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Q5ADP6

- SUS1_CANAL

UniProt

Q5ADP6 - SUS1_CANAL

Protein

Transcription and mRNA export factor SUS1

Gene

SUS1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies By similarity.By similarity

    GO - Molecular functioni

    1. transcription coactivator activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histone deubiquitination Source: UniProtKB-HAMAP
    2. mRNA export from nucleus Source: UniProtKB-HAMAP
    3. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-KW
    5. transcription elongation from RNA polymerase II promoter Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Activator, Chromatin regulator

    Keywords - Biological processi

    mRNA transport, Protein transport, Transcription, Transcription regulation, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription and mRNA export factor SUS1UniRule annotation
    Gene namesi
    Name:SUS1UniRule annotation
    ORF Names:CaO19.14087, CaO19.6795
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005006. orf19.6795.

    Subcellular locationi

    Nucleusnucleoplasm UniRule annotation. Nucleusnuclear pore complex UniRule annotation. CytoplasmP-body UniRule annotation

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB-SubCell
    2. DUBm complex Source: UniProtKB-HAMAP
    3. nuclear pore Source: UniProtKB-SubCell
    4. SAGA complex Source: UniProtKB-HAMAP
    5. transcription export complex 2 Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119Transcription and mRNA export factor SUS1PRO_0000367565Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ENY2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG73507.
    KOiK11368.
    OrthoDBiEOG7RNKCD.

    Family and domain databases

    HAMAPiMF_03046. ENY2_Sus1.
    InterProiIPR018783. TF_enhancer_of_yellow_2.
    [Graphical view]
    PfamiPF10163. EnY2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ADP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTNNSTQQQ DELDQIKSKI QDNLISSGNY DIINKQLKLQ LYESGWYDKV    50
    SQIASRELMD HQQEVNSSNS NSSNSNKKNE LTFDQLFAFV KPKAEELVPN 100
    EVKQDILNRI TKYLDDIIQ 119
    Length:119
    Mass (Da):13,770
    Last modified:April 26, 2005 - v1
    Checksum:i35EEB1600FE8A8EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000029 Genomic DNA. Translation: EAL00902.1.
    AACQ01000028 Genomic DNA. Translation: EAL01027.1.
    RefSeqiXP_719774.1. XM_714681.1.
    XP_719891.1. XM_714798.1.

    Genome annotation databases

    GeneIDi3638515.
    3638656.
    KEGGical:CaO19.14087.
    cal:CaO19.6795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000029 Genomic DNA. Translation: EAL00902.1 .
    AACQ01000028 Genomic DNA. Translation: EAL01027.1 .
    RefSeqi XP_719774.1. XM_714681.1.
    XP_719891.1. XM_714798.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3638515.
    3638656.
    KEGGi cal:CaO19.14087.
    cal:CaO19.6795.

    Organism-specific databases

    CGDi CAL0005006. orf19.6795.

    Phylogenomic databases

    eggNOGi NOG73507.
    KOi K11368.
    OrthoDBi EOG7RNKCD.

    Family and domain databases

    HAMAPi MF_03046. ENY2_Sus1.
    InterProi IPR018783. TF_enhancer_of_yellow_2.
    [Graphical view ]
    Pfami PF10163. EnY2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiSUS1_CANAL
    AccessioniPrimary (citable) accession number: Q5ADP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3