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Protein
Submitted name:

Likely mitochondrial malate dehydrogenase

Gene

MDH1-1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Likely mitochondrial malate dehydrogenaseImported
Submitted name:
Malate dehydrogenase, NAD-dependentImported
Gene namesi
Name:MDH1-1Imported
Synonyms:MDH1Imported
ORF Names:CaO19.12072Imported, CaO19.4602Imported, I503_03482Imported, W5Q_03490Imported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003583. MDH1-1.

PTM / Processingi

Proteomic databases

PRIDEiQ5AMP4.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003583.

Structurei

3D structure databases

SMRiQ5AMP4. Positions 19-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213792.
InParanoidiQ5AMP4.
KOiK00026.
OrthoDBiEOG7GJ6Q7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5AMP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSKVATRSF SSSASNAYKV AVLGAGGGIG QPLSLLLKLN HKVTDLALYD
60 70 80 90 100
IRGAPGVAAD VSHVPTNSTV KGYNPDQIEE ALTGSDVIVI PAGVPRKPGM
110 120 130 140 150
TRDDLFNTNA SIVRDLAKAA ADYAPNAAVC IISNPVNSTV PIVAEVFKSK
160 170 180 190 200
GNYNPNKLFG VTTLDVLRAA RFVSEVAGTN PVNENVPVVG GHSGVTIVPL
210 220 230 240 250
LSQTKHKDLS GETRDALVHR IQFGGDEVVQ AKDGAGSATL SMAQAGARFA
260 270 280 290 300
GAVLDGLAGE KDVIECTFVD SPLFKDEGVD FFSTKVTLGV DGVKTVHPIG
310 320 330
EISDYEEAQV KEAKDTLIKN IKKGVDFVAQ NP
Length:332
Mass (Da):34,728
Last modified:April 25, 2005 - v1
Checksum:i939B7EB71311519A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000006 Genomic DNA. Translation: EAL03937.1.
AACQ01000005 Genomic DNA. Translation: EAL04092.1.
AJJF01000015 Genomic DNA. Translation: KHC77492.1.
JTBX01000033 Genomic DNA. Translation: KHC86744.1.
RefSeqiXP_722674.1. XM_717581.1.
XP_722820.1. XM_717727.1.

Genome annotation databases

GeneIDi3635558.
3635636.
KEGGical:CaO19.12072.
cal:CaO19.4602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000006 Genomic DNA. Translation: EAL03937.1.
AACQ01000005 Genomic DNA. Translation: EAL04092.1.
AJJF01000015 Genomic DNA. Translation: KHC77492.1.
JTBX01000033 Genomic DNA. Translation: KHC86744.1.
RefSeqiXP_722674.1. XM_717581.1.
XP_722820.1. XM_717727.1.

3D structure databases

SMRiQ5AMP4. Positions 19-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0003583.

Proteomic databases

PRIDEiQ5AMP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3635558.
3635636.
KEGGical:CaO19.12072.
cal:CaO19.4602.

Organism-specific databases

CGDiCAL0003583. MDH1-1.

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213792.
InParanoidiQ5AMP4.
KOiK00026.
OrthoDBiEOG7GJ6Q7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314Imported and SC5314 / ATCC MYA-2876Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SC5314Imported.

Entry informationi

Entry nameiQ5AMP4_CANAL
AccessioniPrimary (citable) accession number: Q5AMP4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 25, 2005
Last sequence update: April 25, 2005
Last modified: March 31, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.