Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5AGV4 (EIF3B_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 3 subunit B

Short name=eIF3b
Alternative name(s):
Eukaryotic translation initiation factor 3 90 kDa subunit homolog
Short name=eIF3 p90
Translation initiation factor eIF3 p90 subunit homolog
Gene names
Name:PRT1
ORF Names:CaO19.13937, CaO19.6584
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03001

Subunit structure

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03001.

Sequence similarities

Belongs to the eIF-3 subunit B family.

Contains 1 RRM (RNA recognition motif) domain.

Contains 7 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Eukaryotic translation initiation factor 3 subunit B HAMAP-Rule MF_03001
PRO_0000363813

Regions

Domain37 – 12488RRM
Repeat190 – 22940WD 1 HAMAP-Rule MF_03001
Repeat231 – 29363WD 2 HAMAP-Rule MF_03001
Repeat301 – 33939WD 3 HAMAP-Rule MF_03001
Repeat343 – 38543WD 4 HAMAP-Rule MF_03001
Repeat453 – 50250WD 5 HAMAP-Rule MF_03001
Repeat537 – 57943WD 6 HAMAP-Rule MF_03001
Repeat592 – 63039WD 7 HAMAP-Rule MF_03001
Region1 – 224224Sufficient for interaction with PIC8 By similarity
Region1 – 9898Sufficient for interaction with HCR1 and TIF32 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5AGV4 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: EE3F733AB888577B

FASTA73984,252
        10         20         30         40         50         60 
MSINEEDYLQ LEKEIKLDDI DFSDLEEKYE VNIGLDNYII VDGAPIAPEA KVPVLIKVLR 

        70         80         90        100        110        120 
KLFSQVGEIV EGDEGIYMPL ENGKSKGYLF IQFKSTESAD LAIKKLHGKK LDQNHRLLVN 

       130        140        150        160        170        180 
KLSDMEKYGV DGAVNEEFIE PEIEPFQSHG YLKSWLQDEQ GRDQMVLHFS ETVGVYWNKK 

       190        200        210        220        230        240 
SADPEPVIEP RKGFTSKYAK FSPKGTYLFS IHPQGIQSWG GANFNSIKRF FHQQVRLVDF 

       250        260        270        280        290        300 
SPNEKFMVTL SPIPISLPDS TVDRAQFPFG PESEGHKLVI WNMITGEPVR TFALPPHLEG 

       310        320        330        340        350        360 
QKEMPWPLVK WSYDDKYCAR QGPDALAIYE TESNFQLLDK KLVKVDGIQD FEWAPAGVKL 

       370        380        390        400        410        420 
HNSKAVDGKH VLSYWTPEST NQTARVALMQ IPSREILRTV NLFQVSDCKM HWQSNGKLLC 

       430        440        450        460        470        480 
VKVDRHTKSG KTIFSNLEFF KTNERDIPVE KLELKDVVVN FAWEPNTERF ITISRLDDGN 

       490        500        510        520        530        540 
PNPAIPKNTI SFYAPEVTKG GVNHNSKKKG GAAIAAAVAA AAINNQSSTK YKAYTKIENK 

       550        560        570        580        590        600 
HSNTIFWSPK GRYVVVATIS RTSGELEFFD VSFDDETNKK SLPANVKLLK TDKFSGMTNI 

       610        620        630        640        650        660 
SWDPSGRFVA AWSTSWLHAI ENGYRLYEFT GNLLRDDSID QFKDFVWRPR PPSLLTNSDK 

       670        680        690        700        710        720 
KKVRSNLREY SAQFEEADAM EADAAVKEII LARRKALEEW RKYRAKHISK QGNSKNEVQA 

       730 
EIIEEIKEEI IEEKEEIVE 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000020 Genomic DNA. Translation: EAL02086.1.
AACQ01000016 Genomic DNA. Translation: EAL02620.1.
AP006852 Genomic DNA. Translation: BAE44665.1.
RefSeqXP_720907.1. XM_715814.1.
XP_721420.1. XM_716327.1.
XP_888768.1. XM_883675.1.

3D structure databases

ProteinModelPortalQ5AGV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003307.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3636959.
3637544.
3704235.
KEGGcal:CaO19.13937.
cal:CaO19.6584.
cal:CaO19_6584.

Organism-specific databases

CGDCAL0003307. PRT1.

Phylogenomic databases

eggNOGCOG5354.
KOK03253.
OrthoDBEOG7QG4CT.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
3.30.70.330. 1 hit.
HAMAPMF_03001. eIF3b.
InterProIPR011400. EIF3B.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR14068. PTHR14068. 1 hit.
PfamPF08662. eIF2A. 2 hits.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFPIRSF036424. eIF3b. 1 hit.
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEIF3B_CANAL
AccessionPrimary (citable) accession number: Q5AGV4
Secondary accession number(s): Q3MPJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries

Candida albicans

Candida albicans: entries and gene names