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Protein

Autophagy-related protein 18

Gene

ATG18

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 18
Gene namesi
Name:ATG18
Ordered Locus Names:CAALFM_C100430WA
ORF Names:CaO19.13485, CaO19.6064
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000198706. orf19.6064.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508621 – 558Autophagy-related protein 18Add BLAST558

Proteomic databases

PRIDEiQ5ABA6.

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5ABA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati247 – 287WD 1Add BLAST41
Repeati292 – 331WD 2Add BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi288 – 292FRRGT-motifBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi370 – 389Asp-richAdd BLAST20

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiQ5ABA6.
KOiK17908.
OrthoDBiEOG092C3UKJ.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 2 hits.
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiView protein in PROSITE
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ABA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTSSSSAT ASLQQQLSKQ YANSFSNDGS SFSSKNNQQY SEIVNYISFN
60 70 80 90 100
QDASCITIGL KNGYKIFNCQ PNFGRSFQFK NDESTGIVEM LYCTSLLATV
110 120 130 140 150
AQGEEIGSSP RKLKIINTKT KSTICDLIFP STILQVKLTN TRLIVVLEDQ
160 170 180 190 200
IYLYDITTMK LLHTIETSPN LSGLSAISYD DSNSYLAYPS PPKTITHDSL
210 220 230 240 250
LASGINTNGG SNSTQNNISS VSNTPNRVGD VIIFNLTSLQ PISVIEAHKS
260 270 280 290 300
TIASMAFSNN GLYLATASDK GTIVRIFEVA TGTKLYQFRR GTYPTKIYSL
310 320 330 340 350
RFSADDKYVL ATSSSLTVHI FRLGEEEALE TKHKKKKIPA VATILEEETE
360 370 380 390 400
GSQSNEQTKS IKRNSEEFED IRDDGDDSDV DDEDGDIDDE SLEVIPAKQR
410 420 430 440 450
KLSQGSTNSY TSVNSEDVQS NSPKTEPLID QNRLSMARII RRSSQTLGRK
460 470 480 490 500
AAQKMGDFLP SRFSSILEPT RNFASLKINA HSKDTKSVAV MNNVLQQDLI
510 520 530 540 550
PQTYLASDNA SAKQDFMEVS LFHIYVVTTE GMLYTYGLDP ERGGDCILLN

SHCILDEY
Length:558
Mass (Da):61,694
Last modified:April 12, 2017 - v2
Checksum:iF9293487492E473C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW25741.1.
RefSeqiXP_719026.2. XM_713933.2.

Genome annotation databases

GeneIDi3639285.
KEGGical:CAALFM_C100430WA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW25741.1.
RefSeqiXP_719026.2. XM_713933.2.

3D structure databases

ProteinModelPortaliQ5ABA6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5ABA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3639285.
KEGGical:CAALFM_C100430WA.

Organism-specific databases

CGDiCAL0000198706. orf19.6064.

Phylogenomic databases

InParanoidiQ5ABA6.
KOiK17908.
OrthoDBiEOG092C3UKJ.

Miscellaneous databases

PROiPR:Q5ABA6.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 2 hits.
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiView protein in PROSITE
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATG18_CANAL
AccessioniPrimary (citable) accession number: Q5ABA6
Secondary accession number(s): A0A1D8PC80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: April 12, 2017
Last modified: June 7, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.