Q5ALX8 (APT_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7

Gene names

Name:	APT1
ORF Names:	CaO19.1448, CaO19.9023

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
Cofactor	Magnesium By similarity.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm Nucleus
Ligand	Magnesium Metal-binding
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Adenine phosphoribosyltransferase		PRO_0000227899
Regions
	Nucleotide binding	134 – 138	5	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ALX8 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8CA335A0D1F675F6	FASTA	188	20,877
	10 20 30 40 50 60 MSDRVLEINA LAKELKANLK QFPNFPKEGI LFEDFLPIFT KPDLFNKLVK AFKLHVGEQK 70 80 90 100 110 120 IDYVIGLESR GFLFGPTLAL ALNAGFVPVR KPGKLPGPTF KVEFQKEYGS DEFEIQQDVI 130 140 150 160 170 180 PKGAKVLIVD DILATGGSAF GAGELAKKTG AEIVEYLFVM ELDFLKGRDK LDAPVYTLFG GQEEKFTE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000008 Genomic DNA. Translation: EAL03604.1. AACQ01000007 Genomic DNA. Translation: EAL03751.1.
RefSeq	XP_722359.1. XM_717266.1. XP_722498.1. XM_717405.1.
3D structure databases
ProteinModelPortal	Q5ALX8.
SMR	Q5ALX8. Positions 6-179.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ALX8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3635842. 3635988.
KEGG	cal:CaO19.1448. cal:CaO19.9023.
Organism-specific databases
CGD	CAL0004599. APT1.
Phylogenomic databases
OMA	APVISAM.
PhylomeDB	Q5ALX8.
Family and domain databases
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. Apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_CANAL

Accession

Primary (citable) accession number: Q5ALX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program