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Q5AFP8 (KEX1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:CaJ7.0112, CaO19.7020
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length702 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 702683Pheromone-processing carboxypeptidase KEX1
PRO_0000411907

Regions

Topological domain20 – 555536Lumenal Potential
Transmembrane556 – 57621Helical; Potential
Topological domain577 – 702126Cytoplasmic Potential
Compositional bias524 – 55128Ser-rich

Sites

Active site1841 By similarity
Active site3941 By similarity
Active site4521 By similarity

Amino acid modifications

Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5AFP8 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: C17ACDB9E7F89718

FASTA70278,712
        10         20         30         40         50         60 
MKLILSTLIV FIHTLLVSAL PTKEGSDPNS AKKYLVSDLP GLHENITPDN SIPLMFAGQL 

        70         80         90        100        110        120 
EIYPETDTHY FFWKFSDSNP ETVTNRTIFW LNGGPGCSSM DGALLETGPF RINSQQQVIS 

       130        140        150        160        170        180 
NNGSWHKMGD IIYVDQPAGT GFSYSDTYIT DLDQVAEYFL KFMEKYYELF PEEIGYEIYF 

       190        200        210        220        230        240 
AGESYAGQYI PYIADAILQR NKKLVDGEHK YDLRGVLIGN GWVSPNEQSL SYLPFFKDHG 

       250        260        270        280        290        300 
LIDVHHPKWA TLLAKHEQCQ KIVNKIDSTF DDGVVHYYEV SSSTCEAILT DLLEYTQDTA 

       310        320        330        340        350        360 
SEKDQRCVNM YDYTLRDSYP SCGMNWPYEL VNVGPFLRQE KVMHQLNLIN LKKWNECNGR 

       370        380        390        400        410        420 
VGRTFQARHS IPAVHLLPEL AKEIPVMLFN GANDIICNSQ GVLSYLQKLQ WNGETGFTNK 

       430        440        450        460        470        480 
DNQISWIYDN KEVGYIIWER NISFINIYNS SHMVPYDLPD VSRALIDLIT GKYDEKDVDG 

       490        500        510        520        530        540 
KKSFVTYPLG SRKESDASAD GEENAGSDKV PGDSPSQTID PMISSSTASS SSVESSLSSS 

       550        560        570        580        590        600 
TASADSDSTS SKFTRLIQLA VILVIFWGVY VLYASYKSRP SSIIKKPTNN TSNVTRSSAG 

       610        620        630        640        650        660 
KKKNVQWADQ LNQFEDDERT QEPNQGIIAK AIGKITGSKD TRGRYAPVQR GNGNEYIDDI 

       670        680        690        700 
ELGEGLSDPN VDEFIIGSDD DEEQGQAHSG AATHNQKQKP MN 

« Hide

References

[1]"Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006852 Genomic DNA. Translation: BAE44622.1.
AACQ01000024 Genomic DNA. Translation: EAL01467.1.
RefSeqXP_720314.1. XM_715221.1.
XP_888725.1. XM_883632.1.

3D structure databases

ProteinModelPortalQ5AFP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001969.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3637955.
3703895.
KEGGcal:CaO19.7020.
cal:CaO19_7020.

Organism-specific databases

CGDCAL0001969. orf19.7020.

Phylogenomic databases

eggNOGCOG2939.
KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_CANAL
AccessionPrimary (citable) accession number: Q5AFP8
Secondary accession number(s): Q3MPN8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Candida albicans

Candida albicans: entries and gene names