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Protein

ATP-dependent DNA helicase CHL1

Gene

CHL1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 49ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase CHL1By similarity (EC:3.6.4.12By similarity)
Alternative name(s):
Chromosome loss protein 1By similarity
Gene namesi
Name:CHL1
Ordered Locus Names:CAALFM_C201240CA
ORF Names:CaO19.2000, CaO19.9551
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000177726 orf19.2000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003510061 – 842ATP-dependent DNA helicase CHL1Add BLAST842

Proteomic databases

PRIDEiQ5AD67

Structurei

3D structure databases

ProteinModelPortaliQ5AD67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 417Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST412

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi359 – 362DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi492 – 499Poly-Ser8
Compositional biasi821 – 826Poly-Asn6

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ5AD67
KOiK11273
OrthoDBiEOG092C10ZG

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF13307 Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 6 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5AD67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSESCSRNY NHPYTPYDIQ IQLMDAIYNT IENGYKIGLF ESPTGTGKTL
60 70 80 90 100
SIICSSMTWL RTFKRNNTFL ETNNEVEDVY ESESEEDEPE WVKKAYQSSI
110 120 130 140 150
VNRSKNKLIE YEHYLDKIEK EHAQNKRKEE ELEIKVHKRR KAMTAAGTDL
160 170 180 190 200
SEESYLPMDY YSDSEVGKIE DQNLAITKEI NRLLKKVENK EEVSYINECP
210 220 230 240 250
IKIFFSSRTH SQLNQFSSQL RLTNFQASFE DLEERTKYIP LGSRKQLCIN
260 270 280 290 300
EKVRSKGNDQ SVNDACLDLQ RETNGCQYLP KNYMMSSVTK EFADLSLAKI
310 320 330 340 350
RDIEDLNELG IELNICPYYS VRKGIEMTEI ISLPYQMIFQ DTTRKILNLD
360 370 380 390 400
IKDSIIIIDE AHNIIDVITS MYSIKITSDQ LNKVIKSLKI YLNKFLKRLN
410 420 430 440 450
SGNRINLMKL IKICQILLKF LNTNSEKVKS GDEVQIQDIF KDSTGDLVNI
460 470 480 490 500
HKLDQFLTKS KIAYKIESYI EKTEMETDNG EKKGRITNSG GSSSSSSSSN
510 520 530 540 550
PLLFTIIKFL RTLTNLSKEG KFFWDNENGT ISLNYMLLDP SAVFKEIVDQ
560 570 580 590 600
AKCVLLCGGT MEPMSDYMDY LFPSVPTNKI NTFACGHVIP KENLQVFPIS
610 620 630 640 650
QWNDTNFEFS YQKRNDSKQL MALGEFLIEI TKRVPYGVVI FFPSYKYLDQ
660 670 680 690 700
VLQFWRDTKI LTSIESEKTI FREPKDPSNV EKVLNEYGYL IQTERKGAIL
710 720 730 740 750
FSVVGGKMSE GINFSDDLAR AVIMVGLPYP NAYSGEMVTK RKYIETSELS
760 770 780 790 800
NGGTTTDAKE KSRNYYENLC MRAVNQSIGR SIRHINDYSI IYLVDRRFST
810 820 830 840
PRIQNKLSQW VKERISITTT NNNNNNSIYI MESTTDFFNI IR
Length:842
Mass (Da):97,275
Last modified:April 26, 2005 - v1
Checksum:iA241696BAC817F99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA Translation: AOW27172.1
RefSeqiXP_719450.1, XM_714357.1

Genome annotation databases

EnsemblFungiiAOW27172; AOW27172; CAALFM_C201240CA
GeneIDi3638794
KEGGical:CAALFM_C201240CA

Similar proteinsi

Entry informationi

Entry nameiCHL1_CANAL
AccessioniPrimary (citable) accession number: Q5AD67
Secondary accession number(s): A0A1D8PGA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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