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Q5AD67

- CHL1_CANAL

UniProt

Q5AD67 - CHL1_CANAL

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Protein
ATP-dependent RNA helicase CHL1
Gene
CHL1, CaO19.2000, CaO19.9551
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 498ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent DNA helicase activity Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. DNA helicase activity Source: CGD

GO - Biological processi

  1. DNA duplex unwinding Source: GOC
  2. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase CHL1 (EC:3.6.4.13)
Alternative name(s):
Chromosome loss protein 1
Gene namesi
Name:CHL1
ORF Names:CaO19.2000, CaO19.9551
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842ATP-dependent RNA helicase CHL1
PRO_0000351006Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0004313.

Structurei

3D structure databases

ProteinModelPortaliQ5AD67.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 417412Helicase ATP-binding
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi359 – 3624DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi492 – 4998Poly-Ser
Compositional biasi821 – 8266Poly-Asn

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1199.
KOiK11273.
OrthoDBiEOG7QC84W.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 6 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5AD67-1 [UniParc]FASTAAdd to Basket

« Hide

MVSESCSRNY NHPYTPYDIQ IQLMDAIYNT IENGYKIGLF ESPTGTGKTL    50
SIICSSMTWL RTFKRNNTFL ETNNEVEDVY ESESEEDEPE WVKKAYQSSI 100
VNRSKNKLIE YEHYLDKIEK EHAQNKRKEE ELEIKVHKRR KAMTAAGTDL 150
SEESYLPMDY YSDSEVGKIE DQNLAITKEI NRLLKKVENK EEVSYINECP 200
IKIFFSSRTH SQLNQFSSQL RLTNFQASFE DLEERTKYIP LGSRKQLCIN 250
EKVRSKGNDQ SVNDACLDLQ RETNGCQYLP KNYMMSSVTK EFADLSLAKI 300
RDIEDLNELG IELNICPYYS VRKGIEMTEI ISLPYQMIFQ DTTRKILNLD 350
IKDSIIIIDE AHNIIDVITS MYSIKITSDQ LNKVIKSLKI YLNKFLKRLN 400
SGNRINLMKL IKICQILLKF LNTNSEKVKS GDEVQIQDIF KDSTGDLVNI 450
HKLDQFLTKS KIAYKIESYI EKTEMETDNG EKKGRITNSG GSSSSSSSSN 500
PLLFTIIKFL RTLTNLSKEG KFFWDNENGT ISLNYMLLDP SAVFKEIVDQ 550
AKCVLLCGGT MEPMSDYMDY LFPSVPTNKI NTFACGHVIP KENLQVFPIS 600
QWNDTNFEFS YQKRNDSKQL MALGEFLIEI TKRVPYGVVI FFPSYKYLDQ 650
VLQFWRDTKI LTSIESEKTI FREPKDPSNV EKVLNEYGYL IQTERKGAIL 700
FSVVGGKMSE GINFSDDLAR AVIMVGLPYP NAYSGEMVTK RKYIETSELS 750
NGGTTTDAKE KSRNYYENLC MRAVNQSIGR SIRHINDYSI IYLVDRRFST 800
PRIQNKLSQW VKERISITTT NNNNNNSIYI MESTTDFFNI IR 842
Length:842
Mass (Da):97,275
Last modified:April 26, 2005 - v1
Checksum:iA241696BAC817F99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000031 Genomic DNA. Translation: EAL00566.1.
AACQ01000030 Genomic DNA. Translation: EAL00698.1.
RefSeqiXP_719450.1. XM_714357.1.
XP_719578.1. XM_714485.1.

Genome annotation databases

GeneIDi3638692.
3638794.
KEGGical:CaO19.2000.
cal:CaO19.9551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000031 Genomic DNA. Translation: EAL00566.1 .
AACQ01000030 Genomic DNA. Translation: EAL00698.1 .
RefSeqi XP_719450.1. XM_714357.1.
XP_719578.1. XM_714485.1.

3D structure databases

ProteinModelPortali Q5AD67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0004313.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3638692.
3638794.
KEGGi cal:CaO19.2000.
cal:CaO19.9551.

Phylogenomic databases

eggNOGi COG1199.
KOi K11273.
OrthoDBi EOG7QC84W.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view ]
SMARTi SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 6 hits.
TIGRFAMsi TIGR00604. rad3. 1 hit.
PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCHL1_CANAL
AccessioniPrimary (citable) accession number: Q5AD67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi