Q5ACK7 (DRS1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent RNA helicase DRS1
EC=3.6.4.13

Gene names

Name:	DRS1
ORF Names:	CaO19.7635

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	613 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-binding RNA helicase involved in ribosome assembly By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Associates with pre-ribosomal particles By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Domain	The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similarities	Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding RNA-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to drug Inferred from mutant phenotype PubMed 17604452. Source: CGD ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 613	613	ATP-dependent RNA helicase DRS1		PRO_0000232242
Regions
	Domain	161 – 335	175	Helicase ATP-binding
	Domain	364 – 541	178	Helicase C-terminal
	Nucleotide binding	174 – 181	8	ATP By similarity
	Coiled coil	504 – 552	49	Potential
	Motif	130 – 158	29	Q motif
	Motif	282 – 285	4	DEAD box
	Compositional bias	42 – 122	81	Glu-rich
	Compositional bias	572 – 613	42	Lys-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5ACK7 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 51D53C1547380230	FASTA	613	69,314
	10 20 30 40 50 60 MPDFILTIDS DEEVDVSDSE QLQDINPDFK FQIDGETTNT LEEFDFQENK VKEVDLDEII 70 80 90 100 110 120 KKKGGLKEES DDEELALDGF GMGASKQEEE EEEEEEEVEV PEVKEVVEPE DSAEAIADFY 130 140 150 160 170 180 EESSPQQTHT SFQTLQLSRP VLKGIAELKF TKPTPIQSAS IPIALLGKDI VAGAQTGSGK 190 200 210 220 230 240 TGAYMIPIIE RLLYKPSTST KVIILTPTRE LALQVYEFGK KLSHHVNNLN IGLAVGGLNL 250 260 270 280 290 300 RQQEEQLKTR PDIVIATPGR LIDHIRNSPS FSVQDIQVLV IDEADRMLEE GFQDELTEIL 310 320 330 340 350 360 SLIPKHKRQT LLFSATMNTR IQDLIQLSLQ KPVRIMIDPP KSVASKLLQQ FVRIRKRDQL 370 380 390 400 410 420 KPALLYQLLK GVSSRVVVFV ARKETAHRLR IVLGLLGLKV SELHGALTQE QRLQNVKNFK 430 440 450 460 470 480 SLEVPVLICT DLAARGLDIP KIELVINYDM PKTFEIYLHR VGRTARAGRD GTSITFVGES 490 500 510 520 530 540 SQERAIVKSA IVNGKGVAKT VDWKQAEETN KLLESKESVI DEVLEEEKEA KELLRAEMEL 550 560 570 580 590 600 TKASNLIKHE QEIHSRPKRT WFKGEVMEQL TKHGKKVNSK KRKANEVRKD EGRSYKKTKT 610 DRMKISNKKK SKK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000032 Genomic DNA. Translation: EAL00509.1.
RefSeq	XP_719395.1. XM_714302.1.
3D structure databases
ProteinModelPortal	Q5ACK7.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000864.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639045.
KEGG	cal:CaO19.7635.
Organism-specific databases
CGD	CAL0000864. DRS1.
Phylogenomic databases
eggNOG	COG0513.
KO	K13181.
Family and domain databases
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR027417. P-loop_NTPase. IPR000629. RNA-helicase_DEAD-box_CS. IPR014014. RNA_helicase_DEAD_Q_motif. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00039. DEAD_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51195. Q_MOTIF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DRS1_CANAL

Accession

Primary (citable) accession number: Q5ACK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 26, 2005
Last modified:	May 29, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program