Q5AQ12 (CAF20_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cap-associated protein CAF20

Gene names

Name:	CAF20
ORF Names:	CaO19.4796

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the CAF20 family.

Ontologies

Keywords
Biological process	Protein biosynthesis Translation regulation
Cellular component	Cytoplasm
Molecular function	Initiation factor Protein synthesis inhibitor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Cap-associated protein CAF20		PRO_0000330084

Sequences

	Sequence		Length	Mass (Da)
	Q5AQ12 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8FB349339071C0E5	FASTA	176	20,000
	10 20 30 40 50 60 MAKYTEEQLL ELKSEAHTPK PEILDAFNKL IEEVKESIEQ HQQHQRKWHN GDTYIDEHGH 70 80 90 100 110 120 ERSYHHINRR RQSKGASGVP RPNLRKKSEP VVDEDGWATL SKPKKGSFAE GDAIEERIKF 130 140 150 160 170 RETNNSGAGI KARPNNKNLG SSKAVDPREI ASDKQTKAFN AFAALGDEDD DDEDDE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000001 Genomic DNA. Translation: EAL04784.1.
RefSeq	XP_723482.1. XM_718389.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0004617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3634805.
KEGG	cal:CaO19.4796.
Organism-specific databases
CGD	CAL0004617. orf19.4796.
Phylogenomic databases
eggNOG	NOG47886.
KO	K03261.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CAF20_CANAL

Accession

Primary (citable) accession number: Q5AQ12

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program