Q5AEN1 (CCPR_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c peroxidase, mitochondrial
Short name=CCP
EC=1.11.1.5

Gene names

Name:	CCP1
ORF Names:	CaO19.238, CaO19.7868

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Subunit structure	Forms a one-to-one complex with cytochrome c By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytochrome-c peroxidase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 366		Cytochrome c peroxidase, mitochondrial		PRO_0000045287
Sites
	Active site	123	1	Proton acceptor By similarity
	Active site	263	1	Tryptophan radical intermediate By similarity
	Metal binding	247	1	Iron (heme axial ligand)
	Site	119	1	Transition state stabilizer By similarity
Natural variations
	Natural variant	58	1	E → G in allele CaO19.7868.

Sequences

	Sequence		Length	Mass (Da)
	Q5AEN1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 826D6ED25355E801	FASTA	366	40,754
	10 20 30 40 50 60 MATFAPHISK ITKSSTKFNY GRIAKTFLGV AGSAAIATYF YNNGNPFNNN NNNNNNNEGS 70 80 90 100 110 120 KNAAKALFGA SAGANVKIAK VPEGKSASDY QKVYNDIATK ISENLEFDEN AGYYGQLLRL 130 140 150 160 170 180 AWHTSGTYDK SDNSGGSYGG TMIFAPEEFD PENAGLQVGR EFLMEFLVKY PWISRGDLWT 190 200 210 220 230 240 LGGVAAVQES GGPKIEWRPG RVDDNTASKV PPNGRLPDAS KDGKYVKDLF ARMGFNERET 250 260 270 280 290 300 VALLGAHVLG RCHKHNSGYD GPWGPSFNQF TNVFYTTLLG DWHVKKWDGK KQYEDDETGE 310 320 330 340 350 360 FMMLPTDMAL KEESYFLKYV KMYADDQDLF FKDFAKAFSK LISNGIKYPA DSKPILFKTL DEQDEE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000027 Genomic DNA. Translation: EAL01077.1. AACQ01000026 Genomic DNA. Translation: EAL01211.1.
RefSeq	XP_719937.1. XM_714844.1. XP_720067.1. XM_714974.1.
3D structure databases
ProteinModelPortal	Q5AEN1.
SMR	Q5AEN1. Positions 76-364.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5AEN1.
Protein family/group databases
PeroxiBase	3406. CalCcP02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3638289. 3638350.
KEGG	cal:CaO19.238. cal:CaO19.7868.
Organism-specific databases
CGD	CAL0003960. CCP1.
Phylogenomic databases
PhylomeDB	Q5AEN1.
Family and domain databases
InterPro	IPR002207. Asc_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. [Graphical view]
KO	K00428.
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. False negative. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR_CANAL

Accession

Primary (citable) accession number: Q5AEN1
Secondary accession number(s): Q5AF18

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program