Q5AP59 (ARP6_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-like protein ARP6

Gene names

Name:	ARP6
ORF Names:	CaO19.4904, CaO19.12369

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability By similarity.
Subunit structure	Component of the SWR1 chromatin remodeling complex By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the actin family. ARP6 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Cytoskeleton Nucleus
Molecular function	Activator Chromatin regulator
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Actin-like protein ARP6		PRO_0000089112

Sequences

	Sequence		Length	Mass (Da)
	Q5AP59 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 993B4B11B09513CB	FASTA	446	50,916
	10 20 30 40 50 60 MPEQLQKLVI DNGSYTIKAG FNTGDDDGND TSTPIKVTNA ISKTKDGIIH VGNQYLSHTN 70 80 90 100 110 120 NFSGIQFRRP FEQNNLTSWE TEKPIWDYTL DNLLLQTNDQ SQSTSSSSSS SLQKHKRGKV 130 140 150 160 170 180 IDPDDIHLIL TEQPYQLPQL STNTDQIIFE EYGFNKYYRC IAPSLVPFSV DTNQINDDFV 190 200 210 220 230 240 LVIDSGFNST WIVPMIYQQI HWPAVKKLPI GGNLLNGLLR EMISFRHYDI SEDPILINTI 250 260 270 280 290 300 KESTCFISSS NYQQDLQHKH DLMCEFVLPD FKLTITGFVK NENSMSSQKL PNDTQVLKLY 310 320 330 340 350 360 DERFTVPETY FHPEIIFDNN RTTASSSLLN NAPFKNLTDL IVESIMACPS ITQPLLSANI 370 380 390 400 410 420 CLSGGSTNIP NFKTRLIGEL RKELPSNWKV NIFDKQYDIN RDELSWYGGI NLSNESELLQ 430 440 EISISKKDYF EHGANWCQQQ FGFKNV

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000001 Genomic DNA. Translation: EAL04892.1. AACQ01000002 Genomic DNA. Translation: EAL04698.1.
RefSeq	XP_723397.1. XM_718304.1. XP_723586.1. XM_718493.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5AP59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3634908. 3635128.
KEGG	cal:CaO19.12369. cal:CaO19.4904.
Organism-specific databases
CGD	CAL0006200. orf19.4904.
Phylogenomic databases
OMA	FFHPEIS.
PhylomeDB	Q5AP59.
Family and domain databases
InterPro	IPR004000. Actin-like. [Graphical view]
KO	K11662.
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. False negative. PS00432. ACTINS_2. False negative. PS01132. ACTINS_ACT_LIKE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARP6_CANAL

Accession

Primary (citable) accession number: Q5AP59

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program