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Q5AFK5

- Q5AFK5_CANAL

UniProt

Q5AFK5 - Q5AFK5_CANAL

Protein
Submitted name:

Likely histidyl tRNA-specific guanylyltransferase

Gene

THG1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101ATPImported
    Binding sitei10 – 101GTPImported
    Metal bindingi29 – 291MagnesiumImported
    Metal bindingi30 – 301MagnesiumImported
    Binding sitei43 – 431GTP; via carbonyl oxygenImported
    Binding sitei47 – 471GTP; via amide nitrogenImported
    Metal bindingi76 – 761MagnesiumImported
    Binding sitei76 – 761ATPImported
    Binding sitei76 – 761GTPImported
    Binding sitei132 – 1321ATPImported
    Binding sitei132 – 1321GTPImported
    Binding sitei152 – 1521ATPImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 348ATPImported
    Nucleotide bindingi27 – 348GTPImported
    Nucleotide bindingi44 – 474ATPImported
    Nucleotide bindingi92 – 954ATPImported
    Nucleotide bindingi92 – 954GTPImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. GTP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: InterPro
    4. tRNA guanylyltransferase activity Source: InterPro

    GO - Biological processi

    1. tRNA modification Source: InterPro

    Keywords - Ligandi

    ATP-bindingImported, GTP-bindingImported, MagnesiumImported, Metal-bindingImported, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Likely histidyl tRNA-specific guanylyltransferaseImported
    Gene namesi
    Name:THG1Imported
    ORF Names:CaO19.7063Imported, orf19.7063Imported
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002111. orf19.7063.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0002111.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3WBZX-ray2.39A/B/C/D/E/F/G/H1-268[»]
    3WC0X-ray3.03A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-268[»]
    3WC1X-ray4.18A/B/C/D1-262[»]
    3WC2X-ray3.64A/B/C/D1-268[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG4021.
    KOiK10761.
    OrthoDBiEOG7QVMD6.

    Family and domain databases

    InterProiIPR025845. Thg1_C_dom.
    IPR024956. tRNAHis_GuaTrfase_cat.
    IPR007537. tRNAHis_GuaTrfase_Thg1.
    [Graphical view]
    PANTHERiPTHR12729. PTHR12729. 1 hit.
    PfamiPF04446. Thg1. 1 hit.
    PF14413. Thg1C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028980. tRNAHis_guanylyltransferase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5AFK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANSKYEYVK LFEKENYLLP DTYIIIRVDG KGFHKFSQFY EFEKPNDLKA    50
    LQVMNSAAEK LMSKYSDVML AYGDSDEYSF LLRKNCQLYE RREMKLTTLF 100
    SSLMSTYYMY FWSQYFPDKP LHIDHLPNFD ARAVLYPDFK HIRNYFSWRQ 150
    VDCHINNLYN TTFWNLVLKL KMTPQQAEQR LMGTVASDKN EILFKECGVN 200
    YNNESEMYKK GTIIVREFEN YETEDEAELS KRQVQRLEKK RKKAELKIYH 250
    VDIINDDSWW KSRPWLKD 268
    Length:268
    Mass (Da):32,442
    Last modified:April 26, 2005 - v1
    Checksum:i0BC7B911C05C49EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000024 Genomic DNA. Translation: EAL01510.1.
    RefSeqiXP_720355.1. XM_715262.1.
    XP_888688.1. XM_883595.1.

    Genome annotation databases

    GeneIDi3637997.
    3704204.
    KEGGical:CaO19.7063.
    cal:CaO19_7063.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000024 Genomic DNA. Translation: EAL01510.1 .
    RefSeqi XP_720355.1. XM_715262.1.
    XP_888688.1. XM_883595.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3WBZ X-ray 2.39 A/B/C/D/E/F/G/H 1-268 [» ]
    3WC0 X-ray 3.03 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-268 [» ]
    3WC1 X-ray 4.18 A/B/C/D 1-262 [» ]
    3WC2 X-ray 3.64 A/B/C/D 1-268 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3637997.
    3704204.
    KEGGi cal:CaO19.7063.
    cal:CaO19_7063.

    Organism-specific databases

    CGDi CAL0002111. orf19.7063.

    Phylogenomic databases

    eggNOGi COG4021.
    KOi K10761.
    OrthoDBi EOG7QVMD6.

    Family and domain databases

    InterProi IPR025845. Thg1_C_dom.
    IPR024956. tRNAHis_GuaTrfase_cat.
    IPR007537. tRNAHis_GuaTrfase_Thg1.
    [Graphical view ]
    PANTHERi PTHR12729. PTHR12729. 1 hit.
    Pfami PF04446. Thg1. 1 hit.
    PF14413. Thg1C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028980. tRNAHis_guanylyltransferase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876Imported.
    2. "Structural basis of reverse nucleotide polymerization."
      Nakamura A., Nemoto T., Heinemann I.U., Yamashita K., Sonoda T., Komoda K., Tanaka I., Soll D., Yao M.
      Proc. Natl. Acad. Sci. U.S.A. 110:20970-20975(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) IN COMPLEX WITH ATP; GTP AND MAGNESIUM.

    Entry informationi

    Entry nameiQ5AFK5_CANAL
    AccessioniPrimary (citable) accession number: Q5AFK5
    Secondary accession number(s): Q3MPS5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3