Q5ADP6 (SUS1_CANAL) Reviewed, UniProtKB/Swiss-Prot
Last modified March 19, 2014. Version 47. History...
Names and origin
|Protein names||Recommended name:|
Transcription and mRNA export factor SUS1
|Organism||Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]|
|Taxonomic identifier||237561 [NCBI]|
|Taxonomic lineage||Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida ›|
|Sequence length||119 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies By similarity. HAMAP-Rule MF_03046
Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II By similarity.
Belongs to the ENY2 family.
Sequence annotation (Features)
|||"The diploid genome sequence of Candida albicans."|
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
|AACQ01000029 Genomic DNA. Translation: EAL00902.1.|
AACQ01000028 Genomic DNA. Translation: EAL01027.1.
|RefSeq||XP_719774.1. XM_714681.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
|CGD||CAL0005006. orf19.6795. |
Family and domain databases
|HAMAP||MF_03046. ENY2_Sus1. |
|InterPro||IPR018783. TF_enhancer_of_yellow_2. |
|Pfam||PF10163. EnY2. 1 hit. |
|Accession||Primary (citable) accession number: Q5ADP6|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Fungal Protein Annotation Program|