Q5AGC7 (BUD32_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase BUD32
EC=2.7.11.1

Gene names

Name:	BUD32
ORF Names:	CaO19.4252, CaO19.11727

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the EKC/KEOPS complex which promotes both telomere uncapping and telomere elongation By similarity. The complex is required for efficient recruitment of transcriptional coactivators. Important for bud site selection By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Component of the EKC/KEOPS complex By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Chromosome › telomere By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Cytoplasm Nucleus Telomere
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Serine/threonine-protein kinase BUD32		PRO_0000278908
Regions
	Domain	15 – 296	282	Protein kinase
	Nucleotide binding	21 – 29	9	ATP By similarity
Sites
	Active site	177	1	Proton acceptor By similarity
	Binding site	61	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5AGC7 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 81C9B27FA2A873B7	FASTA	296	33,882
	10 20 30 40 50 60 MTDHLIAKVQ EHVPNIPLKI ISQGAEALVF ETSVHPYYNY NSSEKHHESP SLHNHTTFII 70 80 90 100 110 120 KYRPTKPYRH PKIDLQINKS RTIGEVKFMY KLSKLNIACP NIISTDFNNG IIWMECLGSK 130 140 150 160 170 180 LPNGTISSFK NWLWYLESQE KEDPSINLHD DDQVELVCQK VGQLIGRLHL NDMIHGDLTS 190 200 210 220 230 240 SNIILTEVDT KKNEDTDANN SSVYFEPALI DFGLSSFSGL AEDKAVDLYV LERAILSTHS 250 260 270 280 290 NYADKLNGWL LEGYQQIHDS IEFNKTKQQL GKSKLKDTIK RLEDVRLRGR KRSMLG

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000021 Genomic DNA. Translation: EAL01857.1. AACQ01000022 Genomic DNA. Translation: EAL01724.1.
RefSeq	XP_720561.1. XM_715468.1. XP_720688.1. XM_715595.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5AGC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3637607. 3637728.
KEGG	cal:CaO19.11727. cal:CaO19.4252.
Organism-specific databases
CGD	CAL0000253. orf19.4252.
Phylogenomic databases
PhylomeDB	Q5AGC7.
Family and domain databases
InterPro	IPR022495. Kinase-assoc_endopept-1. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_kinase-like_dom. IPR008266. Tyr_kinase_AS. [Graphical view]
KO	K08851.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR03724. Arch_bud32. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BUD32_CANAL

Accession

Primary (citable) accession number: Q5AGC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program