Q5AI37 (ARX1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable metalloprotease ARX1
EC=3.-.-.-

Alternative name(s):
Associated with ribosomal export complex protein 1

Gene names

Name:	ARX1
ORF Names:	CaO19.10533, CaO19.3015

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm By similarity.
Subunit structure	Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase M24 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	Metal-binding
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 564	564	Probable metalloprotease ARX1		PRO_0000148993

Sequences

	Sequence		Length	Mass (Da)
	Q5AI37 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 1B95FF8831F0CCA8	FASTA	564	62,233
	10 20 30 40 50 60 MQLAVRQEDA DILLKQKNVL DELVVEKYRV AGQITQTALA YITSLINNSY HLQTSPKLTI 70 80 90 100 110 120 QQLCLLTDSF LLKLLSRQYV NKVNEKGIAH PTTINVNQLL NGFSPEIDDE REFFLNQGDV 130 140 150 160 170 180 VTISLGVHID GYTSQVSHTL VIYPPSADAK PEGPLLGSNA DALCACHLAT ESVVVLLGCS 190 200 210 220 230 240 LSPEKLPANL KNVSNTVTGS QIRELVDAIA DSFNCVVVPG SKIRRVRRFL AGQAEGIVAE 250 260 270 280 290 300 RDFKGVVWDE SHQEARLLKQ SNNTSTDLIL SDSNKPVQTN NSSAIPTDDF VVVPGEVYQI 310 320 330 340 350 360 DIRMTGLSDV NEIGIVTTEE IDHFTGKNNK QDFNAKSSIF IRDFAVTHQL KLKTSKKLLG 370 380 390 400 410 420 EIDRQFSVYP FKLDYASKNF PINTESSEDE IKQQIAAIGQ DMKSNRLGAA ELSNRHLIQP 430 440 450 460 470 480 KPIQTTKFIP LKEILLSANP TGKHGIDATK PVLPGMEIPL PNLGVSSLKL KSLLKTGRSI 490 500 510 520 530 540 NNVRESTTVA INENNQELIR LTGGEATAKS NWVHSQYKLP ASLNETIGQL VQISKDKRFG 550 560 IKIKEVVPYK VQQSNMSVES MQID

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000015 Genomic DNA. Translation: EAL02715.1. AACQ01000017 Genomic DNA. Translation: EAL02435.1.
RefSeq	XP_721242.1. XM_716149.1. XP_721513.1. XM_716420.1.
3D structure databases
ProteinModelPortal	Q5AI37.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3636811. 3637175.
KEGG	cal:CaO19.10533. cal:CaO19.3015.
Organism-specific databases
CGD	CAL0001348. orf19.3015.
Phylogenomic databases
eggNOG	COG0024.
KO	K14813.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARX1_CANAL

Accession

Primary (citable) accession number: Q5AI37

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program