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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

SET1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].

GO - Molecular functioni

  • histone methyltransferase activity (H3-K4 specific) Source: CGD
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • cellular developmental process Source: CGD
  • filamentous growth Source: CGD
  • histone H3-K4 methylation Source: CGD
  • induction by symbiont of host defense response Source: CGD
  • pathogenesis Source: CGD
  • phenotypic switching Source: CGD

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
Alternative name(s):
COMPASS component SET1
SET domain-containing protein 1
Gene namesi
Name:SET1
Ordered Locus Names:CAALFM_C100960CA
ORF Names:CaO19.13430, CaO19.6009
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000198993. SET1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697671 – 1040Histone-lysine N-methyltransferase, H3 lysine-4 specificAdd BLAST1040

Proteomic databases

PRIDEiQ5ABG1.

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.By similarity

Protein-protein interaction databases

ELMiQ5ABG1.

Structurei

3D structure databases

ProteinModelPortaliQ5ABG1.
SMRiQ5ABG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini898 – 1015SETPROSITE-ProRule annotationAdd BLAST118
Domaini1024 – 1040Post-SETPROSITE-ProRule annotationAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi626 – 728Glu-richAdd BLAST103

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ5ABG1.
KOiK11422.
OrthoDBiEOG092C3T9B.

Family and domain databases

InterProiView protein in InterPro
IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiView protein in SMART
SM01291. N-SET. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ABG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNNRSGGG ASGGYSRRGY HGSHRGGYRT GRSKYPEDRY LVGGMLSLNK
60 70 80 90 100
GSHYESSDNR YIPNEIGSKS PENRSHRSST KDGRTPSGLS TPLSSSDKVS
110 120 130 140 150
TPISIESING SDRNTGVNNK DSEFPKLSHH SDFTSTIPFS RSINPQKNFM
160 170 180 190 200
VINDSHTPKT DKGIQSKKIR YNGEGVNHVS DPRIAQSNSN LQKPTKKTKK
210 220 230 240 250
TPYKQLPQPK FVYNSDSLGP APMSTIIIWD LPISTSEPFL RNFVSRYGNP
260 270 280 290 300
LEEMTFITDP TTAVPLGIVT FKFQGNPQKA SELAKNFIKT VRQDELKIDG
310 320 330 340 350
ATLKIALNDN ENQLLNRKLE SAKKKMLQQR LQREQEEEKR RQKLVEEQKK
360 370 380 390 400
QELLKKKEKE HQESVKKEKS VEHESTIVST RDKNLVYKPN STVLSMRHNH
410 420 430 440 450
KIISSVILPK DLEKYIKSRP YILIRDKYVP TKKISSHDIK RALKKYDWTR
460 470 480 490 500
VLSDKSGFFI VFNSLNECER CFLNEDNKKF FEYKLVMEMA IPEGFTNNIR
510 520 530 540 550
ENESKSTNDV LDEATNILIK EFQTFLAKDI RERIIAPNIL DLLAHDKYPE
560 570 580 590 600
LVEELKSREQ AAKPKVLVTN NQLKENALSI LEKQRQLFQQ RLPSFRMSHD
610 620 630 640 650
RTQQHKPKRR NSIIPMQHAL NFDDDEDSES HSQSESEDED EDETTASRPL
660 670 680 690 700
TPVVSTMKRE RSSTITSIED DIELEEREIK KQKVKVPAIE AEIAPESSPE
710 720 730 740 750
EGEEEEKEEV EIKQEAEEVD IKFQPTEESP RTVYPEIPFS GDFDLNALQH
760 770 780 790 800
TIKDSEDLLL AQEVLSETTP SGLSNIEYWS WKSKNRKDVQ EISQEEEYIE
810 820 830 840 850
ELPESLQSTT GSFKSEGVRK IPEIEKIGYL PHRKRTNKPI KTIQYEDEDE
860 870 880 890 900
EKPNENTNAV QSSRVNRANN RRFAADITAQ IGSESDVLSL NALTKRKKPV
910 920 930 940 950
TFARSAIHNW GLYAMEPIAA KEMIIEYVGE RIRQQVAEHR EKSYLKTGIG
960 970 980 990 1000
SSYLFRIDDN TVIDATKKGG IARFINHCCS PSCTAKIIKV EGKKRIVIYA
1010 1020 1030 1040
LRDIEANEEL TYDYKFERET NDEERIRCLC GAPGCKGYLN
Length:1,040
Mass (Da):119,161
Last modified:April 26, 2005 - v1
Checksum:i30A4796C4C7B0160
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW25793.1.
RefSeqiXP_718971.1. XM_713878.1.

Genome annotation databases

GeneIDi3639280.
KEGGical:CAALFM_C100960CA.

Similar proteinsi

Entry informationi

Entry nameiSET1_CANAL
AccessioniPrimary (citable) accession number: Q5ABG1
Secondary accession number(s): A0A1D8PCE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: August 30, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families