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Q5AGV4

- EIF3B_CANAL

UniProt

Q5AGV4 - EIF3B_CANAL

Protein

Eukaryotic translation initiation factor 3 subunit B

Gene

PRT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular response to drug Source: CGD
    2. formation of translation preinitiation complex Source: UniProtKB-HAMAP
    3. regulation of translational initiation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit BUniRule annotation
    Short name:
    eIF3bUniRule annotation
    Alternative name(s):
    Eukaryotic translation initiation factor 3 90 kDa subunit homologUniRule annotation
    Short name:
    eIF3 p90UniRule annotation
    Translation initiation factor eIF3 p90 subunit homolog
    Gene namesi
    Name:PRT1UniRule annotation
    ORF Names:CaO19.13937, CaO19.6584
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003307. PRT1.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
    2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
    3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
    4. fungal-type cell wall Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Eukaryotic translation initiation factor 3 subunit BPRO_0000363813Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi5476.CAL0003307.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AGV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 12488RRMUniRule annotationAdd
    BLAST
    Repeati190 – 22940WD 1Add
    BLAST
    Repeati231 – 29363WD 2Add
    BLAST
    Repeati301 – 33939WD 3Add
    BLAST
    Repeati343 – 38543WD 4Add
    BLAST
    Repeati453 – 50250WD 5Add
    BLAST
    Repeati537 – 57943WD 6Add
    BLAST
    Repeati592 – 63039WD 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 224224Sufficient for interaction with PIC8UniRule annotationAdd
    BLAST
    Regioni1 – 9898Sufficient for interaction with HCR1 and TIF32UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-3 subunit B family.UniRule annotation
    Contains 1 RRM (RNA recognition motif) domain.UniRule annotation
    Contains 7 WD repeats.UniRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG5354.
    KOiK03253.
    OrthoDBiEOG7QG4CT.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    3.30.70.330. 1 hit.
    HAMAPiMF_03001. eIF3b.
    InterProiIPR011400. EIF3B.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR013979. TIF_beta_prop-like.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR14068. PTHR14068. 1 hit.
    PfamiPF08662. eIF2A. 2 hits.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036424. eIF3b. 1 hit.
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5AGV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSINEEDYLQ LEKEIKLDDI DFSDLEEKYE VNIGLDNYII VDGAPIAPEA    50
    KVPVLIKVLR KLFSQVGEIV EGDEGIYMPL ENGKSKGYLF IQFKSTESAD 100
    LAIKKLHGKK LDQNHRLLVN KLSDMEKYGV DGAVNEEFIE PEIEPFQSHG 150
    YLKSWLQDEQ GRDQMVLHFS ETVGVYWNKK SADPEPVIEP RKGFTSKYAK 200
    FSPKGTYLFS IHPQGIQSWG GANFNSIKRF FHQQVRLVDF SPNEKFMVTL 250
    SPIPISLPDS TVDRAQFPFG PESEGHKLVI WNMITGEPVR TFALPPHLEG 300
    QKEMPWPLVK WSYDDKYCAR QGPDALAIYE TESNFQLLDK KLVKVDGIQD 350
    FEWAPAGVKL HNSKAVDGKH VLSYWTPEST NQTARVALMQ IPSREILRTV 400
    NLFQVSDCKM HWQSNGKLLC VKVDRHTKSG KTIFSNLEFF KTNERDIPVE 450
    KLELKDVVVN FAWEPNTERF ITISRLDDGN PNPAIPKNTI SFYAPEVTKG 500
    GVNHNSKKKG GAAIAAAVAA AAINNQSSTK YKAYTKIENK HSNTIFWSPK 550
    GRYVVVATIS RTSGELEFFD VSFDDETNKK SLPANVKLLK TDKFSGMTNI 600
    SWDPSGRFVA AWSTSWLHAI ENGYRLYEFT GNLLRDDSID QFKDFVWRPR 650
    PPSLLTNSDK KKVRSNLREY SAQFEEADAM EADAAVKEII LARRKALEEW 700
    RKYRAKHISK QGNSKNEVQA EIIEEIKEEI IEEKEEIVE 739
    Length:739
    Mass (Da):84,252
    Last modified:April 26, 2005 - v1
    Checksum:iEE3F733AB888577B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000020 Genomic DNA. Translation: EAL02086.1.
    AACQ01000016 Genomic DNA. Translation: EAL02620.1.
    AP006852 Genomic DNA. Translation: BAE44665.1.
    RefSeqiXP_720907.1. XM_715814.1.
    XP_721420.1. XM_716327.1.
    XP_888768.1. XM_883675.1.

    Genome annotation databases

    GeneIDi3636959.
    3637544.
    3704235.
    KEGGical:CaO19.13937.
    cal:CaO19.6584.
    cal:CaO19_6584.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000020 Genomic DNA. Translation: EAL02086.1 .
    AACQ01000016 Genomic DNA. Translation: EAL02620.1 .
    AP006852 Genomic DNA. Translation: BAE44665.1 .
    RefSeqi XP_720907.1. XM_715814.1.
    XP_721420.1. XM_716327.1.
    XP_888768.1. XM_883675.1.

    3D structure databases

    ProteinModelPortali Q5AGV4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003307.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3636959.
    3637544.
    3704235.
    KEGGi cal:CaO19.13937.
    cal:CaO19.6584.
    cal:CaO19_6584.

    Organism-specific databases

    CGDi CAL0003307. PRT1.

    Phylogenomic databases

    eggNOGi COG5354.
    KOi K03253.
    OrthoDBi EOG7QG4CT.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    3.30.70.330. 1 hit.
    HAMAPi MF_03001. eIF3b.
    InterProi IPR011400. EIF3B.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR013979. TIF_beta_prop-like.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR14068. PTHR14068. 1 hit.
    Pfami PF08662. eIF2A. 2 hits.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036424. eIF3b. 1 hit.
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
      Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
      Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiEIF3B_CANAL
    AccessioniPrimary (citable) accession number: Q5AGV4
    Secondary accession number(s): Q3MPJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. Translation initiation factors
      List of translation initiation factor entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3