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Q5AFP8

- KEX1_CANAL

UniProt

Q5AFP8 - KEX1_CANAL

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene
KEX1, CaJ7.0112, CaO19.7020
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei184 – 1841 By similarity
Active sitei394 – 3941 By similarity
Active sitei452 – 4521 By similarity

GO - Molecular functioni

  1. carboxypeptidase activity Source: CGD
  2. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CaJ7.0112, CaO19.7020
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001969. orf19.7020.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 555536Lumenal Reviewed predictionAdd
BLAST
Transmembranei556 – 57621Helical; Reviewed predictionAdd
BLAST
Topological domaini577 – 702126Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. fungal-type vacuole Source: CGD
  2. Golgi apparatus Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 702683Pheromone-processing carboxypeptidase KEX1PRO_0000411907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi449 – 4491N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001969.

Structurei

3D structure databases

ProteinModelPortaliQ5AFP8.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi524 – 55128Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AFP8-1 [UniParc]FASTAAdd to Basket

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MKLILSTLIV FIHTLLVSAL PTKEGSDPNS AKKYLVSDLP GLHENITPDN    50
SIPLMFAGQL EIYPETDTHY FFWKFSDSNP ETVTNRTIFW LNGGPGCSSM 100
DGALLETGPF RINSQQQVIS NNGSWHKMGD IIYVDQPAGT GFSYSDTYIT 150
DLDQVAEYFL KFMEKYYELF PEEIGYEIYF AGESYAGQYI PYIADAILQR 200
NKKLVDGEHK YDLRGVLIGN GWVSPNEQSL SYLPFFKDHG LIDVHHPKWA 250
TLLAKHEQCQ KIVNKIDSTF DDGVVHYYEV SSSTCEAILT DLLEYTQDTA 300
SEKDQRCVNM YDYTLRDSYP SCGMNWPYEL VNVGPFLRQE KVMHQLNLIN 350
LKKWNECNGR VGRTFQARHS IPAVHLLPEL AKEIPVMLFN GANDIICNSQ 400
GVLSYLQKLQ WNGETGFTNK DNQISWIYDN KEVGYIIWER NISFINIYNS 450
SHMVPYDLPD VSRALIDLIT GKYDEKDVDG KKSFVTYPLG SRKESDASAD 500
GEENAGSDKV PGDSPSQTID PMISSSTASS SSVESSLSSS TASADSDSTS 550
SKFTRLIQLA VILVIFWGVY VLYASYKSRP SSIIKKPTNN TSNVTRSSAG 600
KKKNVQWADQ LNQFEDDERT QEPNQGIIAK AIGKITGSKD TRGRYAPVQR 650
GNGNEYIDDI ELGEGLSDPN VDEFIIGSDD DEEQGQAHSG AATHNQKQKP 700
MN 702
Length:702
Mass (Da):78,712
Last modified:April 26, 2005 - v1
Checksum:iC17ACDB9E7F89718
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44622.1.
AACQ01000024 Genomic DNA. Translation: EAL01467.1.
RefSeqiXP_720314.1. XM_715221.1.
XP_888725.1. XM_883632.1.

Genome annotation databases

GeneIDi3637955.
3703895.
KEGGical:CaO19.7020.
cal:CaO19_7020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006852 Genomic DNA. Translation: BAE44622.1 .
AACQ01000024 Genomic DNA. Translation: EAL01467.1 .
RefSeqi XP_720314.1. XM_715221.1.
XP_888725.1. XM_883632.1.

3D structure databases

ProteinModelPortali Q5AFP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001969.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3637955.
3703895.
KEGGi cal:CaO19.7020.
cal:CaO19_7020.

Organism-specific databases

CGDi CAL0001969. orf19.7020.

Phylogenomic databases

eggNOGi COG2939.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
    Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
    Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiKEX1_CANAL
AccessioniPrimary (citable) accession number: Q5AFP8
Secondary accession number(s): Q3MPN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi