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Q5AG31

- MED14_CANAL

UniProt

Q5AG31 - MED14_CANAL

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Protein

Mediator of RNA polymerase II transcription subunit 14

Gene

RGR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 14
Alternative name(s):
Mediator complex subunit 14
Gene namesi
Name:RGR1
Synonyms:MED14
ORF Names:CaO19.11825, CaO19.4348
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0069772. orf19.11825.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. mediator complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12701270Mediator of RNA polymerase II transcription subunit 14PRO_0000304597Add
BLAST

Interactioni

Subunit structurei

Component of the Mediator complex.By similarity

Protein-protein interaction databases

BioGridi1220894. 1 interaction.
STRINGi5476.CAL0001020.

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 14 family.Curated

Phylogenomic databases

eggNOGiNOG281210.
InParanoidiQ5AG31.
KOiK15156.
OrthoDBiEOG7G7KXF.

Family and domain databases

InterProiIPR013947. Mediator_Med14.
[Graphical view]
PfamiPF08638. Med14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5AG31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQHQDQSSM PNGKQQHEVT ESSSPPEIPH ITANMIPLSN IIKYYTQEAY
60 70 80 90 100
KQLTTAIENL SMNVNEESDI KRKKYFLNVI INLRQDFIKV YTLIKWASIS
110 120 130 140 150
KDVSKFIDLL NWFRIQEFHF ENLIFQLNAL TGYNAAKLPN SDIITALEVL
160 170 180 190 200
YHGRPKLPSY NYIKSDNLSP QKILETLNDL NLVLMTRFAL MDNIPKRFDY
210 220 230 240 250
EIKDGRAYIR VSNEFEVSIT VGNDLIIDNP EEYYKSPFYF IDFKFLFGAN
260 270 280 290 300
PESGLITFND DKISTKLPTS SHKKLEKLVN QTLLTRGLQG LYELLHKYSN
310 320 330 340 350
SFKIYLLAKQ FQTLLINSRW RGNFQINYQT NKSLIVINYW SQHYLSRNWK
360 370 380 390 400
SFIELGIDSH SNLNYRWFKN GQYCFGDQGN NELDKIFHLQ RRNSNNGVTT
410 420 430 440 450
SSNTISTSAM IAGIRRSTEL SNETAIVDDN DNDNNDTNNT GETENEDLNV
460 470 480 490 500
DLILNVVVNQ HAKSIMSEIY SQLLTRFSET DVSMVSPHQL LLQISPKKST
510 520 530 540 550
VFAINPLTGF FYFIDPTPIQ TYITKKINSP PPTLSQVSIK QSFIPESDMI
560 570 580 590 600
SYVIDQIIQL RLEVFNKEVN TKLATTAWIN NGIIKLSDHE LSKLTQFLIQ
610 620 630 640 650
NEEQEGDDNE EDSSTNTRLD SVLQSFKVQF YRRKNWPSSW FLINMISGVT
660 670 680 690 700
TKSFWWVARI KSISGDWKIQ WAQIIKFHGD NAKQELSPNE SKVFDKPKRT
710 720 730 740 750
VDCSIESEQL NFEFFKTLST LSSNLILDHM ILEELQVRSI KFIKLDWETI
760 770 780 790 800
DDNKIFSKFK QNHDISLKRK NSHNINIDVN VDVADNTSTT TNTKYIRAPK
810 820 830 840 850
LKYESMFLIY NDKLLPIYNS ATILFLKIEL VESNKMYLKL FGNLRNLQIK
860 870 880 890 900
NTSEDIQKLH LNIDEANQYF EIDNTVDLST VINEPKTLLL NLIFNTLNKL
910 920 930 940 950
NSLIKILDQL NKSNVTVLDN SMDNITINIK DKYNDNNDKL IIIKLPEQAT
960 970 980 990 1000
DSIQLLMKNG STTTTDEIDL RNNNILEFEL ILKFLNQYLR ESQSNNHNRQ
1010 1020 1030 1040 1050
QISIIKIIQY LTEINPILQS TKAINQQLAE LKRINSTNNN NNNAKRRSIL
1060 1070 1080 1090 1100
KLSNGLYKLY FNLNIISLTH LQLVFFMNSN TGSNLKKIQR DKIMINLSLI
1110 1120 1130 1140 1150
KFDRFSKPNG NFQDSTNGHL IKISFKDSLI NENLKFKNLF EIIFKNINEL
1160 1170 1180 1190 1200
LITKSKQIKS LNQTENQQQQ QPLKQEDNSD SAIIKKESQS IEDDLLDFGE
1210 1220 1230 1240 1250
YDNDIKPQQQ EPQQNEKENS KTTSKENETV RPDDILIKLN YDYLLSMNNL
1260 1270
QLMINEITKS CFQYLQQQQE
Length:1,270
Mass (Da):147,614
Last modified:September 11, 2007 - v2
Checksum:i56642901C4F70BE3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511K → Q in allele CaO19.4348.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000022 Genomic DNA. Translation: EAL01820.1.
AACQ01000021 Genomic DNA. Translation: EAL01955.1.
RefSeqiXP_720653.1. XM_715560.1.
XP_720782.1. XM_715689.1.

Genome annotation databases

GeneIDi3637672.
3637800.
KEGGical:CaO19.11825.
cal:CaO19.4348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000022 Genomic DNA. Translation: EAL01820.1 .
AACQ01000021 Genomic DNA. Translation: EAL01955.1 .
RefSeqi XP_720653.1. XM_715560.1.
XP_720782.1. XM_715689.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1220894. 1 interaction.
STRINGi 5476.CAL0001020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3637672.
3637800.
KEGGi cal:CaO19.11825.
cal:CaO19.4348.

Organism-specific databases

CGDi CAL0069772. orf19.11825.

Phylogenomic databases

eggNOGi NOG281210.
InParanoidi Q5AG31.
KOi K15156.
OrthoDBi EOG7G7KXF.

Family and domain databases

InterProi IPR013947. Mediator_Med14.
[Graphical view ]
Pfami PF08638. Med14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMED14_CANAL
AccessioniPrimary (citable) accession number: Q5AG31
Secondary accession number(s): Q5AGG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3