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Q5AFP8

- KEX1_CANAL

UniProt

Q5AFP8 - KEX1_CANAL

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei184 – 1841PROSITE-ProRule annotation
    Active sitei394 – 3941PROSITE-ProRule annotation
    Active sitei452 – 4521PROSITE-ProRule annotation

    GO - Molecular functioni

    1. carboxypeptidase activity Source: CGD
    2. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:CaJ7.0112, CaO19.7020
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001969. orf19.7020.

    Subcellular locationi

    GO - Cellular componenti

    1. fungal-type vacuole Source: CGD
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 702683Pheromone-processing carboxypeptidase KEX1PRO_0000411907Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0001969.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AFP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 555536LumenalSequence AnalysisAdd
    BLAST
    Topological domaini577 – 702126CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei556 – 57621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi524 – 55128Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5AFP8-1 [UniParc]FASTAAdd to Basket

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    MKLILSTLIV FIHTLLVSAL PTKEGSDPNS AKKYLVSDLP GLHENITPDN    50
    SIPLMFAGQL EIYPETDTHY FFWKFSDSNP ETVTNRTIFW LNGGPGCSSM 100
    DGALLETGPF RINSQQQVIS NNGSWHKMGD IIYVDQPAGT GFSYSDTYIT 150
    DLDQVAEYFL KFMEKYYELF PEEIGYEIYF AGESYAGQYI PYIADAILQR 200
    NKKLVDGEHK YDLRGVLIGN GWVSPNEQSL SYLPFFKDHG LIDVHHPKWA 250
    TLLAKHEQCQ KIVNKIDSTF DDGVVHYYEV SSSTCEAILT DLLEYTQDTA 300
    SEKDQRCVNM YDYTLRDSYP SCGMNWPYEL VNVGPFLRQE KVMHQLNLIN 350
    LKKWNECNGR VGRTFQARHS IPAVHLLPEL AKEIPVMLFN GANDIICNSQ 400
    GVLSYLQKLQ WNGETGFTNK DNQISWIYDN KEVGYIIWER NISFINIYNS 450
    SHMVPYDLPD VSRALIDLIT GKYDEKDVDG KKSFVTYPLG SRKESDASAD 500
    GEENAGSDKV PGDSPSQTID PMISSSTASS SSVESSLSSS TASADSDSTS 550
    SKFTRLIQLA VILVIFWGVY VLYASYKSRP SSIIKKPTNN TSNVTRSSAG 600
    KKKNVQWADQ LNQFEDDERT QEPNQGIIAK AIGKITGSKD TRGRYAPVQR 650
    GNGNEYIDDI ELGEGLSDPN VDEFIIGSDD DEEQGQAHSG AATHNQKQKP 700
    MN 702
    Length:702
    Mass (Da):78,712
    Last modified:April 26, 2005 - v1
    Checksum:iC17ACDB9E7F89718
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006852 Genomic DNA. Translation: BAE44622.1.
    AACQ01000024 Genomic DNA. Translation: EAL01467.1.
    RefSeqiXP_720314.1. XM_715221.1.
    XP_888725.1. XM_883632.1.

    Genome annotation databases

    GeneIDi3637955.
    3703895.
    KEGGical:CaO19.7020.
    cal:CaO19_7020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006852 Genomic DNA. Translation: BAE44622.1 .
    AACQ01000024 Genomic DNA. Translation: EAL01467.1 .
    RefSeqi XP_720314.1. XM_715221.1.
    XP_888725.1. XM_883632.1.

    3D structure databases

    ProteinModelPortali Q5AFP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001969.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3637955.
    3703895.
    KEGGi cal:CaO19.7020.
    cal:CaO19_7020.

    Organism-specific databases

    CGDi CAL0001969. orf19.7020.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
      Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
      Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiKEX1_CANAL
    AccessioniPrimary (citable) accession number: Q5AFP8
    Secondary accession number(s): Q3MPN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3