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Q5AG31 (MED14_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mediator of RNA polymerase II transcription subunit 14
Alternative name(s):
Mediator complex subunit 14
Gene names
Name:RGR1
Synonyms:MED14
ORF Names:CaO19.11825, CaO19.4348
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length1270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.

Subunit structure

Component of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the Mediator complex subunit 14 family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmediator complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA polymerase II transcription cofactor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12701270Mediator of RNA polymerase II transcription subunit 14
PRO_0000304597

Natural variations

Natural variant511K → Q in allele CaO19.4348.

Sequences

Sequence LengthMass (Da)Tools
Q5AG31 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: 56642901C4F70BE3

FASTA1,270147,614
        10         20         30         40         50         60 
MNQHQDQSSM PNGKQQHEVT ESSSPPEIPH ITANMIPLSN IIKYYTQEAY KQLTTAIENL 

        70         80         90        100        110        120 
SMNVNEESDI KRKKYFLNVI INLRQDFIKV YTLIKWASIS KDVSKFIDLL NWFRIQEFHF 

       130        140        150        160        170        180 
ENLIFQLNAL TGYNAAKLPN SDIITALEVL YHGRPKLPSY NYIKSDNLSP QKILETLNDL 

       190        200        210        220        230        240 
NLVLMTRFAL MDNIPKRFDY EIKDGRAYIR VSNEFEVSIT VGNDLIIDNP EEYYKSPFYF 

       250        260        270        280        290        300 
IDFKFLFGAN PESGLITFND DKISTKLPTS SHKKLEKLVN QTLLTRGLQG LYELLHKYSN 

       310        320        330        340        350        360 
SFKIYLLAKQ FQTLLINSRW RGNFQINYQT NKSLIVINYW SQHYLSRNWK SFIELGIDSH 

       370        380        390        400        410        420 
SNLNYRWFKN GQYCFGDQGN NELDKIFHLQ RRNSNNGVTT SSNTISTSAM IAGIRRSTEL 

       430        440        450        460        470        480 
SNETAIVDDN DNDNNDTNNT GETENEDLNV DLILNVVVNQ HAKSIMSEIY SQLLTRFSET 

       490        500        510        520        530        540 
DVSMVSPHQL LLQISPKKST VFAINPLTGF FYFIDPTPIQ TYITKKINSP PPTLSQVSIK 

       550        560        570        580        590        600 
QSFIPESDMI SYVIDQIIQL RLEVFNKEVN TKLATTAWIN NGIIKLSDHE LSKLTQFLIQ 

       610        620        630        640        650        660 
NEEQEGDDNE EDSSTNTRLD SVLQSFKVQF YRRKNWPSSW FLINMISGVT TKSFWWVARI 

       670        680        690        700        710        720 
KSISGDWKIQ WAQIIKFHGD NAKQELSPNE SKVFDKPKRT VDCSIESEQL NFEFFKTLST 

       730        740        750        760        770        780 
LSSNLILDHM ILEELQVRSI KFIKLDWETI DDNKIFSKFK QNHDISLKRK NSHNINIDVN 

       790        800        810        820        830        840 
VDVADNTSTT TNTKYIRAPK LKYESMFLIY NDKLLPIYNS ATILFLKIEL VESNKMYLKL 

       850        860        870        880        890        900 
FGNLRNLQIK NTSEDIQKLH LNIDEANQYF EIDNTVDLST VINEPKTLLL NLIFNTLNKL 

       910        920        930        940        950        960 
NSLIKILDQL NKSNVTVLDN SMDNITINIK DKYNDNNDKL IIIKLPEQAT DSIQLLMKNG 

       970        980        990       1000       1010       1020 
STTTTDEIDL RNNNILEFEL ILKFLNQYLR ESQSNNHNRQ QISIIKIIQY LTEINPILQS 

      1030       1040       1050       1060       1070       1080 
TKAINQQLAE LKRINSTNNN NNNAKRRSIL KLSNGLYKLY FNLNIISLTH LQLVFFMNSN 

      1090       1100       1110       1120       1130       1140 
TGSNLKKIQR DKIMINLSLI KFDRFSKPNG NFQDSTNGHL IKISFKDSLI NENLKFKNLF 

      1150       1160       1170       1180       1190       1200 
EIIFKNINEL LITKSKQIKS LNQTENQQQQ QPLKQEDNSD SAIIKKESQS IEDDLLDFGE 

      1210       1220       1230       1240       1250       1260 
YDNDIKPQQQ EPQQNEKENS KTTSKENETV RPDDILIKLN YDYLLSMNNL QLMINEITKS 

      1270 
CFQYLQQQQE 

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References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000022 Genomic DNA. Translation: EAL01820.1.
AACQ01000021 Genomic DNA. Translation: EAL01955.1.
RefSeqXP_720653.1. XM_715560.1.
XP_720782.1. XM_715689.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1220894. 1 interaction.
STRING5476.CAL0001020.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3637672.
3637800.
KEGGcal:CaO19.11825.
cal:CaO19.4348.

Organism-specific databases

CGDCAL0069772. orf19.11825.

Phylogenomic databases

eggNOGNOG281210.
KOK15156.
OrthoDBEOG7G7KXF.

Family and domain databases

InterProIPR013947. Mediator_Med14.
[Graphical view]
PfamPF08638. Med14. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMED14_CANAL
AccessionPrimary (citable) accession number: Q5AG31
Secondary accession number(s): Q5AGG6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names