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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei182ATPPROSITE-ProRule annotation1
Active sitei307Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 118ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:CAALFM_C204260WA
ORF Names:CaO19.794, CaO19.8413
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000183529. SSN3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129381 – 608Serine/threonine-protein kinase SSN3Add BLAST608

Proteomic databases

PRIDEiQ5AHK2.

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

BioGridi1220401. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ5AHK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 492Protein kinasePROSITE-ProRule annotationAdd BLAST389

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 47Gln-richAdd BLAST30
Compositional biasi499 – 554Asn-richAdd BLAST56
Compositional biasi558 – 583Gln-richAdd BLAST26

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ5AHK2.
KOiK02208.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AHK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSSASFRK LNNVGISQPS QTTTTTTSAN QPQSQSQQQP LQQSQQQHLH
60 70 80 90 100
MKPNPHIPHH QLPGTVGTRT SIPQPALMAS NSILTLGPFK HRKDLTRESV
110 120 130 140 150
LSTYQIMGYI AAGTYGKVYK AKLKSNKLNK TDDDSGIDGI NNKDIFSESM
160 170 180 190 200
NDLHHDNSSS IMINTTTNIT INNSLPQFFA IKKFKSDNHH HHINNNNNGG
210 220 230 240 250
NHLSKGNNSI HQDEVLHYTG ISQSAIREMS LCRELNNKNI TKLVDIILEN
260 270 280 290 300
KSIYMVFEFC EHDLLQIIHY QSHPDFKPIP CPTIKSLIWQ ILNGVTFLHK
310 320 330 340 350
NWILHRDLKP ANIMVSSQGV VKIGDLGLAR KFKSPLQSLY TGDKVVVTIW
360 370 380 390 400
YRAPELLLGT RHYTPAVDLW AVGCILAELL SLRPIFKGEE AKIDLNNKKS
410 420 430 440 450
VPFQKNQLQK IIEILGTPTT DIWNNLNKYP EYLSFTQHFN QNYPNNLSNW
460 470 480 490 500
FKLINGGNNQ NSEKCLELLS GLLKYDPELR LTADQALLHP YFLELPKVNE
510 520 530 540 550
NAFEGLNYKY PNRKIYTDDN DIMTTAANNN NNNNNNNNNN NNNNNNNNNN
560 570 580 590 600
NNNNSGHQLS QQQNVQIQQV HQMQQQIHSQ QLQSHGANST YKRSGIDDLP

GGIRKKRG
Length:608
Mass (Da):68,962
Last modified:May 10, 2017 - v2
Checksum:i1145A2C882CF3856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA. Translation: AOW27452.1.
RefSeqiXP_720918.2. XM_715825.2.

Genome annotation databases

GeneIDi3637353.
KEGGical:CAALFM_C204260WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSSN3_CANAL
AccessioniPrimary (citable) accession number: Q5AHK2
Secondary accession number(s): A0A1D8PH23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2017
Last modified: June 7, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families