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Q5AG31

- MED14_CANAL

UniProt

Q5AG31 - MED14_CANAL

Protein

Mediator of RNA polymerase II transcription subunit 14

Gene

RGR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.By similarity

    GO - Molecular functioni

    1. RNA polymerase II transcription cofactor activity Source: InterPro

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 14
    Alternative name(s):
    Mediator complex subunit 14
    Gene namesi
    Name:RGR1
    Synonyms:MED14
    ORF Names:CaO19.11825, CaO19.4348
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0069772. orf19.11825.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. mediator complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12701270Mediator of RNA polymerase II transcription subunit 14PRO_0000304597Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the Mediator complex.By similarity

    Protein-protein interaction databases

    BioGridi1220894. 1 interaction.
    STRINGi5476.CAL0001020.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Mediator complex subunit 14 family.Curated

    Phylogenomic databases

    eggNOGiNOG281210.
    KOiK15156.
    OrthoDBiEOG7G7KXF.

    Family and domain databases

    InterProiIPR013947. Mediator_Med14.
    [Graphical view]
    PfamiPF08638. Med14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5AG31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQHQDQSSM PNGKQQHEVT ESSSPPEIPH ITANMIPLSN IIKYYTQEAY     50
    KQLTTAIENL SMNVNEESDI KRKKYFLNVI INLRQDFIKV YTLIKWASIS 100
    KDVSKFIDLL NWFRIQEFHF ENLIFQLNAL TGYNAAKLPN SDIITALEVL 150
    YHGRPKLPSY NYIKSDNLSP QKILETLNDL NLVLMTRFAL MDNIPKRFDY 200
    EIKDGRAYIR VSNEFEVSIT VGNDLIIDNP EEYYKSPFYF IDFKFLFGAN 250
    PESGLITFND DKISTKLPTS SHKKLEKLVN QTLLTRGLQG LYELLHKYSN 300
    SFKIYLLAKQ FQTLLINSRW RGNFQINYQT NKSLIVINYW SQHYLSRNWK 350
    SFIELGIDSH SNLNYRWFKN GQYCFGDQGN NELDKIFHLQ RRNSNNGVTT 400
    SSNTISTSAM IAGIRRSTEL SNETAIVDDN DNDNNDTNNT GETENEDLNV 450
    DLILNVVVNQ HAKSIMSEIY SQLLTRFSET DVSMVSPHQL LLQISPKKST 500
    VFAINPLTGF FYFIDPTPIQ TYITKKINSP PPTLSQVSIK QSFIPESDMI 550
    SYVIDQIIQL RLEVFNKEVN TKLATTAWIN NGIIKLSDHE LSKLTQFLIQ 600
    NEEQEGDDNE EDSSTNTRLD SVLQSFKVQF YRRKNWPSSW FLINMISGVT 650
    TKSFWWVARI KSISGDWKIQ WAQIIKFHGD NAKQELSPNE SKVFDKPKRT 700
    VDCSIESEQL NFEFFKTLST LSSNLILDHM ILEELQVRSI KFIKLDWETI 750
    DDNKIFSKFK QNHDISLKRK NSHNINIDVN VDVADNTSTT TNTKYIRAPK 800
    LKYESMFLIY NDKLLPIYNS ATILFLKIEL VESNKMYLKL FGNLRNLQIK 850
    NTSEDIQKLH LNIDEANQYF EIDNTVDLST VINEPKTLLL NLIFNTLNKL 900
    NSLIKILDQL NKSNVTVLDN SMDNITINIK DKYNDNNDKL IIIKLPEQAT 950
    DSIQLLMKNG STTTTDEIDL RNNNILEFEL ILKFLNQYLR ESQSNNHNRQ 1000
    QISIIKIIQY LTEINPILQS TKAINQQLAE LKRINSTNNN NNNAKRRSIL 1050
    KLSNGLYKLY FNLNIISLTH LQLVFFMNSN TGSNLKKIQR DKIMINLSLI 1100
    KFDRFSKPNG NFQDSTNGHL IKISFKDSLI NENLKFKNLF EIIFKNINEL 1150
    LITKSKQIKS LNQTENQQQQ QPLKQEDNSD SAIIKKESQS IEDDLLDFGE 1200
    YDNDIKPQQQ EPQQNEKENS KTTSKENETV RPDDILIKLN YDYLLSMNNL 1250
    QLMINEITKS CFQYLQQQQE 1270
    Length:1,270
    Mass (Da):147,614
    Last modified:September 11, 2007 - v2
    Checksum:i56642901C4F70BE3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511K → Q in allele CaO19.4348.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000022 Genomic DNA. Translation: EAL01820.1.
    AACQ01000021 Genomic DNA. Translation: EAL01955.1.
    RefSeqiXP_720653.1. XM_715560.1.
    XP_720782.1. XM_715689.1.

    Genome annotation databases

    GeneIDi3637672.
    3637800.
    KEGGical:CaO19.11825.
    cal:CaO19.4348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000022 Genomic DNA. Translation: EAL01820.1 .
    AACQ01000021 Genomic DNA. Translation: EAL01955.1 .
    RefSeqi XP_720653.1. XM_715560.1.
    XP_720782.1. XM_715689.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1220894. 1 interaction.
    STRINGi 5476.CAL0001020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3637672.
    3637800.
    KEGGi cal:CaO19.11825.
    cal:CaO19.4348.

    Organism-specific databases

    CGDi CAL0069772. orf19.11825.

    Phylogenomic databases

    eggNOGi NOG281210.
    KOi K15156.
    OrthoDBi EOG7G7KXF.

    Family and domain databases

    InterProi IPR013947. Mediator_Med14.
    [Graphical view ]
    Pfami PF08638. Med14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiMED14_CANAL
    AccessioniPrimary (citable) accession number: Q5AG31
    Secondary accession number(s): Q5AGG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3