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Q5AHK2

- SSN3_CANAL

UniProt

Q5AHK2 - SSN3_CANAL

Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei182 – 1821ATPPROSITE-ProRule annotation
    Active sitei307 – 3071Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi110 – 1189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
    Alternative name(s):
    Cyclin-dependent kinase 8
    Gene namesi
    Name:SSN3
    Synonyms:CDK8
    ORF Names:CaO19.794, CaO19.8413
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002024. orf19.794.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608Serine/threonine-protein kinase SSN3PRO_0000312938Add
    BLAST

    Proteomic databases

    PRIDEiQ5AHK2.

    Interactioni

    Subunit structurei

    Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

    Protein-protein interaction databases

    BioGridi1220447. 2 interactions.
    STRINGi5476.CAL0002024.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AHK2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 492389Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 4730Gln-richAdd
    BLAST
    Compositional biasi499 – 55456Asn-richAdd
    BLAST
    Compositional biasi558 – 58326Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK02208.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 3 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5AHK2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYSSASFRK LNNVGISQPS QTTTTTTSAN QPQSQSQQQP LQQSQQQHLH    50
    MKPNPHIPHH QLPGTVGTRA SIPQPALMAS NSILTLGPFK HRKDLTRESV 100
    LSTYQIMGYI AAGTYGKVYK AKLKSNKLNK TDDDSGIDGI NNKDIFSESM 150
    NDLHHDNSPS IMINTTTNIT INNSLPQFFA IKKFKSDNHH HHINNNNNGG 200
    NHLSKGNNSI HQDEVLHYTG ISQSAIREMS LCRELNNKNI TKLVDIILEN 250
    KSIYMVFEFC EHDLLQIIHY QSHPDFKPIP CPTIKSLIWQ ILNGVTFLHK 300
    NWILHRDLKP ANIMVSSQGV VKIGDLGLAR KFKSPLQSLY TGDKVVVTIW 350
    YRAPELLLGT RHYTPAVDLW AVGCILAELL SLRPIFKGEE AKIDLNNKKS 400
    VPFQKNQLQK IIEILGTPTT DIWNNLNKYP EYLSFTQHFN QNYPNNLSNW 450
    FKLINGGNNQ NSEKCLELLS GLLKYDPELR LTADQALLHP YFLELPKVNE 500
    NAFEGLNYKY PNRKIYTDDN DIMTTAANNN NNNNNNNNNN NNNNNNNNNN 550
    NNNNSGHQLS QQQNVQIQQV HQMQQQIHSQ QLQSHGANST YKRSGIDDLP 600
    GGIRKKRG 608
    Length:608
    Mass (Da):68,942
    Last modified:April 26, 2005 - v1
    Checksum:i2CD488055F4EC0C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000019 Genomic DNA. Translation: EAL02098.1.
    AACQ01000018 Genomic DNA. Translation: EAL02225.1.
    RefSeqiXP_720918.1. XM_715825.1.
    XP_721039.1. XM_715946.1.

    Genome annotation databases

    GeneIDi3637307.
    3637353.
    KEGGical:CaO19.794.
    cal:CaO19.8413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000019 Genomic DNA. Translation: EAL02098.1 .
    AACQ01000018 Genomic DNA. Translation: EAL02225.1 .
    RefSeqi XP_720918.1. XM_715825.1.
    XP_721039.1. XM_715946.1.

    3D structure databases

    ProteinModelPortali Q5AHK2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1220447. 2 interactions.
    STRINGi 5476.CAL0002024.

    Proteomic databases

    PRIDEi Q5AHK2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3637307.
    3637353.
    KEGGi cal:CaO19.794.
    cal:CaO19.8413.

    Organism-specific databases

    CGDi CAL0002024. orf19.794.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K02208.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 3 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiSSN3_CANAL
    AccessioniPrimary (citable) accession number: Q5AHK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3