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Q5ABR2

- GEM1_CANAL

UniProt

Q5ABR2 - GEM1_CANAL

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Protein

Mitochondrial Rho GTPase 1

Gene

GEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTP 1Sequence Analysis
Nucleotide bindingi41 – 433GTP 1Sequence Analysis
Nucleotide bindingi95 – 984GTP 1Sequence Analysis
Calcium bindingi181 – 192121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi329 – 340122PROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi442 – 4498GTP 2Sequence Analysis
Nucleotide bindingi478 – 4825GTP 2Sequence Analysis
Nucleotide bindingi548 – 5514GTP 2Sequence Analysis

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. GTPase activity Source: InterPro
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular homeostasis Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Alternative name(s):
GTPase EF-hand protein of mitochondria 1
Gene namesi
Name:GEM1
ORF Names:CaO19.13437, CaO19.6016
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Mitochondrial Rho GTPase 1PRO_0000239332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005047.

Structurei

3D structure databases

ProteinModelPortaliQ5ABR2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 620620Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini642 – 6443CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei621 – 64121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 124124Miro 1Add
BLAST
Domaini168 – 20336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini316 – 35136EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini429 – 582154Miro 2Add
BLAST

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 Miro domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1100.
InParanoidiQ5ABR2.
KOiK07870.
OrthoDBiEOG73545F.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR021181. Rho_GTPase_Mt.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF08477. Miro. 2 hits.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ABR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNKRKHNNK RERERERESS INNVQPNEIS EYIPNITTII DTSSSDMTNL
60 70 80 90 100
QKELKRADVI WLVYSDHYTY ERISLHWMPL FRSMGVNLPI ILCANKSDLF
110 120 130 140 150
PKSKSNLKST NSDEFVPLIN EFKEIEAGVR CSAKNNYNVV EAFYLCQRAV
160 170 180 190 200
THPISPIFDA KEGNLKPGAI KPLKRIFWLS DTDQDGYLNF EELSELHKKC
210 220 230 240 250
FGIEASKSDY EEIVNLIDQK ILPSYNTTIE TQTPPQQQHL ATSAGTPNGT
260 270 280 290 300
TTTTSKGISE DGFILLNKIY AESGRHETVW CILRAYHYTN SLSLSDKFLY
310 320 330 340 350
PRLDVNPHSS VELSPTGYKF FVDLFIKFDK DNDGGLNEDE LNTLFRSTPG
360 370 380 390 400
IPKLWVESNF PSSIVCNEEG YVTLQGWLAQ WNLTTFLSYK TTLEYLAYLG
410 420 430 440 450
FDEGNSTKAL KVTKPRKIRQ KNGKTYRNAV NDRNVFNCFI VGAPKAGKSS
460 470 480 490 500
LLESFLHGSY SDIYSPTIQP RLVVKDIELR GGKQCYLILE ELGELEPAIL
510 520 530 540 550
ENKSRLDQCD VICYAYDSSD PESFQYLVEL REKHGHLLDE VPAVFVALKA
560 570 580 590 600
DLDKQQQRCD VQPENYTRDL FLNSPLHVSL AWNSSLHEMF IQLVDAAKTP
610 620 630 640
SSATPGIELE VSVDQDDIKH IIMTGAAIAV VGLVSIWVLN SLRR
Length:644
Mass (Da):73,194
Last modified:June 13, 2006 - v2
Checksum:iC0297BBAA933951F
GO

Sequence cautioni

The sequence EAK99972.1 differs from that shown. Reason: Erroneous initiation.
The sequence EAL00077.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti575 – 5751P → L in allele CaO19.13437.
Natural varianti629 – 6291A → T in allele CaO19.13437.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00077.1. Different initiation.
AACQ01000036 Genomic DNA. Translation: EAK99972.1. Different initiation.
RefSeqiXP_718876.1. XM_713783.1.
XP_718978.1. XM_713885.1.

Genome annotation databases

GeneIDi3639354.
3639386.
KEGGical:CaO19.13437.
cal:CaO19.6016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00077.1 . Different initiation.
AACQ01000036 Genomic DNA. Translation: EAK99972.1 . Different initiation.
RefSeqi XP_718876.1. XM_713783.1.
XP_718978.1. XM_713885.1.

3D structure databases

ProteinModelPortali Q5ABR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639354.
3639386.
KEGGi cal:CaO19.13437.
cal:CaO19.6016.

Phylogenomic databases

eggNOGi COG1100.
InParanoidi Q5ABR2.
KOi K07870.
OrthoDBi EOG73545F.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO.
IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR021181. Rho_GTPase_Mt.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF08477. Miro. 2 hits.
[Graphical view ]
PIRSFi PIRSF037488. Mt_Rho_GTPase. 1 hit.
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiGEM1_CANAL
AccessioniPrimary (citable) accession number: Q5ABR2
Secondary accession number(s): Q5ABF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3