Q5ABX0 (ATM_CANAL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Serine/threonine-protein kinase TEL1 EC=2.7.11.1 Alternative name(s): ATM homolog DNA-damage checkpoint kinase TEL1 Telomere length regulation protein 1 | ||||
| Gene names |
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| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) | ||||
| Taxonomic identifier | 237561 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 2873 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Subunit structure | Associates with DNA double-strand breaks By similarity. |
| Subcellular location | Nucleus By similarity. Chromosome › telomere By similarity. Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks By similarity. |
| Sequence similarities | Belongs to the PI3/PI4-kinase family. ATM subfamily. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 PI3K/PI4K domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair |
| Cellular component | Chromosome Nucleus Telomere |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Chromatin regulator Kinase Serine/threonine-protein kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modificationInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2873 | 2873 | Serine/threonine-protein kinase TEL1 | PRO_0000227698 | |||||
Regions | |||||||||
| Domain | 1830 – 2425 | 596 | FAT | ||||||
| Domain | 2556 – 2873 | 318 | PI3K/PI4K | ||||||
| Domain | 2841 – 2873 | 33 | FATC | ||||||
Natural variations | |||||||||
| Natural variant | 1158 | 1 | P → S in allele CaO19.13026. | ||||||
| Natural variant | 1231 | 1 | K → R in allele CaO19.13026. | ||||||
| Natural variant | 1324 | 1 | L → V in allele CaO19.13026. | ||||||
Sequences
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References
| [1] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AACQ01000034 Genomic DNA. Translation: EAL00247.1. AACQ01000033 Genomic DNA. Translation: EAL00369.1. |
| RefSeq | XP_719142.1. XM_714049.1. XP_719259.1. XM_714166.1. |
3D structure databases | |
| ProteinModelPortal | Q5ABX0. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3639073. 3639263. |
| KEGG | cal:CaO19.13026. cal:CaO19.5580. |
Organism-specific databases | |
| CGD | CAL0006254. orf19.5580. |
Phylogenomic databases | |
| PhylomeDB | Q5ABX0. |
Family and domain databases | |
| InterPro | IPR015519. Ataxia_Telang_Mut. IPR003152. FATC. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR014009. PIK_FAT. IPR021668. TAN. [Graphical view] |
| Gene3D | G3DSA:1.10.1070.11. PI3/4_kinase_cat. 2 hits. |
| KO | K04728. |
| PANTHER | PTHR11139:SF3. Ataxia_Telang_Mut. 1 hit. |
| Pfam | PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. PF11640. TAN. 1 hit. [Graphical view] |
| SMART | SM00146. PI3Kc. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ATM_CANAL | ||||||||
| Accession | Primary (citable) accession number: Q5ABX0 Secondary accession number(s): Q5AC91 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| SIMILARITY comments Index of protein domains and families |