Reviewed, UniProtKB/Swiss-Prot Q5ABX0 (ATM_CANAL)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase TEL1
    EC=2.7.11.1
Alternative name(s):
    DNA-damage checkpoint kinase TEL1
    Telomere length regulation protein 1
    ATM homolog

Gene names

Name:	TEL1
ORF Names:	CaO19.5580, CaO19.13026

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	2873 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Associates with DNA double-strand breaks By similarity.
Subcellular location	NucleusBy similarity. TelomereBy similarity. Note= Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. ATM subfamily. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Chromosomal protein Nucleus Telomere
Molecular function	Chromatin regulator Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2873	2873	Serine/threonine-protein kinase TEL1		PRO_0000227698
Regions
	Domain	1830 – 2425	596	FAT
	Domain	2556 – 2873	318	PI3K/PI4K
	Domain	2841 – 2873	33	FATC
Natural variations
	Natural variant	1158	1	P → S in allele CaO19.13026.
	Natural variant	1231	1	K → R in allele CaO19.13026.
	Natural variant	1324	1	L → V in allele CaO19.13026.

Sequences

	Sequence		Length	Mass (Da)
	Q5ABX0-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8F939ADBAB0F9ADA	FASTA	2,873	327,927
	10 20 30 40 50 60 MSTSDINKTI ALLQSSKIKE RNDALNNLEN IAASKFRLNP KQFRQLTQAI LALIKHESQI 70 80 90 100 110 120 YFNNKSTTVD SRLSQASYNL RLLTEKSIED TRIDFKYRTY LDLCMGIKDQ FFVHSELLEP 130 140 150 160 170 180 CSIDFIKTIT SILNLSYVKE HLNRKEWSIL YIFLVSLINN ILDDCEGSFS NNGNNEKLLI 190 200 210 220 230 240 DLYTALQNLL QCESSVSINY LQLYDNDNYF KLLRILDKTS ELLKKENVII IIIFRIINKL 250 260 270 280 290 300 ITVIATEKFK FVNKLIKIGI RLMVYFHHSH WEKLQEQFLI FINLPGTHDL INLHNLPKLI 310 320 330 340 350 360 GDRYILSEIS TQEDGDSINS QADNQDEVFL YNLGVLIHHL MKKLMSGSFE LKTEDIGMCT 370 380 390 400 410 420 INNSITWFNL KTIYSDSQNY KPWLLTLGVS RLLKSYYDLK QFINKQSNDL QTSLLLYSNG 430 440 450 460 470 480 SPNKNKRQKL GSIADTISDS NSAIELCNKL IHSKESSDNQ VLGLKLLTFY LELYTFEKPK 490 500 510 520 530 540 EQSTESDSMD TTIGENTTFD FVISTTDNTF IDKNVVMKNI LITFDDNSMN FWSSLCARSV 550 560 570 580 590 600 LLDEILQSNH GGFKFKKSFS IQLLKLSLLL LKEPEVANIA CNIIFKLVFE QKTNLSELID 610 620 630 640 650 660 DSVIIQLETL IDLSEINGPY KITEESFQFW YAINKLAIEV NLSKKNFLGR RIQDWMLAKW 670 680 690 700 710 720 DITFSPGADF VSVGSSLANF MYWLSGNSIS YSPTTTQKST YEGDIYEFYY FAQSYDSLEK 730 740 750 760 770 780 FLCLKSVSDS SETIKFDIIS IASSDRIDAI LNKVNSTFMV FDRSSVTSGS LFCWIIVLSN 790 800 810 820 830 840 IVAKVRSMKF VTHELTGLQF QLSAGLNSFK DITLSCEEII DVMEMVNKFL PTDPDTIQIF 850 860 870 880 890 900 IQNFPSEKLV NIIKFDYPGL ADKDNRKSVP EDGFGWEFSR VRDATTPPST TSTSTISLAK 910 920 930 940 950 960 LNYKKIQSLE VSKFIMFTAD IEGKLQSDIL TAFLNYVETL GTDDFLPSLL FVVENIFTDH 970 980 990 1000 1010 1020 SAHFIDEIQL AKLLRIINEK LLSTQNYERN EFVLVVISRF LSATAQVWIN SSDNSLASDF 1030 1040 1050 1060 1070 1080 YSLVSRLYSS GRDDLILTET SIVEYCRFLA HFITHNDERV LSNTDIKNEL LEKFSKSPNN 1090 1100 1110 1120 1130 1140 IKDRLANSFG ELVSLSTVQQ QGQIYSDLFD RFVNPEQSVE SAGTYTKFFT NLSQSSLHIL 1150 1160 1170 1180 1190 1200 RLALFNLLEC SRFPFFIPYL EICLKEFCMI MKLDNANKLF KIFKFEILRN WWKYDSIDAF 1210 1220 1230 1240 1250 1260 PFVLFSYTDL SSFYRDNYRE LIAVALSTKS KSPEISNAFV EQLADLKQSH SETLVAESLS 1270 1280 1290 1300 1310 1320 IIVPLSYSKD GVRNDVFQIL LDYLKNSFKQ EFIDKLPLIV LEIIKFTEIS NEKSFESLGT 1330 1340 1350 1360 1370 1380 DGLLTMLLND TGFSSTIQTA