Q5ABD0 (SNF7_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar-sorting protein SNF7

Alternative name(s):
Vacuolar protein-sorting-associated protein 32

Gene names

Name:	SNF7
Synonyms:	VPS32
ORF Names:	CaO19.13461, CaO19.6040

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. Ref.2
Subunit structure	A component of the endosomal sorting required for transport complex III (ESCRT-III) By similarity.
Subcellular location	Cytoplasm By similarity. Endosome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the SNF7 family.

Ontologies

Keywords
Cellular component	Cytoplasm Endosome Membrane
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to drug Inferred from mutant phenotype PubMed 17005841. Source: CGD cellular response to lithium ion Inferred from mutant phenotype Ref.2PubMed 20581294. Source: CGD cellular response to pH Inferred from mutant phenotype PubMed 15371534Ref.2PubMed 16299290. Source: CGD filamentous growth of a population of unicellular organisms in response to neutral pH Inferred from mutant phenotype PubMed 20581294. Source: CGD fungal-type cell wall organization Inferred from mutant phenotype PubMed 17005841. Source: CGD late endosome to vacuole transport Inferred from mutant phenotype Ref.2PubMed 20026677. Source: CGD pathogenesis Inferred from mutant phenotype PubMed 16299290PubMed 20581294. Source: CGD protein processing Inferred from mutant phenotype Ref.2. Source: CGD protein targeting to vacuole Inferred from mutant phenotype PubMed 18974864. Source: CGD signal transduction Inferred from genetic interaction Ref.2. Source: CGD
Cellular_component	ESCRT III complex Inferred from direct assay PubMed 20026677. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Vacuolar-sorting protein SNF7		PRO_0000211437
Regions
	Coiled coil	18 – 182	165	Potential
	Compositional bias	209 – 215	7	Asp/Glu-rich (acidic)

Sequences

	Sequence		Length	Mass (Da)
	Q5ABD0 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 9570B3B1E1C0419F	FASTA	226	25,890
	10 20 30 40 50 60 MWGYFFGGNS QQKKDLPKKA IVELREHIQT LNKKKNHLQQ QMDDQDQLAR KYVSSKQTTL 70 80 90 100 110 120 AKSALKRKKG YESNLLKVEN QIETLETQLI SIEGANLNLE TMKAMKQGAK AMKQIHGEYD 130 140 150 160 170 180 VDKVEDTMDE IREQVELADE ISEAISRPVG NEFVDEDELD EELKELEAEA KEQEQEHRVP 190 200 210 220 AQKAKPQPVS REEELPQFPS VNKKAPVVEE DEDEEALKAL QAEMGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Snf7p, a component of the ESCRT-III protein complex, is an upstream member of the RIM101 pathway in Candida albicans." Kullas A.L., Li M., Davis D.A. Eukaryot. Cell 3:1609-1618(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000035 Genomic DNA. Translation: EAL00101.1. AACQ01000036 Genomic DNA. Translation: EAK99996.1.
RefSeq	XP_718900.1. XM_713807.1. XP_719002.1. XM_713909.1.
3D structure databases
ProteinModelPortal	Q5ABD0.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005125.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639377. 3639478.
KEGG	cal:CaO19.13461. cal:CaO19.6040.
Organism-specific databases
CGD	CAL0005125. SNF7.
Phylogenomic databases
eggNOG	NOG291419.
KO	K12194.
Family and domain databases
InterPro	IPR005024. Snf7. [Graphical view]
Pfam	PF03357. Snf7. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SNF7_CANAL

Accession

Primary (citable) accession number: Q5ABD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program