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Q5AD67 (CHL1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent RNA helicase CHL1

EC=3.6.4.13
Alternative name(s):
Chromosome loss protein 1
Gene names
Name:CHL1
ORF Names:CaO19.2000, CaO19.9551
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.

Contains 1 helicase ATP-binding domain.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentNucleus
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA duplex unwinding

Inferred from direct assay PubMed 21639847. Source: GOC

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent DNA helicase activity

Inferred from electronic annotation. Source: InterPro

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA helicase activity

Inferred from direct assay PubMed 21639847. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842ATP-dependent RNA helicase CHL1
PRO_0000351006

Regions

Domain6 – 417412Helicase ATP-binding
Nucleotide binding42 – 498ATP By similarity
Motif359 – 3624DEAH box
Compositional bias492 – 4998Poly-Ser
Compositional bias821 – 8266Poly-Asn

Sequences

Sequence LengthMass (Da)Tools
Q5AD67 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: A241696BAC817F99

FASTA84297,275
        10         20         30         40         50         60 
MVSESCSRNY NHPYTPYDIQ IQLMDAIYNT IENGYKIGLF ESPTGTGKTL SIICSSMTWL 

        70         80         90        100        110        120 
RTFKRNNTFL ETNNEVEDVY ESESEEDEPE WVKKAYQSSI VNRSKNKLIE YEHYLDKIEK 

       130        140        150        160        170        180 
EHAQNKRKEE ELEIKVHKRR KAMTAAGTDL SEESYLPMDY YSDSEVGKIE DQNLAITKEI 

       190        200        210        220        230        240 
NRLLKKVENK EEVSYINECP IKIFFSSRTH SQLNQFSSQL RLTNFQASFE DLEERTKYIP 

       250        260        270        280        290        300 
LGSRKQLCIN EKVRSKGNDQ SVNDACLDLQ RETNGCQYLP KNYMMSSVTK EFADLSLAKI 

       310        320        330        340        350        360 
RDIEDLNELG IELNICPYYS VRKGIEMTEI ISLPYQMIFQ DTTRKILNLD IKDSIIIIDE 

       370        380        390        400        410        420 
AHNIIDVITS MYSIKITSDQ LNKVIKSLKI YLNKFLKRLN SGNRINLMKL IKICQILLKF 

       430        440        450        460        470        480 
LNTNSEKVKS GDEVQIQDIF KDSTGDLVNI HKLDQFLTKS KIAYKIESYI EKTEMETDNG 

       490        500        510        520        530        540 
EKKGRITNSG GSSSSSSSSN PLLFTIIKFL RTLTNLSKEG KFFWDNENGT ISLNYMLLDP 

       550        560        570        580        590        600 
SAVFKEIVDQ AKCVLLCGGT MEPMSDYMDY LFPSVPTNKI NTFACGHVIP KENLQVFPIS 

       610        620        630        640        650        660 
QWNDTNFEFS YQKRNDSKQL MALGEFLIEI TKRVPYGVVI FFPSYKYLDQ VLQFWRDTKI 

       670        680        690        700        710        720 
LTSIESEKTI FREPKDPSNV EKVLNEYGYL IQTERKGAIL FSVVGGKMSE GINFSDDLAR 

       730        740        750        760        770        780 
AVIMVGLPYP NAYSGEMVTK RKYIETSELS NGGTTTDAKE KSRNYYENLC MRAVNQSIGR 

       790        800        810        820        830        840 
SIRHINDYSI IYLVDRRFST PRIQNKLSQW VKERISITTT NNNNNNSIYI MESTTDFFNI 


IR 

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References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000031 Genomic DNA. Translation: EAL00566.1.
AACQ01000030 Genomic DNA. Translation: EAL00698.1.
RefSeqXP_719450.1. XM_714357.1.
XP_719578.1. XM_714485.1.

3D structure databases

ProteinModelPortalQ5AD67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0004313.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3638692.
3638794.
KEGGcal:CaO19.2000.
cal:CaO19.9551.

Phylogenomic databases

eggNOGCOG1199.
KOK11273.
OrthoDBEOG7QC84W.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
InterProIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 6 hits.
TIGRFAMsTIGR00604. rad3. 1 hit.
PROSITEPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHL1_CANAL
AccessionPrimary (citable) accession number: Q5AD67
Entry history
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names