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Q5ADP6 (SUS1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription and mRNA export factor SUS1
Gene names
Name:SUS1
ORF Names:CaO19.14087, CaO19.6795
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies By similarity. HAMAP-Rule MF_03046

Subunit structure

Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II By similarity.

Subcellular location

Nucleusnucleoplasm By similarity. Nucleusnuclear pore complex By similarity. CytoplasmP-body By similarity HAMAP-Rule MF_03046.

Sequence similarities

Belongs to the ENY2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 119119Transcription and mRNA export factor SUS1 HAMAP-Rule MF_03046
PRO_0000367565

Sequences

Sequence LengthMass (Da)Tools
Q5ADP6 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 35EEB1600FE8A8EA

FASTA11913,770
        10         20         30         40         50         60 
MSTNNSTQQQ DELDQIKSKI QDNLISSGNY DIINKQLKLQ LYESGWYDKV SQIASRELMD 

        70         80         90        100        110 
HQQEVNSSNS NSSNSNKKNE LTFDQLFAFV KPKAEELVPN EVKQDILNRI TKYLDDIIQ 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000029 Genomic DNA. Translation: EAL00902.1.
AACQ01000028 Genomic DNA. Translation: EAL01027.1.
RefSeqXP_719774.1. XM_714681.1.
XP_719891.1. XM_714798.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3638515.
3638656.
KEGGcal:CaO19.14087.
cal:CaO19.6795.

Organism-specific databases

CGDCAL0005006. orf19.6795.

Phylogenomic databases

eggNOGNOG73507.
KOK11368.
OrthoDBEOG7RNKCD.

Family and domain databases

HAMAPMF_03046. ENY2_Sus1.
InterProIPR018783. TF_enhancer_of_yellow_2.
[Graphical view]
PfamPF10163. EnY2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUS1_CANAL
AccessionPrimary (citable) accession number: Q5ADP6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names