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Q5ADP6

- SUS1_CANAL

UniProt

Q5ADP6 - SUS1_CANAL

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Protein
Transcription and mRNA export factor SUS1
Gene
SUS1, CaO19.14087, CaO19.6795
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies By similarity.UniRule annotation

GO - Molecular functioni

  1. transcription coactivator activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histone deubiquitination Source: UniProtKB-HAMAP
  2. mRNA export from nucleus Source: UniProtKB-HAMAP
  3. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  4. protein transport Source: UniProtKB-KW
  5. transcription elongation from RNA polymerase II promoter Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

mRNA transport, Protein transport, Transcription, Transcription regulation, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription and mRNA export factor SUS1
Gene namesi
Name:SUS1
ORF Names:CaO19.14087, CaO19.6795
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005006. orf19.6795.

Subcellular locationi

Nucleusnucleoplasm By similarity. Nucleusnuclear pore complex By similarity. CytoplasmP-body By similarity UniRule annotation

GO - Cellular componenti

  1. DUBm complex Source: UniProtKB-HAMAP
  2. SAGA complex Source: UniProtKB-HAMAP
  3. cytoplasmic mRNA processing body Source: UniProtKB-SubCell
  4. nuclear pore Source: UniProtKB-SubCell
  5. transcription export complex 2 Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Transcription and mRNA export factor SUS1UniRule annotation
PRO_0000367565Add
BLAST

Interactioni

Subunit structurei

Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the ENY2 family.

Phylogenomic databases

eggNOGiNOG73507.
KOiK11368.
OrthoDBiEOG7RNKCD.

Family and domain databases

HAMAPiMF_03046. ENY2_Sus1.
InterProiIPR018783. TF_enhancer_of_yellow_2.
[Graphical view]
PfamiPF10163. EnY2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ADP6-1 [UniParc]FASTAAdd to Basket

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MSTNNSTQQQ DELDQIKSKI QDNLISSGNY DIINKQLKLQ LYESGWYDKV    50
SQIASRELMD HQQEVNSSNS NSSNSNKKNE LTFDQLFAFV KPKAEELVPN 100
EVKQDILNRI TKYLDDIIQ 119
Length:119
Mass (Da):13,770
Last modified:April 26, 2005 - v1
Checksum:i35EEB1600FE8A8EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000029 Genomic DNA. Translation: EAL00902.1.
AACQ01000028 Genomic DNA. Translation: EAL01027.1.
RefSeqiXP_719774.1. XM_714681.1.
XP_719891.1. XM_714798.1.

Genome annotation databases

GeneIDi3638515.
3638656.
KEGGical:CaO19.14087.
cal:CaO19.6795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000029 Genomic DNA. Translation: EAL00902.1 .
AACQ01000028 Genomic DNA. Translation: EAL01027.1 .
RefSeqi XP_719774.1. XM_714681.1.
XP_719891.1. XM_714798.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3638515.
3638656.
KEGGi cal:CaO19.14087.
cal:CaO19.6795.

Organism-specific databases

CGDi CAL0005006. orf19.6795.

Phylogenomic databases

eggNOGi NOG73507.
KOi K11368.
OrthoDBi EOG7RNKCD.

Family and domain databases

HAMAPi MF_03046. ENY2_Sus1.
InterProi IPR018783. TF_enhancer_of_yellow_2.
[Graphical view ]
Pfami PF10163. EnY2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSUS1_CANAL
AccessioniPrimary (citable) accession number: Q5ADP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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