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Q5AQ12 (CAF20_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cap-associated protein CAF20
Gene names
Name:CAF20
ORF Names:CaO19.4796
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the CAF20 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
Translation regulation
   Cellular componentCytoplasm
   Molecular functionInitiation factor
Protein synthesis inhibitor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontranslation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Cap-associated protein CAF20
PRO_0000330084

Sequences

Sequence LengthMass (Da)Tools
Q5AQ12 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 8FB349339071C0E5

FASTA17620,000
        10         20         30         40         50         60 
MAKYTEEQLL ELKSEAHTPK PEILDAFNKL IEEVKESIEQ HQQHQRKWHN GDTYIDEHGH 

        70         80         90        100        110        120 
ERSYHHINRR RQSKGASGVP RPNLRKKSEP VVDEDGWATL SKPKKGSFAE GDAIEERIKF 

       130        140        150        160        170 
RETNNSGAGI KARPNNKNLG SSKAVDPREI ASDKQTKAFN AFAALGDEDD DDEDDE 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000001 Genomic DNA. Translation: EAL04784.1.
RefSeqXP_723482.1. XM_718389.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0004617.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3634805.
KEGGcal:CaO19.4796.

Organism-specific databases

CGDCAL0004617. orf19.4796.

Phylogenomic databases

eggNOGNOG47886.
KOK03261.
OrthoDBEOG7Z3FHB.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameCAF20_CANAL
AccessionPrimary (citable) accession number: Q5AQ12
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 26, 2005
Last modified: November 13, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names