Q5ABQ7 (ATG3_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 3

Alternative name(s):
Autophagy-related E2-like conjugation enzyme ATG3

Gene names

Name:	ATG3
ORF Names:	CaO19.6020, CaO19.13441

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative E2-like conjugating enzyme involved in autophagy and for the cytoplasm to vacuole transport (Cvt) By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATG3 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport Ubl conjugation pathway
Cellular component	Cytoplasm
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Autophagy-related protein 3		PRO_0000213576
Sites
	Active site	244	1	Glycyl thioester intermediate By similarity
Natural variations
	Natural variant	306	1	V → G in allele CaO19.13441.
	Natural variant	320	1	V → D in allele CaO19.13441.
	Natural variant	324	1	I → M in allele CaO19.13441.
	Natural variant	327	1	D → E in allele CaO19.13441.

Sequences

	Sequence		Length	Mass (Da)
	Q5ABQ7 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 7478664F0EB50243	FASTA	333	38,620
	10 20 30 40 50 60 MSLRSKLSSL REYLTPINHN SNFVTTGEIS PEEFVKAGDY LVYKFPTWQW GNDCPKNLQK 70 80 90 100 110 120 SFLPPDKQYL VTRHVPSYQR ASNYLTGEDK KGANPEEDDE EEEEEDEEGW VKSKKIHKVI 130 140 150 160 170 180 DDTHDSQINK GEEINDIDDF IDENAEEQEH DQIGDHELDD DEFDDLDIIN DSKNNKLRRF 190 200 210 220 230 240 DLYITYSTSY RVPKLYLVGF DSNGIPLLPQ QMFEDINSDY KDKTATIENL PVAHNTTSVS 250 260 270 280 290 300 IHPCKHSSVM KVLMKHSKLN KKNLQQKDES LSDDLSKLSV NEKKTQDEHS QINNDDKEEE 310 320 330 EEGIRVDHYL IIFLKFIASV TPGIEYDYTM DAL

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000035 Genomic DNA. Translation: EAL00081.1. AACQ01000036 Genomic DNA. Translation: EAK99976.1.
RefSeq	XP_718880.1. XM_713787.1. XP_718982.1. XM_713889.1.
3D structure databases
ProteinModelPortal	Q5ABQ7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ABQ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639358. 3639390.
KEGG	cal:CaO19.13441. cal:CaO19.6020.
Organism-specific databases
CGD	CAL0005067. orf19.6020.
Phylogenomic databases
PhylomeDB	Q5ABQ7.
Family and domain databases
InterPro	IPR007135. Autophagy-rel_prot_3. IPR019461. Autophagy-rel_prot_3_C. IPR007134. Autophagy-rel_prot_3_N. [Graphical view]
KO	K08343.
Pfam	PF03987. Autophagy_act_C. 1 hit. PF10381. Autophagy_Cterm. 1 hit. PF03986. Autophagy_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG3_CANAL

Accession

Primary (citable) accession number: Q5ABQ7
Secondary accession number(s): Q5ABF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program