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Protein

Probable metalloprotease ARX1

Gene

ARX1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable metalloprotease ARX1 (EC:3.-.-.-)
Alternative name(s):
Associated with ribosomal export complex protein 1
Gene namesi
Name:ARX1
Ordered Locus Names:CAALFM_C103230CA
ORF Names:CaO19.10533, CaO19.3015
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000194302. ARX1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001489931 – 564Probable metalloprotease ARX1Add BLAST564

Proteomic databases

PRIDEiQ5AI37.

Interactioni

Subunit structurei

Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5AI37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24 family.Curated

Phylogenomic databases

InParanoidiQ5AI37.
KOiK14813.
OrthoDBiEOG092C2TAV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 1 hit.
InterProiView protein in InterPro
IPR000994. Pept_M24.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00557. Peptidase_M24. 1 hit.
SUPFAMiSSF55920. SSF55920. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AI37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLAVRQEDA DILLKQKNVL DELVVEKYRV AGQITQTALA YITSLINNSY
60 70 80 90 100
HLQTSPKLTI QQLCLLTDSF LLKLLSRQYV NKVNEKGIAH PTTINVNQLL
110 120 130 140 150
NGFSPEIDDE REFFLNQGDV VTISLGVHID GYTSQVSHTL VIYPPSADAK
160 170 180 190 200
PEGPLLGSNA DALCACHLAT ESVVVLLGCS LSPEKLPANL KNVSNTVTGS
210 220 230 240 250
QIRELVDAIA DSFNCVVVPG SKIRRVRRFL AGQAEGIVAE RDFKGVVWDE
260 270 280 290 300
SHQEARLLKQ SNNTSTDLIL SDSNKPVQTN NSSAIPTDDF VVVPGEVYQI
310 320 330 340 350
DIRMTGLSDV NEIGIVTTEE IDHFTGKNNK QDFNAKSSIF IRDFAVTHQL
360 370 380 390 400
KLKTSKKLLG EIDRQFSVYP FKLDYASKNF PINTESSEDE IKQQIAAIGQ
410 420 430 440 450
DMKSNRLGAA ELSNRHLIQP KPIQTTKFIP LKEILLSANP TGKHGIDATK
460 470 480 490 500
PVLPGMEIPL PNLGVSSLKL KSLLKTGRSI NNVRESTTVA INENNQELIR
510 520 530 540 550
LTGGEATAKS NWVHSQYKLP ASLNETIGQL VQISKDKRFG IKIKEVVPYK
560
VQQSNMSVES MQID
Length:564
Mass (Da):62,233
Last modified:April 26, 2005 - v1
Checksum:i1B95FF8831F0CCA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW26004.1.
RefSeqiXP_721513.1. XM_716420.1.

Genome annotation databases

EnsemblFungiiEAL02435; EAL02435; CaO19.10533.
EAL02715; EAL02715; CaO19.3015.
GeneIDi3636811.
KEGGical:CAALFM_C103230CA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW26004.1.
RefSeqiXP_721513.1. XM_716420.1.

3D structure databases

ProteinModelPortaliQ5AI37.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5AI37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL02435; EAL02435; CaO19.10533.
EAL02715; EAL02715; CaO19.3015.
GeneIDi3636811.
KEGGical:CAALFM_C103230CA.

Organism-specific databases

CGDiCAL0000194302. ARX1.

Phylogenomic databases

InParanoidiQ5AI37.
KOiK14813.
OrthoDBiEOG092C2TAV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 1 hit.
InterProiView protein in InterPro
IPR000994. Pept_M24.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00557. Peptidase_M24. 1 hit.
SUPFAMiSSF55920. SSF55920. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARX1_CANAL
AccessioniPrimary (citable) accession number: Q5AI37
Secondary accession number(s): A0A1D8PCY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 26, 2005
Last modified: April 12, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.