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Q5ABG1

- SET1_CANAL

UniProt

Q5ABG1 - SET1_CANAL

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

SET1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis.1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K4 specific) Source: CGD

    GO - Biological processi

    1. cellular developmental process Source: CGD
    2. filamentous growth Source: CGD
    3. histone H3-K4 methylation Source: CGD
    4. induction by symbiont of host defense response Source: CGD
    5. pathogenesis Source: CGD
    6. phenotypic switching Source: CGD

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
    Alternative name(s):
    COMPASS component SET1
    SET domain-containing protein 1
    Gene namesi
    Name:SET1
    ORF Names:CaO19.13430, CaO19.6009
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005024. SET1.

    Subcellular locationi

    Nucleus Curated. Chromosome Curated

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10401040Histone-lysine N-methyltransferase, H3 lysine-4 specificPRO_0000269767Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005024.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ABG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini898 – 1015118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1024 – 104017Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi626 – 728103Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    KOiK11422.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ABG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYNNRSGGG ASGGYSRRGY HGSHRGGYRT GRSKYPEDRY LVGGMLSLNK     50
    GSHYESSDNR YIPNEIGSKS PENRSHRSST KDGRTPSGLS TPLSSSDKVS 100
    TPISIESING SDRNTGVNNK DSEFPKLSHH SDFTSTIPFS RSINPQKNFM 150
    VINDSHTPKT DKGIQSKKIR YNGEGVNHVS DPRIAQSNSN LQKPTKKTKK 200
    TPYKQLPQPK FVYNSDSLGP APMSTIIIWD LPISTSEPFL RNFVSRYGNP 250
    LEEMTFITDP TTAVPLGIVT FKFQGNPQKA SELAKNFIKT VRQDELKIDG 300
    ATLKIALNDN ENQLLNRKLE SAKKKMLQQR LQREQEEEKR RQKLVEEQKK 350
    QELLKKKEKE HQESVKKEKS VEHESTIVST RDKNLVYKPN STVLSMRHNH 400
    KIISSVILPK DLEKYIKSRP YILIRDKYVP TKKISSHDIK RALKKYDWTR 450
    VLSDKSGFFI VFNSLNECER CFLNEDNKKF FEYKLVMEMA IPEGFTNNIR 500
    ENESKSTNDV LDEATNILIK EFQTFLAKDI RERIIAPNIL DLLAHDKYPE 550
    LVEELKSREQ AAKPKVLVTN NQLKENALSI LEKQRQLFQQ RLPSFRMSHD 600
    RTQQHKPKRR NSIIPMQHAL NFDDDEDSES HSQSESEDED EDETTASRPL 650
    TPVVSTMKRE RSSTITSIED DIELEEREIK KQKVKVPAIE AEIAPESSPE 700
    EGEEEEKEEV EIKQEAEEVD IKFQPTEESP RTVYPEIPFS GDFDLNALQH 750
    TIKDSEDLLL AQEVLSETTP SGLSNIEYWS WKSKNRKDVQ EISQEEEYIE 800
    ELPESLQSTT GSFKSEGVRK IPEIEKIGYL PHRKRTNKPI KTIQYEDEDE 850
    EKPNENTNAV QSSRVNRANN RRFAADITAQ IGSESDVLSL NALTKRKKPV 900
    TFARSAIHNW GLYAMEPIAA KEMIIEYVGE RIRQQVAEHR EKSYLKTGIG 950
    SSYLFRIDDN TVIDATKKGG IARFINHCCS PSCTAKIIKV EGKKRIVIYA 1000
    LRDIEANEEL TYDYKFERET NDEERIRCLC GAPGCKGYLN 1040
    Length:1,040
    Mass (Da):119,161
    Last modified:April 26, 2005 - v1
    Checksum:i30A4796C4C7B0160
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000035 Genomic DNA. Translation: EAL00070.1.
    AACQ01000036 Genomic DNA. Translation: EAK99965.1.
    RefSeqiXP_718869.1. XM_713776.1.
    XP_718971.1. XM_713878.1.

    Genome annotation databases

    GeneIDi3639280.
    3639438.
    KEGGical:CaO19.13430.
    cal:CaO19.6009.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000035 Genomic DNA. Translation: EAL00070.1 .
    AACQ01000036 Genomic DNA. Translation: EAK99965.1 .
    RefSeqi XP_718869.1. XM_713776.1.
    XP_718971.1. XM_713878.1.

    3D structure databases

    ProteinModelPortali Q5ABG1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639280.
    3639438.
    KEGGi cal:CaO19.13430.
    cal:CaO19.6009.

    Organism-specific databases

    CGDi CAL0005024. SET1.

    Phylogenomic databases

    eggNOGi COG2940.
    KOi K11422.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis."
      Raman S.B., Nguyen M.H., Zhang Z., Cheng S., Jia H.Y., Weisner N., Iczkowski K., Clancy C.J.
      Mol. Microbiol. 60:697-709(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSET1_CANAL
    AccessioniPrimary (citable) accession number: Q5ABG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3