SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5ABA6

- ATG18_CANAL

UniProt

Q5ABA6 - ATG18_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Autophagy-related protein 18
Gene
ATG18, CaO19.13485, CaO19.6064
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication By similarity.

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 18
Gene namesi
Name:ATG18
ORF Names:CaO19.13485, CaO19.6064
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005165. orf19.6064.

Subcellular locationi

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
  3. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Autophagy-related protein 18
PRO_0000050862Add
BLAST

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0005165.

Structurei

3D structure databases

ProteinModelPortaliQ5ABA6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati247 – 28741WD 1
Add
BLAST
Repeati292 – 33140WD 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi288 – 2925FRRGT-motif By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi370 – 38920Asp-rich
Add
BLAST

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane By similarity.
The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions By similarity.

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.
Contains 2 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317564.
KOiK17908.
OrthoDBiEOG7BW0V3.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ABA6-1 [UniParc]FASTAAdd to Basket

« Hide

MLQTSSSSAT ASLQQQLSKQ YANSFSNDGS SFSSKNNQQY SEIVNYISFN    50
QDASCITIGL KNGYKIFNCQ PNFGRSFQFK NDESTGIVEM LYCTSLLATV 100
AQGEEIGSSP RKLKIINTKT KSTICDLIFP STILQVKLTN TRLIVVLEDQ 150
IYLYDITTMK LLHTIETSPN LSGLSAISYD DSNSYLAYPS PPKTITHDSL 200
LASGINTNGG SNSTQNNISS VSNTPNRVGD VIIFNLTSLQ PISVIEAHKS 250
TIASMAFSNN GLYLATASDK GTIVRIFEVA TGTKLYQFRR GTYPTKIYSL 300
RFSADDKYVL ATSSSLTVHI FRLGEEEALE TKHKKKKIPA VATILEEETE 350
GSQSNEQTKS IKRNSEEFED IRDDGDDSDV DDEDGDIDDE SLEVIPAKQR 400
KLSQGSTNSY TSVNSEDVQS NSPKTEPLID QNRLSMARII RRSSQTLGRK 450
AAQKMGDFLP SRFSSILEPT RNFASLKINA HSKDTKSVAV MNNVLQQDLI 500
PQTYLASDNA SAKQDLMEVS LFHIYVVTTE GMLYTYGLDP ERGGDCILLN 550
SHCILDEY 558
Length:558
Mass (Da):61,660
Last modified:April 26, 2005 - v1
Checksum:iF9293CAFEBAC473C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00125.1.
AACQ01000036 Genomic DNA. Translation: EAL00020.1.
RefSeqiXP_718924.1. XM_713831.1.
XP_719026.1. XM_713933.1.

Genome annotation databases

GeneIDi3639285.
3639421.
KEGGical:CaO19.13485.
cal:CaO19.6064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000035 Genomic DNA. Translation: EAL00125.1 .
AACQ01000036 Genomic DNA. Translation: EAL00020.1 .
RefSeqi XP_718924.1. XM_713831.1.
XP_719026.1. XM_713933.1.

3D structure databases

ProteinModelPortali Q5ABA6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005165.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639285.
3639421.
KEGGi cal:CaO19.13485.
cal:CaO19.6064.

Organism-specific databases

CGDi CAL0005165. orf19.6064.

Phylogenomic databases

eggNOGi NOG317564.
KOi K17908.
OrthoDBi EOG7BW0V3.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 2 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiATG18_CANAL
AccessioniPrimary (citable) accession number: Q5ABA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi