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Reviewed, UniProtKB/Swiss-Prot Q5AML6 (CARA_CANAL)

Last modified February 9, 2010. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Carbamoyl-phosphate synthase arginine-specific small chain
      Short name=CPS-A
    EC=6.3.5.5
Alternative name(s):
    Arginine-specific carbamoyl-phosphate synthetase, glutamine chain
Gene names
Name: CPA1
ORF Names: CaO19.4630, CaO19.12100
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the carA family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Carbamoyl-phosphate synthase arginine-specific small chain
PRO_0000290590

Regions

Domain219 – 407189Glutamine amidotransferase type-1
Compositional bias10 – 178Poly-Ala
Compositional bias18 – 236Poly-Thr

Sites

Active site2961Nucleophile By similarity
Active site3801 By similarity
Active site3821 By similarity

Natural variations

Natural variant141A → T in allele CaO19.12100.
Natural variant181T → TATAT in allele CaO19.12100.

Sequences

Sequence LengthMass (Da)Tools
Q5AML6-1 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: A4B30B27F157AB5E

FASTA43046,898
        10         20         30         40         50         60 
MLSATKRYLA TAAAAAATNT TTTSKAFTNT TSQLGRATLT IKDGPVFNGY SFGANRNVSG 

        70         80         90        100        110        120 
EAVFTTSLVG YPESMTDPSY RGQILCFTQP LIGNYGVPSS TAKDQFNLLK YMESPKVQCI 

       130        140        150        160        170        180 
GIVVADAALE YSHWTAVESL QQWCKRSGVA AITGVDTRQL VSYLRDKGSS LGRITIGEEY 

       190        200        210        220        230        240 
DADEDAAFED PGAINLVHKV TTKAPFHIAC PPQYSKGIHI AVLDCGAKEN ILRCLVERGA 

       250        260        270        280        290        300 
SLTVFPYDYP IDKIANKFDG IFISNGPGDP THCSTTVNNL KKIITNHQDL PIFGICLGHQ 

       310        320        330        340        350        360 
LLALASGAKT IKLKYGNRAH NIPAIDLITG NCHITSQNHG YAVDANTLSE NWQPYFTNLN 

       370        380        390        400        410        420 
DLSNEGMIHK YQPIFSTQFH PEAKGGPLDT SFLFDKFFDN INVYKKSNGL NLPPVENSLL 

       430 
VDILPKERVE 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000006 Genomic DNA. Translation: EAL03965.1.
AACQ01000005 Genomic DNA. Translation: EAL04120.1.
RefSeqXP_722702.1.
XP_722848.1.

3D structure databases

HSSPHSSP built from PDB template 1A9X based on UniProtKB P0A6F1.
SMRQ5AML6. Positions 35-407.
ModBaseSearch...

Genome annotation databases

GeneID3635569.
3635715.
KEGGcal:CaO19.12100.
cal:CaO19.4630.

Organism-specific databases

CGDCAL0003663. CPA1.

Phylogenomic databases

OrthoDBEOG9X9907.
PhylomeDBQ5AML6.

Enzyme and pathway databases

BRENDA6.3.5.5. 1124.

Family and domain databases

InterProIPR006220. Anth_synthII.
IPR001317. CarbamoylP_synth_GATase_dom.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR011702. GATASE.
IPR017926. GATASE_1.
IPR000991. GATase_class1_C.
[Graphical view]
PANTHERPTHR11405:SF4. CarA_synth_small. 1 hit.
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
PRINTSPR00097. ANTSNTHASEII.
PR00099. CPSGATASE.
PR00096. GATASE.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCARA_CANAL
AccessionPrimary (citable) accession number: Q5AML6
Secondary accession number(s): Q5AN21
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: April 26, 2005
Last modified: February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents