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Q5ABG1 (SET1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific

EC=2.1.1.43
Alternative name(s):
COMPASS component SET1
SET domain-containing protein 1
Gene names
Name:SET1
ORF Names:CaO19.13430, CaO19.6009
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length1040 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis. Ref.2

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subunit structure

Component of the COMPASS (Set1C) complex By similarity.

Subcellular location

Nucleus Probable. Chromosome Probable.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Contains 1 post-SET domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10401040Histone-lysine N-methyltransferase, H3 lysine-4 specific
PRO_0000269767

Regions

Domain898 – 1015118SET
Domain1024 – 104017Post-SET
Compositional bias626 – 728103Glu-rich

Sequences

Sequence LengthMass (Da)Tools
Q5ABG1 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 30A4796C4C7B0160

FASTA1,040119,161
        10         20         30         40         50         60 
MSYNNRSGGG ASGGYSRRGY HGSHRGGYRT GRSKYPEDRY LVGGMLSLNK GSHYESSDNR 

        70         80         90        100        110        120 
YIPNEIGSKS PENRSHRSST KDGRTPSGLS TPLSSSDKVS TPISIESING SDRNTGVNNK 

       130        140        150        160        170        180 
DSEFPKLSHH SDFTSTIPFS RSINPQKNFM VINDSHTPKT DKGIQSKKIR YNGEGVNHVS 

       190        200        210        220        230        240 
DPRIAQSNSN LQKPTKKTKK TPYKQLPQPK FVYNSDSLGP APMSTIIIWD LPISTSEPFL 

       250        260        270        280        290        300 
RNFVSRYGNP LEEMTFITDP TTAVPLGIVT FKFQGNPQKA SELAKNFIKT VRQDELKIDG 

       310        320        330        340        350        360 
ATLKIALNDN ENQLLNRKLE SAKKKMLQQR LQREQEEEKR RQKLVEEQKK QELLKKKEKE 

       370        380        390        400        410        420 
HQESVKKEKS VEHESTIVST RDKNLVYKPN STVLSMRHNH KIISSVILPK DLEKYIKSRP 

       430        440        450        460        470        480 
YILIRDKYVP TKKISSHDIK RALKKYDWTR VLSDKSGFFI VFNSLNECER CFLNEDNKKF 

       490        500        510        520        530        540 
FEYKLVMEMA IPEGFTNNIR ENESKSTNDV LDEATNILIK EFQTFLAKDI RERIIAPNIL 

       550        560        570        580        590        600 
DLLAHDKYPE LVEELKSREQ AAKPKVLVTN NQLKENALSI LEKQRQLFQQ RLPSFRMSHD 

       610        620        630        640        650        660 
RTQQHKPKRR NSIIPMQHAL NFDDDEDSES HSQSESEDED EDETTASRPL TPVVSTMKRE 

       670        680        690        700        710        720 
RSSTITSIED DIELEEREIK KQKVKVPAIE AEIAPESSPE EGEEEEKEEV EIKQEAEEVD 

       730        740        750        760        770        780 
IKFQPTEESP RTVYPEIPFS GDFDLNALQH TIKDSEDLLL AQEVLSETTP SGLSNIEYWS 

       790        800        810        820        830        840 
WKSKNRKDVQ EISQEEEYIE ELPESLQSTT GSFKSEGVRK IPEIEKIGYL PHRKRTNKPI 

       850        860        870        880        890        900 
KTIQYEDEDE EKPNENTNAV QSSRVNRANN RRFAADITAQ IGSESDVLSL NALTKRKKPV 

       910        920        930        940        950        960 
TFARSAIHNW GLYAMEPIAA KEMIIEYVGE RIRQQVAEHR EKSYLKTGIG SSYLFRIDDN 

       970        980        990       1000       1010       1020 
TVIDATKKGG IARFINHCCS PSCTAKIIKV EGKKRIVIYA LRDIEANEEL TYDYKFERET 

      1030       1040 
NDEERIRCLC GAPGCKGYLN 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis."
Raman S.B., Nguyen M.H., Zhang Z., Cheng S., Jia H.Y., Weisner N., Iczkowski K., Clancy C.J.
Mol. Microbiol. 60:697-709(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000035 Genomic DNA. Translation: EAL00070.1.
AACQ01000036 Genomic DNA. Translation: EAK99965.1.
RefSeqXP_718869.1. XM_713776.1.
XP_718971.1. XM_713878.1.

3D structure databases

ProteinModelPortalQ5ABG1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639280.
3639438.
KEGGcal:CaO19.13430.
cal:CaO19.6009.

Organism-specific databases

CGDCAL0005024. SET1.

Phylogenomic databases

eggNOGCOG2940.
KOK11422.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR015722. Histone-lysine_MeTfrase.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PANTHERPTHR22884:SF10. PTHR22884:SF10. 1 hit.
PfamPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET1_CANAL
AccessionPrimary (citable) accession number: Q5ABG1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names