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Protein

Mitochondrial Rho GTPase 1

Gene

GEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 91GTP 1Sequence analysis8
Nucleotide bindingi113 – 115GTP 1Sequence analysis3
Nucleotide bindingi167 – 170GTP 1Sequence analysis4
Calcium bindingi253 – 2641PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi401 – 4122PROSITE-ProRule annotationAdd BLAST12
Nucleotide bindingi514 – 521GTP 2Sequence analysis8
Nucleotide bindingi550 – 554GTP 2Sequence analysis5
Nucleotide bindingi620 – 623GTP 2Sequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, GTP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Alternative name(s):
GTPase EF-hand protein of mitochondria 1
Gene namesi
Name:GEM1
Ordered Locus Names:CAALFM_C100890WA
ORF Names:CaO19.13437, CaO19.6016
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000185710. C1_00890W_A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 692Mitochondrial intermembraneSequence analysisAdd BLAST692
Transmembranei693 – 713Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini714 – 716CytoplasmicSequence analysis3

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393321 – 716Mitochondrial Rho GTPase 1Add BLAST716

Proteomic databases

PRIDEiQ5ABR2.

Structurei

3D structure databases

ProteinModelPortaliQ5ABR2.
SMRiQ5ABR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 196Miro 1Add BLAST124
Domaini240 – 275EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini388 – 423EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini501 – 654Miro 2Add BLAST154

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ5ABR2.
KOiK07870.
OrthoDBiEOG092C13Q5.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF13202. EF-hand_5. 2 hits.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 2 hits.
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 3 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5ABR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPDAIRVVV CGDDAVGKSS LITSLIKETI IEPQTNNVLP PITISRNDYI
60 70 80 90 100
ESSQEYLNDQ DHHHHHQSSP STMKNKRKHN NKRERERERE SSINNVQPNE
110 120 130 140 150
ISEYIPNITT IIDTSSSDMT NLQKELKRAD VIWLVYSDHY TYERISLHWM
160 170 180 190 200
PLFRSMGVNL PIILCANKSD LFPKSKSNLK STNSDEFVPL INEFKEIEAG
210 220 230 240 250
VRCSAKNNYN VVEAFYLCQR AVTHPISPIF DAKEGNLKPG AIKPLKRIFW
260 270 280 290 300
LSDTDQDGYL NFEELSELHK KCFGIEASKS DYEEIVNLID QKILPSYNTT
310 320 330 340 350
IETQTPPQQQ HLATSAGTPN GTTTTTSKGI SEDGFILLNK IYAESGRHET
360 370 380 390 400
VWCILRAYHY TNSLSLSDKF LYPRLDVNPH SSVELSPTGY KFFVDLFIKF
410 420 430 440 450
DKDNDGGLNE DELNTLFRST PGIPKLWVES NFPSSIVCNE EGYVTLQGWL
460 470 480 490 500
AQWNLTTFLS YKTTLEYLAY LGFDEGNSTK ALKVTKPRKI RQKNGKTYRN
510 520 530 540 550
AVNDRNVFNC FIVGAPKAGK SSLLESFLHG SYSDIYSPTI QPRLVVKDIE
560 570 580 590 600
LRGGKQCYLI LEELGELEPA ILENKSRLDQ CDVICYAYDS SDPESFQYLV
610 620 630 640 650
ELREKHGHLL DEVPAVFVAL KADLDKQQQR CDVQPENYTR DLFLNSPLHV
660 670 680 690 700
SLAWNSSLHE MFIQLVDAAK TPSSATPGIE LEVSVDQDDI KHIIMTGAAI
710
AVVGLVSIWV LNSLRR
Length:716
Mass (Da):81,157
Last modified:April 12, 2017 - v3
Checksum:i63AFA5AC93C4E19E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW25786.1.

Genome annotation databases

EnsemblFungiiEAK99972; EAK99972; CaO19.13437.
EAL00077; EAL00077; CaO19.6016.
KEGGical:CAALFM_C100890WA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW25786.1.

3D structure databases

ProteinModelPortaliQ5ABR2.
SMRiQ5ABR2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5ABR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK99972; EAK99972; CaO19.13437.
EAL00077; EAL00077; CaO19.6016.
KEGGical:CAALFM_C100890WA.

Organism-specific databases

CGDiCAL0000185710. C1_00890W_A.

Phylogenomic databases

InParanoidiQ5ABR2.
KOiK07870.
OrthoDBiEOG092C13Q5.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF13202. EF-hand_5. 2 hits.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 2 hits.
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 3 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGEM1_CANAL
AccessioniPrimary (citable) accession number: Q5ABR2
Secondary accession number(s): A0A1D8PCC5, Q5ABF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: April 12, 2017
Last modified: April 12, 2017
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.