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Q5AHK2 (SSN3_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
ORF Names:CaO19.794, CaO19.8413
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 608608Serine/threonine-protein kinase SSN3
PRO_0000312938

Regions

Domain104 – 492389Protein kinase
Nucleotide binding110 – 1189ATP By similarity
Compositional bias18 – 4730Gln-rich
Compositional bias499 – 55456Asn-rich
Compositional bias558 – 58326Gln-rich

Sites

Active site3071Proton acceptor By similarity
Binding site1821ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5AHK2 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 2CD488055F4EC0C7

FASTA60868,942
        10         20         30         40         50         60 
MSYSSASFRK LNNVGISQPS QTTTTTTSAN QPQSQSQQQP LQQSQQQHLH MKPNPHIPHH 

        70         80         90        100        110        120 
QLPGTVGTRA SIPQPALMAS NSILTLGPFK HRKDLTRESV LSTYQIMGYI AAGTYGKVYK 

       130        140        150        160        170        180 
AKLKSNKLNK TDDDSGIDGI NNKDIFSESM NDLHHDNSPS IMINTTTNIT INNSLPQFFA 

       190        200        210        220        230        240 
IKKFKSDNHH HHINNNNNGG NHLSKGNNSI HQDEVLHYTG ISQSAIREMS LCRELNNKNI 

       250        260        270        280        290        300 
TKLVDIILEN KSIYMVFEFC EHDLLQIIHY QSHPDFKPIP CPTIKSLIWQ ILNGVTFLHK 

       310        320        330        340        350        360 
NWILHRDLKP ANIMVSSQGV VKIGDLGLAR KFKSPLQSLY TGDKVVVTIW YRAPELLLGT 

       370        380        390        400        410        420 
RHYTPAVDLW AVGCILAELL SLRPIFKGEE AKIDLNNKKS VPFQKNQLQK IIEILGTPTT 

       430        440        450        460        470        480 
DIWNNLNKYP EYLSFTQHFN QNYPNNLSNW FKLINGGNNQ NSEKCLELLS GLLKYDPELR 

       490        500        510        520        530        540 
LTADQALLHP YFLELPKVNE NAFEGLNYKY PNRKIYTDDN DIMTTAANNN NNNNNNNNNN 

       550        560        570        580        590        600 
NNNNNNNNNN NNNNSGHQLS QQQNVQIQQV HQMQQQIHSQ QLQSHGANST YKRSGIDDLP 


GGIRKKRG 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000019 Genomic DNA. Translation: EAL02098.1.
AACQ01000018 Genomic DNA. Translation: EAL02225.1.
RefSeqXP_720918.1. XM_715825.1.
XP_721039.1. XM_715946.1.

3D structure databases

ProteinModelPortalQ5AHK2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1220447. 2 interactions.
STRING5476.CAL0002024.

Proteomic databases

PRIDEQ5AHK2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3637307.
3637353.
KEGGcal:CaO19.794.
cal:CaO19.8413.

Organism-specific databases

CGDCAL0002024. orf19.794.

Phylogenomic databases

eggNOGCOG0515.
KOK02208.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 3 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_CANAL
AccessionPrimary (citable) accession number: Q5AHK2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names