Q5ADP6 (SUS1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SUS1

Gene names

Name:	SUS1
ORF Names:	CaO19.14087, CaO19.6795

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B and is involved in the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Has also a role in mRNP biogenesis and maintenance of genome integrity through preventing RNA-mediated genome instability By similarity.
Subunit structure	Component of the transcription regulatory histone acetylation (HAT) complex SAGA and of the mRNA export TREX-2 complex By similarity.
Subcellular location	Nucleus › nucleoplasm By similarity. Nucleus › nuclear pore complex By similarity.
Sequence similarities	Belongs to the ENY2 family.

Ontologies

Keywords
Biological process	Protein transport Transcription Transcription regulation Translocation Transport mRNA transport
Cellular component	Nuclear pore complex Nucleus
Molecular function	Activator Chromatin regulator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Protein SUS1		PRO_0000367565

Sequences

	Sequence		Length	Mass (Da)
	Q5ADP6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 35EEB1600FE8A8EA	FASTA	119	13,770
	10 20 30 40 50 60 MSTNNSTQQQ DELDQIKSKI QDNLISSGNY DIINKQLKLQ LYESGWYDKV SQIASRELMD 70 80 90 100 110 HQQEVNSSNS NSSNSNKKNE LTFDQLFAFV KPKAEELVPN EVKQDILNRI TKYLDDIIQ

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000029 Genomic DNA. Translation: EAL00902.1. AACQ01000028 Genomic DNA. Translation: EAL01027.1.
RefSeq	XP_719774.1. XM_714681.1. XP_719891.1. XM_714798.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3638515. 3638656.
KEGG	cal:CaO19.14087. cal:CaO19.6795.
Organism-specific databases
CGD	CAL0005006. orf19.6795.
Phylogenomic databases
eggNOG	NOG73507.
KO	K11368.
Family and domain databases
InterPro	IPR018783. TF_enhancer_of_yellow_2. [Graphical view]
Pfam	PF10163. EnY2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUS1_CANAL

Accession

Primary (citable) accession number: Q5ADP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program