Q5AKU4 (ATG12_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like protein ATG12

Alternative name(s):
Autophagy-related protein 12

Gene names

Name:	ATG12
ORF Names:	CaO19.5033, CaO19.12500

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Ubiquitin-like protein involved in the cytoplasm to vacuole transport (Cvt) and autophagy. Conjugated to ATG5 By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATG12 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport Ubl conjugation pathway
Cellular component	Cytoplasm
PTM	Isopeptide bond
Gene Ontology (GO)
Biological process	autophagic vacuole assembly Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Ubiquitin-like protein ATG12		PRO_0000212475
Amino acid modifications
	Cross-link	164		Glycyl lysine isopeptide (Gly-Lys) (interchain with K-148 in ATG5) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5AKU4 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: FE96477B6823E062	FASTA	164	18,058
	10 20 30 40 50 60 MSRIIHSEDD DDDDVGSQSS SSLSSPSKSL QQDPIPTKIP LSTSIILEKK LPLEQHQKLS 70 80 90 100 110 120 NLTEGSTAGG HVSNNSLDNK IMIRFVPIGS TPSIQPRVFK ISATQTVSTL NRFLCKKLKF 130 140 150 160 KGVLNLYIQN SFMPLPDEQI GSLYGLFKTN NELIISYCNT IAFG

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000010 Genomic DNA. Translation: EAL03470.1. AACQ01000009 Genomic DNA. Translation: EAL03594.1.
RefSeq	XP_722235.1. XM_717142.1. XP_722349.1. XM_717256.1.
3D structure databases
ProteinModelPortal	Q5AKU4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5AKU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3636046. 3636186.
KEGG	cal:CaO19.12500. cal:CaO19.5033.
Organism-specific databases
CGD	CAL0001643. orf19.5033.
Phylogenomic databases
PhylomeDB	Q5AKU4.
Family and domain databases
InterPro	IPR007242. Autophagy-rel_prot_12. [Graphical view]
KO	K08336.
PANTHER	PTHR13385. APG12. 1 hit.
Pfam	PF04110. APG12. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG12_CANAL

Accession

Primary (citable) accession number: Q5AKU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program