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Protein

Helicase swr1

Gene

swr1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi850 – 857ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase swr1 (EC:3.6.4.12)
Gene namesi
Name:swr1
ORF Names:AN9077
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VI
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743681 – 1698Helicase swr1Add BLAST1698

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00009538.

Structurei

3D structure databases

SMRiQ5ARK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 403HSAPROSITE-ProRule annotationAdd BLAST75
Domaini837 – 1002Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1377 – 1527Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi953 – 956DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi470 – 609Asp-richAdd BLAST140

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000186095.
InParanoidiQ5ARK3.
KOiK11681.
OMAiHEVWGPH.
OrthoDBiEOG092C1YH4.

Family and domain databases

InterProiView protein in InterPro
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiView protein in PROSITE
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ARK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNGTTIGIP PENERVTERA EPVPSDLLPN NSPVNSPTID PTLSEIKDVA
60 70 80 90 100
ADHNEEPPSK RRKVAGSTPS RRSHSRAASP PWKKAGADGP TSKIVDGKRR
110 120 130 140 150
STRVSNVGPV EQPPSDAKPT RSSQKQYVSK AVSSQRNAAV SSPLPMSPSR
160 170 180 190 200
SGINRRSLAG VAVNGSPSTT AKGSIGRRRR ESPSPVSKRA STRTRPDNMD
210 220 230 240 250
AYHPSNGVTP RSNSTKTRST RSFQLASSDF REETADDIGN DGQDEHGQRI
260 270 280 290 300
QRLRIKVKKP ALSIQHPSHV LPTRKYGSFK EWLENEGTGP GRMLTMTDAL
310 320 330 340 350
EEAQKRRQVT EAMEPGGLLS SEVCSAFLPE PQEELPQQFS HQDHLVAHAL
360 370 380 390 400
YFKKLLDKEH RAHRQAAKSL AAACAEVWRK RNKDPEDILR EQQEEMRGKR
410 420 430 440 450
KQLAKDLKKM FELARAEIDR VRLARWEEEQ KAKDQRALDR AIKQSTMLFE
460 470 480 490 500
KRRLEILGET GSDAPETTTD DEEVETDNGS ENDDEEGESN MSTETEEEDG
510 520 530 540 550
DDRDDDVGLT AEELRLKYAN LPDTNPHPDQ SPYSDEDSED SDDIAADNTP
560 570 580 590 600
GDTSGGVNRS PPPDSSGQVE LDEVDPVLID DSDESTDMDD DMGDSDDDGY
610 620 630 640 650
SEAESDDEDG GEPGLLGFFS AKDLSLSNLH QTNSGEGDTH QTGADGDRNE
660 670 680 690 700
DSSFDESEFG SEDPDEVTLV PTGPTNKDLS TPATVTASAE LEPAAMTPSI
710 720 730 740 750
DQTSTEEPIA IGTETPIETV AEDAAALADT EPVDVDVLDT STNDSVPPVM
760 770 780 790 800
SPATNLLKQI ERQQHEPYHS RAASSEASPG TVATKPSEPE SVSSIEAPAE
810 820 830 840 850
KHAQPSESPG PGLKTPIPHL LRGTLREYQH FGLDWLAGLY SNHINGILAD
860 870 880 890 900
EMGLGKTIQT IALLAHLAVE HGVWGPHLVV VPTSVILNWE MEFKKWCPGF
910 920 930 940 950
KIMTYYGNQE ERRQKRRGWM DDNSWNVLIT SYQLVLQDQQ VLKRRSWHYM
960 970 980 990 1000
ILDEAHNIKN FRSQRWQALL TFRTRARLLL TGTPLQNNLT ELWSLLFFLM
1010 1020 1030 1040 1050
PTDGDEAGIE GFADLRNFSE WFRRPVEQIL EHGRETMDDE AKQVVTKLHT
1060 1070 1080 1090 1100
VLRPYILRRL KADVEKQMPG KYEHVVYCRL SKRQRYLYDG FMSRAQTKET
1110 1120 1130 1140 1150
LASGNYLSII NCLMQLRKVC NHPDLFETRP ISTSFAMPRS VATEFETSEA
1160 1170 1180 1190 1200
LVRRRLLYQH PLEKLDLDFL NLVPISREDI SRRLADDSAR IMAYAPFNTL
1210 1220 1230 1240 1250
RERQYHRTNW EMKFNGSTVQ STLEALENDC RKRRMAELER SLYFESKRHG
1260 1270 1280 1290 1300
RRPVYGSSLI EFLTADSKQR PTAHGPLRKR SYADWLSSQS SVLASMMMSL
1310 1320 1330 1340 1350
EERSQAMDGY IQRFACVTPA AVAAGVTEAA LTPISTRHLT NKERFPPHDP
1360 1370 1380 1390 1400
FHEAQMRLSI AFPDKRLLQY DCGKLQRLDK LLRDLKAGGH RALIFTQMTK
1410 1420 1430 1440 1450
MLDVLEQFLN IHGHRYLRLD GTTKVEQRQI LTDRFNNDNR ILAFILSSRS
1460 1470 1480 1490 1500
GGLGINLTGA DTVIFYDLDW NPAMDKQCQD RCHRIGQTRD VHIYRFVSEY
1510 1520 1530 1540 1550
TIESNILRKA NQKRMLDDVV IQEGEFTTDY FTKLDVRDMI GNDEALKDEA
1560 1570 1580 1590 1600
SAAMDRVLEN RVTNTSRVFE QAEDKEDIDA AKNAQKELEH ADDGDFDDRA
1610 1620 1630 1640 1650
NANASGVTAA SASASGAGQT PTQAGTPLPD EAQQSLNANN AEVAEDTADS
1660 1670 1680 1690
DPSVGHIDDY LLRFMEWNMK DEPLVLPVDK SMKKSKKGKE HRLRKRRR
Length:1,698
Mass (Da):190,547
Last modified:November 16, 2011 - v2
Checksum:iFB023CCEF1AADA9D
GO

Sequence cautioni

The sequence EAA61910 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000169 Genomic DNA. Translation: EAA61910.1. Sequence problems.
BN001306 Genomic DNA. Translation: CBF82596.1.
RefSeqiXP_682346.1. XM_677254.1.

Genome annotation databases

EnsemblFungiiCADANIAT00009538; CADANIAP00009538; CADANIAG00009538.
EAA61910; EAA61910; AN9077.2.
GeneIDi2868023.
KEGGiani:AN9077.2.

Similar proteinsi

Entry informationi

Entry nameiSWR1_EMENI
AccessioniPrimary (citable) accession number: Q5ARK3
Secondary accession number(s): C8VH70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 16, 2011
Last modified: July 5, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families