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Protein

Mitochondrial Rho GTPase 1

Gene

GEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTP 1Sequence Analysis
Nucleotide bindingi41 – 433GTP 1Sequence Analysis
Nucleotide bindingi95 – 984GTP 1Sequence Analysis
Calcium bindingi181 – 192121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi329 – 340122PROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi442 – 4498GTP 2Sequence Analysis
Nucleotide bindingi478 – 4825GTP 2Sequence Analysis
Nucleotide bindingi548 – 5514GTP 2Sequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Alternative name(s):
GTPase EF-hand protein of mitochondria 1
Gene namesi
Name:GEM1
ORF Names:CaO19.13437, CaO19.6016
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 620620Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei621 – 64121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini642 – 6443CytoplasmicSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Mitochondrial Rho GTPase 1PRO_0000239332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005047.

Structurei

3D structure databases

ProteinModelPortaliQ5ABR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 124124Miro 1Add
BLAST
Domaini168 – 20336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini316 – 35136EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini429 – 582154Miro 2Add
BLAST

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 Miro domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1100.
InParanoidiQ5ABR2.
KOiK07870.
OrthoDBiEOG73545F.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR021181. Rho_GTPase_Mt.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF08477. Miro. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ABR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKRKHNNK RERERERESS INNVQPNEIS EYIPNITTII DTSSSDMTNL
60 70 80 90 100
QKELKRADVI WLVYSDHYTY ERISLHWMPL FRSMGVNLPI ILCANKSDLF
110 120 130 140 150
PKSKSNLKST NSDEFVPLIN EFKEIEAGVR CSAKNNYNVV EAFYLCQRAV
160 170 180 190 200
THPISPIFDA KEGNLKPGAI KPLKRIFWLS DTDQDGYLNF EELSELHKKC
210 220 230 240 250
FGIEASKSDY EEIVNLIDQK ILPSYNTTIE TQTPPQQQHL ATSAGTPNGT
260 270 280 290 300
TTTTSKGISE DGFILLNKIY AESGRHETVW CILRAYHYTN SLSLSDKFLY
310 320 330 340 350
PRLDVNPHSS VELSPTGYKF FVDLFIKFDK DNDGGLNEDE LNTLFRSTPG
360 370 380 390 400
IPKLWVESNF PSSIVCNEEG YVTLQGWLAQ WNLTTFLSYK TTLEYLAYLG
410 420 430 440 450
FDEGNSTKAL KVTKPRKIRQ KNGKTYRNAV NDRNVFNCFI VGAPKAGKSS
460 470 480 490 500
LLESFLHGSY SDIYSPTIQP RLVVKDIELR GGKQCYLILE ELGELEPAIL
510 520 530 540 550
ENKSRLDQCD VICYAYDSSD PESFQYLVEL REKHGHLLDE VPAVFVALKA
560 570 580 590 600
DLDKQQQRCD VQPENYTRDL FLNSPLHVSL AWNSSLHEMF IQLVDAAKTP
610 620 630 640
SSATPGIELE VSVDQDDIKH IIMTGAAIAV VGLVSIWVLN SLRR
Length:644
Mass (Da):73,194
Last modified:June 13, 2006 - v2
Checksum:iC0297BBAA933951F
GO

Sequence cautioni

The sequence EAK99972.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAL00077.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti575 – 5751P → L in allele CaO19.13437.
Natural varianti629 – 6291A → T in allele CaO19.13437.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00077.1. Different initiation.
AACQ01000036 Genomic DNA. Translation: EAK99972.1. Different initiation.
RefSeqiXP_718876.1. XM_713783.1.
XP_718978.1. XM_713885.1.

Genome annotation databases

GeneIDi3639354.
3639386.
KEGGical:CaO19.13437.
cal:CaO19.6016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00077.1. Different initiation.
AACQ01000036 Genomic DNA. Translation: EAK99972.1. Different initiation.
RefSeqiXP_718876.1. XM_713783.1.
XP_718978.1. XM_713885.1.

3D structure databases

ProteinModelPortaliQ5ABR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0005047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3639354.
3639386.
KEGGical:CaO19.13437.
cal:CaO19.6016.

Phylogenomic databases

eggNOGiCOG1100.
InParanoidiQ5ABR2.
KOiK07870.
OrthoDBiEOG73545F.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR021181. Rho_GTPase_Mt.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF08477. Miro. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiGEM1_CANAL
AccessioniPrimary (citable) accession number: Q5ABR2
Secondary accession number(s): Q5ABF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 27, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.