGSEG 500
VYKLEIGDNA CALGAAYKAV WALERKKDQT FEDLIGARWH EEEFIEKIAD 550
GYQKEAFERY GKAVEGFEKM EQRVLEQEGR K 581
Length:581
Mass (Da):64,025
Last modified:April 26, 2005 - v1
Checksum:i551C8D374CDEF3D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000161 Genomic DNA. Translation: EAA60583.1.
BN001303 Genomic DNA. Translation: CBF78014.1.
RefSeqiXP_682059.1. XM_676967.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006272; CADANIAP00006272; CADANIAG00006272.
GeneIDi2868421.
KEGGiani:AN8790.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000161 Genomic DNA. Translation: EAA60583.1 .
BN001303 Genomic DNA. Translation: CBF78014.1 .
RefSeqi XP_682059.1. XM_676967.1.

3D structure databases

ProteinModelPortali Q5ASE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00006272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00006272 ; CADANIAP00006272 ; CADANIAG00006272 .
GeneIDi 2868421.
KEGGi ani:AN8790.2.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000174850.
KOi K00854.
OMAi GSYSPID.
OrthoDBi EOG7CRTZN.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiXKS1_EMENI
AccessioniPrimary (citable) accession number: Q5ASE0
Secondary accession number(s): C8V9P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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