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Q5AD67

- CHL1_CANAL

UniProt

Q5AD67 - CHL1_CANAL

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Protein

ATP-dependent RNA helicase CHL1

Gene

CHL1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 498ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent DNA helicase activity Source: InterPro
  3. DNA binding Source: UniProtKB-KW
  4. DNA helicase activity Source: CGD

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. DNA duplex unwinding Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase CHL1 (EC:3.6.4.13)
Alternative name(s):
Chromosome loss protein 1
Gene namesi
Name:CHL1
ORF Names:CaO19.2000, CaO19.9551
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842ATP-dependent RNA helicase CHL1PRO_0000351006Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0004313.

Structurei

3D structure databases

ProteinModelPortaliQ5AD67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 417412Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi359 – 3624DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi492 – 4998Poly-Ser
Compositional biasi821 – 8266Poly-Asn

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1199.
InParanoidiQ5AD67.
KOiK11273.
OrthoDBiEOG7QC84W.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 6 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5AD67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSESCSRNY NHPYTPYDIQ IQLMDAIYNT IENGYKIGLF ESPTGTGKTL
60 70 80 90 100
SIICSSMTWL RTFKRNNTFL ETNNEVEDVY ESESEEDEPE WVKKAYQSSI
110 120 130 140 150
VNRSKNKLIE YEHYLDKIEK EHAQNKRKEE ELEIKVHKRR KAMTAAGTDL
160 170 180 190 200
SEESYLPMDY YSDSEVGKIE DQNLAITKEI NRLLKKVENK EEVSYINECP
210 220 230 240 250
IKIFFSSRTH SQLNQFSSQL RLTNFQASFE DLEERTKYIP LGSRKQLCIN
260 270 280 290 300
EKVRSKGNDQ SVNDACLDLQ RETNGCQYLP KNYMMSSVTK EFADLSLAKI
310 320 330 340 350
RDIEDLNELG IELNICPYYS VRKGIEMTEI ISLPYQMIFQ DTTRKILNLD
360 370 380 390 400
IKDSIIIIDE AHNIIDVITS MYSIKITSDQ LNKVIKSLKI YLNKFLKRLN
410 420 430 440 450
SGNRINLMKL IKICQILLKF LNTNSEKVKS GDEVQIQDIF KDSTGDLVNI
460 470 480 490 500
HKLDQFLTKS KIAYKIESYI EKTEMETDNG EKKGRITNSG GSSSSSSSSN
510 520 530 540 550
PLLFTIIKFL RTLTNLSKEG KFFWDNENGT ISLNYMLLDP SAVFKEIVDQ
560 570 580 590 600
AKCVLLCGGT MEPMSDYMDY LFPSVPTNKI NTFACGHVIP KENLQVFPIS
610 620 630 640 650
QWNDTNFEFS YQKRNDSKQL MALGEFLIEI TKRVPYGVVI FFPSYKYLDQ
660 670 680 690 700
VLQFWRDTKI LTSIESEKTI FREPKDPSNV EKVLNEYGYL IQTERKGAIL
710 720 730 740 750
FSVVGGKMSE GINFSDDLAR AVIMVGLPYP NAYSGEMVTK RKYIETSELS
760 770 780 790 800
NGGTTTDAKE KSRNYYENLC MRAVNQSIGR SIRHINDYSI IYLVDRRFST
810 820 830 840
PRIQNKLSQW VKERISITTT NNNNNNSIYI MESTTDFFNI IR
Length:842
Mass (Da):97,275
Last modified:April 26, 2005 - v1
Checksum:iA241696BAC817F99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000031 Genomic DNA. Translation: EAL00566.1.
AACQ01000030 Genomic DNA. Translation: EAL00698.1.
RefSeqiXP_719450.1. XM_714357.1.
XP_719578.1. XM_714485.1.

Genome annotation databases

GeneIDi3638692.
3638794.
KEGGical:CaO19.2000.
cal:CaO19.9551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000031 Genomic DNA. Translation: EAL00566.1 .
AACQ01000030 Genomic DNA. Translation: EAL00698.1 .
RefSeqi XP_719450.1. XM_714357.1.
XP_719578.1. XM_714485.1.

3D structure databases

ProteinModelPortali Q5AD67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0004313.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3638692.
3638794.
KEGGi cal:CaO19.2000.
cal:CaO19.9551.

Phylogenomic databases

eggNOGi COG1199.
InParanoidi Q5AD67.
KOi K11273.
OrthoDBi EOG7QC84W.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view ]
SMARTi SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 6 hits.
TIGRFAMsi TIGR00604. rad3. 1 hit.
PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCHL1_CANAL
AccessioniPrimary (citable) accession number: Q5AD67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3