Q5ANC9 (ATG9_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 9

Gene names

Name:	ATG9
ORF Names:	CaO19.5974, CaO19.13395

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	952 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome By similarity.
Subcellular location	Preautophagosomal structure membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ATG9 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasmic vesicle Membrane
Domain	Transmembrane Transmembrane helix
Gene Ontology (GO)
Biological process	CVT pathway Inferred from mutant phenotype. Source: CGD autophagy Inferred from mutant phenotype. Source: CGD
Cellular component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW pre-autophagosomal structure membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 952	952	Autophagy-related protein 9		PRO_0000119826
Regions
	Topological domain	1 – 260	260	Cytoplasmic By similarity
	Transmembrane	261 – 281	21	Helical; Potential
	Topological domain	282 – 308	27	Lumenal By similarity
	Transmembrane	309 – 329	21	Helical; Potential
	Topological domain	330 – 490	161	Cytoplasmic By similarity
	Transmembrane	491 – 511	21	Helical; Potential
	Topological domain	512 – 577	66	Lumenal By similarity
	Transmembrane	578 – 598	21	Helical; Potential
	Topological domain	599 – 614	16	Cytoplasmic By similarity
	Transmembrane	615 – 635	21	Helical; Potential
	Topological domain	636 – 702	67	Lumenal By similarity
	Transmembrane	703 – 723	21	Helical; Potential
	Topological domain	724 – 952	229	Cytoplasmic By similarity
	Compositional bias	7 – 36	30	Asn-rich
	Compositional bias	52 – 97	46	Gln-rich
	Compositional bias	860 – 877	18	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5ANC9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: C37B451E8DE96250	FASTA	952	110,751
	10 20 30 40 50 60 MSSSSYNPYK NNVNDRLINN STDSFQDNDQ GIPNNNDTFL SRIFGLNSIY NQLQDNYQYY 70 80 90 100 110 120 DPEFDSSLNQ QLQQSIQEND EAEDESLLPQ HQQQQQQAAP MDLSIQDKSA KQKSKSSSLL 130 140 150 160 170 180 NSDSDSDLSS SEDSYVRPNI PQIPSTPIET ENQGSSSKIK FSIPQRAKNF VGKLHPHHEP 190 200 210 220 230 240 TLPVYQTPQE FRRNLPQQQR ASATVNTNYQ RTRNNNRRFI IPPKERALYL WANITNMDEF 250 260 270 280 290 300 LSDVYYYYRG RGLLNIVLSR GFDLIILIFI LIFTVFLKWG IDYSIFFDNL HQEESKHITL 310 320 330 340 350 360 NDMIIPNYFA TIPLSIKFIL FGFSVYILLR SVQLYLDYNY KLKELKNFYH YLLDVTDDEL 370 380 390 400 410 420 MTISWKTIVE KLMLLKDYNS LTSTTKSNNF SENHYVNDLS SKVRLNAHDI ANRIMRRENY 430 440 450 460 470 480 MIALINKDIL DLSVLFMNEK SLLTKTLEWN LKLCIDNFIY NQQGQINGKI LKEYNRNQLA 490 500 510 520 530 540 RELTSRFKLA AIINLILSPF IVIYFVLLYF FRYFNEYKSN PASILGLRQY TPYAEWKLRE 550 560 570 580 590 600 YNELSHLFNK RLIMSMGPAN TYIDQFPKGF LVVNLMRLIN FISGSILAVL VIMGILLEDE 610 620 630 640 650 660 NHSFWSFEIT DGRSALFYIS IFGTIWAITA SSATGTSHES TISTTSQSSN SNSNSNAAST 670 680 690 700 710 720 FVYDPEASLR YVAQFTHYLP SSWNKKLHTI QVKNEFCQLY CLKIIIIINE ILSSVLTPFI 730 740 750 760 770 780 LWFKISHNSG NIIDFYREYS IHVDGLGYVC YFAMFNFEEK DKNMMSDLNK SKKRRKRMKN 790 800 810 820 830 840 KMNKYGKTKM VNPISGKTVN SEIEMTKISK SESERSSDDE SGNEQDYDND EELDYLSYKK 850 860 870 880 890 900 DDKMIKSYMY FLESYGGSKQ PQPQPPQQQQ HPQNQNQTVG GLRNRNPIQS IDPAIMTGNY 910 920 930 940 950 YDQQSLNSSI YNINYKFDDS GLLQDETMNS SSRKKGGVLG MLNQFYKQDI NR

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000003 Genomic DNA. Translation: EAL04477.1. AACQ01000004 Genomic DNA. Translation: EAL04322.1.
RefSeq	XP_723038.1. XM_717945.1. XP_723185.1. XM_718092.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ANC9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3635239. 3635309.
KEGG	cal:CaO19.13395. cal:CaO19.5974.
Organism-specific databases
CGD	CAL0003426. ATG9.
Phylogenomic databases
PhylomeDB	Q5ANC9.
Family and domain databases
InterPro	IPR007241. Autophagy-rel_prot_9. [Graphical view]
PANTHER	PTHR13038. APG9. 1 hit.
Pfam	PF04109. APG9. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG9_CANAL

Accession

Primary (citable) accession number: Q5ANC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program