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Q5ABR2 (GEM1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial Rho GTPase 1

EC=3.6.5.-
Alternative name(s):
GTPase EF-hand protein of mitochondria 1
Gene names
Name:GEM1
ORF Names:CaO19.13437, CaO19.6016
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length644 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass type IV membrane protein By similarity.

Sequence similarities

Belongs to the mitochondrial Rho GTPase family.

Contains 2 EF-hand domains.

Contains 2 Miro domains.

Sequence caution

The sequence EAK99972.1 differs from that shown. Reason: Erroneous initiation.

The sequence EAL00077.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 644644Mitochondrial Rho GTPase 1
PRO_0000239332

Regions

Topological domain1 – 620620Mitochondrial intermembrane Potential
Transmembrane621 – 64121Helical; Anchor for type IV membrane protein; Potential
Topological domain642 – 6443Cytoplasmic Potential
Domain1 – 124124Miro 1
Domain168 – 20336EF-hand 1
Domain316 – 35136EF-hand 2
Domain429 – 582154Miro 2
Nucleotide binding12 – 198GTP 1 Potential
Nucleotide binding41 – 433GTP 1 Potential
Nucleotide binding95 – 984GTP 1 Potential
Calcium binding181 – 192121 Potential
Calcium binding329 – 340122 Potential
Nucleotide binding442 – 4498GTP 2 Potential
Nucleotide binding478 – 4825GTP 2 Potential
Nucleotide binding548 – 5514GTP 2 Potential

Natural variations

Natural variant5751P → L in allele CaO19.13437.
Natural variant6291A → T in allele CaO19.13437.

Sequences

Sequence LengthMass (Da)Tools
Q5ABR2 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: C0297BBAA933951F

FASTA64473,194
        10         20         30         40         50         60 
MKNKRKHNNK RERERERESS INNVQPNEIS EYIPNITTII DTSSSDMTNL QKELKRADVI 

        70         80         90        100        110        120 
WLVYSDHYTY ERISLHWMPL FRSMGVNLPI ILCANKSDLF PKSKSNLKST NSDEFVPLIN 

       130        140        150        160        170        180 
EFKEIEAGVR CSAKNNYNVV EAFYLCQRAV THPISPIFDA KEGNLKPGAI KPLKRIFWLS 

       190        200        210        220        230        240 
DTDQDGYLNF EELSELHKKC FGIEASKSDY EEIVNLIDQK ILPSYNTTIE TQTPPQQQHL 

       250        260        270        280        290        300 
ATSAGTPNGT TTTTSKGISE DGFILLNKIY AESGRHETVW CILRAYHYTN SLSLSDKFLY 

       310        320        330        340        350        360 
PRLDVNPHSS VELSPTGYKF FVDLFIKFDK DNDGGLNEDE LNTLFRSTPG IPKLWVESNF 

       370        380        390        400        410        420 
PSSIVCNEEG YVTLQGWLAQ WNLTTFLSYK TTLEYLAYLG FDEGNSTKAL KVTKPRKIRQ 

       430        440        450        460        470        480 
KNGKTYRNAV NDRNVFNCFI VGAPKAGKSS LLESFLHGSY SDIYSPTIQP RLVVKDIELR 

       490        500        510        520        530        540 
GGKQCYLILE ELGELEPAIL ENKSRLDQCD VICYAYDSSD PESFQYLVEL REKHGHLLDE 

       550        560        570        580        590        600 
VPAVFVALKA DLDKQQQRCD VQPENYTRDL FLNSPLHVSL AWNSSLHEMF IQLVDAAKTP 

       610        620        630        640 
SSATPGIELE VSVDQDDIKH IIMTGAAIAV VGLVSIWVLN SLRR 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000035 Genomic DNA. Translation: EAL00077.1. Different initiation.
AACQ01000036 Genomic DNA. Translation: EAK99972.1. Different initiation.
RefSeqXP_718876.1. XM_713783.1.
XP_718978.1. XM_713885.1.

3D structure databases

ProteinModelPortalQ5ABR2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639354.
3639386.
KEGGcal:CaO19.13437.
cal:CaO19.6016.

Phylogenomic databases

eggNOGCOG1100.
KOK07870.
OrthoDBEOG73545F.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR021181. Rho_GTPase_Mt.
IPR001806. Small_GTPase.
[Graphical view]
PfamPF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF08477. Miro. 2 hits.
[Graphical view]
PIRSFPIRSF037488. Mt_Rho_GTPase. 1 hit.
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGEM1_CANAL
AccessionPrimary (citable) accession number: Q5ABR2
Secondary accession number(s): Q5ABF5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names