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Protein

Histone deacetylase

Gene

RPD31

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108SubstrateUniRule annotation1
Active sitei150Proton acceptorUniRule annotation1
Binding sitei158Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi185Divalent metal cationUniRule annotation1
Metal bindingi187Divalent metal cationUniRule annotation1
Metal bindingi273Divalent metal cationUniRule annotation1
Binding sitei312SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • phenotypic switching Source: CGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulatorSAAS annotation, HydrolaseSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseSAAS annotation (EC:3.5.1.98SAAS annotation)
Gene namesi
Name:RPD31Imported
Ordered Locus Names:orf19.6801Imported
ORF Names:CAALFM_C307000WAImported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000185568. RPD31.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSN6Q5ADP33EBI-10635759,EBI-10635830

Protein-protein interaction databases

IntActiQ5ADP0. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ5ADP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK06067.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 2 hits.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q5ADP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTELPFDEL KVDPNQKKRI AYFYDADIGN YAYGAGHPMK PHRIRMAHSL
60 70 80 90 100
IMNYGLYKKM EIYRAKPATK QEMCQFHTDE YIDFISRVNP DNLDLFTKEQ
110 120 130 140 150
IKFNVGDDCP VFDGLFEYCG ISGGGSMEGA ARLNRGKCDI AINYAGGLHH
160 170 180 190 200
AKKSEASGFC YLNDIVLGII ELLRYHPRVL YIDIDVHHGD GVEEAFYTTD
210 220 230 240 250
RVMTCSFHKY GEFFPGTGEL RDIGVGKGKY HSVNVPLRDG IDDATYKSVF
260 270 280 290 300
EPVISKIIEW YQPSAIVLQC GGDSLSGDRL GCFNLSMNGH ANCINYVKSF
310 320 330 340 350
NIPMMVVGGG GYTMRNVART WAYESGLLNN VKLPDELPYN EYYEYYGPDY
360 370 380 390 400
KLDVRSSNMF NQNSPEFLDK ILTNIIANLE NTKHAPSVQM NEVPNDPEDL
410 420 430 440 450
GDVEEDTAMA IDTKGGSEMS RDAQIQPDNE FYEDDEKDKG EKAIIDNKHE
460 470 480 490 500
DQDSMQVDKS EEPVVEQKDK PQDENNVTGD NIEEDQPQEV NPIEEQPSVE
510 520 530 540 550
KSVVVVEDKL EEVKPVEQKV EEPKEVVDKP EDKHEDKPAE TLTETTTESK
560 570
PEDQPMEDAA KLTEEELKEI EELNKSS
Length:577
Mass (Da):65,369
Last modified:April 26, 2005 - v1
Checksum:iD4CEA42B8E9C02BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017625 Genomic DNA. Translation: AOW28703.1.
RefSeqiXP_719896.1. XM_714803.1.

Genome annotation databases

EnsemblFungiiKHC79238; KHC79238; W5Q_03210.
KHC87001; KHC87001; I503_03210.
GeneIDi3638520.
KEGGical:CAALFM_C307000WA.

Similar proteinsi

Entry informationi

Entry nameiQ5ADP0_CANAL
AccessioniPrimary (citable) accession number: Q5ADP0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: August 30, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported