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Protein

Cap-associated protein CAF20

Gene

CAF20

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, Protein synthesis inhibitor
Biological processProtein biosynthesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cap-associated protein CAF20
Gene namesi
Name:CAF20
Ordered Locus Names:CAALFM_C109350WA
ORF Names:CaO19.4796
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000199949 orf19.4796
EuPathDBiFungiDB:C1_09350W_A

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300841 – 176Cap-associated protein CAF20Add BLAST176

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5AQ12

Family & Domainsi

Sequence similaritiesi

Belongs to the CAF20 family.Curated

Phylogenomic databases

InParanoidiQ5AQ12
KOiK03261
OMAiPNNKNIS
OrthoDBiEOG092C5HX7

Family and domain databases

InterProiView protein in InterPro
IPR031456 Caf20
PfamiView protein in Pfam
PF17052 CAF20, 1 hit

Sequencei

Sequence statusi: Complete.

Q5AQ12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYTEEQLL ELKSEAHTPK PEILDAFNKL IEEVKESIEQ HQQHQRKWHN
60 70 80 90 100
GDTYIDEHGH ERSYHHINRR RQSKGASGVP RPNLRKKSEP VVDEDGWATL
110 120 130 140 150
SKPKKGSFAE GDAIEERIKF RETNNSGAGI KARPNNKNLG SSKAVDPREI
160 170
ASDKQTKAFN AFAALGDEDD DDEDDE
Length:176
Mass (Da):20,000
Last modified:April 26, 2005 - v1
Checksum:i8FB349339071C0E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26569.1
RefSeqiXP_723482.1, XM_718389.2

Genome annotation databases

EnsemblFungiiAOW26569; AOW26569; CAALFM_C109350WA
GeneIDi3634805
KEGGical:CAALFM_C109350WA

Similar proteinsi

Entry informationi

Entry nameiCAF20_CANAL
AccessioniPrimary (citable) accession number: Q5AQ12
Secondary accession number(s): A0A1D8PEK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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