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Q5ABA6

- ATG18_CANAL

UniProt

Q5ABA6 - ATG18_CANAL

Protein

Autophagy-related protein 18

Gene

ATG18

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication By similarity.By similarity

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 18
    Gene namesi
    Name:ATG18
    ORF Names:CaO19.13485, CaO19.6064
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005165. orf19.6064.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
    3. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Autophagy-related protein 18PRO_0000050862Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PI(3,5)P2 regulatory complex.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005165.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ABA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati247 – 28741WD 1Add
    BLAST
    Repeati292 – 33140WD 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi288 – 2925FRRGT-motifBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi370 – 38920Asp-richAdd
    BLAST

    Domaini

    The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
    The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

    Sequence similaritiesi

    Belongs to the WD repeat SVP1 family.Curated
    Contains 2 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG317564.
    KOiK17908.
    OrthoDBiEOG7BW0V3.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ABA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQTSSSSAT ASLQQQLSKQ YANSFSNDGS SFSSKNNQQY SEIVNYISFN    50
    QDASCITIGL KNGYKIFNCQ PNFGRSFQFK NDESTGIVEM LYCTSLLATV 100
    AQGEEIGSSP RKLKIINTKT KSTICDLIFP STILQVKLTN TRLIVVLEDQ 150
    IYLYDITTMK LLHTIETSPN LSGLSAISYD DSNSYLAYPS PPKTITHDSL 200
    LASGINTNGG SNSTQNNISS VSNTPNRVGD VIIFNLTSLQ PISVIEAHKS 250
    TIASMAFSNN GLYLATASDK GTIVRIFEVA TGTKLYQFRR GTYPTKIYSL 300
    RFSADDKYVL ATSSSLTVHI FRLGEEEALE TKHKKKKIPA VATILEEETE 350
    GSQSNEQTKS IKRNSEEFED IRDDGDDSDV DDEDGDIDDE SLEVIPAKQR 400
    KLSQGSTNSY TSVNSEDVQS NSPKTEPLID QNRLSMARII RRSSQTLGRK 450
    AAQKMGDFLP SRFSSILEPT RNFASLKINA HSKDTKSVAV MNNVLQQDLI 500
    PQTYLASDNA SAKQDLMEVS LFHIYVVTTE GMLYTYGLDP ERGGDCILLN 550
    SHCILDEY 558
    Length:558
    Mass (Da):61,660
    Last modified:April 26, 2005 - v1
    Checksum:iF9293CAFEBAC473C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000035 Genomic DNA. Translation: EAL00125.1.
    AACQ01000036 Genomic DNA. Translation: EAL00020.1.
    RefSeqiXP_718924.1. XM_713831.1.
    XP_719026.1. XM_713933.1.

    Genome annotation databases

    GeneIDi3639285.
    3639421.
    KEGGical:CaO19.13485.
    cal:CaO19.6064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000035 Genomic DNA. Translation: EAL00125.1 .
    AACQ01000036 Genomic DNA. Translation: EAL00020.1 .
    RefSeqi XP_718924.1. XM_713831.1.
    XP_719026.1. XM_713933.1.

    3D structure databases

    ProteinModelPortali Q5ABA6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005165.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639285.
    3639421.
    KEGGi cal:CaO19.13485.
    cal:CaO19.6064.

    Organism-specific databases

    CGDi CAL0005165. orf19.6064.

    Phylogenomic databases

    eggNOGi NOG317564.
    KOi K17908.
    OrthoDBi EOG7BW0V3.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiATG18_CANAL
    AccessioniPrimary (citable) accession number: Q5ABA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3