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Q5ABR2

- GEM1_CANAL

UniProt

Q5ABR2 - GEM1_CANAL

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Protein
Mitochondrial Rho GTPase 1
Gene
GEM1, CaO19.13437, CaO19.6016
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTP 1 Reviewed prediction
Nucleotide bindingi41 – 433GTP 1 Reviewed prediction
Nucleotide bindingi95 – 984GTP 1 Reviewed prediction
Calcium bindingi181 – 192121 Reviewed prediction
Add
BLAST
Calcium bindingi329 – 340122 Reviewed prediction
Add
BLAST
Nucleotide bindingi442 – 4498GTP 2 Reviewed prediction
Nucleotide bindingi478 – 4825GTP 2 Reviewed prediction
Nucleotide bindingi548 – 5514GTP 2 Reviewed prediction

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. calcium ion binding Source: InterPro

GO - Biological processi

  1. cellular homeostasis Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Alternative name(s):
GTPase EF-hand protein of mitochondria 1
Gene namesi
Name:GEM1
ORF Names:CaO19.13437, CaO19.6016
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 620620Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei621 – 64121Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini642 – 6443Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Mitochondrial Rho GTPase 1
PRO_0000239332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005047.

Structurei

3D structure databases

ProteinModelPortaliQ5ABR2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 124124Miro 1
Add
BLAST
Domaini168 – 20336EF-hand 1
Add
BLAST
Domaini316 – 35136EF-hand 2
Add
BLAST
Domaini429 – 582154Miro 2
Add
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.
Contains 2 Miro domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1100.
KOiK07870.
OrthoDBiEOG73545F.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR021181. Rho_GTPase_Mt.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF08477. Miro. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ABR2-1 [UniParc]FASTAAdd to Basket

« Hide

MKNKRKHNNK RERERERESS INNVQPNEIS EYIPNITTII DTSSSDMTNL    50
QKELKRADVI WLVYSDHYTY ERISLHWMPL FRSMGVNLPI ILCANKSDLF 100
PKSKSNLKST NSDEFVPLIN EFKEIEAGVR CSAKNNYNVV EAFYLCQRAV 150
THPISPIFDA KEGNLKPGAI KPLKRIFWLS DTDQDGYLNF EELSELHKKC 200
FGIEASKSDY EEIVNLIDQK ILPSYNTTIE TQTPPQQQHL ATSAGTPNGT 250
TTTTSKGISE DGFILLNKIY AESGRHETVW CILRAYHYTN SLSLSDKFLY 300
PRLDVNPHSS VELSPTGYKF FVDLFIKFDK DNDGGLNEDE LNTLFRSTPG 350
IPKLWVESNF PSSIVCNEEG YVTLQGWLAQ WNLTTFLSYK TTLEYLAYLG 400
FDEGNSTKAL KVTKPRKIRQ KNGKTYRNAV NDRNVFNCFI VGAPKAGKSS 450
LLESFLHGSY SDIYSPTIQP RLVVKDIELR GGKQCYLILE ELGELEPAIL 500
ENKSRLDQCD VICYAYDSSD PESFQYLVEL REKHGHLLDE VPAVFVALKA 550
DLDKQQQRCD VQPENYTRDL FLNSPLHVSL AWNSSLHEMF IQLVDAAKTP 600
SSATPGIELE VSVDQDDIKH IIMTGAAIAV VGLVSIWVLN SLRR 644
Length:644
Mass (Da):73,194
Last modified:June 13, 2006 - v2
Checksum:iC0297BBAA933951F
GO

Sequence cautioni

The sequence EAK99972.1 differs from that shown. Reason: Erroneous initiation.
The sequence EAL00077.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti575 – 5751P → L in allele CaO19.13437.
Natural varianti629 – 6291A → T in allele CaO19.13437.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00077.1. Different initiation.
AACQ01000036 Genomic DNA. Translation: EAK99972.1. Different initiation.
RefSeqiXP_718876.1. XM_713783.1.
XP_718978.1. XM_713885.1.

Genome annotation databases

GeneIDi3639354.
3639386.
KEGGical:CaO19.13437.
cal:CaO19.6016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00077.1 . Different initiation.
AACQ01000036 Genomic DNA. Translation: EAK99972.1 . Different initiation.
RefSeqi XP_718876.1. XM_713783.1.
XP_718978.1. XM_713885.1.

3D structure databases

ProteinModelPortali Q5ABR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639354.
3639386.
KEGGi cal:CaO19.13437.
cal:CaO19.6016.

Phylogenomic databases

eggNOGi COG1100.
KOi K07870.
OrthoDBi EOG73545F.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR021181. Rho_GTPase_Mt.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF08477. Miro. 2 hits.
[Graphical view ]
PIRSFi PIRSF037488. Mt_Rho_GTPase. 1 hit.
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiGEM1_CANAL
AccessioniPrimary (citable) accession number: Q5ABR2
Secondary accession number(s): Q5ABF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi