ID   PRP45_CANAL             Reviewed;         286 AA.
AC   Q5AC37; A0A1D8PPV8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   22-FEB-2023, entry version 69.
DE   RecName: Full=Pre-mRNA-processing protein 45;
GN   Name=PRP45; OrderedLocusNames=CAALFM_C602440CA;
GN   ORFNames=CaO19.12959, CaO19.5513;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017628; AOW30177.1; -; Genomic_DNA.
DR   RefSeq; XP_719078.1; XM_713985.1.
DR   AlphaFoldDB; Q5AC37; -.
DR   SMR; Q5AC37; -.
DR   STRING; 237561.Q5AC37; -.
DR   EnsemblFungi; C6_02440C_A-T; C6_02440C_A-T-p1; C6_02440C_A.
DR   GeneID; 3639166; -.
DR   KEGG; cal:CAALFM_C602440CA; -.
DR   CGD; CAL0000177849; PRP45.
DR   VEuPathDB; FungiDB:C6_02440C_A; -.
DR   eggNOG; KOG2441; Eukaryota.
DR   HOGENOM; CLU_085411_0_0_1; -.
DR   InParanoid; Q5AC37; -.
DR   OrthoDB; 5490078at2759; -.
DR   PRO; PR:Q5AC37; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; NUCLEAR PROTEIN SKIP-RELATED; 1.
DR   PANTHER; PTHR12096:SF0; SNW DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..286
FT                   /note="Pre-mRNA-processing protein 45"
FT                   /id="PRO_0000084816"
FT   REGION          111..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          253..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..279
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   286 AA;  33200 MW;  EE23347794848E77 CRC64;
     MASCNLLVIQ TTSIIMFSSL LSRPVNSSYD PSYHFSPVTR EIKNDPTSNG VVSTTKNATP
     LAPSKYDTTI PLKKRYPNLV HNFPKPELDE NVILETKKII DSILNPSDEP TNDINYIKYE
     NPNPNPNPNP NPNQEQQQQS SSSSSKIIQI KQFQEDPMLP PKFKLRKNRH ERIIEDVTFV
     KDLKTKKLTK EDREFWNIPA AVSNWKNSQG FTIGLDKRMI GREHVPIEMN IEKFNDLSTA
     LSDADLQARE DLKQRNEIRQ QKQLQEKRLR DEKIKEIANR SKRRRY
//