Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5AFP8

- KEX1_CANAL

UniProt

Q5AFP8 - KEX1_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei184 – 1841PROSITE-ProRule annotation
Active sitei394 – 3941PROSITE-ProRule annotation
Active sitei452 – 4521PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CaJ7.0112, CaO19.7020
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001969. orf19.7020.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 702683Pheromone-processing carboxypeptidase KEX1PRO_0000411907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001969.

Structurei

3D structure databases

ProteinModelPortaliQ5AFP8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 555536LumenalSequence AnalysisAdd
BLAST
Topological domaini577 – 702126CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei556 – 57621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi524 – 55128Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiQ5AFP8.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AFP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLILSTLIV FIHTLLVSAL PTKEGSDPNS AKKYLVSDLP GLHENITPDN
60 70 80 90 100
SIPLMFAGQL EIYPETDTHY FFWKFSDSNP ETVTNRTIFW LNGGPGCSSM
110 120 130 140 150
DGALLETGPF RINSQQQVIS NNGSWHKMGD IIYVDQPAGT GFSYSDTYIT
160 170 180 190 200
DLDQVAEYFL KFMEKYYELF PEEIGYEIYF AGESYAGQYI PYIADAILQR
210 220 230 240 250
NKKLVDGEHK YDLRGVLIGN GWVSPNEQSL SYLPFFKDHG LIDVHHPKWA
260 270 280 290 300
TLLAKHEQCQ KIVNKIDSTF DDGVVHYYEV SSSTCEAILT DLLEYTQDTA
310 320 330 340 350
SEKDQRCVNM YDYTLRDSYP SCGMNWPYEL VNVGPFLRQE KVMHQLNLIN
360 370 380 390 400
LKKWNECNGR VGRTFQARHS IPAVHLLPEL AKEIPVMLFN GANDIICNSQ
410 420 430 440 450
GVLSYLQKLQ WNGETGFTNK DNQISWIYDN KEVGYIIWER NISFINIYNS
460 470 480 490 500
SHMVPYDLPD VSRALIDLIT GKYDEKDVDG KKSFVTYPLG SRKESDASAD
510 520 530 540 550
GEENAGSDKV PGDSPSQTID PMISSSTASS SSVESSLSSS TASADSDSTS
560 570 580 590 600
SKFTRLIQLA VILVIFWGVY VLYASYKSRP SSIIKKPTNN TSNVTRSSAG
610 620 630 640 650
KKKNVQWADQ LNQFEDDERT QEPNQGIIAK AIGKITGSKD TRGRYAPVQR
660 670 680 690 700
GNGNEYIDDI ELGEGLSDPN VDEFIIGSDD DEEQGQAHSG AATHNQKQKP

MN
Length:702
Mass (Da):78,712
Last modified:April 26, 2005 - v1
Checksum:iC17ACDB9E7F89718
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44622.1.
AACQ01000024 Genomic DNA. Translation: EAL01467.1.
RefSeqiXP_720314.1. XM_715221.1.
XP_888725.1. XM_883632.1.

Genome annotation databases

GeneIDi3637955.
3703895.
KEGGical:CaO19.7020.
cal:CaO19_7020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44622.1 .
AACQ01000024 Genomic DNA. Translation: EAL01467.1 .
RefSeqi XP_720314.1. XM_715221.1.
XP_888725.1. XM_883632.1.

3D structure databases

ProteinModelPortali Q5AFP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001969.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3637955.
3703895.
KEGGi cal:CaO19.7020.
cal:CaO19_7020.

Organism-specific databases

CGDi CAL0001969. orf19.7020.

Phylogenomic databases

eggNOGi COG2939.
InParanoidi Q5AFP8.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
    Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
    Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiKEX1_CANAL
AccessioniPrimary (citable) accession number: Q5AFP8
Secondary accession number(s): Q3MPN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3