Q5AAJ8 (RT109_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase RTT109
EC=2.3.1.48

Gene names

Name:	RTT109
ORF Names:	CaO19.7491

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G2/M phase of the cell cycle and is involved in transcription DNA repair process. Required for efficient pathogenesis in mice suggesting that efficient DNA repair is required for pathogenesis. Plays an important role in the regulation of white-opaque genotoxin induced-switching. Ref.2 Ref.3 Ref.4
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus By similarity.
Disruption phenotype	Leads to a decreased pathogenicity in mice and increased susceptibility to killing by macrophages in vitro. Ref.3
Sequence similarities	Belongs to the RTT109 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair Transcription Transcription regulation Virulence
Cellular component	Nucleus
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW filamentous growth of a population of unicellular organisms Inferred from mutant phenotype Ref.3. Source: CGD negative regulation of filamentous growth of a population of unicellular organisms Inferred from mutant phenotype Ref.3. Source: CGD pathogenesis Inferred from mutant phenotype Ref.3. Source: CGD phenotypic switching Inferred from mutant phenotype Ref.4. Source: CGD regulation of phenotypic switching Inferred from mutant phenotype Ref.4. Source: CGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity (H3-K56 specific) Inferred from mutant phenotype Ref.2. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Histone acetyltransferase RTT109		PRO_0000420188

Sequences

	Sequence		Length	Mass (Da)
	Q5AAJ8 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: DABD3DCD9A24DDF4	FASTA	359	41,735
	10 20 30 40 50 60 MLPPDILQNG EFETIYFQTN PTYIKSPIHI PKSTIGKPDT VKIRHFFALL HQDLVVLGLE 70 80 90 100 110 120 VFVYLQIYSD FVEKYVYVSK CDTVGLEKST IKIGKVIGPV LQYIINYNGY KIKMKNLDEK 130 140 150 160 170 180 SKDLSDPSTL VRLQRLRDKL PDIYPNLPYY NDIPPKEECI EYRTLPKTQN LRLCVFTKPA 190 200 210 220 230 240 KEYLFPNSAK NPYKNLLNGQ SLLRWWISII DSITKGWNNH KLMIPGADKY ATRKFIEKYS 250 260 270 280 290 300 DWSEGHIFKK DGLAVQAIPL FPDDPKGRFL ELVIVECRYG KMTVSRFYQE LAYRQEFLLG 310 320 330 340 350 DCVSLIGCCK ENLEVTYHDD SVSTVTISEY KEFMNSLKSV DFSDRVEVSN FVSNYRKSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy." Wurtele H., Tsao S., Lepine G., Mullick A., Tremblay J., Drogaris P., Lee E.H., Thibault P., Verreault A., Raymond M. Nat. Med. 16:774-780(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[3]	"Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis." Lopes da Rosa J., Boyartchuk V.L., Zhu L.J., Kaufman P.D. Proc. Natl. Acad. Sci. U.S.A. 107:1594-1599(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[4]	"Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3." Stevenson J.S., Liu H. Mol. Microbiol. 81:1078-1091(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000039 Genomic DNA. Translation: EAK99733.1.
RefSeq	XP_718648.1. XM_713555.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005733.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639678.
KEGG	cal:CaO19.7491.
Organism-specific databases
CGD	CAL0005733. orf19.7491.
Phylogenomic databases
eggNOG	COG5087.
KO	K11309.
Family and domain databases
InterPro	IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR016849. Histone_H3-K56_AcTrfase_yeast. [Graphical view]
Pfam	PF08214. KAT11. 1 hit. [Graphical view]
PIRSF	PIRSF027124. Histone_acetylase_Rtt109. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RT109_CANAL

Accession

Primary (citable) accession number: Q5AAJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2012
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program