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Protein

Cap-associated protein CAF20

Gene

CAF20

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).By similarity

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor, Protein synthesis inhibitor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cap-associated protein CAF20
Gene namesi
Name:CAF20
ORF Names:CaO19.4796
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004617. orf19.4796.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Cap-associated protein CAF20PRO_0000330084Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0004617.

Family & Domainsi

Sequence similaritiesi

Belongs to the CAF20 family.Curated

Phylogenomic databases

eggNOGiNOG47886.
InParanoidiQ5AQ12.
KOiK03261.
OrthoDBiEOG7Z3FHB.

Sequencei

Sequence statusi: Complete.

Q5AQ12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYTEEQLL ELKSEAHTPK PEILDAFNKL IEEVKESIEQ HQQHQRKWHN
60 70 80 90 100
GDTYIDEHGH ERSYHHINRR RQSKGASGVP RPNLRKKSEP VVDEDGWATL
110 120 130 140 150
SKPKKGSFAE GDAIEERIKF RETNNSGAGI KARPNNKNLG SSKAVDPREI
160 170
ASDKQTKAFN AFAALGDEDD DDEDDE
Length:176
Mass (Da):20,000
Last modified:April 26, 2005 - v1
Checksum:i8FB349339071C0E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000001 Genomic DNA. Translation: EAL04784.1.
RefSeqiXP_723482.1. XM_718389.1.

Genome annotation databases

GeneIDi3634805.
KEGGical:CaO19.4796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000001 Genomic DNA. Translation: EAL04784.1.
RefSeqiXP_723482.1. XM_718389.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0004617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3634805.
KEGGical:CaO19.4796.

Organism-specific databases

CGDiCAL0004617. orf19.4796.

Phylogenomic databases

eggNOGiNOG47886.
InParanoidiQ5AQ12.
KOiK03261.
OrthoDBiEOG7Z3FHB.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCAF20_CANAL
AccessioniPrimary (citable) accession number: Q5AQ12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 26, 2005
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.