GEMVISFDSS VQLLKKLVEK YHQPEHETFW SSRQIYFLIR 1390 1400 1410 1420 1430 1440 RLSISLKLAT TFEQKVIFLR KFKFVLVLGG KKSIDYAVSR LLVDTLCPLL SNEPKMSADV 1450 1460 1470 1480 1490 1500 FLILQSLTDV YSHRYTYDKS ISLIIQIINS LLETEAVDRS RALLDCIDDF VNTGDQDRAI 1510 1520 1530 1540 1550 1560 CQLLKSSVAI LKGQAVEIES SLIELCLEES GPDYIKQMIL ISRIFGNVVF ATTHSGSKLP 1570 1580 1590 1600 1610 1620 VVEKLLALSK NQIQEFSDGY KLWIANYLSD FYIEGGCKEQ IKALTFDEYE GIPVNDFENE 1630 1640 1650 1660 1670 1680 VRSFDFTLKS IEQYIYKDDF EAAACAESII GVLIRKYETS KREVSKFLNF ETTLEKHSDS 1690 1700 1710 1720 1730 1740 ILPIDFHTCV ILNDKADVEY LGDELIDIIN NFESFLSNGT ELWCTKLYLA LLQELAVETS 1750 1760 1770 1780 1790 1800 IAPLLSTFVI MVPEFAKTSL PVLVCNYLAI KRTHSQDRII SLLNEFLHTS KKSESSIKVF 1810 1820 1830 1840 1850 1860 LQILILIRVG AKIFKKPVFA NVFAKIDKLK FYQLACEVKQ FKTALMLFED VASDTNSDVH 1870 1880 1890 1900 1910 1920 LQDHYQTLQH VYESLDDDDL VFGLPERTTL EYSISMINRV GNSDDRLRFS SAGFDTDMIL 1930 1940 1950 1960 1970 1980 NQEPSYSNIV GSLSAAGLLG VSRALSKNTS FASNDDSQYE WSWKLSKWDL PISKNATKEN 1990 2000 2010 2020 2030 2040 EVIYKTLKQI HDFPMNSQDI CSSSLLNAVD NKVSATNMSV KEFKQEGINW LKTISTVASI 2050 2060 2070 2080 2090 2100 AEIANATGDN IIPMTNQFSE KTQWFGEVEF SMFENLLLAR QTTFGLINDR PISSLPSDTA 2110 2120 2130 2140 2150 2160 WMGALCDLVR YNNLARTNGE YQKMVTSTML VDVVSKKLQS SSLDMVAFNA NNLASFQTAQ 2170 2180 2190 2200 2210 2220 TLWCQGNTNV PVMIMKDLYA AGGIDMSENI LKVDKCLIRA MMVDWMSQSR QEVASSIMEK 2230 2240 2250 2260 2270 2280 YVMPTEELSN HMIDLQQQSK IFSILARFCE EQYKSKSLSE KISKLEKRVL NKENEIKDLK 2290 2300 2310 2320 2330 2340 KQYEKVTVTH AEQKQVQQYY NRLKKQFVSE SKDLESLRKS KQLFSSKAVQ YYMKSIIVDD 2350 2360 2370 2380 2390 2400 FEEENLDKFF SLWLEQSGNN ELNQSIQSDL LALPSYKLVS WCTQLISRLS NETNNFQILL 2410 2420 2430 2440 2450 2460 KKLIINMCLD HPHHSLYLLL SLKKHKPNTN EVLNPSLLSR CAAAQAIWDQ LLLQDHRYVS 2470 2480 2490 2500 2510 2520 GVLLPIDGFT DQCITLAAYK VSKGKSIDLT KFSAGDYWLN ELPAIPPPTE TIRVDPSKQY 2530 2540 2550 2560 2570 2580 KNVPVLHSID KKISIATSGL SLPKIANFIL SNGTEHRVLL KHGTDGIRQD SIMEQVFNKV 2590 2600 2610 2620 2630 2640 NNIFAKDREC NKRGLTIRTY NAVPLGPLSG IIEFVPNSMA FIDVISGYHQ IHDKISYDKA 2650 2660 2670 2680 2690 2700 REMMKSCQSG DKQKRIHSFE QIEAKIKPVM RYFFQETFLT SDSWFESRVK YTHGIATSSI 2710 2720 2730 2740 2750 2760 VGHILGLGDR HCNNILIDRS TGEPIHIDLG VAFDQGKRLA IPETVPFRLT RDIVDGFGVT 2770 2780 2790 2800 2810 2820 GVEGMFKKSC EHTLRVLRTN KEHIISILDV LRWDPLYSWT LSRFKKRKLQ EDETGPGVQP 2830 2840 2850 2860 2870 EEEGSEAGTA IMTVIEKLNA NGLSTEAAVR ELIQEATSTQ NLALIYFGWS PFY

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000034 Genomic DNA. Translation: EAL00247.1. AACQ01000033 Genomic DNA. Translation: EAL00369.1.
RefSeq	XP_719142.1. XP_719259.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3639073. 3639263.
KEGG	cal:CaO19.13026. cal:CaO19.5580.
Organism-specific databases
CGD	CAL0006254. orf19.5580.
Family and domain databases
InterPro	IPR015519. Ataxia_Telang_Mut. IPR003152. FATC. IPR000403. PI3/4_kinase_cat. IPR014009. PIK_FAT. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
PANTHER	PTHR11139:SF3. Ataxia_Telang_Mut. 1 hit.
Pfam	PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATM_CANAL

Accession

Primary (citable) accession number: Q5ABX0
Secondary accession number(s): Q5AC91

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	April 26, 2005
Last modified:	November 4, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)