ID Q5ABC3_CANAL Unreviewed; 426 AA. AC Q5ABC3; DT 26-APR-2005, integrated into UniProtKB/TrEMBL. DT 26-APR-2005, sequence version 1. DT 27-MAR-2024, entry version 146. DE RecName: Full=Elongation factor Tu {ECO:0000256|RuleBase:RU000325}; GN Name=TUF1 {ECO:0000313|CGD:CAL0000198818, GN ECO:0000313|EMBL:AOW25757.1}; GN OrderedLocusNames=CAALFM_C100590WA {ECO:0000313|EMBL:AOW25757.1}, GN orf19.13468 {ECO:0000313|CGD:CAL0000198818}; OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW25757.1, ECO:0000313|Proteomes:UP000000559}; RN [1] {ECO:0000313|EMBL:AOW25757.1, ECO:0000313|Proteomes:UP000000559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559}; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., RA Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). RN [2] {ECO:0000313|EMBL:AOW25757.1, ECO:0000313|Proteomes:UP000000559} RP GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559}; RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52; RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D., RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M., RA Chibana H., Nantel A., Magee P.T.; RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned RT on the eight chromosomes."; RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007). RN [3] {ECO:0000313|EMBL:AOW25757.1, ECO:0000313|Proteomes:UP000000559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559}; RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97; RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.; RT "Assembly of a phased diploid Candida albicans genome facilitates allele- RT specific measurements and provides a simple model for repeat and indel RT structure."; RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013). CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl- CC tRNA to the A-site of ribosomes during protein biosynthesis. CC {ECO:0000256|RuleBase:RU000325}. CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A CC subfamily. {ECO:0000256|ARBA:ARBA00007249, CC ECO:0000256|RuleBase:RU000325}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP017623; AOW25757.1; -; Genomic_DNA. DR RefSeq; XP_719009.1; XM_713916.1. DR AlphaFoldDB; Q5ABC3; -. DR SMR; Q5ABC3; -. DR STRING; 237561.Q5ABC3; -. DR EnsemblFungi; C1_00590W_A-T; C1_00590W_A-T-p1; C1_00590W_A. DR GeneID; 3639360; -. DR KEGG; cal:CAALFM_C100590WA; -. DR CGD; CAL0000198818; TUF1. DR VEuPathDB; FungiDB:C1_00590W_A; -. DR eggNOG; KOG0460; Eukaryota. DR HOGENOM; CLU_007265_0_0_1; -. DR InParanoid; Q5ABC3; -. DR OMA; FHNNYRP; -. DR OrthoDB; 167272at2759; -. DR Proteomes; UP000000559; Chromosome 1. DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule. DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central. DR GO; GO:0070125; P:mitochondrial translational elongation; IBA:GO_Central. DR CDD; cd01884; EF_Tu; 1. DR CDD; cd03697; EFTU_II; 1. DR CDD; cd03707; EFTU_III; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 2.40.30.10; Translation factors; 2. DR HAMAP; MF_00118_B; EF_Tu_B; 1. DR InterPro; IPR041709; EF-Tu_GTP-bd. DR InterPro; IPR004161; EFTu-like_2. DR InterPro; IPR033720; EFTU_2. DR InterPro; IPR031157; G_TR_CS. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR000795; T_Tr_GTP-bd_dom. DR InterPro; IPR009000; Transl_B-barrel_sf. DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C. DR InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org. DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C. DR NCBIfam; TIGR00485; EF-Tu; 1. DR NCBIfam; TIGR00231; small_GTP; 1. DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1. DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1. DR Pfam; PF00009; GTP_EFTU; 1. DR Pfam; PF03144; GTP_EFTU_D2; 1. DR Pfam; PF03143; GTP_EFTU_D3; 1. DR PRINTS; PR00315; ELONGATNFCT. DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF50447; Translation proteins; 1. DR PROSITE; PS00301; G_TR_1; 1. DR PROSITE; PS51722; G_TR_2; 1. PE 3: Inferred from homology; KW Elongation factor {ECO:0000256|ARBA:ARBA00022768, KW ECO:0000256|RuleBase:RU000325}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU000325}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}; KW Reference proteome {ECO:0000313|Proteomes:UP000000559}. FT DOMAIN 34..230 FT /note="Tr-type G" FT /evidence="ECO:0000259|PROSITE:PS51722" SQ SEQUENCE 426 AA; 46706 MW; 1D34A7214D825F7C CRC64; MLKTLTQTLR LTGKAFPKVR PALIRTYAAF DRSKPHVNIG TIGHVDHGKT TLTAAITKVL AEQGGANFLD YGSIDRAPEE RARGITISTA HVEYETKNRH YAHVDCPGHA DYIKNMITGA AQMDGAIIVV AATDGQMPQT REHLLLARQV GVQDLVVFVN KVDTIDDPEM LELVEMEMRE LLSTYGFDGD NTPVIMGSAL MALEDKKPEI GKEAILKLLD AVDEHIPTPS RDLEQPFLLP VEDVFSISGR GTVVTGRVER GVLKKGEEIE IVGGFDKPYK TTVTGIEMFK KELDSAMAGD NCGVLLRGVK RDEIKRGMVL AKPGTATSHK KFLASLYILT SEEGGRSTPF GEGYKPQCFF RTNDVTTTFS FPEGEGVDHS QMIMPGDNIE MVGELIKSCP LEVNQRFNLR EGGKTVGTGL ITRIIE //