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Q5ABD0 (SNF7_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar-sorting protein SNF7
Alternative name(s):
Vacuolar protein-sorting-associated protein 32
Gene names
Name:SNF7
Synonyms:VPS32
ORF Names:CaO19.13461, CaO19.6040
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. Ref.2

Subunit structure

A component of the endosomal sorting required for transport complex III (ESCRT-III) By similarity.

Subcellular location

Cytoplasm By similarity. Endosome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the SNF7 family.

Ontologies

Keywords
   Cellular componentCytoplasm
Endosome
Membrane
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to drug

Inferred from mutant phenotype PubMed 17005841PubMed 17604452. Source: CGD

cellular response to lithium ion

Inferred from mutant phenotype Ref.2PubMed 20581294. Source: CGD

cellular response to pH

Inferred from mutant phenotype PubMed 15371534Ref.2PubMed 16299290PubMed 20581294. Source: CGD

filamentous growth

Inferred from mutant phenotype PubMed 15371534Ref.2PubMed 20581294. Source: CGD

filamentous growth of a population of unicellular organisms

Inferred from mutant phenotype Ref.2. Source: CGD

filamentous growth of a population of unicellular organisms in response to neutral pH

Inferred from mutant phenotype PubMed 20581294. Source: CGD

filamentous growth of a population of unicellular organisms in response to pH

Inferred from mutant phenotype PubMed 15371534PubMed 20581294. Source: CGD

fungal-type cell wall organization

Inferred from mutant phenotype PubMed 17005841. Source: CGD

late endosome to vacuole transport

Inferred from mutant phenotype Ref.2PubMed 20026677. Source: CGD

pathogenesis

Inferred from mutant phenotype PubMed 16299290PubMed 20581294. Source: CGD

positive regulation of transcription, DNA-templated

Traceable author statement PubMed 10341421. Source: CGD

protein processing

Inferred from mutant phenotype Ref.2. Source: CGD

protein targeting to vacuole

Inferred from mutant phenotype PubMed 18974864. Source: CGD

signal transduction

Inferred from genetic interaction Ref.2. Source: CGD

   Cellular_componentESCRT III complex

Inferred from direct assay PubMed 20026677. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Vacuolar-sorting protein SNF7
PRO_0000211437

Regions

Coiled coil18 – 182165 Potential
Compositional bias209 – 2157Asp/Glu-rich (acidic)

Sequences

Sequence LengthMass (Da)Tools
Q5ABD0 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 9570B3B1E1C0419F

FASTA22625,890
        10         20         30         40         50         60 
MWGYFFGGNS QQKKDLPKKA IVELREHIQT LNKKKNHLQQ QMDDQDQLAR KYVSSKQTTL 

        70         80         90        100        110        120 
AKSALKRKKG YESNLLKVEN QIETLETQLI SIEGANLNLE TMKAMKQGAK AMKQIHGEYD 

       130        140        150        160        170        180 
VDKVEDTMDE IREQVELADE ISEAISRPVG NEFVDEDELD EELKELEAEA KEQEQEHRVP 

       190        200        210        220 
AQKAKPQPVS REEELPQFPS VNKKAPVVEE DEDEEALKAL QAEMGL 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Snf7p, a component of the ESCRT-III protein complex, is an upstream member of the RIM101 pathway in Candida albicans."
Kullas A.L., Li M., Davis D.A.
Eukaryot. Cell 3:1609-1618(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000035 Genomic DNA. Translation: EAL00101.1.
AACQ01000036 Genomic DNA. Translation: EAK99996.1.
RefSeqXP_718900.1. XM_713807.1.
XP_719002.1. XM_713909.1.

3D structure databases

ProteinModelPortalQ5ABD0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1222572. 1 interaction.
STRING5476.CAL0005125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639377.
3639478.
KEGGcal:CaO19.13461.
cal:CaO19.6040.

Organism-specific databases

CGDCAL0005125. SNF7.

Phylogenomic databases

eggNOGNOG291419.
KOK12194.
OrthoDBEOG72RN9W.

Family and domain databases

InterProIPR005024. Snf7.
[Graphical view]
PfamPF03357. Snf7. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSNF7_CANAL
AccessionPrimary (citable) accession number: Q5ABD0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names