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Protein

Malate dehydrogenase

Gene

MDH1-1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:MDH1-1Imported
ORF Names:CAALFM_C401900CAImported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

KOiK00026.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AMP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSKVATRSF SSSASNAYKV AVLGAGGGIG QPLSLLLKLN HKVTDLALYD
60 70 80 90 100
IRGAPGVAAD VSHVPTNSTV KGYNPDQIEE ALTGSDVIVI PAGVPRKPGM
110 120 130 140 150
TRDDLFNTNA SIVRDLAKAA ADYAPNAAVC IISNPVNSTV PIVAEVFKSK
160 170 180 190 200
GNYNPNKLFG VTTLDVLRAA RFVSEVAGTN PVNENVPVVG GHSGVTIVPL
210 220 230 240 250
LSQTKHKDLS GETRDALVHR IQFGGDEVVQ AKDGAGSATL SMAQAGARFA
260 270 280 290 300
GAVLDGLAGE KDVIECTFVD SPLFKDEGVD FFSTKVTLGV DGVKTVHPIG
310 320 330
EISDYEEAQV KEAKDTLIKN IKKGVDFVAQ NP
Length:332
Mass (Da):34,728
Last modified:April 26, 2005 - v1
Checksum:i939B7EB71311519A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA. Translation: AOW28961.1.
RefSeqiXP_722674.1. XM_717581.1.
XP_722820.1. XM_717727.1.

Genome annotation databases

EnsemblFungiiEAL03937; EAL03937; CaO19.4602.
EAL04092; EAL04092; CaO19.12072.
KHC77492; KHC77492; W5Q_03490.
KHC86744; KHC86744; I503_03482.
GeneIDi3635558.
3635636.
KEGGical:CaO19.12072.
cal:CaO19.4602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA. Translation: AOW28961.1.
RefSeqiXP_722674.1. XM_717581.1.
XP_722820.1. XM_717727.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL03937; EAL03937; CaO19.4602.
EAL04092; EAL04092; CaO19.12072.
KHC77492; KHC77492; W5Q_03490.
KHC86744; KHC86744; I503_03482.
GeneIDi3635558.
3635636.
KEGGical:CaO19.12072.
cal:CaO19.4602.

Phylogenomic databases

KOiK00026.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5AMP4_CANAL
AccessioniPrimary (citable) accession number: Q5AMP4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 15, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.