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Q5AHK2

- SSN3_CANAL

UniProt

Q5AHK2 - SSN3_CANAL

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Protein

Serine/threonine-protein kinase SSN3

Gene
SSN3, CDK8, CaO19.794, CaO19.8413
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei182 – 1821ATP By similarity
Active sitei307 – 3071Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:CaO19.794, CaO19.8413
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002024. orf19.794.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Serine/threonine-protein kinase SSN3PRO_0000312938Add
BLAST

Proteomic databases

PRIDEiQ5AHK2.

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Protein-protein interaction databases

BioGridi1220447. 2 interactions.
STRINGi5476.CAL0002024.

Structurei

3D structure databases

ProteinModelPortaliQ5AHK2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 492389Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 4730Gln-richAdd
BLAST
Compositional biasi499 – 55456Asn-richAdd
BLAST
Compositional biasi558 – 58326Gln-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK02208.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 3 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5AHK2-1 [UniParc]FASTAAdd to Basket

« Hide

MSYSSASFRK LNNVGISQPS QTTTTTTSAN QPQSQSQQQP LQQSQQQHLH    50
MKPNPHIPHH QLPGTVGTRA SIPQPALMAS NSILTLGPFK HRKDLTRESV 100
LSTYQIMGYI AAGTYGKVYK AKLKSNKLNK TDDDSGIDGI NNKDIFSESM 150
NDLHHDNSPS IMINTTTNIT INNSLPQFFA IKKFKSDNHH HHINNNNNGG 200
NHLSKGNNSI HQDEVLHYTG ISQSAIREMS LCRELNNKNI TKLVDIILEN 250
KSIYMVFEFC EHDLLQIIHY QSHPDFKPIP CPTIKSLIWQ ILNGVTFLHK 300
NWILHRDLKP ANIMVSSQGV VKIGDLGLAR KFKSPLQSLY TGDKVVVTIW 350
YRAPELLLGT RHYTPAVDLW AVGCILAELL SLRPIFKGEE AKIDLNNKKS 400
VPFQKNQLQK IIEILGTPTT DIWNNLNKYP EYLSFTQHFN QNYPNNLSNW 450
FKLINGGNNQ NSEKCLELLS GLLKYDPELR LTADQALLHP YFLELPKVNE 500
NAFEGLNYKY PNRKIYTDDN DIMTTAANNN NNNNNNNNNN NNNNNNNNNN 550
NNNNSGHQLS QQQNVQIQQV HQMQQQIHSQ QLQSHGANST YKRSGIDDLP 600
GGIRKKRG 608
Length:608
Mass (Da):68,942
Last modified:April 26, 2005 - v1
Checksum:i2CD488055F4EC0C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000019 Genomic DNA. Translation: EAL02098.1.
AACQ01000018 Genomic DNA. Translation: EAL02225.1.
RefSeqiXP_720918.1. XM_715825.1.
XP_721039.1. XM_715946.1.

Genome annotation databases

GeneIDi3637307.
3637353.
KEGGical:CaO19.794.
cal:CaO19.8413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000019 Genomic DNA. Translation: EAL02098.1 .
AACQ01000018 Genomic DNA. Translation: EAL02225.1 .
RefSeqi XP_720918.1. XM_715825.1.
XP_721039.1. XM_715946.1.

3D structure databases

ProteinModelPortali Q5AHK2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1220447. 2 interactions.
STRINGi 5476.CAL0002024.

Proteomic databases

PRIDEi Q5AHK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3637307.
3637353.
KEGGi cal:CaO19.794.
cal:CaO19.8413.

Organism-specific databases

CGDi CAL0002024. orf19.794.

Phylogenomic databases

eggNOGi COG0515.
KOi K02208.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 3 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSSN3_CANAL
AccessioniPrimary (citable) accession number: Q5AHK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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