Q5APK7 (NAR1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytosolic Fe-S cluster assembly factor NAR1

Alternative name(s):
Nuclear architecture-related protein 1

Gene names

Name:	NAR1
ORF Names:	CaO19.12221, CaO19.4757

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins By similarity.
Sequence similarities	Belongs to the NARF family.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	iron-sulfur cluster assembly Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW iron-sulfur cluster binding Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	Cytosolic Fe-S cluster assembly factor NAR1		PRO_0000383721
Sites
	Metal binding	20	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	83	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	86	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	89	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	205	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	260	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	497	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	501	1	Iron-sulfur 2 (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5APK7 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 7A275ECC2ED88A7C	FASTA	609	67,319
	10 20 30 40 50 60 MSALLSADDL NDFISPGVAC IKPLASSSTN TTTTTNTTDS YNENGEVEIQ IDSQGNPLEI 70 80 90 100 110 120 SKIDDKQFQT NKLTPAQISL ADCLACSGCI TSAEEVLVAQ HSHQELIKAL QSQKETNKVF 130 140 150 160 170 180 VVSISHQSRA SLAMAYNVSI ENMDKCLIDL FIRQMGFTYI VGTSLGRKLS LINEAKEIIN 190 200 210 220 230 240 RKTKGSGTGG IDSDSSSGPI LSSICPGWVL YAEKTHPYII PKMSTVKSPQ QITGCLLKNL 250 260 270 280 290 300 TSNSLNIEKS KIYHLSIMPC FDKKLESARP EVYEEEEEEE EEKDKALVSV PDVDCVITAK 310 320 330 340 350 360 ELITLLEECP QYQLIPPTLP QEELIGGGCL SMTEIYKQYA PPNWPFIEIS WSNDSGSASG 370 380 390 400 410 420 GYAYNYLTIY RNDLILKGYD GNKFTINLIN GRNPDIYEMR LMYNGENKEK LASAAVVNGF 430 440 450 460 470 480 RNIQNLVRKL KPNTGKTTNT TTTTTKSKVN PLAARRRARM ANNRGKPETK STSEVNSQEM 490 500 510 520 530 540 EIVADASKVD YVEIMACPNG CINGGGQISA PNTTTTTSIT LPQKEIEKQW INAVLEKYNS 550 560 570 580 590 600 IPMFDLSSQS SSSSSPNEII KFIEWSKKFE NQFNISDNRL FKTHFNPVEK NIIMSVDDPA TALLVGSKW

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000002 Genomic DNA. Translation: EAL04550.1. AACQ01000001 Genomic DNA. Translation: EAL04745.1.
RefSeq	XP_723254.1. XM_718161.1. XP_723443.1. XM_718350.1.
3D structure databases
ProteinModelPortal	Q5APK7.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0004486.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3634916. 3635018.
KEGG	cal:CaO19.12221. cal:CaO19.4757.
Organism-specific databases
CGD	CAL0004486. NAR1.
Phylogenomic databases
eggNOG	COG4624.
Family and domain databases
InterPro	IPR009016. Fe_hydrogenase. IPR004108. Fe_hydrogenase_lsu_C. [Graphical view]
Pfam	PF02906. Fe_hyd_lg_C. 1 hit. [Graphical view]
SUPFAM	SSF53920. Fe_hydrog. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NAR1_CANAL

Accession

Primary (citable) accession number: Q5APK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program