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Protein

Eukaryotic translation initiation factor 3 subunit B

Gene

PRT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: CGD

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit BUniRule annotation
Short name:
eIF3bUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 90 kDa subunit homologUniRule annotation
Short name:
eIF3 p90UniRule annotation
Translation initiation factor eIF3 p90 subunit homolog
Gene namesi
Name:PRT1UniRule annotation
Ordered Locus Names:CAALFM_C701450CA
ORF Names:CaO19.13937, CaO19.6584
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 7

Organism-specific databases

CGDiCAL0000183631 PRT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003638131 – 739Eukaryotic translation initiation factor 3 subunit BAdd BLAST739

Proteomic databases

PRIDEiQ5AGV4

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5AGV4
SMRiQ5AGV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 124RRMUniRule annotationAdd BLAST88
Repeati190 – 229WD 1Add BLAST40
Repeati231 – 293WD 2Add BLAST63
Repeati301 – 339WD 3Add BLAST39
Repeati343 – 385WD 4Add BLAST43
Repeati453 – 502WD 5Add BLAST50
Repeati537 – 579WD 6Add BLAST43
Repeati592 – 630WD 7Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 224Sufficient for interaction with PIC8UniRule annotationAdd BLAST224
Regioni1 – 98Sufficient for interaction with HCR1 and TIF32UniRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the eIF-3 subunit B family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiQ5AGV4
KOiK03253
OMAiNFAWEPK
OrthoDBiEOG092C0KCM

Family and domain databases

CDDicd12278 RRM_eIF3B, 1 hit
Gene3Di2.130.10.10, 1 hit
3.30.70.330, 1 hit
HAMAPiMF_03001 eIF3b, 1 hit
InterProiView protein in InterPro
IPR011400 EIF3B
IPR034363 eIF3B_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR14068 PTHR14068, 1 hit
PfamiView protein in Pfam
PF08662 eIF2A, 2 hits
PF00076 RRM_1, 1 hit
PIRSFiPIRSF036424 eIF3b, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q5AGV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSINEEDYLQ LEKEIKLDDI DFSDLEEKYE VNIGLDNYII VDGAPIAPEA
60 70 80 90 100
KVPVLIKVLR KLFSQVGEIV EGDEGIYMPL ENGKSKGYLF IQFKSTESAD
110 120 130 140 150
LAIKKLHGKK LDQNHRLLVN KLSDMEKYGV DGAVNEEFIE PEIEPFQSHG
160 170 180 190 200
YLKSWLQDEQ GRDQMVLHFS ETVGVYWNKK SADPEPVIEP RKGFTSKYAK
210 220 230 240 250
FSPKGTYLFS IHPQGIQSWG GANFNSIKRF FHQQVRLVDF SPNEKFMVTL
260 270 280 290 300
SPIPISLPDS TVDRAQFPFG PESEGHKLVI WNMITGEPVR TFALPPHLEG
310 320 330 340 350
QKEMPWPLVK WSYDDKYCAR QGPDALAIYE TESNFQLLDK KLVKVDGIQD
360 370 380 390 400
FEWAPAGVKL HNSKAVDGKH VLSYWTPEST NQTARVALMQ IPSREILRTV
410 420 430 440 450
NLFQVSDCKM HWQSNGKLLC VKVDRHTKSG KTIFSNLEFF KTNERDIPVE
460 470 480 490 500
KLELKDVVVN FAWEPNTERF ITISRLDDGN PNPAIPKNTI SFYAPEVTKG
510 520 530 540 550
GVNHNSKKKG GAAIAAAVAA AAINNQSSTK YKAYTKIENK HSNTIFWSPK
560 570 580 590 600
GRYVVVATIS RTSGELEFFD VSFDDETNKK SLPANVKLLK TDKFSGMTNI
610 620 630 640 650
SWDPSGRFVA AWSTSWLHAI ENGYRLYEFT GNLLRDDSID QFKDFVWRPR
660 670 680 690 700
PPSLLTNSDK KKVRSNLREY SAQFEEADAM EADAAVKEII LARRKALEEW
710 720 730
RKYRAKHISK QGNSKNEVQA EIIEEIKEEI IEEKEEIVE
Length:739
Mass (Da):84,252
Last modified:April 26, 2005 - v1
Checksum:iEE3F733AB888577B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017629 Genomic DNA Translation: AOW30512.1
AP006852 Genomic DNA Translation: BAE44665.1
RefSeqiXP_721420.1, XM_716327.1

Genome annotation databases

EnsemblFungiiAOW30512; AOW30512; CAALFM_C701450CA
GeneIDi3636959
KEGGical:CAALFM_C701450CA

Similar proteinsi

Entry informationi

Entry nameiEIF3B_CANAL
AccessioniPrimary (citable) accession number: Q5AGV4
Secondary accession number(s): A0A1D8PQU8, Q3MPJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health