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Q5AGV4

- EIF3B_CANAL

UniProt

Q5AGV4 - EIF3B_CANAL

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Protein

Eukaryotic translation initiation factor 3 subunit B

Gene

PRT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular response to drug Source: CGD
  2. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  3. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit BUniRule annotation
Short name:
eIF3bUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 90 kDa subunit homologUniRule annotation
Short name:
eIF3 p90UniRule annotation
Translation initiation factor eIF3 p90 subunit homolog
Gene namesi
Name:PRT1UniRule annotation
ORF Names:CaO19.13937, CaO19.6584
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003307. PRT1.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
  4. fungal-type cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Eukaryotic translation initiation factor 3 subunit BPRO_0000363813Add
BLAST

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi5476.CAL0003307.

Structurei

3D structure databases

ProteinModelPortaliQ5AGV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12488RRMUniRule annotationAdd
BLAST
Repeati190 – 22940WD 1Add
BLAST
Repeati231 – 29363WD 2Add
BLAST
Repeati301 – 33939WD 3Add
BLAST
Repeati343 – 38543WD 4Add
BLAST
Repeati453 – 50250WD 5Add
BLAST
Repeati537 – 57943WD 6Add
BLAST
Repeati592 – 63039WD 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224Sufficient for interaction with PIC8UniRule annotationAdd
BLAST
Regioni1 – 9898Sufficient for interaction with HCR1 and TIF32UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit B family.UniRule annotation
Contains 1 RRM (RNA recognition motif) domain.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG5354.
InParanoidiQ5AGV4.
KOiK03253.
OrthoDBiEOG7QG4CT.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
3.30.70.330. 1 hit.
HAMAPiMF_03001. eIF3b.
InterProiIPR011400. EIF3B.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR14068. PTHR14068. 1 hit.
PfamiPF08662. eIF2A. 2 hits.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF036424. eIF3b. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5AGV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSINEEDYLQ LEKEIKLDDI DFSDLEEKYE VNIGLDNYII VDGAPIAPEA
60 70 80 90 100
KVPVLIKVLR KLFSQVGEIV EGDEGIYMPL ENGKSKGYLF IQFKSTESAD
110 120 130 140 150
LAIKKLHGKK LDQNHRLLVN KLSDMEKYGV DGAVNEEFIE PEIEPFQSHG
160 170 180 190 200
YLKSWLQDEQ GRDQMVLHFS ETVGVYWNKK SADPEPVIEP RKGFTSKYAK
210 220 230 240 250
FSPKGTYLFS IHPQGIQSWG GANFNSIKRF FHQQVRLVDF SPNEKFMVTL
260 270 280 290 300
SPIPISLPDS TVDRAQFPFG PESEGHKLVI WNMITGEPVR TFALPPHLEG
310 320 330 340 350
QKEMPWPLVK WSYDDKYCAR QGPDALAIYE TESNFQLLDK KLVKVDGIQD
360 370 380 390 400
FEWAPAGVKL HNSKAVDGKH VLSYWTPEST NQTARVALMQ IPSREILRTV
410 420 430 440 450
NLFQVSDCKM HWQSNGKLLC VKVDRHTKSG KTIFSNLEFF KTNERDIPVE
460 470 480 490 500
KLELKDVVVN FAWEPNTERF ITISRLDDGN PNPAIPKNTI SFYAPEVTKG
510 520 530 540 550
GVNHNSKKKG GAAIAAAVAA AAINNQSSTK YKAYTKIENK HSNTIFWSPK
560 570 580 590 600
GRYVVVATIS RTSGELEFFD VSFDDETNKK SLPANVKLLK TDKFSGMTNI
610 620 630 640 650
SWDPSGRFVA AWSTSWLHAI ENGYRLYEFT GNLLRDDSID QFKDFVWRPR
660 670 680 690 700
PPSLLTNSDK KKVRSNLREY SAQFEEADAM EADAAVKEII LARRKALEEW
710 720 730
RKYRAKHISK QGNSKNEVQA EIIEEIKEEI IEEKEEIVE
Length:739
Mass (Da):84,252
Last modified:April 26, 2005 - v1
Checksum:iEE3F733AB888577B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000020 Genomic DNA. Translation: EAL02086.1.
AACQ01000016 Genomic DNA. Translation: EAL02620.1.
AP006852 Genomic DNA. Translation: BAE44665.1.
RefSeqiXP_720907.1. XM_715814.1.
XP_721420.1. XM_716327.1.
XP_888768.1. XM_883675.1.

Genome annotation databases

GeneIDi3636959.
3637544.
3704235.
KEGGical:CaO19.13937.
cal:CaO19.6584.
cal:CaO19_6584.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000020 Genomic DNA. Translation: EAL02086.1 .
AACQ01000016 Genomic DNA. Translation: EAL02620.1 .
AP006852 Genomic DNA. Translation: BAE44665.1 .
RefSeqi XP_720907.1. XM_715814.1.
XP_721420.1. XM_716327.1.
XP_888768.1. XM_883675.1.

3D structure databases

ProteinModelPortali Q5AGV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003307.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3636959.
3637544.
3704235.
KEGGi cal:CaO19.13937.
cal:CaO19.6584.
cal:CaO19_6584.

Organism-specific databases

CGDi CAL0003307. PRT1.

Phylogenomic databases

eggNOGi COG5354.
InParanoidi Q5AGV4.
KOi K03253.
OrthoDBi EOG7QG4CT.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
3.30.70.330. 1 hit.
HAMAPi MF_03001. eIF3b.
InterProi IPR011400. EIF3B.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR14068. PTHR14068. 1 hit.
Pfami PF08662. eIF2A. 2 hits.
PF00076. RRM_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF036424. eIF3b. 1 hit.
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
    Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
    Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiEIF3B_CANAL
AccessioniPrimary (citable) accession number: Q5AGV4
Secondary accession number(s): Q3MPJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3