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Q5ABA6 (ATG18_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Autophagy-related protein 18
Gene names
Name:ATG18
ORF Names:CaO19.13485, CaO19.6064
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication By similarity.

Subunit structure

Component of the PI(3,5)P2 regulatory complex By similarity.

Subcellular location

Preautophagosomal structure membrane; Peripheral membrane protein By similarity. Vacuole membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.

Domain

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane By similarity.

The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions By similarity.

Sequence similarities

Belongs to the WD repeat SVP1 family.

Contains 2 WD repeats.

Ontologies

Keywords
   Biological processAutophagy
Protein transport
Transport
   Cellular componentEndosome
Membrane
Vacuole
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processautophagy

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

pre-autophagosomal structure membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Autophagy-related protein 18
PRO_0000050862

Regions

Repeat247 – 28741WD 1
Repeat292 – 33140WD 2
Motif288 – 2925FRRGT-motif By similarity
Compositional bias370 – 38920Asp-rich

Sequences

Sequence LengthMass (Da)Tools
Q5ABA6 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: F9293CAFEBAC473C

FASTA55861,660
        10         20         30         40         50         60 
MLQTSSSSAT ASLQQQLSKQ YANSFSNDGS SFSSKNNQQY SEIVNYISFN QDASCITIGL 

        70         80         90        100        110        120 
KNGYKIFNCQ PNFGRSFQFK NDESTGIVEM LYCTSLLATV AQGEEIGSSP RKLKIINTKT 

       130        140        150        160        170        180 
KSTICDLIFP STILQVKLTN TRLIVVLEDQ IYLYDITTMK LLHTIETSPN LSGLSAISYD 

       190        200        210        220        230        240 
DSNSYLAYPS PPKTITHDSL LASGINTNGG SNSTQNNISS VSNTPNRVGD VIIFNLTSLQ 

       250        260        270        280        290        300 
PISVIEAHKS TIASMAFSNN GLYLATASDK GTIVRIFEVA TGTKLYQFRR GTYPTKIYSL 

       310        320        330        340        350        360 
RFSADDKYVL ATSSSLTVHI FRLGEEEALE TKHKKKKIPA VATILEEETE GSQSNEQTKS 

       370        380        390        400        410        420 
IKRNSEEFED IRDDGDDSDV DDEDGDIDDE SLEVIPAKQR KLSQGSTNSY TSVNSEDVQS 

       430        440        450        460        470        480 
NSPKTEPLID QNRLSMARII RRSSQTLGRK AAQKMGDFLP SRFSSILEPT RNFASLKINA 

       490        500        510        520        530        540 
HSKDTKSVAV MNNVLQQDLI PQTYLASDNA SAKQDLMEVS LFHIYVVTTE GMLYTYGLDP 

       550 
ERGGDCILLN SHCILDEY 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000035 Genomic DNA. Translation: EAL00125.1.
AACQ01000036 Genomic DNA. Translation: EAL00020.1.
RefSeqXP_718924.1. XM_713831.1.
XP_719026.1. XM_713933.1.

3D structure databases

ProteinModelPortalQ5ABA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639285.
3639421.
KEGGcal:CaO19.13485.
cal:CaO19.6064.

Organism-specific databases

CGDCAL0005165. orf19.6064.

Phylogenomic databases

eggNOGNOG317564.
KOK17908.
OrthoDBEOG7BW0V3.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
PROSITEPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATG18_CANAL
AccessionPrimary (citable) accession number: Q5ABA6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names