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Q5AD67

- CHL1_CANAL

UniProt

Q5AD67 - CHL1_CANAL

Protein

ATP-dependent RNA helicase CHL1

Gene

CHL1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi42 – 498ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent DNA helicase activity Source: InterPro
    3. DNA binding Source: UniProtKB-KW
    4. DNA helicase activity Source: CGD

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. DNA duplex unwinding Source: GOC

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent RNA helicase CHL1 (EC:3.6.4.13)
    Alternative name(s):
    Chromosome loss protein 1
    Gene namesi
    Name:CHL1
    ORF Names:CaO19.2000, CaO19.9551
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 842842ATP-dependent RNA helicase CHL1PRO_0000351006Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0004313.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5AD67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 417412Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi359 – 3624DEAH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi492 – 4998Poly-Ser
    Compositional biasi821 – 8266Poly-Asn

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1199.
    KOiK11273.
    OrthoDBiEOG7QC84W.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR006555. ATP-dep_Helicase_C.
    IPR010614. DEAD_2.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR013020. DNA_helicase_DNA-repair_Rad3.
    IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
    IPR006554. Helicase-like_DEXD_c2.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF06733. DEAD_2. 1 hit.
    PF13307. Helicase_C_2. 1 hit.
    [Graphical view]
    SMARTiSM00488. DEXDc2. 1 hit.
    SM00491. HELICc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 6 hits.
    TIGRFAMsiTIGR00604. rad3. 1 hit.
    PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51193. HELICASE_ATP_BIND_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5AD67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSESCSRNY NHPYTPYDIQ IQLMDAIYNT IENGYKIGLF ESPTGTGKTL    50
    SIICSSMTWL RTFKRNNTFL ETNNEVEDVY ESESEEDEPE WVKKAYQSSI 100
    VNRSKNKLIE YEHYLDKIEK EHAQNKRKEE ELEIKVHKRR KAMTAAGTDL 150
    SEESYLPMDY YSDSEVGKIE DQNLAITKEI NRLLKKVENK EEVSYINECP 200
    IKIFFSSRTH SQLNQFSSQL RLTNFQASFE DLEERTKYIP LGSRKQLCIN 250
    EKVRSKGNDQ SVNDACLDLQ RETNGCQYLP KNYMMSSVTK EFADLSLAKI 300
    RDIEDLNELG IELNICPYYS VRKGIEMTEI ISLPYQMIFQ DTTRKILNLD 350
    IKDSIIIIDE AHNIIDVITS MYSIKITSDQ LNKVIKSLKI YLNKFLKRLN 400
    SGNRINLMKL IKICQILLKF LNTNSEKVKS GDEVQIQDIF KDSTGDLVNI 450
    HKLDQFLTKS KIAYKIESYI EKTEMETDNG EKKGRITNSG GSSSSSSSSN 500
    PLLFTIIKFL RTLTNLSKEG KFFWDNENGT ISLNYMLLDP SAVFKEIVDQ 550
    AKCVLLCGGT MEPMSDYMDY LFPSVPTNKI NTFACGHVIP KENLQVFPIS 600
    QWNDTNFEFS YQKRNDSKQL MALGEFLIEI TKRVPYGVVI FFPSYKYLDQ 650
    VLQFWRDTKI LTSIESEKTI FREPKDPSNV EKVLNEYGYL IQTERKGAIL 700
    FSVVGGKMSE GINFSDDLAR AVIMVGLPYP NAYSGEMVTK RKYIETSELS 750
    NGGTTTDAKE KSRNYYENLC MRAVNQSIGR SIRHINDYSI IYLVDRRFST 800
    PRIQNKLSQW VKERISITTT NNNNNNSIYI MESTTDFFNI IR 842
    Length:842
    Mass (Da):97,275
    Last modified:April 26, 2005 - v1
    Checksum:iA241696BAC817F99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000031 Genomic DNA. Translation: EAL00566.1.
    AACQ01000030 Genomic DNA. Translation: EAL00698.1.
    RefSeqiXP_719450.1. XM_714357.1.
    XP_719578.1. XM_714485.1.

    Genome annotation databases

    GeneIDi3638692.
    3638794.
    KEGGical:CaO19.2000.
    cal:CaO19.9551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000031 Genomic DNA. Translation: EAL00566.1 .
    AACQ01000030 Genomic DNA. Translation: EAL00698.1 .
    RefSeqi XP_719450.1. XM_714357.1.
    XP_719578.1. XM_714485.1.

    3D structure databases

    ProteinModelPortali Q5AD67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0004313.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3638692.
    3638794.
    KEGGi cal:CaO19.2000.
    cal:CaO19.9551.

    Phylogenomic databases

    eggNOGi COG1199.
    KOi K11273.
    OrthoDBi EOG7QC84W.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR006555. ATP-dep_Helicase_C.
    IPR010614. DEAD_2.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR013020. DNA_helicase_DNA-repair_Rad3.
    IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
    IPR006554. Helicase-like_DEXD_c2.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF06733. DEAD_2. 1 hit.
    PF13307. Helicase_C_2. 1 hit.
    [Graphical view ]
    SMARTi SM00488. DEXDc2. 1 hit.
    SM00491. HELICc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 6 hits.
    TIGRFAMsi TIGR00604. rad3. 1 hit.
    PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51193. HELICASE_ATP_BIND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiCHL1_CANAL
    AccessioniPrimary (citable) accession number: Q5AD67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3