SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5ABG1

- SET1_CANAL

UniProt

Q5ABG1 - SET1_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene
SET1, CaO19.13430, CaO19.6009
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K4 specific) Source: CGD

GO - Biological processi

  1. cellular developmental process Source: CGD
  2. filamentous growth Source: CGD
  3. histone H3-K4 methylation Source: CGD
  4. induction by symbiont of host defense response Source: CGD
  5. pathogenesis Source: CGD
  6. phenotypic switching Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
Alternative name(s):
COMPASS component SET1
SET domain-containing protein 1
Gene namesi
Name:SET1
ORF Names:CaO19.13430, CaO19.6009
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005024. SET1.

Subcellular locationi

Nucleus Inferred. Chromosome Inferred

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10401040Histone-lysine N-methyltransferase, H3 lysine-4 specificPRO_0000269767Add
BLAST

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0005024.

Structurei

3D structure databases

ProteinModelPortaliQ5ABG1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini898 – 1015118SETAdd
BLAST
Domaini1024 – 104017Post-SETAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi626 – 728103Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ABG1-1 [UniParc]FASTAAdd to Basket

« Hide

MSYNNRSGGG ASGGYSRRGY HGSHRGGYRT GRSKYPEDRY LVGGMLSLNK     50
GSHYESSDNR YIPNEIGSKS PENRSHRSST KDGRTPSGLS TPLSSSDKVS 100
TPISIESING SDRNTGVNNK DSEFPKLSHH SDFTSTIPFS RSINPQKNFM 150
VINDSHTPKT DKGIQSKKIR YNGEGVNHVS DPRIAQSNSN LQKPTKKTKK 200
TPYKQLPQPK FVYNSDSLGP APMSTIIIWD LPISTSEPFL RNFVSRYGNP 250
LEEMTFITDP TTAVPLGIVT FKFQGNPQKA SELAKNFIKT VRQDELKIDG 300
ATLKIALNDN ENQLLNRKLE SAKKKMLQQR LQREQEEEKR RQKLVEEQKK 350
QELLKKKEKE HQESVKKEKS VEHESTIVST RDKNLVYKPN STVLSMRHNH 400
KIISSVILPK DLEKYIKSRP YILIRDKYVP TKKISSHDIK RALKKYDWTR 450
VLSDKSGFFI VFNSLNECER CFLNEDNKKF FEYKLVMEMA IPEGFTNNIR 500
ENESKSTNDV LDEATNILIK EFQTFLAKDI RERIIAPNIL DLLAHDKYPE 550
LVEELKSREQ AAKPKVLVTN NQLKENALSI LEKQRQLFQQ RLPSFRMSHD 600
RTQQHKPKRR NSIIPMQHAL NFDDDEDSES HSQSESEDED EDETTASRPL 650
TPVVSTMKRE RSSTITSIED DIELEEREIK KQKVKVPAIE AEIAPESSPE 700
EGEEEEKEEV EIKQEAEEVD IKFQPTEESP RTVYPEIPFS GDFDLNALQH 750
TIKDSEDLLL AQEVLSETTP SGLSNIEYWS WKSKNRKDVQ EISQEEEYIE 800
ELPESLQSTT GSFKSEGVRK IPEIEKIGYL PHRKRTNKPI KTIQYEDEDE 850
EKPNENTNAV QSSRVNRANN RRFAADITAQ IGSESDVLSL NALTKRKKPV 900
TFARSAIHNW GLYAMEPIAA KEMIIEYVGE RIRQQVAEHR EKSYLKTGIG 950
SSYLFRIDDN TVIDATKKGG IARFINHCCS PSCTAKIIKV EGKKRIVIYA 1000
LRDIEANEEL TYDYKFERET NDEERIRCLC GAPGCKGYLN 1040
Length:1,040
Mass (Da):119,161
Last modified:April 26, 2005 - v1
Checksum:i30A4796C4C7B0160
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00070.1.
AACQ01000036 Genomic DNA. Translation: EAK99965.1.
RefSeqiXP_718869.1. XM_713776.1.
XP_718971.1. XM_713878.1.

Genome annotation databases

GeneIDi3639280.
3639438.
KEGGical:CaO19.13430.
cal:CaO19.6009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00070.1 .
AACQ01000036 Genomic DNA. Translation: EAK99965.1 .
RefSeqi XP_718869.1. XM_713776.1.
XP_718971.1. XM_713878.1.

3D structure databases

ProteinModelPortali Q5ABG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639280.
3639438.
KEGGi cal:CaO19.13430.
cal:CaO19.6009.

Organism-specific databases

CGDi CAL0005024. SET1.

Phylogenomic databases

eggNOGi COG2940.
KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis."
    Raman S.B., Nguyen M.H., Zhang Z., Cheng S., Jia H.Y., Weisner N., Iczkowski K., Clancy C.J.
    Mol. Microbiol. 60:697-709(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSET1_CANAL
AccessioniPrimary (citable) accession number: Q5ABG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi