Q5AG31 (MED14_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mediator of RNA polymerase II transcription subunit 14

Alternative name(s):
Mediator complex subunit 14

Gene names

Name:	RGR1
Synonyms:	MED14
ORF Names:	CaO19.11825, CaO19.4348

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	1270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.
Subunit structure	Component of the Mediator complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Mediator complex subunit 14 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mediator complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA polymerase II transcription cofactor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1270	1270	Mediator of RNA polymerase II transcription subunit 14		PRO_0000304597
Natural variations
	Natural variant	51	1	K → Q in allele CaO19.4348.

Sequences

	Sequence		Length	Mass (Da)
	Q5AG31 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: 56642901C4F70BE3	FASTA	1,270	147,614
	10 20 30 40 50 60 MNQHQDQSSM PNGKQQHEVT ESSSPPEIPH ITANMIPLSN IIKYYTQEAY KQLTTAIENL 70 80 90 100 110 120 SMNVNEESDI KRKKYFLNVI INLRQDFIKV YTLIKWASIS KDVSKFIDLL NWFRIQEFHF 130 140 150 160 170 180 ENLIFQLNAL TGYNAAKLPN SDIITALEVL YHGRPKLPSY NYIKSDNLSP QKILETLNDL 190 200 210 220 230 240 NLVLMTRFAL MDNIPKRFDY EIKDGRAYIR VSNEFEVSIT VGNDLIIDNP EEYYKSPFYF 250 260 270 280 290 300 IDFKFLFGAN PESGLITFND DKISTKLPTS SHKKLEKLVN QTLLTRGLQG LYELLHKYSN 310 320 330 340 350 360 SFKIYLLAKQ FQTLLINSRW RGNFQINYQT NKSLIVINYW SQHYLSRNWK SFIELGIDSH 370 380 390 400 410 420 SNLNYRWFKN GQYCFGDQGN NELDKIFHLQ RRNSNNGVTT SSNTISTSAM IAGIRRSTEL 430 440 450 460 470 480 SNETAIVDDN DNDNNDTNNT GETENEDLNV DLILNVVVNQ HAKSIMSEIY SQLLTRFSET 490 500 510 520 530 540 DVSMVSPHQL LLQISPKKST VFAINPLTGF FYFIDPTPIQ TYITKKINSP PPTLSQVSIK 550 560 570 580 590 600 QSFIPESDMI SYVIDQIIQL RLEVFNKEVN TKLATTAWIN NGIIKLSDHE LSKLTQFLIQ 610 620 630 640 650 660 NEEQEGDDNE EDSSTNTRLD SVLQSFKVQF YRRKNWPSSW FLINMISGVT TKSFWWVARI 670 680 690 700 710 720 KSISGDWKIQ WAQIIKFHGD NAKQELSPNE SKVFDKPKRT VDCSIESEQL NFEFFKTLST 730 740 750 760 770 780 LSSNLILDHM ILEELQVRSI KFIKLDWETI DDNKIFSKFK QNHDISLKRK NSHNINIDVN 790 800 810 820 830 840 VDVADNTSTT TNTKYIRAPK LKYESMFLIY NDKLLPIYNS ATILFLKIEL VESNKMYLKL 850 860 870 880 890 900 FGNLRNLQIK NTSEDIQKLH LNIDEANQYF EIDNTVDLST VINEPKTLLL NLIFNTLNKL 910 920 930 940 950 960 NSLIKILDQL NKSNVTVLDN SMDNITINIK DKYNDNNDKL IIIKLPEQAT DSIQLLMKNG 970 980 990 1000 1010 1020 STTTTDEIDL RNNNILEFEL ILKFLNQYLR ESQSNNHNRQ QISIIKIIQY LTEINPILQS 1030 1040 1050 1060 1070 1080 TKAINQQLAE LKRINSTNNN NNNAKRRSIL KLSNGLYKLY FNLNIISLTH LQLVFFMNSN 1090 1100 1110 1120 1130 1140 TGSNLKKIQR DKIMINLSLI KFDRFSKPNG NFQDSTNGHL IKISFKDSLI NENLKFKNLF 1150 1160 1170 1180 1190 1200 EIIFKNINEL LITKSKQIKS LNQTENQQQQ QPLKQEDNSD SAIIKKESQS IEDDLLDFGE 1210 1220 1230 1240 1250 1260 YDNDIKPQQQ EPQQNEKENS KTTSKENETV RPDDILIKLN YDYLLSMNNL QLMINEITKS 1270 CFQYLQQQQE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000022 Genomic DNA. Translation: EAL01820.1. AACQ01000021 Genomic DNA. Translation: EAL01955.1.
RefSeq	XP_720653.1. XM_715560.1. XP_720782.1. XM_715689.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001020.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3637672. 3637800.
KEGG	cal:CaO19.11825. cal:CaO19.4348.
Organism-specific databases
CGD	CAL0069772. orf19.11825.
Phylogenomic databases
eggNOG	NOG281210.
KO	K15156.
Family and domain databases
InterPro	IPR013947. Mediator_Med14. [Graphical view]
Pfam	PF08638. Med14. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MED14_CANAL

Accession

Primary (citable) accession number: Q5AG31
Secondary accession number(s): Q5AGG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	April 3, 2013
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program