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Protein

Autophagy-related protein 18

Gene

ATG18

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 18
Gene namesi
Name:ATG18
ORF Names:CaO19.13485, CaO19.6064
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005165. orf19.6064.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Autophagy-related protein 18PRO_0000050862Add
BLAST

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5ABA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati247 – 28741WD 1Add
BLAST
Repeati292 – 33140WD 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi288 – 2925FRRGT-motifBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi370 – 38920Asp-richAdd
BLAST

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 2 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317564.
InParanoidiQ5ABA6.
KOiK17908.
OrthoDBiEOG7BW0V3.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ABA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTSSSSAT ASLQQQLSKQ YANSFSNDGS SFSSKNNQQY SEIVNYISFN
60 70 80 90 100
QDASCITIGL KNGYKIFNCQ PNFGRSFQFK NDESTGIVEM LYCTSLLATV
110 120 130 140 150
AQGEEIGSSP RKLKIINTKT KSTICDLIFP STILQVKLTN TRLIVVLEDQ
160 170 180 190 200
IYLYDITTMK LLHTIETSPN LSGLSAISYD DSNSYLAYPS PPKTITHDSL
210 220 230 240 250
LASGINTNGG SNSTQNNISS VSNTPNRVGD VIIFNLTSLQ PISVIEAHKS
260 270 280 290 300
TIASMAFSNN GLYLATASDK GTIVRIFEVA TGTKLYQFRR GTYPTKIYSL
310 320 330 340 350
RFSADDKYVL ATSSSLTVHI FRLGEEEALE TKHKKKKIPA VATILEEETE
360 370 380 390 400
GSQSNEQTKS IKRNSEEFED IRDDGDDSDV DDEDGDIDDE SLEVIPAKQR
410 420 430 440 450
KLSQGSTNSY TSVNSEDVQS NSPKTEPLID QNRLSMARII RRSSQTLGRK
460 470 480 490 500
AAQKMGDFLP SRFSSILEPT RNFASLKINA HSKDTKSVAV MNNVLQQDLI
510 520 530 540 550
PQTYLASDNA SAKQDLMEVS LFHIYVVTTE GMLYTYGLDP ERGGDCILLN

SHCILDEY
Length:558
Mass (Da):61,660
Last modified:April 26, 2005 - v1
Checksum:iF9293CAFEBAC473C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00125.1.
AACQ01000036 Genomic DNA. Translation: EAL00020.1.
RefSeqiXP_718924.1. XM_713831.1.
XP_719026.1. XM_713933.1.

Genome annotation databases

GeneIDi3639285.
3639421.
KEGGical:CaO19.13485.
cal:CaO19.6064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00125.1.
AACQ01000036 Genomic DNA. Translation: EAL00020.1.
RefSeqiXP_718924.1. XM_713831.1.
XP_719026.1. XM_713933.1.

3D structure databases

ProteinModelPortaliQ5ABA6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3639285.
3639421.
KEGGical:CaO19.13485.
cal:CaO19.6064.

Organism-specific databases

CGDiCAL0005165. orf19.6064.

Phylogenomic databases

eggNOGiNOG317564.
InParanoidiQ5ABA6.
KOiK17908.
OrthoDBiEOG7BW0V3.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiATG18_CANAL
AccessioniPrimary (citable) accession number: Q5ABA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: April 26, 2005
Last modified: June 24, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.