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Protein

Mediator of RNA polymerase II transcription subunit 14

Gene

MED14

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 14
Alternative name(s):
Mediator complex subunit 14
Gene namesi
Name:MED14
Synonyms:RGR1
Ordered Locus Names:CAALFM_C503160WA
ORF Names:CaO19.11825, CaO19.4348
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 5

Organism-specific databases

CGDiCAL0000182774. MED14.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003045971 – 1261Mediator of RNA polymerase II transcription subunit 14Add BLAST1261

Proteomic databases

PRIDEiQ5AG31.

Interactioni

Subunit structurei

Component of the Mediator complex.By similarity

Protein-protein interaction databases

BioGridi1220766. 1 interactor.

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 14 family.Curated

Phylogenomic databases

InParanoidiQ5AG31.
KOiK15156.
OrthoDBiEOG092C0NN4.

Family and domain databases

InterProiView protein in InterPro
IPR013947. Mediator_Med14.
PfamiView protein in Pfam
PF08638. Med14. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AG31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNGKQQHEV TESSSPPEIP HITANMIPLS NIIKYYTQEA YKQLTTAIEN
60 70 80 90 100
LSMNVNEESD IKRKKYFLNV IINLRQDFIK VYTLIKWASI SKDVSKFIDL
110 120 130 140 150
LNWFRIQEFH FENLIFQLNA LTGYNAAKLP NSDIITALEV LYHGRPKLPS
160 170 180 190 200
YNYIKSDNLS PQKILETLND LNLVLMTRFA LMDNIPKRFD YEIKDGRAYI
210 220 230 240 250
RVSNEFEVSI TVGNDLIIDN PEEYYKSPFY FIDFKFLFGA NPESGLITFN
260 270 280 290 300
DDKISTKLPT SSHKKLEKLV NQTLLTRGLQ GLYELLHKYS NSFKIYLLAK
310 320 330 340 350
QFQTLLINSR WRGNFQINYQ TNKSLIVINY WSQHYLSRNW KSFIELGIDS
360 370 380 390 400
HSNLNYRWFK NGQYCFGDQG NNELDKIFHL QRRNSNNGVT TSSNTISTSA
410 420 430 440 450
MIAGIRRSTE LSNETAIVDD NDNDNDDTNN TGETENEDLN VDLILNVVVN
460 470 480 490 500
QHAKSIMSEI YSQLLTRFSE TDVSMVSPHQ LLLQISPKKS TVFAINPLTG
510 520 530 540 550
FFYFIDPTPI QTYITKKINS PPPTLSQVSI KQSFIPESDM ISYVIDQIIQ
560 570 580 590 600
LRLEVFNKEV NTKLATTAWI NNGIIKLSDH ELSKLTQFLI QNEEQEGDDN
610 620 630 640 650
EEDSSTNTRL DSVLQSFKVQ FYRRKNWPSS WFLINMISGV TTKSFWWVAR
660 670 680 690 700
IKSISGDWKI QWAQIIKFHG DNAKQELSPN ESKVFDKPKR TVDCSIESEQ
710 720 730 740 750
LNFEFFKTLS TLSSNLILDH MILEELQVRS IKFIKLDWET IDDNKIFSKF
760 770 780 790 800
KQNHDISLKR KNSHNINIDV NVDVADNTST TTNTKYIRAP KLKYESMFLI
810 820 830 840 850
YNDKLLPIYN SATILFLKIE LVESNKMYLK LFGNLRNLQI KNTSEDIQKL
860 870 880 890 900
HLNIDEANQY FEIDNTVDLS TVINEPKTLL LNLIFNTLNK LNSLIKILDQ
910 920 930 940 950
LNKSNVTVLD NSMDNITINI KDKYNDNNDK LIIIKLPEQA TDSIQLLMKN
960 970 980 990 1000
GSTTTTDEID LRNNNILEFE LILKFLNQYL RESKSNNHNR QQISIIKIIQ
1010 1020 1030 1040 1050
YLTEINPILQ STKAINQQLA ELKRINSTNN NNNNAKRRSI LKLSNGLYKL
1060 1070 1080 1090 1100
YFNLNIISLT HLQLVFFMNS NTGSNLKKIQ RDKIMINLSL IKFDRFSKPN
1110 1120 1130 1140 1150
GNFQDSTNGH LIKISFKDSL INENLKFKNL FEIIFKNINE LLITKSKQIK
1160 1170 1180 1190 1200
SLNQTENQQQ QQPLKQEDNS DSAIIKKESQ SIEDDLLDFG EYDNDIKPQQ
1210 1220 1230 1240 1250
QEPQQNEKEN SKTTSKENET VRPDDILIKL NYDYLLSMNN LQLMINEITK
1260
SCFQYLQQQQ E
Length:1,261
Mass (Da):146,559
Last modified:May 10, 2017 - v3
Checksum:i7A796D77FFCC52D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017627 Genomic DNA. Translation: AOW29736.1.
RefSeqiXP_720653.2. XM_715560.2.

Genome annotation databases

GeneIDi3637800.
KEGGical:CAALFM_C503160WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMED14_CANAL
AccessioniPrimary (citable) accession number: Q5AG31
Secondary accession number(s): A0A1D8PNN0, Q5AGG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 10, 2017
Last modified: July 5, 2017
This is version 63 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families