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Protein

Malate dehydrogenase

Gene

MDH1-1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Active sitei192Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:MDH1-1Imported
Ordered Locus Names:orf19.4602Imported
ORF Names:CAALFM_C401900CAImported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Organism-specific databases

CGDiCAL0000181799. MDH1-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Structurei

3D structure databases

ProteinModelPortaliQ5AMP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

KOiK00026.
OrthoDBiEOG092C34N7.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AMP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSKVATRSF SSSASNAYKV AVLGAGGGIG QPLSLLLKLN HKVTDLALYD
60 70 80 90 100
IRGAPGVAAD VSHVPTNSTV KGYNPDQIEE ALTGSDVIVI PAGVPRKPGM
110 120 130 140 150
TRDDLFNTNA SIVRDLAKAA ADYAPNAAVC IISNPVNSTV PIVAEVFKSK
160 170 180 190 200
GNYNPNKLFG VTTLDVLRAA RFVSEVAGTN PVNENVPVVG GHSGVTIVPL
210 220 230 240 250
LSQTKHKDLS GETRDALVHR IQFGGDEVVQ AKDGAGSATL SMAQAGARFA
260 270 280 290 300
GAVLDGLAGE KDVIECTFVD SPLFKDEGVD FFSTKVTLGV DGVKTVHPIG
310 320 330
EISDYEEAQV KEAKDTLIKN IKKGVDFVAQ NP
Length:332
Mass (Da):34,728
Last modified:April 26, 2005 - v1
Checksum:i939B7EB71311519A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA. Translation: AOW28961.1.
RefSeqiXP_722674.1. XM_717581.1.

Genome annotation databases

EnsemblFungiiAOW28961; AOW28961; CAALFM_C401900CA.
KHC77492; KHC77492; W5Q_03490.
KHC86744; KHC86744; I503_03482.
GeneIDi3635636.
KEGGical:CAALFM_C401900CA.

Similar proteinsi

Entry informationi

Entry nameiQ5AMP4_CANAL
AccessioniPrimary (citable) accession number: Q5AMP4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported