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Q5ABR2

- GEM1_CANAL

UniProt

Q5ABR2 - GEM1_CANAL

Protein

Mitochondrial Rho GTPase 1

Gene

GEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTP 1Sequence Analysis
    Nucleotide bindingi41 – 433GTP 1Sequence Analysis
    Nucleotide bindingi95 – 984GTP 1Sequence Analysis
    Calcium bindingi181 – 192121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi329 – 340122PROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi442 – 4498GTP 2Sequence Analysis
    Nucleotide bindingi478 – 4825GTP 2Sequence Analysis
    Nucleotide bindingi548 – 5514GTP 2Sequence Analysis

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. GTPase activity Source: InterPro
    3. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular homeostasis Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium, GTP-binding, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
    Alternative name(s):
    GTPase EF-hand protein of mitochondria 1
    Gene namesi
    Name:GEM1
    ORF Names:CaO19.13437, CaO19.6016
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 644644Mitochondrial Rho GTPase 1PRO_0000239332Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0005047.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ABR2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 620620Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini642 – 6443CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei621 – 64121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 124124Miro 1Add
    BLAST
    Domaini168 – 20336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini316 – 35136EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini429 – 582154Miro 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the mitochondrial Rho GTPase family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 Miro domains.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1100.
    KOiK07870.
    OrthoDBiEOG73545F.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR013566. EF_hand_assoc_1.
    IPR013567. EF_hand_assoc_2.
    IPR002048. EF_hand_dom.
    IPR020860. MIRO.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR021181. Rho_GTPase_Mt.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF13202. EF-hand_5. 1 hit.
    PF08355. EF_assoc_1. 1 hit.
    PF08356. EF_assoc_2. 1 hit.
    PF08477. Miro. 2 hits.
    [Graphical view]
    PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS51423. MIRO. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ABR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNKRKHNNK RERERERESS INNVQPNEIS EYIPNITTII DTSSSDMTNL    50
    QKELKRADVI WLVYSDHYTY ERISLHWMPL FRSMGVNLPI ILCANKSDLF 100
    PKSKSNLKST NSDEFVPLIN EFKEIEAGVR CSAKNNYNVV EAFYLCQRAV 150
    THPISPIFDA KEGNLKPGAI KPLKRIFWLS DTDQDGYLNF EELSELHKKC 200
    FGIEASKSDY EEIVNLIDQK ILPSYNTTIE TQTPPQQQHL ATSAGTPNGT 250
    TTTTSKGISE DGFILLNKIY AESGRHETVW CILRAYHYTN SLSLSDKFLY 300
    PRLDVNPHSS VELSPTGYKF FVDLFIKFDK DNDGGLNEDE LNTLFRSTPG 350
    IPKLWVESNF PSSIVCNEEG YVTLQGWLAQ WNLTTFLSYK TTLEYLAYLG 400
    FDEGNSTKAL KVTKPRKIRQ KNGKTYRNAV NDRNVFNCFI VGAPKAGKSS 450
    LLESFLHGSY SDIYSPTIQP RLVVKDIELR GGKQCYLILE ELGELEPAIL 500
    ENKSRLDQCD VICYAYDSSD PESFQYLVEL REKHGHLLDE VPAVFVALKA 550
    DLDKQQQRCD VQPENYTRDL FLNSPLHVSL AWNSSLHEMF IQLVDAAKTP 600
    SSATPGIELE VSVDQDDIKH IIMTGAAIAV VGLVSIWVLN SLRR 644
    Length:644
    Mass (Da):73,194
    Last modified:June 13, 2006 - v2
    Checksum:iC0297BBAA933951F
    GO

    Sequence cautioni

    The sequence EAK99972.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAL00077.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti575 – 5751P → L in allele CaO19.13437.
    Natural varianti629 – 6291A → T in allele CaO19.13437.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000035 Genomic DNA. Translation: EAL00077.1. Different initiation.
    AACQ01000036 Genomic DNA. Translation: EAK99972.1. Different initiation.
    RefSeqiXP_718876.1. XM_713783.1.
    XP_718978.1. XM_713885.1.

    Genome annotation databases

    GeneIDi3639354.
    3639386.
    KEGGical:CaO19.13437.
    cal:CaO19.6016.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000035 Genomic DNA. Translation: EAL00077.1 . Different initiation.
    AACQ01000036 Genomic DNA. Translation: EAK99972.1 . Different initiation.
    RefSeqi XP_718876.1. XM_713783.1.
    XP_718978.1. XM_713885.1.

    3D structure databases

    ProteinModelPortali Q5ABR2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639354.
    3639386.
    KEGGi cal:CaO19.13437.
    cal:CaO19.6016.

    Phylogenomic databases

    eggNOGi COG1100.
    KOi K07870.
    OrthoDBi EOG73545F.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    3.40.50.300. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR013566. EF_hand_assoc_1.
    IPR013567. EF_hand_assoc_2.
    IPR002048. EF_hand_dom.
    IPR020860. MIRO.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR021181. Rho_GTPase_Mt.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF13202. EF-hand_5. 1 hit.
    PF08355. EF_assoc_1. 1 hit.
    PF08356. EF_assoc_2. 1 hit.
    PF08477. Miro. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF037488. Mt_Rho_GTPase. 1 hit.
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS51423. MIRO. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiGEM1_CANAL
    AccessioniPrimary (citable) accession number: Q5ABR2
    Secondary accession number(s): Q5ABF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3