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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

SET1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  • histone methyltransferase activity (H3-K4 specific) Source: CGD

GO - Biological processi

  • cellular developmental process Source: CGD
  • filamentous growth Source: CGD
  • histone H3-K4 methylation Source: CGD
  • induction by symbiont of host defense response Source: CGD
  • pathogenesis Source: CGD
  • phenotypic switching Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
Alternative name(s):
COMPASS component SET1
SET domain-containing protein 1
Gene namesi
Name:SET1
ORF Names:CaO19.13430, CaO19.6009
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005024. SET1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10401040Histone-lysine N-methyltransferase, H3 lysine-4 specificPRO_0000269767Add
BLAST

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0005024.

Structurei

3D structure databases

ProteinModelPortaliQ5ABG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini898 – 1015118SETPROSITE-ProRule annotationAdd
BLAST
Domaini1024 – 104017Post-SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi626 – 728103Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ5ABG1.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ABG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNNRSGGG ASGGYSRRGY HGSHRGGYRT GRSKYPEDRY LVGGMLSLNK
60 70 80 90 100
GSHYESSDNR YIPNEIGSKS PENRSHRSST KDGRTPSGLS TPLSSSDKVS
110 120 130 140 150
TPISIESING SDRNTGVNNK DSEFPKLSHH SDFTSTIPFS RSINPQKNFM
160 170 180 190 200
VINDSHTPKT DKGIQSKKIR YNGEGVNHVS DPRIAQSNSN LQKPTKKTKK
210 220 230 240 250
TPYKQLPQPK FVYNSDSLGP APMSTIIIWD LPISTSEPFL RNFVSRYGNP
260 270 280 290 300
LEEMTFITDP TTAVPLGIVT FKFQGNPQKA SELAKNFIKT VRQDELKIDG
310 320 330 340 350
ATLKIALNDN ENQLLNRKLE SAKKKMLQQR LQREQEEEKR RQKLVEEQKK
360 370 380 390 400
QELLKKKEKE HQESVKKEKS VEHESTIVST RDKNLVYKPN STVLSMRHNH
410 420 430 440 450
KIISSVILPK DLEKYIKSRP YILIRDKYVP TKKISSHDIK RALKKYDWTR
460 470 480 490 500
VLSDKSGFFI VFNSLNECER CFLNEDNKKF FEYKLVMEMA IPEGFTNNIR
510 520 530 540 550
ENESKSTNDV LDEATNILIK EFQTFLAKDI RERIIAPNIL DLLAHDKYPE
560 570 580 590 600
LVEELKSREQ AAKPKVLVTN NQLKENALSI LEKQRQLFQQ RLPSFRMSHD
610 620 630 640 650
RTQQHKPKRR NSIIPMQHAL NFDDDEDSES HSQSESEDED EDETTASRPL
660 670 680 690 700
TPVVSTMKRE RSSTITSIED DIELEEREIK KQKVKVPAIE AEIAPESSPE
710 720 730 740 750
EGEEEEKEEV EIKQEAEEVD IKFQPTEESP RTVYPEIPFS GDFDLNALQH
760 770 780 790 800
TIKDSEDLLL AQEVLSETTP SGLSNIEYWS WKSKNRKDVQ EISQEEEYIE
810 820 830 840 850
ELPESLQSTT GSFKSEGVRK IPEIEKIGYL PHRKRTNKPI KTIQYEDEDE
860 870 880 890 900
EKPNENTNAV QSSRVNRANN RRFAADITAQ IGSESDVLSL NALTKRKKPV
910 920 930 940 950
TFARSAIHNW GLYAMEPIAA KEMIIEYVGE RIRQQVAEHR EKSYLKTGIG
960 970 980 990 1000
SSYLFRIDDN TVIDATKKGG IARFINHCCS PSCTAKIIKV EGKKRIVIYA
1010 1020 1030 1040
LRDIEANEEL TYDYKFERET NDEERIRCLC GAPGCKGYLN
Length:1,040
Mass (Da):119,161
Last modified:April 26, 2005 - v1
Checksum:i30A4796C4C7B0160
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00070.1.
AACQ01000036 Genomic DNA. Translation: EAK99965.1.
RefSeqiXP_718869.1. XM_713776.1.
XP_718971.1. XM_713878.1.

Genome annotation databases

GeneIDi3639280.
3639438.
KEGGical:CaO19.13430.
cal:CaO19.6009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00070.1.
AACQ01000036 Genomic DNA. Translation: EAK99965.1.
RefSeqiXP_718869.1. XM_713776.1.
XP_718971.1. XM_713878.1.

3D structure databases

ProteinModelPortaliQ5ABG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0005024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3639280.
3639438.
KEGGical:CaO19.13430.
cal:CaO19.6009.

Organism-specific databases

CGDiCAL0005024. SET1.

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ5ABG1.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis."
    Raman S.B., Nguyen M.H., Zhang Z., Cheng S., Jia H.Y., Weisner N., Iczkowski K., Clancy C.J.
    Mol. Microbiol. 60:697-709(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSET1_CANAL
AccessioniPrimary (citable) accession number: Q5ABG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: May 27, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.