Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5AFK5

- Q5AFK5_CANAL

UniProt

Q5AFK5 - Q5AFK5_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Likely histidyl tRNA-specific guanylyltransferase

Gene

THG1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101ATPImported
Binding sitei10 – 101GTPImported
Metal bindingi29 – 291MagnesiumImported
Metal bindingi30 – 301MagnesiumImported
Binding sitei43 – 431GTP; via carbonyl oxygenImported
Binding sitei47 – 471GTP; via amide nitrogenImported
Metal bindingi76 – 761MagnesiumImported
Binding sitei76 – 761ATPImported
Binding sitei76 – 761GTPImported
Binding sitei132 – 1321ATPImported
Binding sitei132 – 1321GTPImported
Binding sitei152 – 1521ATPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 348ATPImported
Nucleotide bindingi27 – 348GTPImported
Nucleotide bindingi44 – 474ATPImported
Nucleotide bindingi92 – 954ATPImported
Nucleotide bindingi92 – 954GTPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. magnesium ion binding Source: InterPro
  4. tRNA guanylyltransferase activity Source: InterPro

GO - Biological processi

  1. tRNA modification Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseImported, Transferase

Keywords - Ligandi

ATP-bindingImported, GTP-bindingImported, MagnesiumImported, Metal-bindingImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Likely histidyl tRNA-specific guanylyltransferaseImported
Gene namesi
Name:THG1Imported
ORF Names:CaO19.7063Imported, orf19.7063Imported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002111. orf19.7063.

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002111.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WBZX-ray2.39A/B/C/D/E/F/G/H1-268[»]
3WC0X-ray3.03A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-268[»]
3WC1X-ray4.18A/B/C/D1-262[»]
3WC2X-ray3.64A/B/C/D1-268[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4021.
InParanoidiQ5AFK5.
KOiK10761.
OrthoDBiEOG7QVMD6.

Family and domain databases

InterProiIPR025845. Thg1_C_dom.
IPR024956. tRNAHis_GuaTrfase_cat.
IPR007537. tRNAHis_GuaTrfase_Thg1.
[Graphical view]
PANTHERiPTHR12729. PTHR12729. 1 hit.
PfamiPF04446. Thg1. 1 hit.
PF14413. Thg1C. 1 hit.
[Graphical view]
PIRSFiPIRSF028980. tRNAHis_guanylyltransferase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AFK5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANSKYEYVK LFEKENYLLP DTYIIIRVDG KGFHKFSQFY EFEKPNDLKA
60 70 80 90 100
LQVMNSAAEK LMSKYSDVML AYGDSDEYSF LLRKNCQLYE RREMKLTTLF
110 120 130 140 150
SSLMSTYYMY FWSQYFPDKP LHIDHLPNFD ARAVLYPDFK HIRNYFSWRQ
160 170 180 190 200
VDCHINNLYN TTFWNLVLKL KMTPQQAEQR LMGTVASDKN EILFKECGVN
210 220 230 240 250
YNNESEMYKK GTIIVREFEN YETEDEAELS KRQVQRLEKK RKKAELKIYH
260
VDIINDDSWW KSRPWLKD
Length:268
Mass (Da):32,442
Last modified:April 26, 2005 - v1
Checksum:i0BC7B911C05C49EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000024 Genomic DNA. Translation: EAL01510.1.
RefSeqiXP_720355.1. XM_715262.1.
XP_888688.1. XM_883595.1.

Genome annotation databases

GeneIDi3637997.
3704204.
KEGGical:CaO19.7063.
cal:CaO19_7063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000024 Genomic DNA. Translation: EAL01510.1 .
RefSeqi XP_720355.1. XM_715262.1.
XP_888688.1. XM_883595.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3WBZ X-ray 2.39 A/B/C/D/E/F/G/H 1-268 [» ]
3WC0 X-ray 3.03 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-268 [» ]
3WC1 X-ray 4.18 A/B/C/D 1-262 [» ]
3WC2 X-ray 3.64 A/B/C/D 1-268 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3637997.
3704204.
KEGGi cal:CaO19.7063.
cal:CaO19_7063.

Organism-specific databases

CGDi CAL0002111. orf19.7063.

Phylogenomic databases

eggNOGi COG4021.
InParanoidi Q5AFK5.
KOi K10761.
OrthoDBi EOG7QVMD6.

Family and domain databases

InterProi IPR025845. Thg1_C_dom.
IPR024956. tRNAHis_GuaTrfase_cat.
IPR007537. tRNAHis_GuaTrfase_Thg1.
[Graphical view ]
PANTHERi PTHR12729. PTHR12729. 1 hit.
Pfami PF04446. Thg1. 1 hit.
PF14413. Thg1C. 1 hit.
[Graphical view ]
PIRSFi PIRSF028980. tRNAHis_guanylyltransferase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876Imported.
  2. "Structural basis of reverse nucleotide polymerization."
    Nakamura A., Nemoto T., Heinemann I.U., Yamashita K., Sonoda T., Komoda K., Tanaka I., Soll D., Yao M.
    Proc. Natl. Acad. Sci. U.S.A. 110:20970-20975(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) IN COMPLEX WITH ATP; GTP AND MAGNESIUM.

Entry informationi

Entry nameiQ5AFK5_CANAL
AccessioniPrimary (citable) accession number: Q5AFK5
Secondary accession number(s): Q3MPS5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3