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Q5AAJ8

- RT109_CANAL

UniProt

Q5AAJ8 - RT109_CANAL

Protein

Histone acetyltransferase RTT109

Gene

RTT109

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G2/M phase of the cell cycle and is involved in transcription DNA repair process. Required for efficient pathogenesis in mice suggesting that efficient DNA repair is required for pathogenesis. Plays an important role in the regulation of white-opaque genotoxin induced-switching.3 Publications

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. H3 histone acetyltransferase activity Source: CGD
    2. histone acetyltransferase activity (H3-K56 specific) Source: CGD

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: UniProtKB-KW
    2. filamentous growth Source: CGD
    3. filamentous growth of a population of unicellular organisms Source: CGD
    4. histone acetylation Source: CGD
    5. histone H3-K56 acetylation Source: CGD
    6. negative regulation of filamentous growth of a population of unicellular organisms Source: CGD
    7. pathogenesis Source: CGD
    8. phenotypic switching Source: CGD
    9. regulation of phenotypic switching Source: CGD
    10. regulation of transcription, DNA-templated Source: UniProtKB-KW
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    DNA damage, Transcription, Transcription regulation, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase RTT109 (EC:2.3.1.48)
    Gene namesi
    Name:RTT109
    ORF Names:CaO19.7491
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005733. orf19.7491.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Leads to a decreased pathogenicity in mice and increased susceptibility to killing by macrophages in vitro.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Histone acetyltransferase RTT109PRO_0000420188Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0005733.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RTT109 family.Curated

    Phylogenomic databases

    eggNOGiCOG5087.
    KOiK11309.
    OrthoDBiEOG79PJZ1.

    Family and domain databases

    InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR016849. Histone_H3-K56_AcTrfase_yeast.
    [Graphical view]
    PfamiPF08214. KAT11. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027124. Histone_acetylase_Rtt109. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5AAJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPPDILQNG EFETIYFQTN PTYIKSPIHI PKSTIGKPDT VKIRHFFALL    50
    HQDLVVLGLE VFVYLQIYSD FVEKYVYVSK CDTVGLEKST IKIGKVIGPV 100
    LQYIINYNGY KIKMKNLDEK SKDLSDPSTL VRLQRLRDKL PDIYPNLPYY 150
    NDIPPKEECI EYRTLPKTQN LRLCVFTKPA KEYLFPNSAK NPYKNLLNGQ 200
    SLLRWWISII DSITKGWNNH KLMIPGADKY ATRKFIEKYS DWSEGHIFKK 250
    DGLAVQAIPL FPDDPKGRFL ELVIVECRYG KMTVSRFYQE LAYRQEFLLG 300
    DCVSLIGCCK ENLEVTYHDD SVSTVTISEY KEFMNSLKSV DFSDRVEVSN 350
    FVSNYRKSK 359
    Length:359
    Mass (Da):41,735
    Last modified:April 26, 2005 - v1
    Checksum:iDABD3DCD9A24DDF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000039 Genomic DNA. Translation: EAK99733.1.
    RefSeqiXP_718648.1. XM_713555.1.

    Genome annotation databases

    GeneIDi3639678.
    KEGGical:CaO19.7491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000039 Genomic DNA. Translation: EAK99733.1 .
    RefSeqi XP_718648.1. XM_713555.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639678.
    KEGGi cal:CaO19.7491.

    Organism-specific databases

    CGDi CAL0005733. orf19.7491.

    Phylogenomic databases

    eggNOGi COG5087.
    KOi K11309.
    OrthoDBi EOG79PJZ1.

    Family and domain databases

    InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR016849. Histone_H3-K56_AcTrfase_yeast.
    [Graphical view ]
    Pfami PF08214. KAT11. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027124. Histone_acetylase_Rtt109. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy."
      Wurtele H., Tsao S., Lepine G., Mullick A., Tremblay J., Drogaris P., Lee E.H., Thibault P., Verreault A., Raymond M.
      Nat. Med. 16:774-780(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis."
      Lopes da Rosa J., Boyartchuk V.L., Zhu L.J., Kaufman P.D.
      Proc. Natl. Acad. Sci. U.S.A. 107:1594-1599(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    4. "Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3."
      Stevenson J.S., Liu H.
      Mol. Microbiol. 81:1078-1091(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRT109_CANAL
    AccessioniPrimary (citable) accession number: Q5AAJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2012
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3