Q5AEI2 (ATG10_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like-conjugating enzyme ATG10
EC=6.3.2.-

Alternative name(s):
Autophagy-related protein 10

Gene names

Name:	ATG10
ORF Names:	CaO19.286, CaO19.7918

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	E2-like enzyme involved in autophagy and for the cytoplasm to vacuole transport (Cvt). Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATG10 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport Ubl conjugation pathway
Cellular component	Cytoplasm
Molecular function	Ligase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ligase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Ubiquitin-like-conjugating enzyme ATG10		PRO_0000096186
Sites
	Active site	135	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5AEI2 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 12EE99E1A5A5A072	FASTA	177	20,668
	10 20 30 40 50 60 MITNQQFNDN IEEFISIMLA NLKLKGTDFE FSVNNNYVNK WNIDKMYSFV SVSVKQLRID 70 80 90 100 110 120 FTISFDDLYG VPLLNMRLYD NDTFLTSPMA QRTLAVGICR VDLHNHHLLQ QPWLQVHPCE 130 140 150 160 170 TLQTIDSHLK NTPTCKYNSV IQYLCCWFGL YGLPSIFPQF SVRPNIYINN VQSCKIK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000027 Genomic DNA. Translation: EAL01125.1. AACQ01000026 Genomic DNA. Translation: EAL01261.1.
RefSeq	XP_719983.1. XM_714890.1. XP_720115.1. XM_715022.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3638243. 3638380.
KEGG	cal:CaO19.286. cal:CaO19.7918.
Organism-specific databases
CGD	CAL0004090. orf19.286.
Phylogenomic databases
PhylomeDB	Q5AEI2.
Family and domain databases
InterPro	IPR007135. Autophagy-rel_prot_3. [Graphical view]
Pfam	PF03987. Autophagy_act_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG10_CANAL

Accession

Primary (citable) accession number: Q5AEI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program