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Q5AG31

- MED14_CANAL

UniProt

Q5AG31 - MED14_CANAL

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Protein

Mediator of RNA polymerase II transcription subunit 14

Gene
RGR1, MED14, CaO19.11825, CaO19.4348
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 14
Alternative name(s):
Mediator complex subunit 14
Gene namesi
Name:RGR1
Synonyms:MED14
ORF Names:CaO19.11825, CaO19.4348
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0069772. orf19.11825.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. mediator complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12701270Mediator of RNA polymerase II transcription subunit 14PRO_0000304597Add
BLAST

Interactioni

Subunit structurei

Component of the Mediator complex By similarity.

Protein-protein interaction databases

BioGridi1220894. 1 interaction.
STRINGi5476.CAL0001020.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG281210.
KOiK15156.
OrthoDBiEOG7G7KXF.

Family and domain databases

InterProiIPR013947. Mediator_Med14.
[Graphical view]
PfamiPF08638. Med14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5AG31-1 [UniParc]FASTAAdd to Basket

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MNQHQDQSSM PNGKQQHEVT ESSSPPEIPH ITANMIPLSN IIKYYTQEAY     50
KQLTTAIENL SMNVNEESDI KRKKYFLNVI INLRQDFIKV YTLIKWASIS 100
KDVSKFIDLL NWFRIQEFHF ENLIFQLNAL TGYNAAKLPN SDIITALEVL 150
YHGRPKLPSY NYIKSDNLSP QKILETLNDL NLVLMTRFAL MDNIPKRFDY 200
EIKDGRAYIR VSNEFEVSIT VGNDLIIDNP EEYYKSPFYF IDFKFLFGAN 250
PESGLITFND DKISTKLPTS SHKKLEKLVN QTLLTRGLQG LYELLHKYSN 300
SFKIYLLAKQ FQTLLINSRW RGNFQINYQT NKSLIVINYW SQHYLSRNWK 350
SFIELGIDSH SNLNYRWFKN GQYCFGDQGN NELDKIFHLQ RRNSNNGVTT 400
SSNTISTSAM IAGIRRSTEL SNETAIVDDN DNDNNDTNNT GETENEDLNV 450
DLILNVVVNQ HAKSIMSEIY SQLLTRFSET DVSMVSPHQL LLQISPKKST 500
VFAINPLTGF FYFIDPTPIQ TYITKKINSP PPTLSQVSIK QSFIPESDMI 550
SYVIDQIIQL RLEVFNKEVN TKLATTAWIN NGIIKLSDHE LSKLTQFLIQ 600
NEEQEGDDNE EDSSTNTRLD SVLQSFKVQF YRRKNWPSSW FLINMISGVT 650
TKSFWWVARI KSISGDWKIQ WAQIIKFHGD NAKQELSPNE SKVFDKPKRT 700
VDCSIESEQL NFEFFKTLST LSSNLILDHM ILEELQVRSI KFIKLDWETI 750
DDNKIFSKFK QNHDISLKRK NSHNINIDVN VDVADNTSTT TNTKYIRAPK 800
LKYESMFLIY NDKLLPIYNS ATILFLKIEL VESNKMYLKL FGNLRNLQIK 850
NTSEDIQKLH LNIDEANQYF EIDNTVDLST VINEPKTLLL NLIFNTLNKL 900
NSLIKILDQL NKSNVTVLDN SMDNITINIK DKYNDNNDKL IIIKLPEQAT 950
DSIQLLMKNG STTTTDEIDL RNNNILEFEL ILKFLNQYLR ESQSNNHNRQ 1000
QISIIKIIQY LTEINPILQS TKAINQQLAE LKRINSTNNN NNNAKRRSIL 1050
KLSNGLYKLY FNLNIISLTH LQLVFFMNSN TGSNLKKIQR DKIMINLSLI 1100
KFDRFSKPNG NFQDSTNGHL IKISFKDSLI NENLKFKNLF EIIFKNINEL 1150
LITKSKQIKS LNQTENQQQQ QPLKQEDNSD SAIIKKESQS IEDDLLDFGE 1200
YDNDIKPQQQ EPQQNEKENS KTTSKENETV RPDDILIKLN YDYLLSMNNL 1250
QLMINEITKS CFQYLQQQQE 1270
Length:1,270
Mass (Da):147,614
Last modified:September 11, 2007 - v2
Checksum:i56642901C4F70BE3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511K → Q in allele CaO19.4348.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000022 Genomic DNA. Translation: EAL01820.1.
AACQ01000021 Genomic DNA. Translation: EAL01955.1.
RefSeqiXP_720653.1. XM_715560.1.
XP_720782.1. XM_715689.1.

Genome annotation databases

GeneIDi3637672.
3637800.
KEGGical:CaO19.11825.
cal:CaO19.4348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000022 Genomic DNA. Translation: EAL01820.1 .
AACQ01000021 Genomic DNA. Translation: EAL01955.1 .
RefSeqi XP_720653.1. XM_715560.1.
XP_720782.1. XM_715689.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1220894. 1 interaction.
STRINGi 5476.CAL0001020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3637672.
3637800.
KEGGi cal:CaO19.11825.
cal:CaO19.4348.

Organism-specific databases

CGDi CAL0069772. orf19.11825.

Phylogenomic databases

eggNOGi NOG281210.
KOi K15156.
OrthoDBi EOG7G7KXF.

Family and domain databases

InterProi IPR013947. Mediator_Med14.
[Graphical view ]
Pfami PF08638. Med14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMED14_CANAL
AccessioniPrimary (citable) accession number: Q5AG31
Secondary accession number(s): Q5AGG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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