Q5ABG1 (SET1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific
EC=2.1.1.43

Alternative name(s):
COMPASS component SET1
SET domain-containing protein 1

Gene names

Name:	SET1
ORF Names:	CaO19.13430, CaO19.6009

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	1040 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis. Ref.2
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subunit structure	Component of the COMPASS (Set1C) complex By similarity.
Subcellular location	Nucleus Probable. Chromosome Probable.
Sequence similarities	Contains 1 post-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosome Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular developmental process Inferred from mutant phenotype PubMed 19555456. Source: CGD filamentous growth Inferred from mutant phenotype Ref.2. Source: CGD induction by symbiont of host defense response Inferred from direct assay Ref.2. Source: CGD pathogenesis Inferred from mutant phenotype Ref.2. Source: CGD phenotypic switching Inferred from mutant phenotype PubMed 19555456. Source: CGD
Cellular_component	Set1C/COMPASS complex Inferred from electronic annotation. Source: InterPro chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H3-K4 specific) Inferred from mutant phenotype Ref.2. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1040	1040	Histone-lysine N-methyltransferase, H3 lysine-4 specific		PRO_0000269767
Regions
	Domain	897 – 1019	123	SET
	Domain	1024 – 1040	17	Post-SET
	Compositional bias	626 – 728	103	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5ABG1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 30A4796C4C7B0160	FASTA	1,040	119,161
	10 20 30 40 50 60 MSYNNRSGGG ASGGYSRRGY HGSHRGGYRT GRSKYPEDRY LVGGMLSLNK GSHYESSDNR 70 80 90 100 110 120 YIPNEIGSKS PENRSHRSST KDGRTPSGLS TPLSSSDKVS TPISIESING SDRNTGVNNK 130 140 150 160 170 180 DSEFPKLSHH SDFTSTIPFS RSINPQKNFM VINDSHTPKT DKGIQSKKIR YNGEGVNHVS 190 200 210 220 230 240 DPRIAQSNSN LQKPTKKTKK TPYKQLPQPK FVYNSDSLGP APMSTIIIWD LPISTSEPFL 250 260 270 280 290 300 RNFVSRYGNP LEEMTFITDP TTAVPLGIVT FKFQGNPQKA SELAKNFIKT VRQDELKIDG 310 320 330 340 350 360 ATLKIALNDN ENQLLNRKLE SAKKKMLQQR LQREQEEEKR RQKLVEEQKK QELLKKKEKE 370 380 390 400 410 420 HQESVKKEKS VEHESTIVST RDKNLVYKPN STVLSMRHNH KIISSVILPK DLEKYIKSRP 430 440 450 460 470 480 YILIRDKYVP TKKISSHDIK RALKKYDWTR VLSDKSGFFI VFNSLNECER CFLNEDNKKF 490 500 510 520 530 540 FEYKLVMEMA IPEGFTNNIR ENESKSTNDV LDEATNILIK EFQTFLAKDI RERIIAPNIL 550 560 570 580 590 600 DLLAHDKYPE LVEELKSREQ AAKPKVLVTN NQLKENALSI LEKQRQLFQQ RLPSFRMSHD 610 620 630 640 650 660 RTQQHKPKRR NSIIPMQHAL NFDDDEDSES HSQSESEDED EDETTASRPL TPVVSTMKRE 670 680 690 700 710 720 RSSTITSIED DIELEEREIK KQKVKVPAIE AEIAPESSPE EGEEEEKEEV EIKQEAEEVD 730 740 750 760 770 780 IKFQPTEESP RTVYPEIPFS GDFDLNALQH TIKDSEDLLL AQEVLSETTP SGLSNIEYWS 790 800 810 820 830 840 WKSKNRKDVQ EISQEEEYIE ELPESLQSTT GSFKSEGVRK IPEIEKIGYL PHRKRTNKPI 850 860 870 880 890 900 KTIQYEDEDE EKPNENTNAV QSSRVNRANN RRFAADITAQ IGSESDVLSL NALTKRKKPV 910 920 930 940 950 960 TFARSAIHNW GLYAMEPIAA KEMIIEYVGE RIRQQVAEHR EKSYLKTGIG SSYLFRIDDN 970 980 990 1000 1010 1020 TVIDATKKGG IARFINHCCS PSCTAKIIKV EGKKRIVIYA LRDIEANEEL TYDYKFERET 1030 1040 NDEERIRCLC GAPGCKGYLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis." Raman S.B., Nguyen M.H., Zhang Z., Cheng S., Jia H.Y., Weisner N., Iczkowski K., Clancy C.J. Mol. Microbiol. 60:697-709(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000035 Genomic DNA. Translation: EAL00070.1. AACQ01000036 Genomic DNA. Translation: EAK99965.1.
RefSeq	XP_718869.1. XM_713776.1. XP_718971.1. XM_713878.1.
3D structure databases
ProteinModelPortal	Q5ABG1.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005024.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639280. 3639438.
KEGG	cal:CaO19.13430. cal:CaO19.6009.
Organism-specific databases
CGD	CAL0005024. SET1.
Phylogenomic databases
eggNOG	COG2940.
KO	K11422.
Family and domain databases
InterPro	IPR024657. COMPASS_Set1_N-SET. IPR017111. Hist_H3-K4_MeTrfase_1_fun. IPR015722. Histone-lysine_MeTfrase. IPR003616. Post-SET_dom. IPR024636. SET_assoc. IPR001214. SET_dom. [Graphical view]
PANTHER	PTHR22884:SF10. PTHR22884:SF10. 1 hit.
Pfam	PF11764. N-SET. 1 hit. PF00856. SET. 1 hit. PF11767. SET_assoc. 1 hit. [Graphical view]
PIRSF	PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMART	SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET1_CANAL

Accession

Primary (citable) accession number: Q5ABG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program